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The map label for this gene is mutM

Identifier: 38234118

GI number: 38234118

Start: 1569776

End: 1570666

Strand: Reverse

Name: mutM

Synonym: DIP1543

Alternate gene names: 38234118

Gene position: 1570666-1569776 (Counterclockwise)

Preceding gene: 38234119

Following gene: 38234117

Centisome position: 63.11

GC content: 48.6

Gene sequence:

>891_bases
ATGCCTGAGCTTCCTGAAGTTGAGGTTGTACGTCGCGGGCTAACACCTTATGTGCTTGGCGCAACTATCACTGATGTTGC
CGTTGAGCACCCCCGCAGCATTAGGACAATCGAAGGCGGGGCCGCCGAACTCATAGGGTCGCTACAAGGTCGTGAGGTCA
CGCGCATAGGTCGCCGTGGCAAATTTTTGTGGTTTGAGCTCACAGGCCATGGTGATTATGCATGCGGATTTCCTCAGCAA
GGGCTACTGGTTCATTTGGGAATGAGCGGTCAAATGCTGATAAAAACTCAAAACTCGGCTCTGCATCCTCATCGTAGAAT
TCGTACCACGATTGTTCGCTCAGATGCTCAGGAATGCTTCGAGCTTTGGTTTGTCGATCAGCGCACTTTTGGCTATTGGG
CACCCACCACATTTGTAGAAACTGCTCACGGTTGCGTTCCAGAACAGATCACTCACATAGCGCGTGATCTTTTGGACCCT
CAACTCAAAAGAGAAAATCTAGCGCGATTGATCCGCAAGAAAAATAGTGAGATTAAAAGAGTTCTGCTTAACCAAGAAAT
TGTCTCTGGAATAGGCAATATTTACGCCGATGAGATGTTGTGGGCTGCACGAATCCATCCACAAACTCCTGCGTCGCATT
TGTCTGTCGCACAATTAAGTAATTTGCTCGAACACGGTCAGCGAGTCATGAACGCGGCTTTAGACCAAGGTGGAACTAGC
TTCGATTCTCTTTATGTTAACGTCAATGGCCAATCGGGGTATTTTGATGTATCGCTTCATGCATACGGCCAGCAAGGCCA
AGCGTGCGATCGCTGTGGTTCGAATATTATCCGCGAAAAGTTTGCTAACCGCTCGAGTCATTTTTGCCCACGTTGTCAGC
TTATGCACTAG

Upstream 100 bases:

>100_bases
TTGGAACAAACAAAAAACTTGCGGAGCAAGCTGCAGCCCACAAAGCGGTTGGCTTCCTTCAAGATAATCCCGCGTTTGTC
TAACAACTCGGAGGATCTTC

Downstream 100 bases:

>100_bases
GCCACAATGAGTGATCGACATAGCATTGTCGCGGAAAACGTTATCAAAACCATAGGTAAATTTACGTGATGGCTGCATGT
GCCAGTACTATTTCACTCTA

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MPELPEVEVVRRGLTPYVLGATITDVAVEHPRSIRTIEGGAAELIGSLQGREVTRIGRRGKFLWFELTGHGDYACGFPQQ
GLLVHLGMSGQMLIKTQNSALHPHRRIRTTIVRSDAQECFELWFVDQRTFGYWAPTTFVETAHGCVPEQITHIARDLLDP
QLKRENLARLIRKKNSEIKRVLLNQEIVSGIGNIYADEMLWAARIHPQTPASHLSVAQLSNLLEHGQRVMNAALDQGGTS
FDSLYVNVNGQSGYFDVSLHAYGQQGQACDRCGSNIIREKFANRSSHFCPRCQLMH

Sequences:

>Translated_296_residues
MPELPEVEVVRRGLTPYVLGATITDVAVEHPRSIRTIEGGAAELIGSLQGREVTRIGRRGKFLWFELTGHGDYACGFPQQ
GLLVHLGMSGQMLIKTQNSALHPHRRIRTTIVRSDAQECFELWFVDQRTFGYWAPTTFVETAHGCVPEQITHIARDLLDP
QLKRENLARLIRKKNSEIKRVLLNQEIVSGIGNIYADEMLWAARIHPQTPASHLSVAQLSNLLEHGQRVMNAALDQGGTS
FDSLYVNVNGQSGYFDVSLHAYGQQGQACDRCGSNIIREKFANRSSHFCPRCQLMH
>Mature_295_residues
PELPEVEVVRRGLTPYVLGATITDVAVEHPRSIRTIEGGAAELIGSLQGREVTRIGRRGKFLWFELTGHGDYACGFPQQG
LLVHLGMSGQMLIKTQNSALHPHRRIRTTIVRSDAQECFELWFVDQRTFGYWAPTTFVETAHGCVPEQITHIARDLLDPQ
LKRENLARLIRKKNSEIKRVLLNQEIVSGIGNIYADEMLWAARIHPQTPASHLSVAQLSNLLEHGQRVMNAALDQGGTSF
DSLYVNVNGQSGYFDVSLHAYGQQGQACDRCGSNIIREKFANRSSHFCPRCQLMH

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger

Homologues:

Organism=Escherichia coli, GI1790066, Length=293, Percent_Identity=34.8122866894198, Blast_Score=159, Evalue=3e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FPG_CORDI (Q6NGH4)

Other databases:

- EMBL:   BX248358
- RefSeq:   NP_939885.1
- ProteinModelPortal:   Q6NGH4
- SMR:   Q6NGH4
- GeneID:   2650732
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1543
- NMPDR:   fig|257309.1.peg.1476
- HOGENOM:   HBG690070
- OMA:   RMTGQLL
- PhylomeDB:   Q6NGH4
- ProtClustDB:   PRK01103
- BioCyc:   CDIP257309:DIP1543-MONOMER
- BRENDA:   3.2.2.23
- BRENDA:   4.2.99.18
- HAMAP:   MF_00103
- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663
- SMART:   SM00898
- TIGRFAMs:   TIGR00577

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS; SSF81624 Form_DNAglyc_cat; SSF46946 Ribosomal_H2TH

EC number: =3.2.2.23; =4.2.99.18

Molecular weight: Translated: 33183; Mature: 33052

Theoretical pI: Translated: 8.10; Mature: 8.10

Prosite motif: PS51068 FPG_CAT; PS01242 ZF_FPG_1; PS51066 ZF_FPG_2

Important sites: ACT_SITE 2-2 ACT_SITE 3-3 ACT_SITE 61-61 ACT_SITE 284-284 BINDING 104-104 BINDING 128-128 BINDING 174-174

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVEVVRRGLTPYVLGATITDVAVEHPRSIRTIEGGAAELIGSLQGREVTRIGRRG
CCCCCHHHHHHCCCCCEEHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCCCHHHHHCCCC
KFLWFELTGHGDYACGFPQQGLLVHLGMSGQMLIKTQNSALHPHRRIRTTIVRSDAQECF
CEEEEEEECCCCCCCCCCCCCEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
ELWFVDQRTFGYWAPTTFVETAHGCVPEQITHIARDLLDPQLKRENLARLIRKKNSEIKR
HHHHHCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHCCHHHHH
VLLNQEIVSGIGNIYADEMLWAARIHPQTPASHLSVAQLSNLLEHGQRVMNAALDQGGTS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
FDSLYVNVNGQSGYFDVSLHAYGQQGQACDRCGSNIIREKFANRSSHFCPRCQLMH
EEEEEEEECCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
PELPEVEVVRRGLTPYVLGATITDVAVEHPRSIRTIEGGAAELIGSLQGREVTRIGRRG
CCCCHHHHHHCCCCCEEHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCCCHHHHHCCCC
KFLWFELTGHGDYACGFPQQGLLVHLGMSGQMLIKTQNSALHPHRRIRTTIVRSDAQECF
CEEEEEEECCCCCCCCCCCCCEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
ELWFVDQRTFGYWAPTTFVETAHGCVPEQITHIARDLLDPQLKRENLARLIRKKNSEIKR
HHHHHCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHCCHHHHH
VLLNQEIVSGIGNIYADEMLWAARIHPQTPASHLSVAQLSNLLEHGQRVMNAALDQGGTS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
FDSLYVNVNGQSGYFDVSLHAYGQQGQACDRCGSNIIREKFANRSSHFCPRCQLMH
EEEEEEEECCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14602910