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The map label for this gene is rnc

Identifier: 38234119

GI number: 38234119

Start: 1570684

End: 1571433

Strand: Reverse

Name: rnc

Synonym: DIP1544

Alternate gene names: 38234119

Gene position: 1571433-1570684 (Counterclockwise)

Preceding gene: 38234120

Following gene: 38234118

Centisome position: 63.14

GC content: 50.53

Gene sequence:

>750_bases
GTGAGCAGGAGAAAAAAGCGCGTCACTGGTGAGCAGGCGCTACGACTTGAATTCGAGAGCGTTGATCACCAACCACTGAT
TGATGCGTTGGGGGTTGACATCCCACGTGAGCTACTCGTGCTGGCGTTAACACACCGTTCGTTTGCAAACGAAAATGGCA
TGCTGCCCAACAATGAGCGCTTGGAGTTTCTAGGCGATTCCGTCTTAGGACTTTCTGTCGCAGGGCAGTTGTATCAGCAG
TACACGTCGAGCCCTGAAAGCGATATTTCCAAGATGCGCGCGAGTATCGTGAGCCGTTATGGGCTTGCAGACATTGCTCG
CGAAATTAACCTAGGGCAGCACATTTTGCTGGGTAAAGGTGAACAGCTTCACGACGGTCGCAGCAAAGACTCAATTCTCG
CAGATACGACGGAGGCGCTTCTCGGTGCTATCTACCTAGCGCATGGTTTTGAAATTGCTCGTGACACGGTGCTTCGTTTG
TTCAAGCACAAAATTGATACGGCAAGTGCTACGGGTCTTCACCAAGATTGGAAAACCACCTTGCAAGAGCGTTTGGCAGA
GCGCAACCTTGAGATGCCAACATATACCTCTACTGTTACAGGTCCAGAGCATGAGCAAACTTTCACAGCAGAGGTTGCAG
TTCATGGCACTGTGCTAGGAACTGGTGTTGGAACAAACAAAAAACTTGCGGAGCAAGCTGCAGCCCACAAAGCGGTTGGC
TTCCTTCAAGATAATCCCGCGTTTGTCTAA

Upstream 100 bases:

>100_bases
GCGGTTGTGTGCAGTCGGATTCTGATGTGCCAGAACCTGATGGTATTGCAGGAGAAACAGAACTAGTTGATCCTCGTTGG
GCTGGATTGGAGAAGTTCCT

Downstream 100 bases:

>100_bases
CAACTCGGAGGATCTTCATGCCTGAGCTTCCTGAAGTTGAGGTTGTACGTCGCGGGCTAACACCTTATGTGCTTGGCGCA
ACTATCACTGATGTTGCCGT

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MSRRKKRVTGEQALRLEFESVDHQPLIDALGVDIPRELLVLALTHRSFANENGMLPNNERLEFLGDSVLGLSVAGQLYQQ
YTSSPESDISKMRASIVSRYGLADIAREINLGQHILLGKGEQLHDGRSKDSILADTTEALLGAIYLAHGFEIARDTVLRL
FKHKIDTASATGLHQDWKTTLQERLAERNLEMPTYTSTVTGPEHEQTFTAEVAVHGTVLGTGVGTNKKLAEQAAAHKAVG
FLQDNPAFV

Sequences:

>Translated_249_residues
MSRRKKRVTGEQALRLEFESVDHQPLIDALGVDIPRELLVLALTHRSFANENGMLPNNERLEFLGDSVLGLSVAGQLYQQ
YTSSPESDISKMRASIVSRYGLADIAREINLGQHILLGKGEQLHDGRSKDSILADTTEALLGAIYLAHGFEIARDTVLRL
FKHKIDTASATGLHQDWKTTLQERLAERNLEMPTYTSTVTGPEHEQTFTAEVAVHGTVLGTGVGTNKKLAEQAAAHKAVG
FLQDNPAFV
>Mature_248_residues
SRRKKRVTGEQALRLEFESVDHQPLIDALGVDIPRELLVLALTHRSFANENGMLPNNERLEFLGDSVLGLSVAGQLYQQY
TSSPESDISKMRASIVSRYGLADIAREINLGQHILLGKGEQLHDGRSKDSILADTTEALLGAIYLAHGFEIARDTVLRLF
KHKIDTASATGLHQDWKTTLQERLAERNLEMPTYTSTVTGPEHEQTFTAEVAVHGTVLGTGVGTNKKLAEQAAAHKAVGF
LQDNPAFV

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030234, Length=223, Percent_Identity=28.2511210762332, Blast_Score=74, Evalue=9e-14,
Organism=Homo sapiens, GI155030236, Length=223, Percent_Identity=28.2511210762332, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1788920, Length=196, Percent_Identity=41.3265306122449, Blast_Score=135, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17506883, Length=215, Percent_Identity=29.7674418604651, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI193202651, Length=215, Percent_Identity=29.7674418604651, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17137682, Length=230, Percent_Identity=27.8260869565217, Blast_Score=67, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_CORDI (Q6NGH3)

Other databases:

- EMBL:   BX248358
- RefSeq:   NP_939886.1
- ProteinModelPortal:   Q6NGH3
- SMR:   Q6NGH3
- GeneID:   2650733
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1544
- NMPDR:   fig|257309.1.peg.1477
- HOGENOM:   HBG744556
- OMA:   ALTHKSF
- PhylomeDB:   Q6NGH3
- ProtClustDB:   PRK00102
- BioCyc:   CDIP257309:DIP1544-MONOMER
- BRENDA:   3.1.26.3
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 27353; Mature: 27222

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRRKKRVTGEQALRLEFESVDHQPLIDALGVDIPRELLVLALTHRSFANENGMLPNNER
CCCCHHHCCCHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCH
LEFLGDSVLGLSVAGQLYQQYTSSPESDISKMRASIVSRYGLADIAREINLGQHILLGKG
HHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
EQLHDGRSKDSILADTTEALLGAIYLAHGFEIARDTVLRLFKHKIDTASATGLHQDWKTT
CHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCHHHHHHH
LQERLAERNLEMPTYTSTVTGPEHEQTFTAEVAVHGTVLGTGVGTNKKLAEQAAAHKAVG
HHHHHHHCCCCCCCCCCCCCCCCCCCEEEEHEEEECEEEECCCCCCHHHHHHHHHHHHHH
FLQDNPAFV
HCCCCCCCC
>Mature Secondary Structure 
SRRKKRVTGEQALRLEFESVDHQPLIDALGVDIPRELLVLALTHRSFANENGMLPNNER
CCCHHHCCCHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCH
LEFLGDSVLGLSVAGQLYQQYTSSPESDISKMRASIVSRYGLADIAREINLGQHILLGKG
HHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
EQLHDGRSKDSILADTTEALLGAIYLAHGFEIARDTVLRLFKHKIDTASATGLHQDWKTT
CHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCHHHHHHH
LQERLAERNLEMPTYTSTVTGPEHEQTFTAEVAVHGTVLGTGVGTNKKLAEQAAAHKAVG
HHHHHHHCCCCCCCCCCCCCCCCCCCEEEEHEEEECEEEECCCCCCHHHHHHHHHHHHHH
FLQDNPAFV
HCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14602910