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The map label for this gene is lepB [H]

Identifier: 38234095

GI number: 38234095

Start: 1539177

End: 1540034

Strand: Reverse

Name: lepB [H]

Synonym: DIP1516

Alternate gene names: 38234095

Gene position: 1540034-1539177 (Counterclockwise)

Preceding gene: 38234096

Following gene: 38234094

Centisome position: 61.88

GC content: 48.37

Gene sequence:

>858_bases
ATGAAGCGCTCAGTTTTCTCTTTTTGTATGATGCAGCAAGCGTCGCTGGGCGTTTTTCATTCGATGGCTGAAACAGCTGC
TAGAGTTCTCAAAGTGAGTTCAGCTAATAACGAGACTGTGTCCCCCACGGAAGGCGTCGAAACGCACGACAAGGAAAAGA
AGCAACTGCCATGGTTTGTGGAAATCCCTGTCGTCGTAGTGGTGACCCTTCTTGTGATCACCTTGCTTCAAACGTTCGTT
GGACGGGTCTATATGATCCCAAGTCAGTCAATGGAGCCGACACTTCATGGATGTGCAGGGTGTACCGGAGACCGAATTTA
TGTAGATAAGCTGGCTTATCGTTTTGGTGAACCAGAAGCCGGCGACGTTGTAGTTTTTGCAGGTACAGAATCATGGAACA
CCGGATTTACCACTTCACGGTCAGAAAATCCTCTGGTTCGTGGAATACAAAATGCGGGTGCTTTCGTCGGATTAGTAGCA
CCAGACGAAAACGACCTTGTAAAACGCATCGTAGCAACAGGGGGTCAAACGGTGCAGTGCCTTGAAGGCGATGAAGGTGT
CAAAGTAGACGGTAAAGTCATCGACTCGTCATATACTCTGATGCCACCAGCGTATCCGGTCGACCAGACCACAGGATCAG
AGGCGTGCGGCGGCTTTTACTTCGGACCTATCAAGGTACCTGAAGGAAATTACTTCATGATGGGCGATAACCGGACAAAC
TCCGCGGATTCTCGTTACCACATTGGTGATCAGTATCAAGGCACCATCCCTAAAGAAAACCTCAAGGGGAAAGTTCAGTT
CAAGATTTTCCCATTTAACCGTATTGGTGCAGTCGAGGATTACGATATCCAACAGTGA

Upstream 100 bases:

>100_bases
CTAGAGCTGTGAACAGTATAAACGCAAGAAATTAGGACATGGATCACTGCTGGAAAGATCAAGGAATAACGTTAAGAGCT
TCCTTGCTCAGTGCTCTAGT

Downstream 100 bases:

>100_bases
TCACTCAAGAACACTACTGTGCGTTGCCAGCTCCCAAAATTCGGACGCTGAAGCATCTTCGAACCTTCGAAGTTACTTTG
GATAAACATGGTCTTGGGCC

Product: putative signal peptidase

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MKRSVFSFCMMQQASLGVFHSMAETAARVLKVSSANNETVSPTEGVETHDKEKKQLPWFVEIPVVVVVTLLVITLLQTFV
GRVYMIPSQSMEPTLHGCAGCTGDRIYVDKLAYRFGEPEAGDVVVFAGTESWNTGFTTSRSENPLVRGIQNAGAFVGLVA
PDENDLVKRIVATGGQTVQCLEGDEGVKVDGKVIDSSYTLMPPAYPVDQTTGSEACGGFYFGPIKVPEGNYFMMGDNRTN
SADSRYHIGDQYQGTIPKENLKGKVQFKIFPFNRIGAVEDYDIQQ

Sequences:

>Translated_285_residues
MKRSVFSFCMMQQASLGVFHSMAETAARVLKVSSANNETVSPTEGVETHDKEKKQLPWFVEIPVVVVVTLLVITLLQTFV
GRVYMIPSQSMEPTLHGCAGCTGDRIYVDKLAYRFGEPEAGDVVVFAGTESWNTGFTTSRSENPLVRGIQNAGAFVGLVA
PDENDLVKRIVATGGQTVQCLEGDEGVKVDGKVIDSSYTLMPPAYPVDQTTGSEACGGFYFGPIKVPEGNYFMMGDNRTN
SADSRYHIGDQYQGTIPKENLKGKVQFKIFPFNRIGAVEDYDIQQ
>Mature_285_residues
MKRSVFSFCMMQQASLGVFHSMAETAARVLKVSSANNETVSPTEGVETHDKEKKQLPWFVEIPVVVVVTLLVITLLQTFV
GRVYMIPSQSMEPTLHGCAGCTGDRIYVDKLAYRFGEPEAGDVVVFAGTESWNTGFTTSRSENPLVRGIQNAGAFVGLVA
PDENDLVKRIVATGGQTVQCLEGDEGVKVDGKVIDSSYTLMPPAYPVDQTTGSEACGGFYFGPIKVPEGNYFMMGDNRTN
SADSRYHIGDQYQGTIPKENLKGKVQFKIFPFNRIGAVEDYDIQQ

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 31193; Mature: 31193

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00501 SPASE_I_1 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRSVFSFCMMQQASLGVFHSMAETAARVLKVSSANNETVSPTEGVETHDKEKKQLPWFV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCHHHCCCEEE
EIPVVVVVTLLVITLLQTFVGRVYMIPSQSMEPTLHGCAGCTGDRIYVDKLAYRFGEPEA
ECHHHHHHHHHHHHHHHHHHCEEEECCCCCCCCCHHHHCCCCCCEEHHHHHHHHCCCCCC
GDVVVFAGTESWNTGFTTSRSENPLVRGIQNAGAFVGLVAPDENDLVKRIVATGGQTVQC
CCEEEEECCCCCCCCCCCCCCCCHHHHHHCCCCCEEEEECCCHHHHHHHHHHCCCCEEEE
LEGDEGVKVDGKVIDSSYTLMPPAYPVDQTTGSEACGGFYFGPIKVPEGNYFMMGDNRTN
EECCCCCEECCEEECCCEEECCCCCCCCCCCCCCCCCCEEECCEECCCCCEEEECCCCCC
SADSRYHIGDQYQGTIPKENLKGKVQFKIFPFNRIGAVEDYDIQQ
CCCCEEECCCCCCCCCCCCCCCCEEEEEEECCHHCCCCCCCCCCC
>Mature Secondary Structure
MKRSVFSFCMMQQASLGVFHSMAETAARVLKVSSANNETVSPTEGVETHDKEKKQLPWFV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCHHHCCCEEE
EIPVVVVVTLLVITLLQTFVGRVYMIPSQSMEPTLHGCAGCTGDRIYVDKLAYRFGEPEA
ECHHHHHHHHHHHHHHHHHHCEEEECCCCCCCCCHHHHCCCCCCEEHHHHHHHHCCCCCC
GDVVVFAGTESWNTGFTTSRSENPLVRGIQNAGAFVGLVAPDENDLVKRIVATGGQTVQC
CCEEEEECCCCCCCCCCCCCCCCHHHHHHCCCCCEEEEECCCHHHHHHHHHHCCCCEEEE
LEGDEGVKVDGKVIDSSYTLMPPAYPVDQTTGSEACGGFYFGPIKVPEGNYFMMGDNRTN
EECCCCCEECCEEECCCEEECCCCCCCCCCCCCCCCCCEEECCEECCCCCEEEECCCCCC
SADSRYHIGDQYQGTIPKENLKGKVQFKIFPFNRIGAVEDYDIQQ
CCCCEEECCCCCCCCCCCCCCCCEEEEEEECCHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]