| Definition | Corynebacterium diphtheriae NCTC 13129 chromosome, complete genome. |
|---|---|
| Accession | NC_002935 |
| Length | 2,488,635 |
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The map label for this gene is dxr
Identifier: 38234079
GI number: 38234079
Start: 1524586
End: 1525749
Strand: Reverse
Name: dxr
Synonym: DIP1500
Alternate gene names: 38234079
Gene position: 1525749-1524586 (Counterclockwise)
Preceding gene: 38234081
Following gene: 38234078
Centisome position: 61.31
GC content: 52.32
Gene sequence:
>1164_bases GTGAGAAAGAAAATCTTGATTCTGGGCAGCACTGGTTCCATCGGCACGCAGGCGCTTGAGGTTATAGCTTCGCGCCAAGA CCAATTTGAGGTGGTAGGTATTGCCGCGGGTGGCCGAGATCCACAATTAATTATCCAGCAAGCTCAGATGCTGGGTTTGG CGGCAGACCATGTTGCTGTGGCCAATGAGAAATCGGCAACTCAAGTCAGTCGTGCACTTGGGGCAGCGGTATTAAGCGGA AGGGATGCTGCTACCGACCTCGTTGAGTCAGTGCCAGCGGATACGGTACTTAACGGCCTTGTGGGTTCTATGGGGCTGCG GGCTACCTTGGCTACGATTCAACTAGGTGAAGTTCTGGCCTTAGCTAATAAGGAATCGTTGGTTGCCGGTGGTACGTTTG TCACATCTCAGGCTGCCCCAGGGCAAATCGTGCCTGTGGATTCCGAACATTCTGCGATGGCGCAGTGTTTGCGATCAGGG GCATCAGCGGAAGTGTCAAAGTTGGTTCTGACTGCTTCAGGTGGCCCATTCCGTGGCTGGTCACGGGAGGAGATGTGGGA TGTTACTCCTGAGCAAGCTGCGGCACATCCAACGTGGTCGATGGGGCAGATGAATACATTGAATTCGGCCACTTTGATAA ATAAAGGATTGGAGTTAATTGAGGCCACTTTGCTCTTTGACATCCCAGCTGACCGTATTGAGGTGACTGTTCATCCGCAG TCGATTGTTCATTCGATGGTCACGTTTTGTGATGGTGCAACAATTGCTCAAGCATCGCCACCATCCATGTTGCTGTCAAT TTCTCATGCTTTGGCATGGCCTCACCGAGTTCCAGAAGCGCAACCGGCTTTGGATTTCTCTCAAGCAAGTACGTGGGATT TCATGCCAGTAGATAATGAGGCTTTCCCCGCAGTTGAGTTAGCGCGCGAGGTGGCTTTGAAACAGGGAACGTATCCGGCA GTGTATAACGCGGCAAATGAGCAGGCGGCCGCTGCGTTTCTTCGTGGTCGCATTAAGTTCCCACAGATTGTCGATATTGT CGGCGAAGTGGTGGCAGGATCTTCACAGTTTGCTGGTGTAGCCTCATCGGTCGAAGAAATTATTGCGCACGAAAGTGAGT CGCGTAGACGAGCAGACGCGCTCGTCGATAAGCTTTCTCGCTGA
Upstream 100 bases:
>100_bases ATCCTAAAGATGGCGCCCATAAGGGGGGAATCTATAGTCCGAGTAACGAACAAACGCGCTGAGAATCCCGCAGGTTGTTT CATGGGACATAATGGATTAG
Downstream 100 bases:
>100_bases TTAGTTGCGTTGTTGTAGGTACCCTGCAAGGAGTTTGTGCACCCGTGGCCTCATATTTACTTGGCGTTGTTTTATTTGCG ACTGGCATCGCCATCACTAT
Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase
Products: NA
Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase
Number of amino acids: Translated: 387; Mature: 387
Protein sequence:
>387_residues MRKKILILGSTGSIGTQALEVIASRQDQFEVVGIAAGGRDPQLIIQQAQMLGLAADHVAVANEKSATQVSRALGAAVLSG RDAATDLVESVPADTVLNGLVGSMGLRATLATIQLGEVLALANKESLVAGGTFVTSQAAPGQIVPVDSEHSAMAQCLRSG ASAEVSKLVLTASGGPFRGWSREEMWDVTPEQAAAHPTWSMGQMNTLNSATLINKGLELIEATLLFDIPADRIEVTVHPQ SIVHSMVTFCDGATIAQASPPSMLLSISHALAWPHRVPEAQPALDFSQASTWDFMPVDNEAFPAVELAREVALKQGTYPA VYNAANEQAAAAFLRGRIKFPQIVDIVGEVVAGSSQFAGVASSVEEIIAHESESRRRADALVDKLSR
Sequences:
>Translated_387_residues MRKKILILGSTGSIGTQALEVIASRQDQFEVVGIAAGGRDPQLIIQQAQMLGLAADHVAVANEKSATQVSRALGAAVLSG RDAATDLVESVPADTVLNGLVGSMGLRATLATIQLGEVLALANKESLVAGGTFVTSQAAPGQIVPVDSEHSAMAQCLRSG ASAEVSKLVLTASGGPFRGWSREEMWDVTPEQAAAHPTWSMGQMNTLNSATLINKGLELIEATLLFDIPADRIEVTVHPQ SIVHSMVTFCDGATIAQASPPSMLLSISHALAWPHRVPEAQPALDFSQASTWDFMPVDNEAFPAVELAREVALKQGTYPA VYNAANEQAAAAFLRGRIKFPQIVDIVGEVVAGSSQFAGVASSVEEIIAHESESRRRADALVDKLSR >Mature_387_residues MRKKILILGSTGSIGTQALEVIASRQDQFEVVGIAAGGRDPQLIIQQAQMLGLAADHVAVANEKSATQVSRALGAAVLSG RDAATDLVESVPADTVLNGLVGSMGLRATLATIQLGEVLALANKESLVAGGTFVTSQAAPGQIVPVDSEHSAMAQCLRSG ASAEVSKLVLTASGGPFRGWSREEMWDVTPEQAAAHPTWSMGQMNTLNSATLINKGLELIEATLLFDIPADRIEVTVHPQ SIVHSMVTFCDGATIAQASPPSMLLSISHALAWPHRVPEAQPALDFSQASTWDFMPVDNEAFPAVELAREVALKQGTYPA VYNAANEQAAAAFLRGRIKFPQIVDIVGEVVAGSSQFAGVASSVEEIIAHESESRRRADALVDKLSR
Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)
COG id: COG0743
COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the DXR family
Homologues:
Organism=Escherichia coli, GI1786369, Length=359, Percent_Identity=39.2757660167131, Blast_Score=227, Evalue=1e-60,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): DXR_CORDI (Q6NGL1)
Other databases:
- EMBL: BX248358 - RefSeq: NP_939846.1 - ProteinModelPortal: Q6NGL1 - SMR: Q6NGL1 - GeneID: 2650384 - GenomeReviews: BX248353_GR - KEGG: cdi:DIP1500 - NMPDR: fig|257309.1.peg.1437 - HOGENOM: HBG430762 - OMA: IHSMVEY - ProtClustDB: PRK05447 - BioCyc: CDIP257309:DIP1500-MONOMER - BRENDA: 1.1.1.267 - HAMAP: MF_00183 - InterPro: IPR003821 - InterPro: IPR013644 - InterPro: IPR013512 - InterPro: IPR016040 - Gene3D: G3DSA:3.40.50.720 - PIRSF: PIRSF006205 - TIGRFAMs: TIGR00243
Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom
EC number: =1.1.1.267
Molecular weight: Translated: 40705; Mature: 40705
Theoretical pI: Translated: 4.78; Mature: 4.78
Prosite motif: NA
Important sites: BINDING 124-124 BINDING 149-149 BINDING 173-173 BINDING 196-196 BINDING 218-218
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.5 %Cys (Translated Protein) 2.6 %Met (Translated Protein) 3.1 %Cys+Met (Translated Protein) 0.5 %Cys (Mature Protein) 2.6 %Met (Mature Protein) 3.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MRKKILILGSTGSIGTQALEVIASRQDQFEVVGIAAGGRDPQLIIQQAQMLGLAADHVAV CCCEEEEEECCCCHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHEE ANEKSATQVSRALGAAVLSGRDAATDLVESVPADTVLNGLVGSMGLRATLATIQLGEVLA CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH LANKESLVAGGTFVTSQAAPGQIVPVDSEHSAMAQCLRSGASAEVSKLVLTASGGPFRGW HCCCCCEEECCCEEECCCCCCCEEECCCCHHHHHHHHHCCCCCCEEEEEEEECCCCCCCC SREEMWDVTPEQAAAHPTWSMGQMNTLNSATLINKGLELIEATLLFDIPADRIEVTVHPQ CCHHHCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEECCCCCEEEEECHH SIVHSMVTFCDGATIAQASPPSMLLSISHALAWPHRVPEAQPALDFSQASTWDFMPVDNE HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC AFPAVELAREVALKQGTYPAVYNAANEQAAAAFLRGRIKFPQIVDIVGEVVAGSSQFAGV CCCHHHHHHHHHHHCCCCCHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHH ASSVEEIIAHESESRRRADALVDKLSR HHHHHHHHHCCCHHHHHHHHHHHHHCC >Mature Secondary Structure MRKKILILGSTGSIGTQALEVIASRQDQFEVVGIAAGGRDPQLIIQQAQMLGLAADHVAV CCCEEEEEECCCCHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHEE ANEKSATQVSRALGAAVLSGRDAATDLVESVPADTVLNGLVGSMGLRATLATIQLGEVLA CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH LANKESLVAGGTFVTSQAAPGQIVPVDSEHSAMAQCLRSGASAEVSKLVLTASGGPFRGW HCCCCCEEECCCEEECCCCCCCEEECCCCHHHHHHHHHCCCCCCEEEEEEEECCCCCCCC SREEMWDVTPEQAAAHPTWSMGQMNTLNSATLINKGLELIEATLLFDIPADRIEVTVHPQ CCHHHCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEECCCCCEEEEECHH SIVHSMVTFCDGATIAQASPPSMLLSISHALAWPHRVPEAQPALDFSQASTWDFMPVDNE HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC AFPAVELAREVALKQGTYPAVYNAANEQAAAAFLRGRIKFPQIVDIVGEVVAGSSQFAGV CCCHHHHHHHHHHHCCCCCHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHH ASSVEEIIAHESESRRRADALVDKLSR HHHHHHHHHCCCHHHHHHHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 14602910