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The map label for this gene is guaA [C]

Identifier: 38233870

GI number: 38233870

Start: 1294271

End: 1294999

Strand: Direct

Name: guaA [C]

Synonym: DIP1285

Alternate gene names: 38233870

Gene position: 1294271-1294999 (Clockwise)

Preceding gene: 38233869

Following gene: 38233871

Centisome position: 52.01

GC content: 45.13

Gene sequence:

>729_bases
GTGACATATATGGTTTCAATTTTGCTGGTATCCCCGCGGCCTGGACATGATGTGGCAACCGCTGAACGTAATGACGTGCT
TCGTGCTACTGGGCTTGCACCTGAGCAATTAGAGCAGGTACTTATTGATGACGTCGAGAAGCATCTCCCCGATTTCTCTC
GCTTCGATGGCATCATCGTCGGTGGAAGTCCACTTAATATCAGCAATGAAACATATTCGGATTGGCAAAAACATGTCCAT
ACCGAGTTATCTCGCATTGTCTACTCTGCTATTCCATCATTTTTTATTTGCTATGGAAATTCATTTCTCGTCGATCTAAC
TGGTGGAACAGTCGGACGCACTCATCCAGAGGATTCCGGAGCTACTATAGTTTCGTTAACGGCCGATGGTCTAACCGACC
GTATTACTCGTGACCTTCCAACAACTTTCACATCGCTGACTGGGCATACAGAAAACGCGATCTGTCTAGGAGATTCTACA
GTCTTATTAGCAACTGGAGACACCTGTCCCATTCAGATGATTCGAGCTAACGAAACCACATGGGCATGCCAATTTCACGC
AGAGATGGATGCACAAGCCATGAAAACTCGAATGGATTTTTATAAAGACTACGGTTACTTCTCACCTGAGGATTATGACG
CAATCGTATCTTCACTTCCTAGCATTGACACCACGTATTCCAATCGAGTGCTTCGTAATTTTATCGAGGTATGTGAAGGA
AAACGGTAG

Upstream 100 bases:

>100_bases
GGTGGCGATACCGATAACTTAGAACGAGTATTGGATTTGGTTGAAGAATCAGTTCGATCATCACAACCCAGCTAGGTCAA
TATAGACAAAGTAGTCTAGA

Downstream 100 bases:

>100_bases
ATAGTGTTACCCCGTGTGGGGTACCCGACTTATTCAAGCCATTACCCTCTTCCTGTTTAATTCTTTTGAAAGAAGTAATA
TAACCCCCATGTTTGCCATT

Product: glutamine amidotransferase

Products: AMP; L-Glutamate; GMP; H+; Diphosphate [C]

Alternate protein names: Glutamine Amidotransferase Class-I; GMP Synthase Family Protein; Amino Transferase; GMP Synthase; Glutamine Amidotransferase Class I; Class I Glutamine Amidotransferase; Glutamine-Hydrolyzing GMP Synthase

Number of amino acids: Translated: 242; Mature: 241

Protein sequence:

>242_residues
MTYMVSILLVSPRPGHDVATAERNDVLRATGLAPEQLEQVLIDDVEKHLPDFSRFDGIIVGGSPLNISNETYSDWQKHVH
TELSRIVYSAIPSFFICYGNSFLVDLTGGTVGRTHPEDSGATIVSLTADGLTDRITRDLPTTFTSLTGHTENAICLGDST
VLLATGDTCPIQMIRANETTWACQFHAEMDAQAMKTRMDFYKDYGYFSPEDYDAIVSSLPSIDTTYSNRVLRNFIEVCEG
KR

Sequences:

>Translated_242_residues
MTYMVSILLVSPRPGHDVATAERNDVLRATGLAPEQLEQVLIDDVEKHLPDFSRFDGIIVGGSPLNISNETYSDWQKHVH
TELSRIVYSAIPSFFICYGNSFLVDLTGGTVGRTHPEDSGATIVSLTADGLTDRITRDLPTTFTSLTGHTENAICLGDST
VLLATGDTCPIQMIRANETTWACQFHAEMDAQAMKTRMDFYKDYGYFSPEDYDAIVSSLPSIDTTYSNRVLRNFIEVCEG
KR
>Mature_241_residues
TYMVSILLVSPRPGHDVATAERNDVLRATGLAPEQLEQVLIDDVEKHLPDFSRFDGIIVGGSPLNISNETYSDWQKHVHT
ELSRIVYSAIPSFFICYGNSFLVDLTGGTVGRTHPEDSGATIVSLTADGLTDRITRDLPTTFTSLTGHTENAICLGDSTV
LLATGDTCPIQMIRANETTWACQFHAEMDAQAMKTRMDFYKDYGYFSPEDYDAIVSSLPSIDTTYSNRVLRNFIEVCEGK
R

Specific function: Catalyzes The Synthesis Of Gmp From Xmp. [C]

COG id: COG0518

COG function: function code F; GMP synthase - Glutamine amidotransferase domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 6.3.5.2 [C]

Molecular weight: Translated: 26816; Mature: 26685

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: PS00144 ASN_GLN_ASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYMVSILLVSPRPGHDVATAERNDVLRATGLAPEQLEQVLIDDVEKHLPDFSRFDGIIV
CCEEEEEEEECCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHCCCHHHHCCEEE
GGSPLNISNETYSDWQKHVHTELSRIVYSAIPSFFICYGNSFLVDLTGGTVGRTHPEDSG
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEECCEEEEEECCCCCCCCCCCCCC
ATIVSLTADGLTDRITRDLPTTFTSLTGHTENAICLGDSTVLLATGDTCPIQMIRANETT
CEEEEEECCCHHHHHHHHCCHHHHHHCCCCCCEEEECCCEEEEEECCCCCEEEEECCCCE
WACQFHAEMDAQAMKTRMDFYKDYGYFSPEDYDAIVSSLPSIDTTYSNRVLRNFIEVCEG
EEEEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCC
KR
CC
>Mature Secondary Structure 
TYMVSILLVSPRPGHDVATAERNDVLRATGLAPEQLEQVLIDDVEKHLPDFSRFDGIIV
CEEEEEEEECCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHCCCHHHHCCEEE
GGSPLNISNETYSDWQKHVHTELSRIVYSAIPSFFICYGNSFLVDLTGGTVGRTHPEDSG
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEECCEEEEEECCCCCCCCCCCCCC
ATIVSLTADGLTDRITRDLPTTFTSLTGHTENAICLGDSTVLLATGDTCPIQMIRANETT
CEEEEEECCCHHHHHHHHCCHHHHHHCCCCCCEEEECCCEEEEEECCCCCEEEEECCCCE
WACQFHAEMDAQAMKTRMDFYKDYGYFSPEDYDAIVSSLPSIDTTYSNRVLRNFIEVCEG
EEEEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCC
KR
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.35 {8-azaXMP}} 1 {NH4+}} 0.42 {6-thioXMP}} 0.53 {ATP}} 2 {1-ribosyl-4,6-dihydroxypyrazolo[3,4-d]-pyrimidine} 0.058 {XMP}} 0.029 {XMP}} [C]

Substrates: ATP; L-Glutamine; H2O; Xanthosine 5'-phosphate [C]

Specific reaction: ATP + L-Glutamine + H2O + Xanthosine 5'-phosphate --> AMP + L-Glutamate + GMP + (2) H+ + Diphosphate [C]

General reaction: Amination [C]

Inhibitor: 1, N6-Ethenoadenosine; 1-Methyl adenosine 5'-phosphate 5'-phosphate; 2', 3'-Dihydroadenosine; 2'-Deoxyadenosine; 2, 6-Diaminopurine ribonucleoside; 2-Amino-6-methyl thiopurine ribonucleoside; 2-Fluoroadenosine; 3'-Deoxyadenosine; 5'-Azido-5'-deoxyadenosin

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA