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The map label for this gene is fhs

Identifier: 38233841

GI number: 38233841

Start: 1256231

End: 1257883

Strand: Reverse

Name: fhs

Synonym: DIP1253

Alternate gene names: 38233841

Gene position: 1257883-1256231 (Counterclockwise)

Preceding gene: 38233842

Following gene: 38233838

Centisome position: 50.55

GC content: 47.91

Gene sequence:

>1653_bases
ATGCCGACGGACGTTGAAATTGCCCAAGCTCATACCCTCGAGCCCATCACTGACATTGCCAATCGAGCTGGAGTACCTTC
CGATGCTCTGATCCCTTATGGCTTTACAAAAGCGAAAATAGATATTAATCGGATTGCGAGCGAAAACACTGGAAAGCTCG
TGCTCGTGACAGGGATTTCACCAACGCCTGCCGGCGAAGGTAAATCGACTGTCCTCATTGGTCTTTCGGACGCAATGAGA
CTACGCGGCCATAATTCCATTGTTGCTATTCGCGAACCTTCTCTAGGCCCCGTAATGGGAATTAAAGGTGGAGCCGCAGG
TGGTGGATATTCACAGATCGTTCCTATGGAAGACATCAATCTGCATTTCACTGGAGACTTTCATGCAATCACGGCAGCTA
ACAACACGCTGGCAGCAATGATTGACAATCATATTCATCAAGGCAATACTCTAGGAATTGATGTCCGTCGGATTACTTGG
CAACGTTGCCTGGATGTAAACGACCGCTGTTTGCGCAAAGTTGTGACTGGCCTAGGTGGTAAAGCACATGGGGTGCCAAC
TGAAACAGGATTCACGATTACAGCCGCGAGTGAAATCATGGCGATTCTATGTCTGGCATTAGATCTAACAGATTTGGAAG
CACGCTTGGCACGGATTGTTGTAGGCCAGACATTTAGCAGTGAACCAGTTACCGTTGGTCAACTTAATGCGCAAGGAGCA
CTTGCAGCGTTGCTTCGTGATGCAGTTAATCCAAATTTAGTTCAAACATTGGGTGGAACACCTGCGTTGTGCCATGGTGG
GCCATTCGCGAATATTGCCCATGGGTGTAACTCTCTTATCGCTACAAAAACGGCGCTGTCACTCGGAGATGTCGTACTGA
CGGAAGCAGGATTCGGGTCCGACCTCGGTGCCGAAAAATTCTTCGATATTAAGTCGCGCGTAGGTGACCTCAATGTTGCT
GCAACCGTCGTTGTCGCAACTGTAAGGTCTCTTAAATACAACGCCGGCGTTCCTAAAGATGAGCTCACAACCGAAAACCT
TGAAGCTCTTGCATCTGGAGTCGTCAATCTCGAACGGCACGTTGAAAATATTCGTGCGTTTGGTATCGAACCAATTGTTG
CACTGAATAAATTTGCCTCGGACACTGATGCAGAAATCAATCAGCTCAAAGCTTGGGCTGAAACCATGTCGGTTCAATTG
ATCCCAGTCGAAGTTTGGGCTCATGGTGGGCAAGGCGCGCTAGAACTTGCCGACGCAGTTGCAGTCTCGATGCAAAATCA
AACTTCGCATCACCTTTATGACCCCGAACTGGGAATTGAAGCATCACTGCTCACAATTGCGCAAAAAATCTACGGCGCGG
CAGATGTTGAGTTGTCGAAGCAAGCGCGTCAAGATCTGGCATATTTGCAAGAAAATGGATGGGATCGCTTGCCAGTATGT
ATTTCCAAAACACAATATTCATTCAGTGATGATCCATCTCAGCTAGGGCGTCCAGAAGGACATACTCTTCACGTTCGCAA
TTTATTGCCACGAATCGGTGCAGGATTTATCGTTGCTCTTACCGGTGATGTCATGACCATGCCTGGCCTTCCGAAAAAAC
CAGCCGCTGAAAACATCGGAGTTGAAAATGGAGAGATTAAAGGCCTTTTCTAA

Upstream 100 bases:

>100_bases
TAGTTCAAGGGTGTCGAGGCTTATTAATTTGCTCAGCCATCGATACTCCTTTGTTAGTGCTTGTTCACCAGTACCTCGAC
TAGAAAGCATCGAATCGCCA

Downstream 100 bases:

>100_bases
AAGGTAATTAAGCGGGAAGCAGGTACCATACAATGGCCGCTTCCCGCTTTGATCGGCTTCTAGTGCTCTTGCTCTAAAAA
AGTGTCCCAATCTTGTTGTC

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS

Number of amino acids: Translated: 550; Mature: 549

Protein sequence:

>550_residues
MPTDVEIAQAHTLEPITDIANRAGVPSDALIPYGFTKAKIDINRIASENTGKLVLVTGISPTPAGEGKSTVLIGLSDAMR
LRGHNSIVAIREPSLGPVMGIKGGAAGGGYSQIVPMEDINLHFTGDFHAITAANNTLAAMIDNHIHQGNTLGIDVRRITW
QRCLDVNDRCLRKVVTGLGGKAHGVPTETGFTITAASEIMAILCLALDLTDLEARLARIVVGQTFSSEPVTVGQLNAQGA
LAALLRDAVNPNLVQTLGGTPALCHGGPFANIAHGCNSLIATKTALSLGDVVLTEAGFGSDLGAEKFFDIKSRVGDLNVA
ATVVVATVRSLKYNAGVPKDELTTENLEALASGVVNLERHVENIRAFGIEPIVALNKFASDTDAEINQLKAWAETMSVQL
IPVEVWAHGGQGALELADAVAVSMQNQTSHHLYDPELGIEASLLTIAQKIYGAADVELSKQARQDLAYLQENGWDRLPVC
ISKTQYSFSDDPSQLGRPEGHTLHVRNLLPRIGAGFIVALTGDVMTMPGLPKKPAAENIGVENGEIKGLF

Sequences:

>Translated_550_residues
MPTDVEIAQAHTLEPITDIANRAGVPSDALIPYGFTKAKIDINRIASENTGKLVLVTGISPTPAGEGKSTVLIGLSDAMR
LRGHNSIVAIREPSLGPVMGIKGGAAGGGYSQIVPMEDINLHFTGDFHAITAANNTLAAMIDNHIHQGNTLGIDVRRITW
QRCLDVNDRCLRKVVTGLGGKAHGVPTETGFTITAASEIMAILCLALDLTDLEARLARIVVGQTFSSEPVTVGQLNAQGA
LAALLRDAVNPNLVQTLGGTPALCHGGPFANIAHGCNSLIATKTALSLGDVVLTEAGFGSDLGAEKFFDIKSRVGDLNVA
ATVVVATVRSLKYNAGVPKDELTTENLEALASGVVNLERHVENIRAFGIEPIVALNKFASDTDAEINQLKAWAETMSVQL
IPVEVWAHGGQGALELADAVAVSMQNQTSHHLYDPELGIEASLLTIAQKIYGAADVELSKQARQDLAYLQENGWDRLPVC
ISKTQYSFSDDPSQLGRPEGHTLHVRNLLPRIGAGFIVALTGDVMTMPGLPKKPAAENIGVENGEIKGLF
>Mature_549_residues
PTDVEIAQAHTLEPITDIANRAGVPSDALIPYGFTKAKIDINRIASENTGKLVLVTGISPTPAGEGKSTVLIGLSDAMRL
RGHNSIVAIREPSLGPVMGIKGGAAGGGYSQIVPMEDINLHFTGDFHAITAANNTLAAMIDNHIHQGNTLGIDVRRITWQ
RCLDVNDRCLRKVVTGLGGKAHGVPTETGFTITAASEIMAILCLALDLTDLEARLARIVVGQTFSSEPVTVGQLNAQGAL
AALLRDAVNPNLVQTLGGTPALCHGGPFANIAHGCNSLIATKTALSLGDVVLTEAGFGSDLGAEKFFDIKSRVGDLNVAA
TVVVATVRSLKYNAGVPKDELTTENLEALASGVVNLERHVENIRAFGIEPIVALNKFASDTDAEINQLKAWAETMSVQLI
PVEVWAHGGQGALELADAVAVSMQNQTSHHLYDPELGIEASLLTIAQKIYGAADVELSKQARQDLAYLQENGWDRLPVCI
SKTQYSFSDDPSQLGRPEGHTLHVRNLLPRIGAGFIVALTGDVMTMPGLPKKPAAENIGVENGEIKGLF

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family

Homologues:

Organism=Homo sapiens, GI36796743, Length=622, Percent_Identity=42.2829581993569, Blast_Score=418, Evalue=1e-117,
Organism=Homo sapiens, GI222136639, Length=620, Percent_Identity=41.4516129032258, Blast_Score=416, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI17568737, Length=628, Percent_Identity=41.7197452229299, Blast_Score=418, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17568739, Length=628, Percent_Identity=41.7197452229299, Blast_Score=418, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6319558, Length=632, Percent_Identity=40.6645569620253, Blast_Score=412, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6321643, Length=625, Percent_Identity=40.32, Blast_Score=397, Evalue=1e-111,
Organism=Drosophila melanogaster, GI62472483, Length=622, Percent_Identity=41.8006430868167, Blast_Score=416, Evalue=1e-116,
Organism=Drosophila melanogaster, GI45551871, Length=622, Percent_Identity=41.8006430868167, Blast_Score=416, Evalue=1e-116,
Organism=Drosophila melanogaster, GI24645718, Length=622, Percent_Identity=41.8006430868167, Blast_Score=416, Evalue=1e-116,
Organism=Drosophila melanogaster, GI17137370, Length=622, Percent_Identity=41.8006430868167, Blast_Score=416, Evalue=1e-116,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FTHS_CORDI (Q6NH87)

Other databases:

- EMBL:   BX248357
- RefSeq:   NP_939608.1
- ProteinModelPortal:   Q6NH87
- GeneID:   2649808
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1253
- NMPDR:   fig|257309.1.peg.1199
- HOGENOM:   HBG677721
- OMA:   EIMAVLC
- PhylomeDB:   Q6NH87
- ProtClustDB:   PRK13505
- BioCyc:   CDIP257309:DIP1253-MONOMER
- BRENDA:   6.3.4.3
- HAMAP:   MF_01543
- InterPro:   IPR000559
- InterPro:   IPR020628

Pfam domain/function: PF01268 FTHFS

EC number: =6.3.4.3

Molecular weight: Translated: 58099; Mature: 57968

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS00721 FTHFS_1; PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTDVEIAQAHTLEPITDIANRAGVPSDALIPYGFTKAKIDINRIASENTGKLVLVTGIS
CCCCCCHHHHCCCCHHHHHHHHCCCCCCCCCCCCCEEEEEEHHHHCCCCCCCEEEEECCC
PTPAGEGKSTVLIGLSDAMRLRGHNSIVAIREPSLGPVMGIKGGAAGGGYSQIVPMEDIN
CCCCCCCCCEEEEEECHHHHHCCCCCEEEEECCCCCCEEECCCCCCCCCCCEECEECCCE
LHFTGDFHAITAANNTLAAMIDNHIHQGNTLGIDVRRITWQRCLDVNDRCLRKVVTGLGG
EEEECCEEEEEECCCCHHHHHHHHHCCCCEEEEEHHHHHHHHHCCCCHHHHHHHHHHCCC
KAHGVPTETGFTITAASEIMAILCLALDLTDLEARLARIVVGQTFSSEPVTVGQLNAQGA
CCCCCCCCCCEEEEEHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHH
LAALLRDAVNPNLVQTLGGTPALCHGGPFANIAHGCNSLIATKTALSLGDVVLTEAGFGS
HHHHHHHHCCCCHHHHCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCC
DLGAEKFFDIKSRVGDLNVAATVVVATVRSLKYNAGVPKDELTTENLEALASGVVNLERH
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHHHHHHH
VENIRAFGIEPIVALNKFASDTDAEINQLKAWAETMSVQLIPVEVWAHGGQGALELADAV
HHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHEEEEEEEEEEECCCCCHHHHHHHH
AVSMQNQTSHHLYDPELGIEASLLTIAQKIYGAADVELSKQARQDLAYLQENGWDRLPVC
HHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCEE
ISKTQYSFSDDPSQLGRPEGHTLHVRNLLPRIGAGFIVALTGDVMTMPGLPKKPAAENIG
EECCCCCCCCCHHHCCCCCCCEEEHHHHHHHHCCCEEEEEECCEEECCCCCCCCCCCCCC
VENGEIKGLF
CCCCCEECCC
>Mature Secondary Structure 
PTDVEIAQAHTLEPITDIANRAGVPSDALIPYGFTKAKIDINRIASENTGKLVLVTGIS
CCCCCHHHHCCCCHHHHHHHHCCCCCCCCCCCCCEEEEEEHHHHCCCCCCCEEEEECCC
PTPAGEGKSTVLIGLSDAMRLRGHNSIVAIREPSLGPVMGIKGGAAGGGYSQIVPMEDIN
CCCCCCCCCEEEEEECHHHHHCCCCCEEEEECCCCCCEEECCCCCCCCCCCEECEECCCE
LHFTGDFHAITAANNTLAAMIDNHIHQGNTLGIDVRRITWQRCLDVNDRCLRKVVTGLGG
EEEECCEEEEEECCCCHHHHHHHHHCCCCEEEEEHHHHHHHHHCCCCHHHHHHHHHHCCC
KAHGVPTETGFTITAASEIMAILCLALDLTDLEARLARIVVGQTFSSEPVTVGQLNAQGA
CCCCCCCCCCEEEEEHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHH
LAALLRDAVNPNLVQTLGGTPALCHGGPFANIAHGCNSLIATKTALSLGDVVLTEAGFGS
HHHHHHHHCCCCHHHHCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCC
DLGAEKFFDIKSRVGDLNVAATVVVATVRSLKYNAGVPKDELTTENLEALASGVVNLERH
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHHHHHHH
VENIRAFGIEPIVALNKFASDTDAEINQLKAWAETMSVQLIPVEVWAHGGQGALELADAV
HHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHEEEEEEEEEEECCCCCHHHHHHHH
AVSMQNQTSHHLYDPELGIEASLLTIAQKIYGAADVELSKQARQDLAYLQENGWDRLPVC
HHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCEE
ISKTQYSFSDDPSQLGRPEGHTLHVRNLLPRIGAGFIVALTGDVMTMPGLPKKPAAENIG
EECCCCCCCCCHHHCCCCCCCEEEHHHHHHHHCCCEEEEEECCEEECCCCCCCCCCCCCC
VENGEIKGLF
CCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14602910