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The map label for this gene is pepE [H]

Identifier: 38233826

GI number: 38233826

Start: 1239661

End: 1240800

Strand: Reverse

Name: pepE [H]

Synonym: DIP1238

Alternate gene names: 38233826

Gene position: 1240800-1239661 (Counterclockwise)

Preceding gene: 38233827

Following gene: 38233825

Centisome position: 49.86

GC content: 48.25

Gene sequence:

>1140_bases
ATGACCAATACATTTCCTTCACGTGTGTACACAAAGAGACTCCAGCAAGCCTCTCGAGGAGCAATCAACCACGGGCTTCG
CGGTGTGGTGATCGGCCCAGGACCTCAACTGGAGTATCTCACTGGTCTACGTGTAAATACCCACGAGCGTTTTAGTGCTT
TGATTATCCCCGCAGGTTTTTCTTCACTATCTGATGCGGTATTGGTTGTGCCCTCAGTTGATCGTGGCGATGTGGTTCGC
AGCGCCATAACGGAAATGGGCGTTACAATTCAGTACTGGGATGATGGGGAAGATGCACATACCCTAGCTATGAATGCCTT
ATCGCCGCTTCGCGACGCGGATGTAATCGGAGTTGATGATCACCTTGAAGCGACACATCTCATTAGCCTGATGGGGCTTG
CAGGACAAGGCGTCTCTTTTGTATTAGCAAACACTGTTATGAGCGAGCTTTTTATCAATAAAGACCCTGATGAAATCTCA
CAACTTCGCTCGGCTGGTGAAGCAATTGACCGAGTTCACGCCGAAGTTCCCCACCTGATTACTGCGGGCCGTACAGAAGC
CGAAGTTGCACAAGATCTTCATCGCTTAATAGCCCAAGAACATTCCGCAATCGATTTCATTATTGTTGGAAGTGGACCCA
ATGGGGCGAATCCACACCATGATTTTTCAGACCGTATTCTCAACACTGGTGACATTGTGGTCGTTGATATCGGAGGAACT
TTCGGAGCTGGATATCATTCGGATTGCACGCGCACTTTTGTTGTTGGTGGTCCACAGCATCTACCCTCCGACGCTAAAAA
TTTATACGCAGTGCTAGAAAAAGCCCAAGAGGCTGCAGTAGCTCACGTTCGCCCAGGGGTAACGGCCGAATCTGTAGATA
ATGTCGCGCGAGAGATCATCACGCAAGCAGGATATGGAGAATATTTCATTCACCGAACCGGACATGGAATCGGACTATCT
ACGCACGAAGAACCCTTCATTATGAAAGGGAATAAGTTAGTGCTTCAACCTGGAATGGTGTTTTCCATTGAGCCAGGAAT
CTATATTCCAGGAAAATACGGCGCCCGAATCGAGGACATAGTCGTCGTTACTGAATCAGGCTGTGAACGTTTAAATAACC
AGCCGCGAACATTGCAATGA

Upstream 100 bases:

>100_bases
GCAAGGCTATCGACGCTATCCGCAGAGGCGTCGTGGCGATCGGAAACTAGATTTCATTAACTACCTCGGTGTGTGACACC
GAGGTTTACTATTAATCACT

Downstream 100 bases:

>100_bases
GCTACAACATGGAAAAAGTAACAGAAACTGTCGTCATTGTAGGAGCTTCAAGCGAAATCGCAGGGAGGATTGCCATCAAT
CTTGCCTGCAACCGCGACTT

Product: putative dipeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 379; Mature: 378

Protein sequence:

>379_residues
MTNTFPSRVYTKRLQQASRGAINHGLRGVVIGPGPQLEYLTGLRVNTHERFSALIIPAGFSSLSDAVLVVPSVDRGDVVR
SAITEMGVTIQYWDDGEDAHTLAMNALSPLRDADVIGVDDHLEATHLISLMGLAGQGVSFVLANTVMSELFINKDPDEIS
QLRSAGEAIDRVHAEVPHLITAGRTEAEVAQDLHRLIAQEHSAIDFIIVGSGPNGANPHHDFSDRILNTGDIVVVDIGGT
FGAGYHSDCTRTFVVGGPQHLPSDAKNLYAVLEKAQEAAVAHVRPGVTAESVDNVAREIITQAGYGEYFIHRTGHGIGLS
THEEPFIMKGNKLVLQPGMVFSIEPGIYIPGKYGARIEDIVVVTESGCERLNNQPRTLQ

Sequences:

>Translated_379_residues
MTNTFPSRVYTKRLQQASRGAINHGLRGVVIGPGPQLEYLTGLRVNTHERFSALIIPAGFSSLSDAVLVVPSVDRGDVVR
SAITEMGVTIQYWDDGEDAHTLAMNALSPLRDADVIGVDDHLEATHLISLMGLAGQGVSFVLANTVMSELFINKDPDEIS
QLRSAGEAIDRVHAEVPHLITAGRTEAEVAQDLHRLIAQEHSAIDFIIVGSGPNGANPHHDFSDRILNTGDIVVVDIGGT
FGAGYHSDCTRTFVVGGPQHLPSDAKNLYAVLEKAQEAAVAHVRPGVTAESVDNVAREIITQAGYGEYFIHRTGHGIGLS
THEEPFIMKGNKLVLQPGMVFSIEPGIYIPGKYGARIEDIVVVTESGCERLNNQPRTLQ
>Mature_378_residues
TNTFPSRVYTKRLQQASRGAINHGLRGVVIGPGPQLEYLTGLRVNTHERFSALIIPAGFSSLSDAVLVVPSVDRGDVVRS
AITEMGVTIQYWDDGEDAHTLAMNALSPLRDADVIGVDDHLEATHLISLMGLAGQGVSFVLANTVMSELFINKDPDEISQ
LRSAGEAIDRVHAEVPHLITAGRTEAEVAQDLHRLIAQEHSAIDFIIVGSGPNGANPHHDFSDRILNTGDIVVVDIGGTF
GAGYHSDCTRTFVVGGPQHLPSDAKNLYAVLEKAQEAAVAHVRPGVTAESVDNVAREIITQAGYGEYFIHRTGHGIGLST
HEEPFIMKGNKLVLQPGMVFSIEPGIYIPGKYGARIEDIVVVTESGCERLNNQPRTLQ

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=249, Percent_Identity=28.5140562248996, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI260593665, Length=310, Percent_Identity=26.1290322580645, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI149589008, Length=310, Percent_Identity=26.1290322580645, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI264681563, Length=209, Percent_Identity=30.1435406698565, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI93141226, Length=167, Percent_Identity=33.5329341317365, Blast_Score=73, Evalue=5e-13,
Organism=Escherichia coli, GI1788728, Length=275, Percent_Identity=39.6363636363636, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI1789275, Length=288, Percent_Identity=29.8611111111111, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1786364, Length=252, Percent_Identity=25.7936507936508, Blast_Score=75, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: 3.4.-.- [C]

Molecular weight: Translated: 40815; Mature: 40683

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNTFPSRVYTKRLQQASRGAINHGLRGVVIGPGPQLEYLTGLRVNTHERFSALIIPAGF
CCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEHEECCEECCCCCEEEEEEECCC
SSLSDAVLVVPSVDRGDVVRSAITEMGVTIQYWDDGEDAHTLAMNALSPLRDADVIGVDD
CCCCCCEEEEECCCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCCCCEECCCC
HLEATHLISLMGLAGQGVSFVLANTVMSELFINKDPDEISQLRSAGEAIDRVHAEVPHLI
CHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHE
TAGRTEAEVAQDLHRLIAQEHSAIDFIIVGSGPNGANPHHDFSDRILNTGDIVVVDIGGT
ECCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHCCCCCEEEEECCCC
FGAGYHSDCTRTFVVGGPQHLPSDAKNLYAVLEKAQEAAVAHVRPGVTAESVDNVAREII
CCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
TQAGYGEYFIHRTGHGIGLSTHEEPFIMKGNKLVLQPGMVFSIEPGIYIPGKYGARIEDI
HHCCCCCEEEEECCCCCCCCCCCCCEEEECCEEEECCCEEEEECCCEEECCCCCCCEEEE
VVVTESGCERLNNQPRTLQ
EEEECHHHHHHCCCCCCCC
>Mature Secondary Structure 
TNTFPSRVYTKRLQQASRGAINHGLRGVVIGPGPQLEYLTGLRVNTHERFSALIIPAGF
CCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEHEECCEECCCCCEEEEEEECCC
SSLSDAVLVVPSVDRGDVVRSAITEMGVTIQYWDDGEDAHTLAMNALSPLRDADVIGVDD
CCCCCCEEEEECCCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCCCCEECCCC
HLEATHLISLMGLAGQGVSFVLANTVMSELFINKDPDEISQLRSAGEAIDRVHAEVPHLI
CHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCHHE
TAGRTEAEVAQDLHRLIAQEHSAIDFIIVGSGPNGANPHHDFSDRILNTGDIVVVDIGGT
ECCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHCCCCCEEEEECCCC
FGAGYHSDCTRTFVVGGPQHLPSDAKNLYAVLEKAQEAAVAHVRPGVTAESVDNVAREII
CCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
TQAGYGEYFIHRTGHGIGLSTHEEPFIMKGNKLVLQPGMVFSIEPGIYIPGKYGARIEDI
HHCCCCCEEEEECCCCCCCCCCCCCEEEECCEEEECCCEEEEECCCEEECCCCCCCEEEE
VVVTESGCERLNNQPRTLQ
EEEECHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]