Click here to switch to the map view.

The map label for this gene is ppa

Identifier: 15899143

GI number: 15899143

Start: 2178312

End: 2178830

Strand: Reverse

Name: ppa

Synonym: SSO2390

Alternate gene names: 15899143

Gene position: 2178830-2178312 (Counterclockwise)

Preceding gene: 15899144

Following gene: 15899142

Centisome position: 72.82

GC content: 36.22

Gene sequence:

>519_bases
ATGAAATTAGGCCCTGGGAAAAAGGCCCCAGATGAAATAAATGTATTCATAGAAATACCTATGGGTTCAAATATTAAATA
CGAATACGATGAAGAAGAGGACATTATTAAAGTAGATAGGGTTTTATATACATCAATGGTATATCCATTTAATTATGGTT
TTATTCCAGAGACTTTAGAAGAAGATGGGGATCCATTAGACGTATTAGTCCTAGGAAATTACTCACTAATGCCAGGTACA
GTGATAGAAGCAAGACCTATAGGAATGATTTACATGAGGGATGAGGAAGGTGAAGACGCCAAGGTAATAGCAGTGCCAAG
AAATAAGACGGATCCGTCATTTTCTAATATTAACGATGTTAAAGATCTTCCGGAGGCTATTAGAAATAAGATCGTACATT
TCTTTGAGCACTATAAAGAACTAGAGCCAAATAAATGGGTAAAGATTAGCGGATGGGGAAGCGTAGCTGAGGCTAAGGAA
AGAATTAAAAAAGCGATTGAGAGAAAGAAACAAGGATGA

Upstream 100 bases:

>100_bases
TTACTTTCGATAGAGCCATTAAATCAGATAAGAGAACTGGTCACTAGAATAATGAATAGTTTAAATAAGCTGAATCCAAA
ATAATAGGCGGTGAAAAGAT

Downstream 100 bases:

>100_bases
TAAGGGAAATTTTTGAAATTTTGCTTTTTATATCATCATTTTTTACATCTTTATGGATACTCCTTCAAGCATTCTACTAT
AAAGTTTCTAATCAAAACAT

Product: inorganic pyrophosphatase

Products: NA

Alternate protein names: Pyrophosphate phospho-hydrolase; PPase

Number of amino acids: Translated: 172; Mature: 172

Protein sequence:

>172_residues
MKLGPGKKAPDEINVFIEIPMGSNIKYEYDEEEDIIKVDRVLYTSMVYPFNYGFIPETLEEDGDPLDVLVLGNYSLMPGT
VIEARPIGMIYMRDEEGEDAKVIAVPRNKTDPSFSNINDVKDLPEAIRNKIVHFFEHYKELEPNKWVKISGWGSVAEAKE
RIKKAIERKKQG

Sequences:

>Translated_172_residues
MKLGPGKKAPDEINVFIEIPMGSNIKYEYDEEEDIIKVDRVLYTSMVYPFNYGFIPETLEEDGDPLDVLVLGNYSLMPGT
VIEARPIGMIYMRDEEGEDAKVIAVPRNKTDPSFSNINDVKDLPEAIRNKIVHFFEHYKELEPNKWVKISGWGSVAEAKE
RIKKAIERKKQG
>Mature_172_residues
MKLGPGKKAPDEINVFIEIPMGSNIKYEYDEEEDIIKVDRVLYTSMVYPFNYGFIPETLEEDGDPLDVLVLGNYSLMPGT
VIEARPIGMIYMRDEEGEDAKVIAVPRNKTDPSFSNINDVKDLPEAIRNKIVHFFEHYKELEPNKWVKISGWGSVAEAKE
RIKKAIERKKQG

Specific function: Unknown

COG id: COG0221

COG function: function code C; Inorganic pyrophosphatase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PPase family

Homologues:

Organism=Homo sapiens, GI29171702, Length=164, Percent_Identity=29.2682926829268, Blast_Score=64, Evalue=8e-11,
Organism=Escherichia coli, GI1790673, Length=167, Percent_Identity=51.497005988024, Blast_Score=175, Evalue=2e-45,

Paralogues:

None

Copy number: 5480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 200 Molecules/Cell In: Early Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): IPYR_SULSO (Q97W51)

Other databases:

- EMBL:   AE006641
- PIR:   C90410
- RefSeq:   NP_343748.1
- ProteinModelPortal:   Q97W51
- SMR:   Q97W51
- GeneID:   1453865
- GenomeReviews:   AE006641_GR
- KEGG:   sso:SSO2390
- NMPDR:   fig|273057.1.peg.2171
- HOGENOM:   HBG529150
- OMA:   KKPGTCT
- PhylomeDB:   Q97W51
- ProtClustDB:   PRK01250
- BioCyc:   SSOL273057:SSO2390-MONOMER
- BRENDA:   3.6.1.1
- GO:   GO:0005737
- HAMAP:   MF_00209
- InterPro:   IPR008162
- Gene3D:   G3DSA:3.90.80.10
- PANTHER:   PTHR10286

Pfam domain/function: PF00719 Pyrophosphatase; SSF50324 Pyrophosphatase

EC number: =3.6.1.1

Molecular weight: Translated: 19695; Mature: 19695

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00387 PPASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLGPGKKAPDEINVFIEIPMGSNIKYEYDEEEDIIKVDRVLYTSMVYPFNYGFIPETLE
CCCCCCCCCCCEEEEEEEECCCCCCEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHH
EDGDPLDVLVLGNYSLMPGTVIEARPIGMIYMRDEEGEDAKVIAVPRNKTDPSFSNINDV
CCCCCEEEEEECCCCCCCCCEEEECCCEEEEEECCCCCCEEEEEECCCCCCCCCCCCHHH
KDLPEAIRNKIVHFFEHYKELEPNKWVKISGWGSVAEAKERIKKAIERKKQG
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKLGPGKKAPDEINVFIEIPMGSNIKYEYDEEEDIIKVDRVLYTSMVYPFNYGFIPETLE
CCCCCCCCCCCEEEEEEEECCCCCCEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHH
EDGDPLDVLVLGNYSLMPGTVIEARPIGMIYMRDEEGEDAKVIAVPRNKTDPSFSNINDV
CCCCCEEEEEECCCCCCCCCEEEECCCEEEEEECCCCCCEEEEEECCCCCCCCCCCCHHH
KDLPEAIRNKIVHFFEHYKELEPNKWVKISGWGSVAEAKERIKKAIERKKQG
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11427726