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The map label for this gene is gcvPA [H]

Identifier: 15897805

GI number: 15897805

Start: 780980

End: 782347

Strand: Reverse

Name: gcvPA [H]

Synonym: SSO0918

Alternate gene names: 15897805

Gene position: 782347-780980 (Counterclockwise)

Preceding gene: 15897816

Following gene: 15897804

Centisome position: 26.15

GC content: 34.58

Gene sequence:

>1368_bases
ATGTATAAGCATCCTTGGCTTCCAAACCTAGACCTAACAGATGAGATGTTGAAAGAGATAGGAGTAAACTCCCTTGACGA
CTTATTCAATGATATACCGGCTGAAATCAAAATAAATAGATTATTAAAAGTAGCAAAAGACAAACCACTATCAGAATATG
AAATTGAAAAAGAAATTTATGAAAAAGTGAAGAAGAACGTAGAACTTGAAGCACCACCTTTCATTGGGGCTGGTATTTGC
CCCCATTACATCCCTAATGCCGTAAAATTTATCATAGGCAGATCAGAATTTTATACATCCTATACTCCGTATCAGCCAGA
AATTTCTCAAGGCATATTACAAGCATTGTTTGAATATCAAAGTTTAATGGCTGAACTACTAGAGATGGATGTAGTCAACG
CTTCAATGTATGATTGGGGTTCTGCACTAGCTGAGGCCGTATTAATGGCTAATAGAATAAATGGAAAAAAGACTGTCCTA
GTACCTGAAAATGCTAACCCATTTCATAAAGAAGTAATGAGAACATGGATACAAGGAAAGGGAATAAAAATAGAGGAAGT
TAAGTATGATAAGAATTCCGGCGAAGTTGATATAGAGGATCTGGAGAAGAAATCTAGTAGTAATGATGTATCTGCAATAT
ATGTACAACAACCAAATTTCTTTGGGATTTTTGAAAGTAACATTGAACATATTATTGACGTTGCTAAGCATAAAAAAGCT
TTAAGTATTATTGGAGTTAATCCGCTTTCACTTGGTCTAATAAAACCACCGGGAAGCTATGAAGCTGACATAGTTGTAGG
TGATGGTCAAGAACTAGGACTTCCGTTAAATTTTGGAGGACCTTTAATGGGGATATTTGCAGTAAGATGGGATATGGGAT
TGGTAAGGCAAATGCCAGGTAGGATAGTGGGAATTACAAGAGACGTAAATAACAATATGGGATTTACGCTGATTCTTCAA
ACTAGAGAACAATTCATCAAGAGGGAAAAGGCAACCTCTAATATAACTACAAATGAAGCCTTGTTAGCGTTAGCTAATGC
TGTCTATTTAAGCTTATTAGGAAAAGAGGGAATAAGAGAACTTGCAGAGGAGATTTACTTCAGAAGTCACTATGCTGCTA
AAAGGCTAACTGAAATAGATAACGTAATTATGCCATTTACTTCAGACTTTTTCGAAGAATTTGTAATTAAATTCCCTATA
GAATATAATATAATAAATGACAAATTGAAAGAAAGAAAACTACAAGGTGGATTAAAATTGTCTATTCATACATCTCTCTT
TTGTGTAACAGAGGTTCATGATAAAAAGTCAATAGATCTATTAGTATCAACGATACAAGAGGCGATAAAAAGTGTGGAGA
CAAGCTAA

Upstream 100 bases:

>100_bases
ACCAGCAAACTCTCCAAAATTTGCTCCCAACTTTTCCTCAACGTCATGAAAAGGTGAAACAAACATATATTAAAAATGCA
TTAAAGTTGTATTAAGGCTT

Downstream 100 bases:

>100_bases
ATGGAATGAGCCTTTAATATTCGAGCTAAACAAAAGTGGTGCAGCTAGACAAGGTTTCTTGATAAATAAGGACGAGGAGA
TAAGAAGTCAGATTAAGGAA

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1 [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MYKHPWLPNLDLTDEMLKEIGVNSLDDLFNDIPAEIKINRLLKVAKDKPLSEYEIEKEIYEKVKKNVELEAPPFIGAGIC
PHYIPNAVKFIIGRSEFYTSYTPYQPEISQGILQALFEYQSLMAELLEMDVVNASMYDWGSALAEAVLMANRINGKKTVL
VPENANPFHKEVMRTWIQGKGIKIEEVKYDKNSGEVDIEDLEKKSSSNDVSAIYVQQPNFFGIFESNIEHIIDVAKHKKA
LSIIGVNPLSLGLIKPPGSYEADIVVGDGQELGLPLNFGGPLMGIFAVRWDMGLVRQMPGRIVGITRDVNNNMGFTLILQ
TREQFIKREKATSNITTNEALLALANAVYLSLLGKEGIRELAEEIYFRSHYAAKRLTEIDNVIMPFTSDFFEEFVIKFPI
EYNIINDKLKERKLQGGLKLSIHTSLFCVTEVHDKKSIDLLVSTIQEAIKSVETS

Sequences:

>Translated_455_residues
MYKHPWLPNLDLTDEMLKEIGVNSLDDLFNDIPAEIKINRLLKVAKDKPLSEYEIEKEIYEKVKKNVELEAPPFIGAGIC
PHYIPNAVKFIIGRSEFYTSYTPYQPEISQGILQALFEYQSLMAELLEMDVVNASMYDWGSALAEAVLMANRINGKKTVL
VPENANPFHKEVMRTWIQGKGIKIEEVKYDKNSGEVDIEDLEKKSSSNDVSAIYVQQPNFFGIFESNIEHIIDVAKHKKA
LSIIGVNPLSLGLIKPPGSYEADIVVGDGQELGLPLNFGGPLMGIFAVRWDMGLVRQMPGRIVGITRDVNNNMGFTLILQ
TREQFIKREKATSNITTNEALLALANAVYLSLLGKEGIRELAEEIYFRSHYAAKRLTEIDNVIMPFTSDFFEEFVIKFPI
EYNIINDKLKERKLQGGLKLSIHTSLFCVTEVHDKKSIDLLVSTIQEAIKSVETS
>Mature_455_residues
MYKHPWLPNLDLTDEMLKEIGVNSLDDLFNDIPAEIKINRLLKVAKDKPLSEYEIEKEIYEKVKKNVELEAPPFIGAGIC
PHYIPNAVKFIIGRSEFYTSYTPYQPEISQGILQALFEYQSLMAELLEMDVVNASMYDWGSALAEAVLMANRINGKKTVL
VPENANPFHKEVMRTWIQGKGIKIEEVKYDKNSGEVDIEDLEKKSSSNDVSAIYVQQPNFFGIFESNIEHIIDVAKHKKA
LSIIGVNPLSLGLIKPPGSYEADIVVGDGQELGLPLNFGGPLMGIFAVRWDMGLVRQMPGRIVGITRDVNNNMGFTLILQ
TREQFIKREKATSNITTNEALLALANAVYLSLLGKEGIRELAEEIYFRSHYAAKRLTEIDNVIMPFTSDFFEEFVIKFPI
EYNIINDKLKERKLQGGLKLSIHTSLFCVTEVHDKKSIDLLVSTIQEAIKSVETS

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=354, Percent_Identity=35.8757062146893, Blast_Score=213, Evalue=3e-55,
Organism=Escherichia coli, GI1789269, Length=377, Percent_Identity=31.8302387267904, Blast_Score=167, Evalue=9e-43,
Organism=Caenorhabditis elegans, GI17535605, Length=389, Percent_Identity=34.9614395886889, Blast_Score=194, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6323843, Length=362, Percent_Identity=35.6353591160221, Blast_Score=193, Evalue=6e-50,
Organism=Drosophila melanogaster, GI24645648, Length=353, Percent_Identity=37.6770538243626, Blast_Score=227, Evalue=2e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 51368; Mature: 51368

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKHPWLPNLDLTDEMLKEIGVNSLDDLFNDIPAEIKINRLLKVAKDKPLSEYEIEKEIY
CCCCCCCCCCCCHHHHHHHCCCCHHHHHHHCCCCCEEHHHHHHHHCCCCCHHHHHHHHHH
EKVKKNVELEAPPFIGAGICPHYIPNAVKFIIGRSEFYTSYTPYQPEISQGILQALFEYQ
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHHHHHHHHH
SLMAELLEMDVVNASMYDWGSALAEAVLMANRINGKKTVLVPENANPFHKEVMRTWIQGK
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCC
GIKIEEVKYDKNSGEVDIEDLEKKSSSNDVSAIYVQQPNFFGIFESNIEHIIDVAKHKKA
CCEEEEEEECCCCCCCCHHHHHCCCCCCCEEEEEEECCCEEEEHHHHHHHHHHHHHHHCE
LSIIGVNPLSLGLIKPPGSYEADIVVGDGQELGLPLNFGGPLMGIFAVRWDMGLVRQMPG
EEEEECCCCEEEEECCCCCCCEEEEEECCCCCCEEECCCCHHHHHHHHHHHHHHHHHCCC
RIVGITRDVNNNMGFTLILQTREQFIKREKATSNITTNEALLALANAVYLSLLGKEGIRE
CEEEEEEECCCCCCEEEEEHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LAEEIYFRSHYAAKRLTEIDNVIMPFTSDFFEEFVIKFPIEYNIINDKLKERKLQGGLKL
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHCCCEE
SIHTSLFCVTEVHDKKSIDLLVSTIQEAIKSVETS
EEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MYKHPWLPNLDLTDEMLKEIGVNSLDDLFNDIPAEIKINRLLKVAKDKPLSEYEIEKEIY
CCCCCCCCCCCCHHHHHHHCCCCHHHHHHHCCCCCEEHHHHHHHHCCCCCHHHHHHHHHH
EKVKKNVELEAPPFIGAGICPHYIPNAVKFIIGRSEFYTSYTPYQPEISQGILQALFEYQ
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHHHHHHHHH
SLMAELLEMDVVNASMYDWGSALAEAVLMANRINGKKTVLVPENANPFHKEVMRTWIQGK
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCC
GIKIEEVKYDKNSGEVDIEDLEKKSSSNDVSAIYVQQPNFFGIFESNIEHIIDVAKHKKA
CCEEEEEEECCCCCCCCHHHHHCCCCCCCEEEEEEECCCEEEEHHHHHHHHHHHHHHHCE
LSIIGVNPLSLGLIKPPGSYEADIVVGDGQELGLPLNFGGPLMGIFAVRWDMGLVRQMPG
EEEEECCCCEEEEECCCCCCCEEEEEECCCCCCEEECCCCHHHHHHHHHHHHHHHHHCCC
RIVGITRDVNNNMGFTLILQTREQFIKREKATSNITTNEALLALANAVYLSLLGKEGIRE
CEEEEEEECCCCCCEEEEEHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LAEEIYFRSHYAAKRLTEIDNVIMPFTSDFFEEFVIKFPIEYNIINDKLKERKLQGGLKL
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHCCCEE
SIHTSLFCVTEVHDKKSIDLLVSTIQEAIKSVETS
EEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA