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The map label for this gene is lukD

Identifier: 15927393

GI number: 15927393

Start: 1869247

End: 1870230

Strand: Reverse

Name: lukD

Synonym: SA1637

Alternate gene names: 15927393

Gene position: 1870230-1869247 (Counterclockwise)

Preceding gene: 15927394

Following gene: 15927390

Centisome position: 66.44

GC content: 31.71

Gene sequence:

>984_bases
ATGAAAATGAAAAAATTAGTCAAATCATCAGTTGCTTCATCAATTGCACTGCTTTTGCTATCGAATACAGTTGATGCAGC
TCAACATATCACACCTGTAAGCGAGAAAAAAGTAGATGACAAAATCACTTTATACAAAACAACAGCAACATCTGATAATG
ATAAATTGAATATTTCTCAAATTTTAACGTTTAATTTCATTAAGGATAAAAGTTATGACAAAGATACATTAGTACTTAAG
GCAGCCGGAAACATTAATTCAGGTTATAAAAAGCCTAATCCAAAAGATTACAATTACTCACAGTTTTATTGGGGCGGTAA
GTATAATGTTTCGGTTAGTTCAGAATCAAATGATGCTGTAAATGTTGTTGACTATGCACCTAAAAATCAAAATGAAGAAT
TCCAAGTTCAACAAACATTAGGTTATTCTTATGGCGGAGATATTAATATATCTAATGGCTTATCAGGTGGATTGAATGGA
TCAAAATCATTTTCAGAAACAATAAATTATAAACAAGAAAGTTACAGAACTACGATTGATAGAAAAACAAATCATAAATC
AATTGGCTGGGGTGTTGAGGCGCACAAAATTATGAATAATGGTTGGGGACCATATGGTAGAGATAGTTATGACCCAACAT
ATGGTAATGAACTGTTTTTAGGTGGTAGACAAAGTAGTTCAAATGCTGGACAAAATTTCTTGCCAACACATCAAATGCCT
TTATTGGCGCGTGGTAACTTTAACCCAGAATTTATAAGCGTACTTTCTCATAAACAAAATGATACAAAAAAATCTAAAAT
CAAAGTAACTTACCAAAGAGAAATGGATAGATATACTAATCAATGGAATCGACTACACTGGATTGGTAATAACTACAAAA
ATCAAAATACAGTAACGTTTACATCTACTTATGAAGTTGACTGGCAAAACCATACTGTTAAATTAATCGGTACGGATTCT
AAAGAAACTAATCCTGGAGTATAG

Upstream 100 bases:

>100_bases
GCAGAAAGAAAGCATAATGCATTTGTAAATAGAAACTTTGTAGTTAGATATGAAGTTAATTGGAAAACACACGAAATTAA
AGTGAAAGGACATAATTAAT

Downstream 100 bases:

>100_bases
AATTGTATATGATTAAATAATCAACAAAGTGCAATTATTTCAATTATCAAACGGAATTAAAGAACTAACATAATTTTTAT
TTACACACATGATAATTTTT

Product: leukotoxin, LukD

Products: NA

Alternate protein names: H-gamma-1; H-gamma-I [H]

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MKMKKLVKSSVASSIALLLLSNTVDAAQHITPVSEKKVDDKITLYKTTATSDNDKLNISQILTFNFIKDKSYDKDTLVLK
AAGNINSGYKKPNPKDYNYSQFYWGGKYNVSVSSESNDAVNVVDYAPKNQNEEFQVQQTLGYSYGGDINISNGLSGGLNG
SKSFSETINYKQESYRTTIDRKTNHKSIGWGVEAHKIMNNGWGPYGRDSYDPTYGNELFLGGRQSSSNAGQNFLPTHQMP
LLARGNFNPEFISVLSHKQNDTKKSKIKVTYQREMDRYTNQWNRLHWIGNNYKNQNTVTFTSTYEVDWQNHTVKLIGTDS
KETNPGV

Sequences:

>Translated_327_residues
MKMKKLVKSSVASSIALLLLSNTVDAAQHITPVSEKKVDDKITLYKTTATSDNDKLNISQILTFNFIKDKSYDKDTLVLK
AAGNINSGYKKPNPKDYNYSQFYWGGKYNVSVSSESNDAVNVVDYAPKNQNEEFQVQQTLGYSYGGDINISNGLSGGLNG
SKSFSETINYKQESYRTTIDRKTNHKSIGWGVEAHKIMNNGWGPYGRDSYDPTYGNELFLGGRQSSSNAGQNFLPTHQMP
LLARGNFNPEFISVLSHKQNDTKKSKIKVTYQREMDRYTNQWNRLHWIGNNYKNQNTVTFTSTYEVDWQNHTVKLIGTDS
KETNPGV
>Mature_327_residues
MKMKKLVKSSVASSIALLLLSNTVDAAQHITPVSEKKVDDKITLYKTTATSDNDKLNISQILTFNFIKDKSYDKDTLVLK
AAGNINSGYKKPNPKDYNYSQFYWGGKYNVSVSSESNDAVNVVDYAPKNQNEEFQVQQTLGYSYGGDINISNGLSGGLNG
SKSFSETINYKQESYRTTIDRKTNHKSIGWGVEAHKIMNNGWGPYGRDSYDPTYGNELFLGGRQSSSNAGQNFLPTHQMP
LLARGNFNPEFISVLSHKQNDTKKSKIKVTYQREMDRYTNQWNRLHWIGNNYKNQNTVTFTSTYEVDWQNHTVKLIGTDS
KETNPGV

Specific function: Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerolysin family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003963
- InterPro:   IPR001340
- InterPro:   IPR016183 [H]

Pfam domain/function: PF07968 Leukocidin [H]

EC number: NA

Molecular weight: Translated: 36903; Mature: 36903

Theoretical pI: Translated: 9.65; Mature: 9.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMKKLVKSSVASSIALLLLSNTVDAAQHITPVSEKKVDDKITLYKTTATSDNDKLNISQ
CCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCHHHCCCCEEEEEEEECCCCCCCEEHHH
ILTFNFIKDKSYDKDTLVLKAAGNINSGYKKPNPKDYNYSQFYWGGKYNVSVSSESNDAV
EEEEEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEECCEEEEEECCCCCCCE
NVVDYAPKNQNEEFQVQQTLGYSYGGDINISNGLSGGLNGSKSFSETINYKQESYRTTID
EEEECCCCCCCCCEEEEECCCCCCCCCEEECCCCCCCCCCCCHHHHHHCCCHHHHHHHHC
RKTNHKSIGWGVEAHKIMNNGWGPYGRDSYDPTYGNELFLGGRQSSSNAGQNFLPTHQMP
CCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCC
LLARGNFNPEFISVLSHKQNDTKKSKIKVTYQREMDRYTNQWNRLHWIGNNYKNQNTVTF
EEEECCCCHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHCCEEEEECCCCCCCCEEEE
TSTYEVDWQNHTVKLIGTDSKETNPGV
EEEEEEECCCCEEEEEECCCCCCCCCC
>Mature Secondary Structure
MKMKKLVKSSVASSIALLLLSNTVDAAQHITPVSEKKVDDKITLYKTTATSDNDKLNISQ
CCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCHHHCCCCEEEEEEEECCCCCCCEEHHH
ILTFNFIKDKSYDKDTLVLKAAGNINSGYKKPNPKDYNYSQFYWGGKYNVSVSSESNDAV
EEEEEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEECCEEEEEECCCCCCCE
NVVDYAPKNQNEEFQVQQTLGYSYGGDINISNGLSGGLNGSKSFSETINYKQESYRTTID
EEEECCCCCCCCCEEEEECCCCCCCCCEEECCCCCCCCCCCCHHHHHHCCCHHHHHHHHC
RKTNHKSIGWGVEAHKIMNNGWGPYGRDSYDPTYGNELFLGGRQSSSNAGQNFLPTHQMP
CCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCC
LLARGNFNPEFISVLSHKQNDTKKSKIKVTYQREMDRYTNQWNRLHWIGNNYKNQNTVTF
EEEECCCCHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHCCEEEEECCCCCCCCEEEE
TSTYEVDWQNHTVKLIGTDSKETNPGV
EEEEEEECCCCEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA