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The map label for this gene is lukE

Identifier: 15927394

GI number: 15927394

Start: 1870232

End: 1871167

Strand: Reverse

Name: lukE

Synonym: SA1638

Alternate gene names: 15927394

Gene position: 1871167-1870232 (Counterclockwise)

Preceding gene: 15927398

Following gene: 15927393

Centisome position: 66.48

GC content: 32.69

Gene sequence:

>936_bases
ATGTTTAAGAAAAAAATGTTAGCTGCAACTTTGTCAGTAGGACTGATTGCGCCTTTAGCATCTCCGATTCAAGAATCTAG
AGCTAATACTAATATAGAGAATATTGGTGATGGTGCTGAAGTAATCAAACGTACGGAGGATGTAAGTAGTAAGAAATGGG
GCGTTACTCAAAATGTTCAATTCGACTTTGTAAAAGATAAAAAATATAACAAAGATGCTTTAATTGTTAAAATGCAAGGT
TTTATTAATTCCAGAACTTCATTTTCAGATGTGAAGGGTAGTGGATATGAATTGACTAAACGAATGATTTGGCCATTCCA
ATATAATATAGGACTGACGACTAAAGATCCAAATGTTAGCTTAATCAATTACCTTCCTAAAAACAAAATAGAAACTACTG
ATGTTGGTCAAACATTAGGATATAACATTGGAGGTAATTTCCAGTCAGCACCATCTATAGGTGGCAATGGCTCATTTAAT
TATTCTAAAACAATTAGTTATACCCAAAAGAGTTATGTCAGTGAAGTAGACAAGCAAAACTCAAAATCAGTTAAATGGGG
TGTTAAAGCAAACGAATTTGTTACGCCTGATGGTAAAAAATCTGCGCATGATAGATATTTATTCGTACAAAGTCCAAATG
GTCCAACAGGTTCAGCAAGAGAATATTTTGCTCCTGATAATCAATTGCCACCTTTAGTTCAAAGTGGCTTTAATCCATCA
TTTATCACTACACTATCACATGAAAAAGGTTCAAGTGATACGAGTGAATTTGAAATTTCATATGGTAGAAACTTAGATAT
TACATATGCGACTTTATTCCCTAGAACTGGTATTTACGCAGAAAGAAAGCATAATGCATTTGTAAATAGAAACTTTGTAG
TTAGATATGAAGTTAATTGGAAAACACACGAAATTAAAGTGAAAGGACATAATTAA

Upstream 100 bases:

>100_bases
TAGCATTTTATTTTTTTAATGAACAGTTAATTTTATAAATAAGTGAAATAATCTAGAATAAATTTGTATTAAAAATTTAT
ATAGAAAGAAAGTGAAACTT

Downstream 100 bases:

>100_bases
TATGAAAATGAAAAAATTAGTCAAATCATCAGTTGCTTCATCAATTGCACTGCTTTTGCTATCGAATACAGTTGATGCAG
CTCAACATATCACACCTGTA

Product: leukotoxin LukE

Products: NA

Alternate protein names: H-gamma-2; H-gamma-II [H]

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MFKKKMLAATLSVGLIAPLASPIQESRANTNIENIGDGAEVIKRTEDVSSKKWGVTQNVQFDFVKDKKYNKDALIVKMQG
FINSRTSFSDVKGSGYELTKRMIWPFQYNIGLTTKDPNVSLINYLPKNKIETTDVGQTLGYNIGGNFQSAPSIGGNGSFN
YSKTISYTQKSYVSEVDKQNSKSVKWGVKANEFVTPDGKKSAHDRYLFVQSPNGPTGSAREYFAPDNQLPPLVQSGFNPS
FITTLSHEKGSSDTSEFEISYGRNLDITYATLFPRTGIYAERKHNAFVNRNFVVRYEVNWKTHEIKVKGHN

Sequences:

>Translated_311_residues
MFKKKMLAATLSVGLIAPLASPIQESRANTNIENIGDGAEVIKRTEDVSSKKWGVTQNVQFDFVKDKKYNKDALIVKMQG
FINSRTSFSDVKGSGYELTKRMIWPFQYNIGLTTKDPNVSLINYLPKNKIETTDVGQTLGYNIGGNFQSAPSIGGNGSFN
YSKTISYTQKSYVSEVDKQNSKSVKWGVKANEFVTPDGKKSAHDRYLFVQSPNGPTGSAREYFAPDNQLPPLVQSGFNPS
FITTLSHEKGSSDTSEFEISYGRNLDITYATLFPRTGIYAERKHNAFVNRNFVVRYEVNWKTHEIKVKGHN
>Mature_311_residues
MFKKKMLAATLSVGLIAPLASPIQESRANTNIENIGDGAEVIKRTEDVSSKKWGVTQNVQFDFVKDKKYNKDALIVKMQG
FINSRTSFSDVKGSGYELTKRMIWPFQYNIGLTTKDPNVSLINYLPKNKIETTDVGQTLGYNIGGNFQSAPSIGGNGSFN
YSKTISYTQKSYVSEVDKQNSKSVKWGVKANEFVTPDGKKSAHDRYLFVQSPNGPTGSAREYFAPDNQLPPLVQSGFNPS
FITTLSHEKGSSDTSEFEISYGRNLDITYATLFPRTGIYAERKHNAFVNRNFVVRYEVNWKTHEIKVKGHN

Specific function: Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerolysin family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003963
- InterPro:   IPR001340
- InterPro:   IPR016183 [H]

Pfam domain/function: PF07968 Leukocidin [H]

EC number: NA

Molecular weight: Translated: 34819; Mature: 34819

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKKKMLAATLSVGLIAPLASPIQESRANTNIENIGDGAEVIKRTEDVSSKKWGVTQNVQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHCCCCCCCCCCCCCE
FDFVKDKKYNKDALIVKMQGFINSRTSFSDVKGSGYELTKRMIWPFQYNIGLTTKDPNVS
EEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCCEEHHEEECEEEEEEEEECCCCCEE
LINYLPKNKIETTDVGQTLGYNIGGNFQSAPSIGGNGSFNYSKTISYTQKSYVSEVDKQN
EEECCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHCCC
SKSVKWGVKANEFVTPDGKKSAHDRYLFVQSPNGPTGSAREYFAPDNQLPPLVQSGFNPS
CCCEEECCCCCCEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHCCCCCC
FITTLSHEKGSSDTSEFEISYGRNLDITYATLFPRTGIYAERKHNAFVNRNFVVRYEVNW
EEEEECCCCCCCCCCEEEEECCCCCEEEEEEECCCCCCEECCCCCEEECCCEEEEEEECC
KTHEIKVKGHN
EEEEEEEECCC
>Mature Secondary Structure
MFKKKMLAATLSVGLIAPLASPIQESRANTNIENIGDGAEVIKRTEDVSSKKWGVTQNVQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHCCCCCCCCCCCCCE
FDFVKDKKYNKDALIVKMQGFINSRTSFSDVKGSGYELTKRMIWPFQYNIGLTTKDPNVS
EEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCCEEHHEEECEEEEEEEEECCCCCEE
LINYLPKNKIETTDVGQTLGYNIGGNFQSAPSIGGNGSFNYSKTISYTQKSYVSEVDKQN
EEECCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHCCC
SKSVKWGVKANEFVTPDGKKSAHDRYLFVQSPNGPTGSAREYFAPDNQLPPLVQSGFNPS
CCCEEECCCCCCEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHCCCCCC
FITTLSHEKGSSDTSEFEISYGRNLDITYATLFPRTGIYAERKHNAFVNRNFVVRYEVNW
EEEEECCCCCCCCCCEEEEECCCCCEEEEEEECCCCCCEECCCCCEEECCCEEEEEEECC
KTHEIKVKGHN
EEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA