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The map label for this gene is trpC

Identifier: 15926950

GI number: 15926950

Start: 1375540

End: 1376322

Strand: Direct

Name: trpC

Synonym: SA1202

Alternate gene names: 15926950

Gene position: 1375540-1376322 (Clockwise)

Preceding gene: 15926949

Following gene: 15926951

Centisome position: 48.87

GC content: 32.18

Gene sequence:

>783_bases
ATGACGATTTTAGCAGAAATTGTTAAATATAAACAGTCACTTTTACAAAATGGCTATTATCAAGACAAACTTAATACCTT
GAAAAGTGTGAAGATTCAGAATAAAAAATCTTTTATAAACGCAATTGAGAAAGAACCAAAGCTAGCAATTATTGCAGAAA
TTAAATCGAAGAGTCCTACAGTTAATGACTTACCTGAACGAGATTTATCGCAACAAATCTCAGATTATGAAAAGTACGGT
GCAAATGCCGTGTCCATTTTAACTGATGAAAAGTACTTTGGTGGTAGTTTTGAAAGATTACAAGCATTGACAACAAAAAC
AACATTACCCGTATTATGCAAAGACTTTATTATAGACCCGCTTCAAATTGATGTTGCTAAACAAGCTGGTGCATCTATGA
TTTTATTGATCGTTAACATCTTATCGGATAAACAATTGAAAGATTTATATAACTACGCTATATCGCAAAATCTAGAAGTG
TTAATTGAAGTACATGATCGCCATGAATTAGAACGTGCCTATAAGGTTAATGCTAAATTGATTGGTGTAAATAACAGGGA
CTTAAAACGATTTGTCACAAATGTGGAACATACAAATACTATTTTAGAAAATAAAAAACCCAATCATCATTATATTTCTG
AAAGTGGTATTCACGATGCATCTGATGTAAGAAAAATCTTGCATAGTGGTATCGATGGCTTACTAATAGGTGAGGCGCTT
ATGCGTTGTGACAATCTATCTGAATTTTTACCACAACTGAAAATGCAAAAGGTGAAGTCATGA

Upstream 100 bases:

>100_bases
GAGAAAGTGGATACCATCGCAGAAGGCATAGAACTTGCAACTACATTGATTGATAATGGTGAAGCATTGAAAAAATACCA
TCAAATGAGAGGTGAATAAT

Downstream 100 bases:

>100_bases
TGAAATTGAAATTTTGTGGCTTTACATCAATAAAGGATGTTACAGCGGCCAGTCAATTACCTATTGATGCGATAGGTTTC
ATCCATTATGAAAAAAGTAA

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 260; Mature: 259

Protein sequence:

>260_residues
MTILAEIVKYKQSLLQNGYYQDKLNTLKSVKIQNKKSFINAIEKEPKLAIIAEIKSKSPTVNDLPERDLSQQISDYEKYG
ANAVSILTDEKYFGGSFERLQALTTKTTLPVLCKDFIIDPLQIDVAKQAGASMILLIVNILSDKQLKDLYNYAISQNLEV
LIEVHDRHELERAYKVNAKLIGVNNRDLKRFVTNVEHTNTILENKKPNHHYISESGIHDASDVRKILHSGIDGLLIGEAL
MRCDNLSEFLPQLKMQKVKS

Sequences:

>Translated_260_residues
MTILAEIVKYKQSLLQNGYYQDKLNTLKSVKIQNKKSFINAIEKEPKLAIIAEIKSKSPTVNDLPERDLSQQISDYEKYG
ANAVSILTDEKYFGGSFERLQALTTKTTLPVLCKDFIIDPLQIDVAKQAGASMILLIVNILSDKQLKDLYNYAISQNLEV
LIEVHDRHELERAYKVNAKLIGVNNRDLKRFVTNVEHTNTILENKKPNHHYISESGIHDASDVRKILHSGIDGLLIGEAL
MRCDNLSEFLPQLKMQKVKS
>Mature_259_residues
TILAEIVKYKQSLLQNGYYQDKLNTLKSVKIQNKKSFINAIEKEPKLAIIAEIKSKSPTVNDLPERDLSQQISDYEKYGA
NAVSILTDEKYFGGSFERLQALTTKTTLPVLCKDFIIDPLQIDVAKQAGASMILLIVNILSDKQLKDLYNYAISQNLEVL
IEVHDRHELERAYKVNAKLIGVNNRDLKRFVTNVEHTNTILENKKPNHHYISESGIHDASDVRKILHSGIDGLLIGEALM
RCDNLSEFLPQLKMQKVKS

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=245, Percent_Identity=36.734693877551, Blast_Score=141, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6322638, Length=216, Percent_Identity=35.6481481481481, Blast_Score=129, Evalue=4e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_STAA1 (A7X234)

Other databases:

- EMBL:   AP009324
- RefSeq:   YP_001441948.1
- ProteinModelPortal:   A7X234
- SMR:   A7X234
- STRING:   A7X234
- EnsemblBacteria:   EBSTAT00000003362
- GeneID:   5561064
- GenomeReviews:   AP009324_GR
- KEGG:   saw:SAHV_1358
- eggNOG:   COG0134
- GeneTree:   EBGT00050000025434
- HOGENOM:   HBG540956
- OMA:   VDLPLLC
- ProtClustDB:   PRK00278
- BioCyc:   SAUR418127:SAHV_1358-MONOMER
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 29509; Mature: 29378

Theoretical pI: Translated: 8.59; Mature: 8.59

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTILAEIVKYKQSLLQNGYYQDKLNTLKSVKIQNKKSFINAIEKEPKLAIIAEIKSKSPT
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCC
VNDLPERDLSQQISDYEKYGANAVSILTDEKYFGGSFERLQALTTKTTLPVLCKDFIIDP
CCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
LQIDVAKQAGASMILLIVNILSDKQLKDLYNYAISQNLEVLIEVHDRHELERAYKVNAKL
HHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHCCCEE
IGVNNRDLKRFVTNVEHTNTILENKKPNHHYISESGIHDASDVRKILHSGIDGLLIGEAL
EECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHH
MRCDNLSEFLPQLKMQKVKS
HHHCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TILAEIVKYKQSLLQNGYYQDKLNTLKSVKIQNKKSFINAIEKEPKLAIIAEIKSKSPT
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCC
VNDLPERDLSQQISDYEKYGANAVSILTDEKYFGGSFERLQALTTKTTLPVLCKDFIIDP
CCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
LQIDVAKQAGASMILLIVNILSDKQLKDLYNYAISQNLEVLIEVHDRHELERAYKVNAKL
HHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHCCCEE
IGVNNRDLKRFVTNVEHTNTILENKKPNHHYISESGIHDASDVRKILHSGIDGLLIGEAL
EECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHH
MRCDNLSEFLPQLKMQKVKS
HHHCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA