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The map label for this gene is purC

Identifier: 15926652

GI number: 15926652

Start: 1043201

End: 1043905

Strand: Direct

Name: purC

Synonym: SA0918

Alternate gene names: 15926652

Gene position: 1043201-1043905 (Clockwise)

Preceding gene: 15926651

Following gene: 15926653

Centisome position: 37.06

GC content: 28.94

Gene sequence:

>705_bases
ATGACATTATTATATGAAGGAAAAGCGAAGCGCATTTTCTCAACAAATCAAGAAAATGAATTAAGAGTTGAATATAAAGA
TGAAGTTACTGCTGGAAACGGGGCTAAGAAAGACACAATGGCAGGTAAGGGGCGATTAAATAATCAAATTACTTCTATTA
TATTTAAATATTTACAAGAAAATGGAATAGAAAGTCACTTTATTAAACAATTATCTGAAACAGAACAATTAGTTAAGCCT
GTGAAAATAATTCCATTAGAAGTAGTTGTTCGTAATATTGCTAGTGGATCTATTACAAAGCGTTTAGGTTTTGAAAATGG
TGAAGTTTTTAGAGAACCACTTGTAGAATTTTTCTATAAAAATGATGCGTTAAATGATCCGTTGATAACGGATGACCATG
TTAAATTGCTCAATATAGCATCAGATGAAGATATTGAAATACTAAAATCCAAAGCATTAAAGATTAATAATGTGTTGAAA
CAATTAATGGATGCTATGAATTTAAAATTAGTAGATTTTAAAATCGAATTTGGAAAGACTGAGACTGGTCAAATTTTGTT
AGCGGATGAAATATCTCCAGATACATGTCGAATTTGGGATAAAGCTACCAATGCAAACTTTGATAAAGATGTATATAGAA
ATAACACTGGATCACTGATTGAAACATATCAAATATTTTTAAACAAATTGGAGGATTTAAAATAA

Upstream 100 bases:

>100_bases
TAAAGATAGCAGAAAAATGGGGCATATGACTGTACTAACGAATGATGTAAACCAAACTGAACAAGATATGTACGCTAAAT
TTGAGGGGAGTAATTAAAGC

Downstream 100 bases:

>100_bases
TGAAAACAATTGAACTACATATCACATTACAACCACAAGTATTAGATACGCAAGGACAAACGCTTACTCGAGCTGTACAT
GACTTAGGTTATGCACAAGT

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase

Number of amino acids: Translated: 234; Mature: 233

Protein sequence:

>234_residues
MTLLYEGKAKRIFSTNQENELRVEYKDEVTAGNGAKKDTMAGKGRLNNQITSIIFKYLQENGIESHFIKQLSETEQLVKP
VKIIPLEVVVRNIASGSITKRLGFENGEVFREPLVEFFYKNDALNDPLITDDHVKLLNIASDEDIEILKSKALKINNVLK
QLMDAMNLKLVDFKIEFGKTETGQILLADEISPDTCRIWDKATNANFDKDVYRNNTGSLIETYQIFLNKLEDLK

Sequences:

>Translated_234_residues
MTLLYEGKAKRIFSTNQENELRVEYKDEVTAGNGAKKDTMAGKGRLNNQITSIIFKYLQENGIESHFIKQLSETEQLVKP
VKIIPLEVVVRNIASGSITKRLGFENGEVFREPLVEFFYKNDALNDPLITDDHVKLLNIASDEDIEILKSKALKINNVLK
QLMDAMNLKLVDFKIEFGKTETGQILLADEISPDTCRIWDKATNANFDKDVYRNNTGSLIETYQIFLNKLEDLK
>Mature_233_residues
TLLYEGKAKRIFSTNQENELRVEYKDEVTAGNGAKKDTMAGKGRLNNQITSIIFKYLQENGIESHFIKQLSETEQLVKPV
KIIPLEVVVRNIASGSITKRLGFENGEVFREPLVEFFYKNDALNDPLITDDHVKLLNIASDEDIEILKSKALKINNVLKQ
LMDAMNLKLVDFKIEFGKTETGQILLADEISPDTCRIWDKATNANFDKDVYRNNTGSLIETYQIFLNKLEDLK

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family

Homologues:

Organism=Homo sapiens, GI119220557, Length=221, Percent_Identity=35.7466063348416, Blast_Score=135, Evalue=3e-32,
Organism=Homo sapiens, GI5453539, Length=221, Percent_Identity=35.7466063348416, Blast_Score=135, Evalue=3e-32,
Organism=Homo sapiens, GI119220559, Length=228, Percent_Identity=34.6491228070175, Blast_Score=127, Evalue=8e-30,
Organism=Escherichia coli, GI1788820, Length=227, Percent_Identity=41.8502202643172, Blast_Score=187, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI17531275, Length=227, Percent_Identity=37.4449339207048, Blast_Score=134, Evalue=5e-32,
Organism=Drosophila melanogaster, GI18860083, Length=222, Percent_Identity=32.8828828828829, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24583917, Length=222, Percent_Identity=31.981981981982, Blast_Score=108, Evalue=2e-24,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PUR7_STAA1 (A7X0V7)

Other databases:

- EMBL:   AP009324
- RefSeq:   YP_001441648.1
- ProteinModelPortal:   A7X0V7
- SMR:   A7X0V7
- STRING:   A7X0V7
- EnsemblBacteria:   EBSTAT00000003706
- GeneID:   5561005
- GenomeReviews:   AP009324_GR
- KEGG:   saw:SAHV_1058
- eggNOG:   COG0152
- GeneTree:   EBGT00050000025507
- HOGENOM:   HBG306070
- OMA:   YKDDALG
- ProtClustDB:   PRK09362
- BioCyc:   SAUR418127:SAHV_1058-MONOMER
- HAMAP:   MF_00137
- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236
- Gene3D:   G3DSA:3.30.470.20
- PANTHER:   PTHR11609
- TIGRFAMs:   TIGR00081

Pfam domain/function: PF01259 SAICAR_synt

EC number: =6.3.2.6

Molecular weight: Translated: 26693; Mature: 26562

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS01057 SAICAR_SYNTHETASE_1; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLLYEGKAKRIFSTNQENELRVEYKDEVTAGNGAKKDTMAGKGRLNNQITSIIFKYLQE
CCEEECCCCCCEECCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
NGIESHFIKQLSETEQLVKPVKIIPLEVVVRNIASGSITKRLGFENGEVFREPLVEFFYK
CCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHHHH
NDALNDPLITDDHVKLLNIASDEDIEILKSKALKINNVLKQLMDAMNLKLVDFKIEFGKT
CCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCC
ETGQILLADEISPDTCRIWDKATNANFDKDVYRNNTGSLIETYQIFLNKLEDLK
CCCCEEEECCCCCCCEEEECCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TLLYEGKAKRIFSTNQENELRVEYKDEVTAGNGAKKDTMAGKGRLNNQITSIIFKYLQE
CEEECCCCCCEECCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
NGIESHFIKQLSETEQLVKPVKIIPLEVVVRNIASGSITKRLGFENGEVFREPLVEFFYK
CCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHHHH
NDALNDPLITDDHVKLLNIASDEDIEILKSKALKINNVLKQLMDAMNLKLVDFKIEFGKT
CCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCC
ETGQILLADEISPDTCRIWDKATNANFDKDVYRNNTGSLIETYQIFLNKLEDLK
CCCCEEEECCCCCCCEEEECCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA