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The map label for this gene is purK

Identifier: 15926651

GI number: 15926651

Start: 1042073

End: 1043197

Strand: Direct

Name: purK

Synonym: SA0917

Alternate gene names: 15926651

Gene position: 1042073-1043197 (Clockwise)

Preceding gene: 15926650

Following gene: 15926652

Centisome position: 37.02

GC content: 32.98

Gene sequence:

>1125_bases
ATGAACTTCAATAAATTAAAGTTTGGTGCGACTATTGGCATTATTGGTGGTGGTCAGCTTGGAAAGATGATGGCACAATC
AGCTCAAAAAATGGGTTATAAAGTGGTTGTATTGGATCCTTCTGAAGATTGTCCATGTAGATACGTTGCACACGAATTTA
TACAAGCCAAGTATGACGATGAAAAGGCACTCAATCAATTAGGACAAAAATGTGATGTGATTACTTATGAATTTGAAAAC
ATTTCAGCCCAACAATTAAAACTATTATGTGAAAAGTACAATATTCCGCAAGGTTACCAAGCTATACAGTTATTACAAGA
CCGCTTAACTGAAAAAGAAACATTAAAAAGTGCTGGTACCAAAGTTGTCCCGTTCATTTCAGTAAAAGAATCTACAGATA
TTGACAAAGCAATTGAAACATTAGGATATCCTTTTATTGTAAAAACTAGATTTGGTGGCTACGATGGCAAAGGTCAAGTT
TTAATTAACAACGAAAAAGACTTACAAGAAGGTTTTAAATTAATTGAAACTAGTGAATGCGTAGCTGAAAAATATTTGAA
TATCAAGAAAGAAGTATCTCTTACTGTTACAAGAGGAAACAACAATCAAATCACTTTTTTCCCATTACAAGAAAATGAGC
ATAGAAATCAAATACTTTTCAAAACAATTGTTCCAGCGAGAATAGATAAAACAGCTGAGGCGAAAGAGCAAGTTAATAAA
ATTATCCAATCGATTCATTTCATTGGAACATTTACAGTGGAATTTTTTATAGATAGTAACAACCAATTGTATGTGAACGA
GATTGCACCAAGGCCTCACAATTCCGGACATTATTCAATTGAAGCATGTGATTATTCACAATTTGATACTCATATTTTAG
CAGTTACCGGACAATCATTACCAAATTCAATTGAATTATTAAAGCCTGCAGTCATGATGAACTTACTAGGTAAAGACTTA
GATTTATTGGAAAATGAATTTAATGAACATCCAGAGTGGCACTTACATATTTATGGTAAGTCTGGGCGTAAAGATAGCAG
AAAAATGGGGCATATGACTGTACTAACGAATGATGTAAACCAAACTGAACAAGATATGTACGCTAAATTTGAGGGGAGTA
ATTAA

Upstream 100 bases:

>100_bases
ATACTTGCAGCAAGAATGTTAAGTATTCAAAATCCTTCTTTAGTTGAAAAACTAAATCAGTATGAATCTTCGTTAATTCA
AAAAGTGGAGGACATGCAAA

Downstream 100 bases:

>100_bases
AGCATGACATTATTATATGAAGGAAAAGCGAAGCGCATTTTCTCAACAAATCAAGAAAATGAATTAAGAGTTGAATATAA
AGATGAAGTTACTGCTGGAA

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MNFNKLKFGATIGIIGGGQLGKMMAQSAQKMGYKVVVLDPSEDCPCRYVAHEFIQAKYDDEKALNQLGQKCDVITYEFEN
ISAQQLKLLCEKYNIPQGYQAIQLLQDRLTEKETLKSAGTKVVPFISVKESTDIDKAIETLGYPFIVKTRFGGYDGKGQV
LINNEKDLQEGFKLIETSECVAEKYLNIKKEVSLTVTRGNNNQITFFPLQENEHRNQILFKTIVPARIDKTAEAKEQVNK
IIQSIHFIGTFTVEFFIDSNNQLYVNEIAPRPHNSGHYSIEACDYSQFDTHILAVTGQSLPNSIELLKPAVMMNLLGKDL
DLLENEFNEHPEWHLHIYGKSGRKDSRKMGHMTVLTNDVNQTEQDMYAKFEGSN

Sequences:

>Translated_374_residues
MNFNKLKFGATIGIIGGGQLGKMMAQSAQKMGYKVVVLDPSEDCPCRYVAHEFIQAKYDDEKALNQLGQKCDVITYEFEN
ISAQQLKLLCEKYNIPQGYQAIQLLQDRLTEKETLKSAGTKVVPFISVKESTDIDKAIETLGYPFIVKTRFGGYDGKGQV
LINNEKDLQEGFKLIETSECVAEKYLNIKKEVSLTVTRGNNNQITFFPLQENEHRNQILFKTIVPARIDKTAEAKEQVNK
IIQSIHFIGTFTVEFFIDSNNQLYVNEIAPRPHNSGHYSIEACDYSQFDTHILAVTGQSLPNSIELLKPAVMMNLLGKDL
DLLENEFNEHPEWHLHIYGKSGRKDSRKMGHMTVLTNDVNQTEQDMYAKFEGSN
>Mature_374_residues
MNFNKLKFGATIGIIGGGQLGKMMAQSAQKMGYKVVVLDPSEDCPCRYVAHEFIQAKYDDEKALNQLGQKCDVITYEFEN
ISAQQLKLLCEKYNIPQGYQAIQLLQDRLTEKETLKSAGTKVVPFISVKESTDIDKAIETLGYPFIVKTRFGGYDGKGQV
LINNEKDLQEGFKLIETSECVAEKYLNIKKEVSLTVTRGNNNQITFFPLQENEHRNQILFKTIVPARIDKTAEAKEQVNK
IIQSIHFIGTFTVEFFIDSNNQLYVNEIAPRPHNSGHYSIEACDYSQFDTHILAVTGQSLPNSIELLKPAVMMNLLGKDL
DLLENEFNEHPEWHLHIYGKSGRKDSRKMGHMTVLTNDVNQTEQDMYAKFEGSN

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=359, Percent_Identity=28.6908077994429, Blast_Score=151, Evalue=8e-38,
Organism=Escherichia coli, GI1788155, Length=373, Percent_Identity=23.8605898123324, Blast_Score=87, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324702, Length=381, Percent_Identity=31.2335958005249, Blast_Score=208, Evalue=1e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR006140
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C; PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 42422; Mature: 42422

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFNKLKFGATIGIIGGGQLGKMMAQSAQKMGYKVVVLDPSEDCPCRYVAHEFIQAKYDD
CCCCEEEECEEEEEECCCHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHCCCH
EKALNQLGQKCDVITYEFENISAQQLKLLCEKYNIPQGYQAIQLLQDRLTEKETLKSAGT
HHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCC
KVVPFISVKESTDIDKAIETLGYPFIVKTRFGGYDGKGQVLINNEKDLQEGFKLIETSEC
EEEEEEEECCCCCHHHHHHHCCCCEEEEEECCCCCCCCCEEECCCHHHHHHHHHHHHHHH
VAEKYLNIKKEVSLTVTRGNNNQITFFPLQENEHRNQILFKTIVPARIDKTAEAKEQVNK
HHHHHHCCCEEEEEEEEECCCCEEEEEECCCCCCCCEEEEEECCCHHCCCHHHHHHHHHH
IIQSIHFIGTFTVEFFIDSNNQLYVNEIAPRPHNSGHYSIEACDYSQFDTHILAVTGQSL
HHHHHHHEEEEEEEEEECCCCEEEEEECCCCCCCCCCEEEEECCCCCCCCEEEEEECCCC
PNSIELLKPAVMMNLLGKDLDLLENEFNEHPEWHLHIYGKSGRKDSRKMGHMTVLTNDVN
CCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEEEECCCCCCHHHCCCEEEEECCCC
QTEQDMYAKFEGSN
HHHHHHEEEECCCC
>Mature Secondary Structure
MNFNKLKFGATIGIIGGGQLGKMMAQSAQKMGYKVVVLDPSEDCPCRYVAHEFIQAKYDD
CCCCEEEECEEEEEECCCHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHCCCH
EKALNQLGQKCDVITYEFENISAQQLKLLCEKYNIPQGYQAIQLLQDRLTEKETLKSAGT
HHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCC
KVVPFISVKESTDIDKAIETLGYPFIVKTRFGGYDGKGQVLINNEKDLQEGFKLIETSEC
EEEEEEEECCCCCHHHHHHHCCCCEEEEEECCCCCCCCCEEECCCHHHHHHHHHHHHHHH
VAEKYLNIKKEVSLTVTRGNNNQITFFPLQENEHRNQILFKTIVPARIDKTAEAKEQVNK
HHHHHHCCCEEEEEEEEECCCCEEEEEECCCCCCCCEEEEEECCCHHCCCHHHHHHHHHH
IIQSIHFIGTFTVEFFIDSNNQLYVNEIAPRPHNSGHYSIEACDYSQFDTHILAVTGQSL
HHHHHHHEEEEEEEEEECCCCEEEEEECCCCCCCCCCEEEEECCCCCCCCEEEEEECCCC
PNSIELLKPAVMMNLLGKDLDLLENEFNEHPEWHLHIYGKSGRKDSRKMGHMTVLTNDVN
CCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEEEECCCCCCHHHCCCEEEEECCCC
QTEQDMYAKFEGSN
HHHHHHEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA