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The map label for this gene is nupC

Identifier: 15926198

GI number: 15926198

Start: 559257

End: 560471

Strand: Reverse

Name: nupC

Synonym: SA0479

Alternate gene names: 15926198

Gene position: 560471-559257 (Counterclockwise)

Preceding gene: 15926227

Following gene: 15926195

Centisome position: 19.91

GC content: 33.09

Gene sequence:

>1215_bases
ATGCATATTCTAATTGGGATTATCGGAATTATCTTCTTTTTAGCACTTGCGTTTCTATTTAGCTCAGACAGGAAAAATAT
TCGCTGGAAATATGTAGGAATTTTACTTGCAATTCAGCTTATCTTTGCATTTATCTTGCTTAAAACTACAATGGGAATCA
AGGTTATTGGTGGTATTTCAAACGGTTTTAACTACTTATTATTAAAAGCAGCAGATGGTGTTAACTTTGTATTCGGTGGT
ATTCAATATATCGATCCTAAGCAACCACCATTCTTCTTCAGTGTATTATTACCTATCGTATTTATTTCAGCGATTATCGG
TATCCTTCAATACACAAAGATTTTACCTTTAATCATTAATGTTTTAGGATTCTTAATTTCTAAAATTAATGGTATGGGAC
GTTTAGAATCATACAATGCAGTTGCTGCAGCAATTTTAGGACAATCTGAAGTATTTATTTCAATTAAAAAACAATTACCA
TACATACCTAAGCAACGTTTATACACATTAACAGCTTCAGCAATGTCGACTGTTTCTGCTTCAATTATCGGTGCATACTT
TACCTTAATTGAACCTAAATATGTTGTAACGGCTGTTGTCTTAAACTTATTTGGTGGTTTCATCATCGCTTCAATTATTA
ACCCTTATAAAGTTAATGAAGAAGATGACAAATTATTAGTTGAAGAAACTGAAGAAAGACAACAATCATTCTTCGAAATG
CTAGGAGAATATATTTTAGATGGATTTAAAGTAGCTGTCATTGTAGGTGCAATGTTAATCGGATACATTGCCATTATCGC
TCTATTAAATGGAATTGTAAGCAATATCTTTAGTACAGTTTCAGGTGGCGCTATTTCTTGGGATTTCCAAACATTAATTG
GTTTTGTCTTTGCACCATTTGCATTCTTAGTCGGTGTGCCATGGCAAGATGCAGTTCAAGCCGGTTCAGTTATGGCGACA
AAACTATTATCTAACGAATTTGTAGCAATGCAAGCACTTGGTAAACTTAGTGATTTATCTGAACACGCAAAAGGTGTTAC
ATCTGTATTCTTAGTATCATTTGCTAACTTTAGCTCTATTGGTATTATTTCAGGTGCTATTAAATCACTTAATGACAAAA
AAGGAGATACAGTTGCCCGCTTTGGTTTGAAATTATTATTCGGTGCAACACTAGTATCTTTCATTTCAGCTGCAATCGCT
GGATTCTTTATTTAA

Upstream 100 bases:

>100_bases
TTCAATTAATTTGTTTTTATATTTTCAAAAATTTATGATGTTAGCCCTTCCATTTTATTGTATGATAGATTGTAGAAAAA
ACTAAAGGAATGAGAAATAT

Downstream 100 bases:

>100_bases
CAAATACATCAACATCGAATTAATCCCTTCAAAATTTTGACTATTCTCAGTCTCTTTGAAGGGGTTTTTTCTTATGTATA
TCTTTATTTTTTATCATTTT

Product: pyrimidine nucleoside transport protein

Products: uridine [Cytoplasm]; thymidine [Cytoplasm]; inosine [Cytoplasm]; Deoxyuridine [Cytoplasm]; deoxyinosine [Cytoplasm]; deoxycytidine [Cytoplasm]; deoxyadenosine [Cytoplasm]; cytidine [Cytoplasm]; Proton [Cytoplasm]; adenosine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MHILIGIIGIIFFLALAFLFSSDRKNIRWKYVGILLAIQLIFAFILLKTTMGIKVIGGISNGFNYLLLKAADGVNFVFGG
IQYIDPKQPPFFFSVLLPIVFISAIIGILQYTKILPLIINVLGFLISKINGMGRLESYNAVAAAILGQSEVFISIKKQLP
YIPKQRLYTLTASAMSTVSASIIGAYFTLIEPKYVVTAVVLNLFGGFIIASIINPYKVNEEDDKLLVEETEERQQSFFEM
LGEYILDGFKVAVIVGAMLIGYIAIIALLNGIVSNIFSTVSGGAISWDFQTLIGFVFAPFAFLVGVPWQDAVQAGSVMAT
KLLSNEFVAMQALGKLSDLSEHAKGVTSVFLVSFANFSSIGIISGAIKSLNDKKGDTVARFGLKLLFGATLVSFISAAIA
GFFI

Sequences:

>Translated_404_residues
MHILIGIIGIIFFLALAFLFSSDRKNIRWKYVGILLAIQLIFAFILLKTTMGIKVIGGISNGFNYLLLKAADGVNFVFGG
IQYIDPKQPPFFFSVLLPIVFISAIIGILQYTKILPLIINVLGFLISKINGMGRLESYNAVAAAILGQSEVFISIKKQLP
YIPKQRLYTLTASAMSTVSASIIGAYFTLIEPKYVVTAVVLNLFGGFIIASIINPYKVNEEDDKLLVEETEERQQSFFEM
LGEYILDGFKVAVIVGAMLIGYIAIIALLNGIVSNIFSTVSGGAISWDFQTLIGFVFAPFAFLVGVPWQDAVQAGSVMAT
KLLSNEFVAMQALGKLSDLSEHAKGVTSVFLVSFANFSSIGIISGAIKSLNDKKGDTVARFGLKLLFGATLVSFISAAIA
GFFI
>Mature_404_residues
MHILIGIIGIIFFLALAFLFSSDRKNIRWKYVGILLAIQLIFAFILLKTTMGIKVIGGISNGFNYLLLKAADGVNFVFGG
IQYIDPKQPPFFFSVLLPIVFISAIIGILQYTKILPLIINVLGFLISKINGMGRLESYNAVAAAILGQSEVFISIKKQLP
YIPKQRLYTLTASAMSTVSASIIGAYFTLIEPKYVVTAVVLNLFGGFIIASIINPYKVNEEDDKLLVEETEERQQSFFEM
LGEYILDGFKVAVIVGAMLIGYIAIIALLNGIVSNIFSTVSGGAISWDFQTLIGFVFAPFAFLVGVPWQDAVQAGSVMAT
KLLSNEFVAMQALGKLSDLSEHAKGVTSVFLVSFANFSSIGIISGAIKSLNDKKGDTVARFGLKLLFGATLVSFISAAIA
GFFI

Specific function: Transports Nucleosides With A High Affinity Except Guanosine And Deoxyguanosine. Driven By A Proton Motive Force. [C]

COG id: COG1972

COG function: function code F; Nucleoside permease

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family [H]

Homologues:

Organism=Homo sapiens, GI42542381, Length=419, Percent_Identity=25.7756563245823, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI11545853, Length=426, Percent_Identity=25.8215962441315, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI227116277, Length=419, Percent_Identity=23.8663484486874, Blast_Score=119, Evalue=7e-27,
Organism=Escherichia coli, GI1788737, Length=388, Percent_Identity=56.1855670103093, Blast_Score=405, Evalue=1e-114,
Organism=Escherichia coli, GI1788485, Length=420, Percent_Identity=30, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI1788488, Length=420, Percent_Identity=31.4285714285714, Blast_Score=166, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17560276, Length=397, Percent_Identity=26.7002518891688, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71991794, Length=410, Percent_Identity=25.609756097561, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI25146537, Length=203, Percent_Identity=26.6009852216749, Blast_Score=68, Evalue=8e-12,
Organism=Drosophila melanogaster, GI45552517, Length=405, Percent_Identity=25.9259259259259, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI19921868, Length=405, Percent_Identity=25.9259259259259, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI45552519, Length=405, Percent_Identity=25.9259259259259, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI281360430, Length=406, Percent_Identity=25.1231527093596, Blast_Score=115, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008276
- InterPro:   IPR018270
- InterPro:   IPR011657
- InterPro:   IPR002668 [H]

Pfam domain/function: PF07662 Nucleos_tra2_C; PF01773 Nucleos_tra2_N [H]

EC number: NA

Molecular weight: Translated: 43806; Mature: 43806

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHILIGIIGIIFFLALAFLFSSDRKNIRWKYVGILLAIQLIFAFILLKTTMGIKVIGGIS
CHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCC
NGFNYLLLKAADGVNFVFGGIQYIDPKQPPFFFSVLLPIVFISAIIGILQYTKILPLIIN
CCCEEEEEEECCCCEEHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLGFLISKINGMGRLESYNAVAAAILGQSEVFISIKKQLPYIPKQRLYTLTASAMSTVSA
HHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHEEEEHHHCCCCCHHHHHHHHHHHHHHHHH
SIIGAYFTLIEPKYVVTAVVLNLFGGFIIASIINPYKVNEEDDKLLVEETEERQQSFFEM
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHH
LGEYILDGFKVAVIVGAMLIGYIAIIALLNGIVSNIFSTVSGGAISWDFQTLIGFVFAPF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHH
AFLVGVPWQDAVQAGSVMATKLLSNEFVAMQALGKLSDLSEHAKGVTSVFLVSFANFSSI
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
GIISGAIKSLNDKKGDTVARFGLKLLFGATLVSFISAAIAGFFI
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHILIGIIGIIFFLALAFLFSSDRKNIRWKYVGILLAIQLIFAFILLKTTMGIKVIGGIS
CHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCC
NGFNYLLLKAADGVNFVFGGIQYIDPKQPPFFFSVLLPIVFISAIIGILQYTKILPLIIN
CCCEEEEEEECCCCEEHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLGFLISKINGMGRLESYNAVAAAILGQSEVFISIKKQLPYIPKQRLYTLTASAMSTVSA
HHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHEEEEHHHCCCCCHHHHHHHHHHHHHHHHH
SIIGAYFTLIEPKYVVTAVVLNLFGGFIIASIINPYKVNEEDDKLLVEETEERQQSFFEM
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHH
LGEYILDGFKVAVIVGAMLIGYIAIIALLNGIVSNIFSTVSGGAISWDFQTLIGFVFAPF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHH
AFLVGVPWQDAVQAGSVMATKLLSNEFVAMQALGKLSDLSEHAKGVTSVFLVSFANFSSI
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
GIISGAIKSLNDKKGDTVARFGLKLLFGATLVSFISAAIAGFFI
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: uridine [Periplasm]; thymidine [Periplasm]; inosine [Periplasm]; Deoxyuridine [Periplasm]; deoxyinosine [Periplasm]; deoxycytidine [Periplasm]; deoxyadenosine [Periplasm]; cytidine [Periplasm]; Proton [Periplasm]; adenosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uridine [Periplasm] = Proton [Cytoplasm] + uridine [Cytoplasm] Proton [Periplasm] + thymidine [Periplasm] = Proton [Cytoplasm] + thymidine [Cytoplasm] Proton [Periplasm] + inosine [Periplasm] = Proton [Cytoplasm] + inosine [Cytoplasm]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8550462; 8867804; 9384377 [H]