Click here to switch to the map view.

The map label for this gene is prs

Identifier: 15926177

GI number: 15926177

Start: 528566

End: 529531

Strand: Direct

Name: prs

Synonym: SA0458

Alternate gene names: 15926177

Gene position: 528566-529531 (Clockwise)

Preceding gene: 15926176

Following gene: 15926178

Centisome position: 18.78

GC content: 35.3

Gene sequence:

>966_bases
ATGTTAAATAATGAATATAAGAATTCGTCATTAAAGATTTTTTCATTGAAAGGAAACGAAGCATTAGCGCAAGAAGTTGC
TGACCAAGTAGGAATTGAACTAGGTAAATGTTCAGTTAAACGTTTTAGTGATGGAGAAATTCAAATTAATATCGAAGAGA
GTATTCGTGGTTGTGACGTATTTATTATTCAACCAACATCATATCCTGTGAATCTACATTTAATGGAATTATTAATTATG
ATTGATGCTTGTAAACGTGCTTCTGCAGCAACAATCAATATTGTAGTGCCATATTATGGATATGCAAGACAAGATAGAAA
AGCCCGTAGCCGTGAGCCAATCACTGCTAAATTAGTTGCAAACTTAATCGAAACAGCTGGCGCAACTCGTATGATTGCGT
TAGACTTACATGCACCACAAATTCAAGGATTCTTTGATATTCCAATTGACCACTTAATGGGTGTGCCAATTCTTGCTAAA
CATTTCAAAGATGATCCGAATATTAACCCAGAAGAATGTGTCGTTGTTTCACCAGACCATGGCGGTGTTACACGTGCACG
TAAATTAGCTGACATTTTAAAAACTCCAATTGCAATTATAGATAAACGTCGTCCTAGACCAAATGTTGCTGAAGTGATGA
ACATTGTTGGTGAGATTGAAGGACGTACGGCAATTATTATTGACGATATTATTGATACAGCAGGTACAATCACTTTAGCT
GCACAAGCATTAAAAGATAAAGGTGCTAAAGAAGTATATGCTTGTTGTACACACCCTGTTTTATCAGGACCGGCTAAAGA
ACGTATCGAAAATTCTGCTATAAAAGAATTAATCGTAACAAACTCAATTCATTTAGATGAAGATCGCAAACCATCTAACA
CTAAAGAATTATCTGTTGCTGGTTTAATCGCACAAGCTATCATTCGTGTATACGAAAGAGAATCAGTTAGCGTATTATTT
GACTAA

Upstream 100 bases:

>100_bases
AATATTAATGTAATCTTTATGATTTAATGATTCGCATAGTAATGGAGTTACATTTTATATATAATAGTAATTGCGTAAGT
AAATAATTGGAGGACTATAA

Downstream 100 bases:

>100_bases
TATTTAAAAGGCGTTTGACGAACATATTCCAAACGTGTATAATAGTTTCGTTCGTGATTATACGAATAAATAAACACTTG
CAAGCAACGATGATGTTGAT

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MLNNEYKNSSLKIFSLKGNEALAQEVADQVGIELGKCSVKRFSDGEIQINIEESIRGCDVFIIQPTSYPVNLHLMELLIM
IDACKRASAATINIVVPYYGYARQDRKARSREPITAKLVANLIETAGATRMIALDLHAPQIQGFFDIPIDHLMGVPILAK
HFKDDPNINPEECVVVSPDHGGVTRARKLADILKTPIAIIDKRRPRPNVAEVMNIVGEIEGRTAIIIDDIIDTAGTITLA
AQALKDKGAKEVYACCTHPVLSGPAKERIENSAIKELIVTNSIHLDEDRKPSNTKELSVAGLIAQAIIRVYERESVSVLF
D

Sequences:

>Translated_321_residues
MLNNEYKNSSLKIFSLKGNEALAQEVADQVGIELGKCSVKRFSDGEIQINIEESIRGCDVFIIQPTSYPVNLHLMELLIM
IDACKRASAATINIVVPYYGYARQDRKARSREPITAKLVANLIETAGATRMIALDLHAPQIQGFFDIPIDHLMGVPILAK
HFKDDPNINPEECVVVSPDHGGVTRARKLADILKTPIAIIDKRRPRPNVAEVMNIVGEIEGRTAIIIDDIIDTAGTITLA
AQALKDKGAKEVYACCTHPVLSGPAKERIENSAIKELIVTNSIHLDEDRKPSNTKELSVAGLIAQAIIRVYERESVSVLF
D
>Mature_321_residues
MLNNEYKNSSLKIFSLKGNEALAQEVADQVGIELGKCSVKRFSDGEIQINIEESIRGCDVFIIQPTSYPVNLHLMELLIM
IDACKRASAATINIVVPYYGYARQDRKARSREPITAKLVANLIETAGATRMIALDLHAPQIQGFFDIPIDHLMGVPILAK
HFKDDPNINPEECVVVSPDHGGVTRARKLADILKTPIAIIDKRRPRPNVAEVMNIVGEIEGRTAIIIDDIIDTAGTITLA
AQALKDKGAKEVYACCTHPVLSGPAKERIENSAIKELIVTNSIHLDEDRKPSNTKELSVAGLIAQAIIRVYERESVSVLF
D

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI28557709, Length=314, Percent_Identity=46.4968152866242, Blast_Score=275, Evalue=4e-74,
Organism=Homo sapiens, GI4506127, Length=312, Percent_Identity=45.5128205128205, Blast_Score=275, Evalue=5e-74,
Organism=Homo sapiens, GI4506129, Length=310, Percent_Identity=45.8064516129032, Blast_Score=273, Evalue=2e-73,
Organism=Homo sapiens, GI84875539, Length=313, Percent_Identity=45.3674121405751, Blast_Score=267, Evalue=8e-72,
Organism=Homo sapiens, GI4506133, Length=346, Percent_Identity=36.4161849710983, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI194018537, Length=347, Percent_Identity=34.8703170028818, Blast_Score=177, Evalue=8e-45,
Organism=Homo sapiens, GI310128524, Length=132, Percent_Identity=36.3636363636364, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI310115209, Length=132, Percent_Identity=36.3636363636364, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI310118259, Length=132, Percent_Identity=36.3636363636364, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI310119946, Length=132, Percent_Identity=36.3636363636364, Blast_Score=86, Evalue=4e-17,
Organism=Escherichia coli, GI1787458, Length=314, Percent_Identity=49.0445859872611, Blast_Score=317, Evalue=9e-88,
Organism=Caenorhabditis elegans, GI25149168, Length=313, Percent_Identity=45.3674121405751, Blast_Score=275, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI17554702, Length=313, Percent_Identity=45.3674121405751, Blast_Score=275, Evalue=3e-74,
Organism=Caenorhabditis elegans, GI71989924, Length=313, Percent_Identity=45.3674121405751, Blast_Score=273, Evalue=7e-74,
Organism=Caenorhabditis elegans, GI17554704, Length=310, Percent_Identity=45.4838709677419, Blast_Score=273, Evalue=9e-74,
Organism=Caenorhabditis elegans, GI17570245, Length=347, Percent_Identity=35.1585014409222, Blast_Score=196, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6320946, Length=315, Percent_Identity=43.1746031746032, Blast_Score=249, Evalue=5e-67,
Organism=Saccharomyces cerevisiae, GI6321776, Length=314, Percent_Identity=42.3566878980892, Blast_Score=241, Evalue=1e-64,
Organism=Saccharomyces cerevisiae, GI6319403, Length=314, Percent_Identity=41.0828025477707, Blast_Score=239, Evalue=3e-64,
Organism=Saccharomyces cerevisiae, GI6322667, Length=197, Percent_Identity=41.6243654822335, Blast_Score=155, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6324511, Length=274, Percent_Identity=32.8467153284672, Blast_Score=135, Evalue=1e-32,
Organism=Drosophila melanogaster, GI21355239, Length=314, Percent_Identity=46.1783439490446, Blast_Score=265, Evalue=2e-71,
Organism=Drosophila melanogaster, GI45551540, Length=337, Percent_Identity=43.3234421364985, Blast_Score=254, Evalue=5e-68,
Organism=Drosophila melanogaster, GI24651458, Length=359, Percent_Identity=33.983286908078, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI24651456, Length=359, Percent_Identity=33.983286908078, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI281362873, Length=359, Percent_Identity=33.983286908078, Blast_Score=185, Evalue=3e-47,
Organism=Drosophila melanogaster, GI24651454, Length=359, Percent_Identity=33.983286908078, Blast_Score=185, Evalue=3e-47,
Organism=Drosophila melanogaster, GI24651462, Length=378, Percent_Identity=32.2751322751323, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24651464, Length=378, Percent_Identity=32.2751322751323, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI45552010, Length=378, Percent_Identity=32.2751322751323, Blast_Score=175, Evalue=3e-44,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 35284; Mature: 35284

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNNEYKNSSLKIFSLKGNEALAQEVADQVGIELGKCSVKRFSDGEIQINIEESIRGCDV
CCCCCCCCCCEEEEEECCCHHHHHHHHHHHCCEECCCEEEECCCCEEEEEEHHCCCCCEE
FIIQPTSYPVNLHLMELLIMIDACKRASAATINIVVPYYGYARQDRKARSREPITAKLVA
EEECCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHCCCCHHHHHHH
NLIETAGATRMIALDLHAPQIQGFFDIPIDHLMGVPILAKHFKDDPNINPEECVVVSPDH
HHHHHCCCCEEEEEECCCCCCCCEEECCHHHHCCCHHHHHHCCCCCCCCCCCEEEECCCC
GGVTRARKLADILKTPIAIIDKRRPRPNVAEVMNIVGEIEGRTAIIIDDIIDTAGTITLA
CCHHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEEEHHHCCCCHHHHH
AQALKDKGAKEVYACCTHPVLSGPAKERIENSAIKELIVTNSIHLDEDRKPSNTKELSVA
HHHHHCCCHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHCCEECCCCCCCCCCHHHHHH
GLIAQAIIRVYERESVSVLFD
HHHHHHHHHHHCCCCEEEEEC
>Mature Secondary Structure
MLNNEYKNSSLKIFSLKGNEALAQEVADQVGIELGKCSVKRFSDGEIQINIEESIRGCDV
CCCCCCCCCCEEEEEECCCHHHHHHHHHHHCCEECCCEEEECCCCEEEEEEHHCCCCCEE
FIIQPTSYPVNLHLMELLIMIDACKRASAATINIVVPYYGYARQDRKARSREPITAKLVA
EEECCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHCCCCHHHHHHH
NLIETAGATRMIALDLHAPQIQGFFDIPIDHLMGVPILAKHFKDDPNINPEECVVVSPDH
HHHHHCCCCEEEEEECCCCCCCCEEECCHHHHCCCHHHHHHCCCCCCCCCCCEEEECCCC
GGVTRARKLADILKTPIAIIDKRRPRPNVAEVMNIVGEIEGRTAIIIDDIIDTAGTITLA
CCHHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEEEHHHCCCCHHHHH
AQALKDKGAKEVYACCTHPVLSGPAKERIENSAIKELIVTNSIHLDEDRKPSNTKELSVA
HHHHHCCCHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHCCEECCCCCCCCCCHHHHHH
GLIAQAIIRVYERESVSVLFD
HHHHHHHHHHHCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA