Click here to switch to the map view.

The map label for this gene is glmU

Identifier: 15926176

GI number: 15926176

Start: 527067

End: 528419

Strand: Direct

Name: glmU

Synonym: SA0457

Alternate gene names: 15926176

Gene position: 527067-528419 (Clockwise)

Preceding gene: 161376700

Following gene: 15926177

Centisome position: 18.72

GC content: 39.25

Gene sequence:

>1353_bases
ATGCGAAGACACGCGATAATTTTGGCAGCAGGTAAAGGCACAAGAATGAAATCTAAAAAGTATAAAGTGCTACACGAGGT
TGCTGGGAAACCTATGGTCGAACATGTATTGGAAAGTGTGAAAGGCTCTGGTGTCGATCAAGTTGTAACCATCGTAGGAC
ATGGTGCTGAAAGTGTAAAAGGACATTTAGGCGAGCGTTCTTTATACAGTTTTCAAGAGAAACAACTCGGTACTGCGCAT
GCAGTGCAAATGGCGAAATCACACTTAGAAGACAAGGAAGGTACGACAATCGTTGTATGTGGTGACACACCGCTCATCAC
AAAGGAAACATTAGAAACATTGATTGCGCATCATGAGGATGCTAATGCTCAAGCAACTGTATTATCTGCATCGATTCAAC
AACCATATGGATACGGAAGAATCGTTCGAAATGCGTCAGGTCGTTTAGAACGCATAGTTGAAGAGAAAGATGCAACGCAA
GCTGAAAAGGATATTAATGAAATTAGTTCAGGTATTTTTGCGTTTAATAATAAAACGTTGTTTGAAAAATTAACACAAGT
GAAAAATGATAATGCGCAAGGTGAATATTACCTCCCTGATGTATTGTCGTTAATTTTAAATGATGGCGGCATCGTAGAAG
TGTATCGTACCAATGATGTTGAAGAAATCATGGGTGTAAATGATCGTGTAATGCTTAGTCAGGCTGAGAAGGCGATGCAA
CGTCGTACGAATCATTATCACATGCTAAATGGTGTGACAATCATCGATCCTGACAGCACTTTTATTGGTCCAGACGTTAC
AATTGGTAGTGATACAGTCATTGAACCAGGCGTACGAATTAATGGTCGTACAGAAATTGGCGAAGATGTTGTTATTGGTC
AGTACTCTGAAATTAACAATAGTACGATTGAAAATGGTGCATGTATTCAACAGTCTGTTGTTAATGATGCTAGCGTAGGA
GCTAATACTAAGGTCGGACCGTTTGCGCAATTGAGACCAGGCGCGCAATTAGGTGCAGATGTTAAGGTTGGAAATTTTGT
AGAAATTAAAAAAGCAGATCTTAAAGATGGTGCCAAGGTTTCACATTTAAGTTATATTGGCGATGCTGTAATTGGCGAAC
GTACTAATATTGGTTGCGGAACGATTACAGTTAACTATGATGGTGAAAATAAATTTAAAACTATCGTCGGCAAAGATTCA
TTTGTAGGTTGCAATGTTAATTTAGTAGCACCTGTAACAATTGGTGATGATGTATTGGTGGCAGCTGGTTCCACAATCAC
AGATGACGTACCAAATGACAGTTTAGCTGTGGCAAGAGCAAGACAAACAACAAAAGAAGGATATAGGAAATAA

Upstream 100 bases:

>100_bases
TTACAACGAATTAAAAACAATGCCTTTTATATGTTGAAAGAGTATTGCAGATTAAATTATAATAATGACGAAGTGTAAAA
TTTAATGGGGGTTAATGTTC

Downstream 100 bases:

>100_bases
TCATTTACGTATTTAAAATGGCTAGGATAAAAGGATAATCCTATGTAATATTAATGTAATCTTTATGATTTAATGATTCG
CATAGTAATGGAGTTACATT

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MRRHAIILAAGKGTRMKSKKYKVLHEVAGKPMVEHVLESVKGSGVDQVVTIVGHGAESVKGHLGERSLYSFQEKQLGTAH
AVQMAKSHLEDKEGTTIVVCGDTPLITKETLETLIAHHEDANAQATVLSASIQQPYGYGRIVRNASGRLERIVEEKDATQ
AEKDINEISSGIFAFNNKTLFEKLTQVKNDNAQGEYYLPDVLSLILNDGGIVEVYRTNDVEEIMGVNDRVMLSQAEKAMQ
RRTNHYHMLNGVTIIDPDSTFIGPDVTIGSDTVIEPGVRINGRTEIGEDVVIGQYSEINNSTIENGACIQQSVVNDASVG
ANTKVGPFAQLRPGAQLGADVKVGNFVEIKKADLKDGAKVSHLSYIGDAVIGERTNIGCGTITVNYDGENKFKTIVGKDS
FVGCNVNLVAPVTIGDDVLVAAGSTITDDVPNDSLAVARARQTTKEGYRK

Sequences:

>Translated_450_residues
MRRHAIILAAGKGTRMKSKKYKVLHEVAGKPMVEHVLESVKGSGVDQVVTIVGHGAESVKGHLGERSLYSFQEKQLGTAH
AVQMAKSHLEDKEGTTIVVCGDTPLITKETLETLIAHHEDANAQATVLSASIQQPYGYGRIVRNASGRLERIVEEKDATQ
AEKDINEISSGIFAFNNKTLFEKLTQVKNDNAQGEYYLPDVLSLILNDGGIVEVYRTNDVEEIMGVNDRVMLSQAEKAMQ
RRTNHYHMLNGVTIIDPDSTFIGPDVTIGSDTVIEPGVRINGRTEIGEDVVIGQYSEINNSTIENGACIQQSVVNDASVG
ANTKVGPFAQLRPGAQLGADVKVGNFVEIKKADLKDGAKVSHLSYIGDAVIGERTNIGCGTITVNYDGENKFKTIVGKDS
FVGCNVNLVAPVTIGDDVLVAAGSTITDDVPNDSLAVARARQTTKEGYRK
>Mature_450_residues
MRRHAIILAAGKGTRMKSKKYKVLHEVAGKPMVEHVLESVKGSGVDQVVTIVGHGAESVKGHLGERSLYSFQEKQLGTAH
AVQMAKSHLEDKEGTTIVVCGDTPLITKETLETLIAHHEDANAQATVLSASIQQPYGYGRIVRNASGRLERIVEEKDATQ
AEKDINEISSGIFAFNNKTLFEKLTQVKNDNAQGEYYLPDVLSLILNDGGIVEVYRTNDVEEIMGVNDRVMLSQAEKAMQ
RRTNHYHMLNGVTIIDPDSTFIGPDVTIGSDTVIEPGVRINGRTEIGEDVVIGQYSEINNSTIENGACIQQSVVNDASVG
ANTKVGPFAQLRPGAQLGADVKVGNFVEIKKADLKDGAKVSHLSYIGDAVIGERTNIGCGTITVNYDGENKFKTIVGKDS
FVGCNVNLVAPVTIGDDVLVAAGSTITDDVPNDSLAVARARQTTKEGYRK

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc [H]

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=391, Percent_Identity=23.2736572890026, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI11761619, Length=351, Percent_Identity=23.0769230769231, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1790168, Length=449, Percent_Identity=43.652561247216, Blast_Score=342, Evalue=2e-95,
Organism=Caenorhabditis elegans, GI133931050, Length=320, Percent_Identity=26.875, Blast_Score=97, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6320148, Length=390, Percent_Identity=24.6153846153846, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI21355443, Length=370, Percent_Identity=25.6756756756757, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24644084, Length=370, Percent_Identity=25.6756756756757, Blast_Score=90, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005882
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 48516; Mature: 48516

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00622 HTH_LUXR_1 ; PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRHAIILAAGKGTRMKSKKYKVLHEVAGKPMVEHVLESVKGSGVDQVVTIVGHGAESVK
CCCEEEEEECCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHEEEEECCCHHHHH
GHLGERSLYSFQEKQLGTAHAVQMAKSHLEDKEGTTIVVCGDTPLITKETLETLIAHHED
HHCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCC
ANAQATVLSASIQQPYGYGRIVRNASGRLERIVEEKDATQAEKDINEISSGIFAFNNKTL
CCCEEEEEEHHHCCCCCCHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHH
FEKLTQVKNDNAQGEYYLPDVLSLILNDGGIVEVYRTNDVEEIMGVNDRVMLSQAEKAMQ
HHHHHHHCCCCCCCCEEHHHHHHHHHCCCCEEEEEECCCHHHHHCCCCHHHHHHHHHHHH
RRTNHYHMLNGVTIIDPDSTFIGPDVTIGSDTVIEPGVRINGRTEIGEDVVIGQYSEINN
HHCCCEEEECCEEEECCCCCCCCCCEEECCCCEECCCCEECCCCCCCCCEEEECHHHCCC
STIENGACIQQSVVNDASVGANTKVGPFAQLRPGAQLGADVKVGNFVEIKKADLKDGAKV
CCCCCCCHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCC
SHLSYIGDAVIGERTNIGCGTITVNYDGENKFKTIVGKDSFVGCNVNLVAPVTIGDDVLV
HHHHHHHHHHHCCCCCCCEEEEEEEECCCCCEEEEECCCCEEECCEEEEEEEEECCCEEE
AAGSTITDDVPNDSLAVARARQTTKEGYRK
ECCCCCCCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRRHAIILAAGKGTRMKSKKYKVLHEVAGKPMVEHVLESVKGSGVDQVVTIVGHGAESVK
CCCEEEEEECCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHEEEEECCCHHHHH
GHLGERSLYSFQEKQLGTAHAVQMAKSHLEDKEGTTIVVCGDTPLITKETLETLIAHHED
HHCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCC
ANAQATVLSASIQQPYGYGRIVRNASGRLERIVEEKDATQAEKDINEISSGIFAFNNKTL
CCCEEEEEEHHHCCCCCCHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHH
FEKLTQVKNDNAQGEYYLPDVLSLILNDGGIVEVYRTNDVEEIMGVNDRVMLSQAEKAMQ
HHHHHHHCCCCCCCCEEHHHHHHHHHCCCCEEEEEECCCHHHHHCCCCHHHHHHHHHHHH
RRTNHYHMLNGVTIIDPDSTFIGPDVTIGSDTVIEPGVRINGRTEIGEDVVIGQYSEINN
HHCCCEEEECCEEEECCCCCCCCCCEEECCCCEECCCCEECCCCCCCCCEEEECHHHCCC
STIENGACIQQSVVNDASVGANTKVGPFAQLRPGAQLGADVKVGNFVEIKKADLKDGAKV
CCCCCCCHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCC
SHLSYIGDAVIGERTNIGCGTITVNYDGENKFKTIVGKDSFVGCNVNLVAPVTIGDDVLV
HHHHHHHHHHHCCCCCCCEEEEEEEECCCCCEEEEECCCCEEECCEEEEEEEEECCCEEE
AAGSTITDDVPNDSLAVARARQTTKEGYRK
ECCCCCCCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA