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The map label for this gene is obgE [H]

Identifier: 161378150

GI number: 161378150

Start: 1105047

End: 1106354

Strand: Reverse

Name: obgE [H]

Synonym: SPy_1333

Alternate gene names: 161378150

Gene position: 1106354-1105047 (Counterclockwise)

Preceding gene: 15675276

Following gene: 15675272

Centisome position: 59.72

GC content: 44.34

Gene sequence:

>1308_bases
ATGTTTTTAGATACGGCAAAAATCAGTGTCCAAGCAGGCCGTGGTGGCGATGGTATGGTAGCTTTTCGTCGTGAAAAGTA
CGTCCCAAATGGCGGTCCTTGGGGAGGAGACGGCGGTAAAGGTGGCTCAGTTATCTTCCGAGTGGACGAAGGTTTGCGTA
CCTTGATGGATTTCCGGTATAATCGTAAATTCAAGGCGAAATCTGGTGAAAAAGGTATGACCAAAGGCATGCACGGCCGT
GGTGCAGAAGATTTGATTGTCTTTGTTCCTCAAGGGACAACGGTTCGTGATGCTGAAACTGGAAAAGTAATTACAGACTT
AGTAGAACATGGTCAAGAAGTGGTCATTGCTAAGGGTGGTCGTGGTGGCCGTGGGAATATTCGTTTTGCAACTCCTCGTA
ATCCTGCGCCAGAGATTGCTGAAAATGGTGAGCCAGGTGAGGAACGTCAGTTAGAGTTAGAACTCAAAATCTTAGCTGAC
GTTGGCTTGGTCGGATTCCCATCTGTTGGGAAATCAACCTTGTTAAGTGTTGTGTCATCAGCTAAACCGAAAATTGGTGC
CTATCATTTTACCACTATTGTTCCTAATCTTGGAATGGTTCGTACAAAGTCAGGTGATAGCTTTGCTATGGCAGATCTGC
CAGGTTTGATTGAAGGTGCTAGCCAAGGGGTTGGTTTAGGAACTCAATTCCTCCGTCATATCGAGCGGACACGGGTTATT
CTTCATGTGATTGACATGTCTGCTAGTGAGGGTCGTGATCCTTACGAAGATTATGTTTCCATTAATAACGAGCTGGAAAC
CTATAATTTGCGATTGATGGAGCGCCCACAGATTATTGTGGCTAATAAAATGGACATACCAGAGGCTCAAGAAAACTTGA
AAGCCTTCAAGAAAAAATTGGCTGCCCAATATGACGAGTTTGATGATTTGCCAATGATTTTCCCTATTTCAAGCCTAGCA
CATCAAGGCTTAGAGAACTTGTTAGAAGCAACGGCAGAATTACTCGCTAAAACAGACGAATTCTTATTATATGATGAATC
TGATCTGGTGGACGAGGAAGCTTACTATGGCTTTGCTGAGACTGAAAAAGACTTTGAGATCACACGTGACGATGACGCTA
CTTGGGTCTTGTCTGGTGAGAAGTTAGAACGTCTCTTTGTCATGACCAATATGGAACGTGATGAGTCCATCATGAAATTT
GCCCGTCAATTGCGCGGTATGGGGGTTGACGAAGCTCTTCGTGAACGTGGAGCAAAAGATGGGGATCCTGTTCGTATTGG
CAAGTTTGAATTTGAATTTGTGGATTAA

Upstream 100 bases:

>100_bases
GCGGGCTTATTGCGAGTGCCCTATCAGTATTAATGTAAGGAAACGCTGAAAGGCGTTTTTTTAAAGTAAAAGAAAGTTAG
AGAATAAAAAAAGTATGAGT

Downstream 100 bases:

>100_bases
GGCAATCTATTACAATAGCAGTGTGATAGTGCTCTTGTGTGTTATCTTTAAGATGGAGGTTTCTGATTATGGGTGATAAA
CCGATATCCTTTAAGGATAA

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg [H]

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MFLDTAKISVQAGRGGDGMVAFRREKYVPNGGPWGGDGGKGGSVIFRVDEGLRTLMDFRYNRKFKAKSGEKGMTKGMHGR
GAEDLIVFVPQGTTVRDAETGKVITDLVEHGQEVVIAKGGRGGRGNIRFATPRNPAPEIAENGEPGEERQLELELKILAD
VGLVGFPSVGKSTLLSVVSSAKPKIGAYHFTTIVPNLGMVRTKSGDSFAMADLPGLIEGASQGVGLGTQFLRHIERTRVI
LHVIDMSASEGRDPYEDYVSINNELETYNLRLMERPQIIVANKMDIPEAQENLKAFKKKLAAQYDEFDDLPMIFPISSLA
HQGLENLLEATAELLAKTDEFLLYDESDLVDEEAYYGFAETEKDFEITRDDDATWVLSGEKLERLFVMTNMERDESIMKF
ARQLRGMGVDEALRERGAKDGDPVRIGKFEFEFVD

Sequences:

>Translated_435_residues
MFLDTAKISVQAGRGGDGMVAFRREKYVPNGGPWGGDGGKGGSVIFRVDEGLRTLMDFRYNRKFKAKSGEKGMTKGMHGR
GAEDLIVFVPQGTTVRDAETGKVITDLVEHGQEVVIAKGGRGGRGNIRFATPRNPAPEIAENGEPGEERQLELELKILAD
VGLVGFPSVGKSTLLSVVSSAKPKIGAYHFTTIVPNLGMVRTKSGDSFAMADLPGLIEGASQGVGLGTQFLRHIERTRVI
LHVIDMSASEGRDPYEDYVSINNELETYNLRLMERPQIIVANKMDIPEAQENLKAFKKKLAAQYDEFDDLPMIFPISSLA
HQGLENLLEATAELLAKTDEFLLYDESDLVDEEAYYGFAETEKDFEITRDDDATWVLSGEKLERLFVMTNMERDESIMKF
ARQLRGMGVDEALRERGAKDGDPVRIGKFEFEFVD
>Mature_435_residues
MFLDTAKISVQAGRGGDGMVAFRREKYVPNGGPWGGDGGKGGSVIFRVDEGLRTLMDFRYNRKFKAKSGEKGMTKGMHGR
GAEDLIVFVPQGTTVRDAETGKVITDLVEHGQEVVIAKGGRGGRGNIRFATPRNPAPEIAENGEPGEERQLELELKILAD
VGLVGFPSVGKSTLLSVVSSAKPKIGAYHFTTIVPNLGMVRTKSGDSFAMADLPGLIEGASQGVGLGTQFLRHIERTRVI
LHVIDMSASEGRDPYEDYVSINNELETYNLRLMERPQIIVANKMDIPEAQENLKAFKKKLAAQYDEFDDLPMIFPISSLA
HQGLENLLEATAELLAKTDEFLLYDESDLVDEEAYYGFAETEKDFEITRDDDATWVLSGEKLERLFVMTNMERDESIMKF
ARQLRGMGVDEALRERGAKDGDPVRIGKFEFEFVD

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain [H]

Homologues:

Organism=Homo sapiens, GI24308117, Length=327, Percent_Identity=42.2018348623853, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI111955139, Length=295, Percent_Identity=37.6271186440678, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI111955063, Length=180, Percent_Identity=39.4444444444444, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI4758796, Length=127, Percent_Identity=40.9448818897638, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI4557537, Length=121, Percent_Identity=38.0165289256198, Blast_Score=75, Evalue=9e-14,
Organism=Escherichia coli, GI1789574, Length=330, Percent_Identity=46.3636363636364, Blast_Score=261, Evalue=4e-71,
Organism=Escherichia coli, GI1787454, Length=138, Percent_Identity=33.3333333333333, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17508313, Length=332, Percent_Identity=39.1566265060241, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17552324, Length=322, Percent_Identity=31.3664596273292, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17555344, Length=152, Percent_Identity=34.8684210526316, Blast_Score=79, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI71981008, Length=118, Percent_Identity=38.9830508474576, Blast_Score=78, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17509631, Length=140, Percent_Identity=31.4285714285714, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6321962, Length=192, Percent_Identity=38.5416666666667, Blast_Score=124, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6321612, Length=203, Percent_Identity=31.0344827586207, Blast_Score=80, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6319281, Length=126, Percent_Identity=38.0952380952381, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI20129375, Length=299, Percent_Identity=41.1371237458194, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI24585318, Length=370, Percent_Identity=33.7837837837838, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI17981711, Length=127, Percent_Identity=37.7952755905512, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21356473, Length=126, Percent_Identity=35.7142857142857, Blast_Score=72, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014100
- InterPro:   IPR015349
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF09269 DUF1967; PF01018 GTP1_OBG; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 48115; Mature: 48115

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLDTAKISVQAGRGGDGMVAFRREKYVPNGGPWGGDGGKGGSVIFRVDEGLRTLMDFRY
CCCCCEEEEEEECCCCCCEEEEEHHCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHC
NRKFKAKSGEKGMTKGMHGRGAEDLIVFVPQGTTVRDAETGKVITDLVEHGQEVVIAKGG
CCEECCCCCCCCCCCCCCCCCCCCEEEEECCCCEECCCCCCHHHHHHHHCCCEEEEEECC
RGGRGNIRFATPRNPAPEIAENGEPGEERQLELELKILADVGLVGFPSVGKSTLLSVVSS
CCCCCCEEEECCCCCCCHHHCCCCCCCCCEEEEEEEEEECCCCCCCCCCCHHHHHHHHHH
AKPKIGAYHFTTIVPNLGMVRTKSGDSFAMADLPGLIEGASQGVGLGTQFLRHIERTRVI
CCCCCCEEEEEECCCCCCEEEECCCCCEEECCCCHHHHCCCCCCCHHHHHHHHHHHHHEE
LHVIDMSASEGRDPYEDYVSINNELETYNLRLMERPQIIVANKMDIPEAQENLKAFKKKL
EEEEECCCCCCCCCHHHHHHCCCCEEEEEEEEECCCCEEEECCCCCCHHHHHHHHHHHHH
AAQYDEFDDLPMIFPISSLAHQGLENLLEATAELLAKTDEFLLYDESDLVDEEAYYGFAE
HHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHCCCCC
TEKDFEITRDDDATWVLSGEKLERLFVMTNMERDESIMKFARQLRGMGVDEALRERGAKD
CCCCCEEECCCCCEEEEECHHHHEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHCCCCC
GDPVRIGKFEFEFVD
CCCEEEEEEEEEECC
>Mature Secondary Structure
MFLDTAKISVQAGRGGDGMVAFRREKYVPNGGPWGGDGGKGGSVIFRVDEGLRTLMDFRY
CCCCCEEEEEEECCCCCCEEEEEHHCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHC
NRKFKAKSGEKGMTKGMHGRGAEDLIVFVPQGTTVRDAETGKVITDLVEHGQEVVIAKGG
CCEECCCCCCCCCCCCCCCCCCCCEEEEECCCCEECCCCCCHHHHHHHHCCCEEEEEECC
RGGRGNIRFATPRNPAPEIAENGEPGEERQLELELKILADVGLVGFPSVGKSTLLSVVSS
CCCCCCEEEECCCCCCCHHHCCCCCCCCCEEEEEEEEEECCCCCCCCCCCHHHHHHHHHH
AKPKIGAYHFTTIVPNLGMVRTKSGDSFAMADLPGLIEGASQGVGLGTQFLRHIERTRVI
CCCCCCEEEEEECCCCCCEEEECCCCCEEECCCCHHHHCCCCCCCHHHHHHHHHHHHHEE
LHVIDMSASEGRDPYEDYVSINNELETYNLRLMERPQIIVANKMDIPEAQENLKAFKKKL
EEEEECCCCCCCCCHHHHHHCCCCEEEEEEEEECCCCEEEECCCCCCHHHHHHHHHHHHH
AAQYDEFDDLPMIFPISSLAHQGLENLLEATAELLAKTDEFLLYDESDLVDEEAYYGFAE
HHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHCCCCC
TEKDFEITRDDDATWVLSGEKLERLFVMTNMERDESIMKFARQLRGMGVDEALRERGAKD
CCCCCEEECCCCCEEEEECHHHHEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHCCCCC
GDPVRIGKFEFEFVD
CCCEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA