Definition | Streptococcus pyogenes M1 GAS chromosome, complete genome. |
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Accession | NC_002737 |
Length | 1,852,441 |
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The map label for this gene is htrA [H]
Identifier: 15675945
GI number: 15675945
Start: 1850352
End: 1851575
Strand: Direct
Name: htrA [H]
Synonym: SPy_2216
Alternate gene names: 15675945
Gene position: 1850352-1851575 (Clockwise)
Preceding gene: 15675943
Following gene: 15675946
Centisome position: 99.89
GC content: 34.4
Gene sequence:
>1224_bases ATGCCAAGTATGAAACATATCTTAAAATCCTTAAGTATTTTACTAATTGGATTTTTAGGAGGATTAATAGCAATTATTAC ATTCAATAATCTCTACCCACATTCTCCATCAAAAATAAATTCAGGTAAGGCAACAACTAGTAATATGGTTTTTAACAACA CAACCAATACTACTAAAGCTGTCAAAGCTGTTCAAAATGCAGTTGTATCAGTTATTAATTATCAAGATAACCCTTCTTCA TCCCTTTCTAACCCTTATACAAAACTCTTTGGAGAAGGGCGTTCAAAAGAGAATAAGGATGCTGAATTATCTATTTTTAG TGAAGGATCTGGGGTCATTTATCGAAAAGATGGCAACTCCGCTTACGTTGTTACTAATAACCATGTTATCGACGGAGCTA AACGAATTGAAATTCTTATGGCAGACGGATCTAAAGTTGTTGGTGAATTAGTTGGAGCTGATACTTATTCGGATTTAGCT GTTGTTAAGATCTCTTCAGATAAGATAAAAACAGTAGCTGAATTTGCAGATTCTACAAAACTAAATGTTGGAGAAGTTGC TATTGCTATCGGCAGCCCACTAGGAACACAATACGCTAATTCTGTTACTCAAGGAATCGTCTCTAGTTTAAGTCGTACTG TAACTTTAAAAAACGAGAATGGTGAGACTGTCTCAACAAATGCTATTCAGACAGATGCTGCTATTAACCCTGGAAACTCT GGTGGACCACTAATTAATATTGAGGGGCAAGTAATCGGAATTAATTCAAGTAAAATTTCTTCTACCCCAACTGGTAGCAA CGGTAATAGTGGTGCTGTTGAAGGAATTGGTTTTGCTATCCCATCTACTGATGTTATTAAAATTATTAAACAACTAGAAA CTAATGGTGAAGTTATCAGACCTGCTCTTGGAATATCCATGGTCAATTTAAATGACTTATCCACAAATGCTCTTAGTCAA ATTAATATTCCAACTAGTGTAACTGGTGGTATTGTAGTAGCAGAAGTTAAGGAAGGAATGCCGGCATCTGGCAAACTTGC TCAGTACGATGTGATTACAGAAATTGATGGCAAAACAGTTAATTCAATTAGTGATTTACAAAGTAGTCTATACGGACACG ATATTAATGATACTATTAAAGTAACTTTTTATAGAGGAACTACAAAGAAAAAAGCAGATATCAAATTAACAAAAACTACT CAAGATTTGACTAAAACGCAGTAA
Upstream 100 bases:
>100_bases AGTAATCCACAGGCTGTGGATTACTTTTCTTTTTTTTATTTTTAAGGTATAATTAAGCAAAGTTCTATAAGCTATGGACA AATAATTCGGAGGACAAAAC
Downstream 100 bases:
>100_bases ACAAGCTACCTAAATACTATTACATTTTATCACATAAAACAGTCCAAAGGACTGTTTTATGTTTCTTATTCTATCCAGGA ACTCCCTTATGACAAAAGAA
Product: putative serine protease
Products: NA
Alternate protein names: HtrALl [H]
Number of amino acids: Translated: 407; Mature: 406
Protein sequence:
>407_residues MPSMKHILKSLSILLIGFLGGLIAIITFNNLYPHSPSKINSGKATTSNMVFNNTTNTTKAVKAVQNAVVSVINYQDNPSS SLSNPYTKLFGEGRSKENKDAELSIFSEGSGVIYRKDGNSAYVVTNNHVIDGAKRIEILMADGSKVVGELVGADTYSDLA VVKISSDKIKTVAEFADSTKLNVGEVAIAIGSPLGTQYANSVTQGIVSSLSRTVTLKNENGETVSTNAIQTDAAINPGNS GGPLINIEGQVIGINSSKISSTPTGSNGNSGAVEGIGFAIPSTDVIKIIKQLETNGEVIRPALGISMVNLNDLSTNALSQ INIPTSVTGGIVVAEVKEGMPASGKLAQYDVITEIDGKTVNSISDLQSSLYGHDINDTIKVTFYRGTTKKKADIKLTKTT QDLTKTQ
Sequences:
>Translated_407_residues MPSMKHILKSLSILLIGFLGGLIAIITFNNLYPHSPSKINSGKATTSNMVFNNTTNTTKAVKAVQNAVVSVINYQDNPSS SLSNPYTKLFGEGRSKENKDAELSIFSEGSGVIYRKDGNSAYVVTNNHVIDGAKRIEILMADGSKVVGELVGADTYSDLA VVKISSDKIKTVAEFADSTKLNVGEVAIAIGSPLGTQYANSVTQGIVSSLSRTVTLKNENGETVSTNAIQTDAAINPGNS GGPLINIEGQVIGINSSKISSTPTGSNGNSGAVEGIGFAIPSTDVIKIIKQLETNGEVIRPALGISMVNLNDLSTNALSQ INIPTSVTGGIVVAEVKEGMPASGKLAQYDVITEIDGKTVNSISDLQSSLYGHDINDTIKVTFYRGTTKKKADIKLTKTT QDLTKTQ >Mature_406_residues PSMKHILKSLSILLIGFLGGLIAIITFNNLYPHSPSKINSGKATTSNMVFNNTTNTTKAVKAVQNAVVSVINYQDNPSSS LSNPYTKLFGEGRSKENKDAELSIFSEGSGVIYRKDGNSAYVVTNNHVIDGAKRIEILMADGSKVVGELVGADTYSDLAV VKISSDKIKTVAEFADSTKLNVGEVAIAIGSPLGTQYANSVTQGIVSSLSRTVTLKNENGETVSTNAIQTDAAINPGNSG GPLINIEGQVIGINSSKISSTPTGSNGNSGAVEGIGFAIPSTDVIKIIKQLETNGEVIRPALGISMVNLNDLSTNALSQI NIPTSVTGGIVVAEVKEGMPASGKLAQYDVITEIDGKTVNSISDLQSSLYGHDINDTIKVTFYRGTTKKKADIKLTKTTQ DLTKTQ
Specific function: Degrades abnormal exported proteins. Needed for the propeptide processing of a natural pro-protein and for the maturation of a native protein. Responsible for the housekeeping of exported proteins [H]
COG id: COG0265
COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Gene ontology:
Cell location: Cell membrane; Single-pass membrane protein (Probable) [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 PDZ (DHR) domain [H]
Homologues:
Organism=Homo sapiens, GI24308541, Length=289, Percent_Identity=32.1799307958478, Blast_Score=122, Evalue=8e-28, Organism=Homo sapiens, GI4506141, Length=268, Percent_Identity=32.8358208955224, Blast_Score=121, Evalue=1e-27, Organism=Homo sapiens, GI22129776, Length=276, Percent_Identity=31.8840579710145, Blast_Score=113, Evalue=4e-25, Organism=Homo sapiens, GI7019477, Length=273, Percent_Identity=30.03663003663, Blast_Score=95, Evalue=9e-20, Organism=Escherichia coli, GI1786356, Length=294, Percent_Identity=37.0748299319728, Blast_Score=155, Evalue=5e-39, Organism=Escherichia coli, GI1789629, Length=331, Percent_Identity=36.2537764350453, Blast_Score=146, Evalue=2e-36, Organism=Escherichia coli, GI1789630, Length=366, Percent_Identity=32.7868852459016, Blast_Score=118, Evalue=7e-28, Organism=Drosophila melanogaster, GI24646839, Length=307, Percent_Identity=31.5960912052117, Blast_Score=122, Evalue=3e-28,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001478 - InterPro: IPR009003 - InterPro: IPR001254 - InterPro: IPR001940 [H]
Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]
EC number: 3.4.21.- [C]
Molecular weight: Translated: 42761; Mature: 42630
Theoretical pI: Translated: 7.77; Mature: 7.77
Prosite motif: PS50106 PDZ
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.0 %Cys (Translated Protein) 1.5 %Met (Translated Protein) 1.5 %Cys+Met (Translated Protein) 0.0 %Cys (Mature Protein) 1.2 %Met (Mature Protein) 1.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MPSMKHILKSLSILLIGFLGGLIAIITFNNLYPHSPSKINSGKATTSNMVFNNTTNTTKA CCCHHHHHHHHHHHHHHHHHHHEEEHEECCCCCCCCCCCCCCCCEECCEEEECCCCHHHH VKAVQNAVVSVINYQDNPSSSLSNPYTKLFGEGRSKENKDAELSIFSEGSGVIYRKDGNS HHHHHHHHHEEEECCCCCCCCCCCCHHHHHCCCCCCCCCCCEEEEEECCCEEEEEECCCE AYVVTNNHVIDGAKRIEILMADGSKVVGELVGADTYSDLAVVKISSDKIKTVAEFADSTK EEEEECCEEECCCEEEEEEEECCCHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHCCCC LNVGEVAIAIGSPLGTQYANSVTQGIVSSLSRTVTLKNENGETVSTNAIQTDAAINPGNS CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHEEEEEECCCCCEEECCEEEECCCCCCCCC GGPLINIEGQVIGINSSKISSTPTGSNGNSGAVEGIGFAIPSTDVIKIIKQLETNGEVIR CCCEEEECCEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCEEE PALGISMVNLNDLSTNALSQINIPTSVTGGIVVAEVKEGMPASGKLAQYDVITEIDGKTV HHHCEEEEEECCCCCCCHHEECCCCCCCCCEEEEEECCCCCCCCCEEEEEEEEECCCCCH NSISDLQSSLYGHDINDTIKVTFYRGTTKKKADIKLTKTTQDLTKTQ HHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCEEEEEECHHHHHCCC >Mature Secondary Structure PSMKHILKSLSILLIGFLGGLIAIITFNNLYPHSPSKINSGKATTSNMVFNNTTNTTKA CCHHHHHHHHHHHHHHHHHHHEEEHEECCCCCCCCCCCCCCCCEECCEEEECCCCHHHH VKAVQNAVVSVINYQDNPSSSLSNPYTKLFGEGRSKENKDAELSIFSEGSGVIYRKDGNS HHHHHHHHHEEEECCCCCCCCCCCCHHHHHCCCCCCCCCCCEEEEEECCCEEEEEECCCE AYVVTNNHVIDGAKRIEILMADGSKVVGELVGADTYSDLAVVKISSDKIKTVAEFADSTK EEEEECCEEECCCEEEEEEEECCCHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHCCCC LNVGEVAIAIGSPLGTQYANSVTQGIVSSLSRTVTLKNENGETVSTNAIQTDAAINPGNS CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHEEEEEECCCCCEEECCEEEECCCCCCCCC GGPLINIEGQVIGINSSKISSTPTGSNGNSGAVEGIGFAIPSTDVIKIIKQLETNGEVIR CCCEEEECCEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCEEE PALGISMVNLNDLSTNALSQINIPTSVTGGIVVAEVKEGMPASGKLAQYDVITEIDGKTV HHHCEEEEEECCCCCCCHHEECCCCCCCCCEEEEEECCCCCCCCCEEEEEEEEECCCCCH NSISDLQSSLYGHDINDTIKVTFYRGTTKKKADIKLTKTTQDLTKTQ HHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCEEEEEECHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: Serine endopeptidases [C]
General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 10712686; 11337471 [H]