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The map label for this gene is mutL

Identifier: 15675871

GI number: 15675871

Start: 1771381

End: 1773363

Strand: Reverse

Name: mutL

Synonym: SPy_2121

Alternate gene names: 15675871

Gene position: 1773363-1771381 (Counterclockwise)

Preceding gene: 15675872

Following gene: 15675870

Centisome position: 95.73

GC content: 39.59

Gene sequence:

>1983_bases
ATGACAAACATTATTGAATTACCGGAAGTTCTCGCCAACCAAATTGCAGCTGGTGAAGTTGTAGAAAGGCCAGCGAGTGT
TGTCAAGGAATTGGTTGAGAATGCTATTGATGCTAAAAGTAGCCAGATTACCGTTGAAATTGAAGAGTCTGGCCTTAAGA
TGATACAGGTTACAGACAACGGTGAGGGAATGTCTCATGAAGATTTACCTTTAAGTCTGCGTCGCCACGCTACTAGTAAA
ATTAAGAGTCAGAGTGATTTGTTTAGAATTAGAACACTTGGCTTCCGTGGAGAGGCTTTACCGTCTGTTGCCTCTATCAG
TAAAATCACGATAAAAACAGCAACAAAAGAAGTCACTCACGGTTCTCTTCTTATAGCTACTGGTGGGGAAATTGAGACAC
TTGAAGCGATCTCAACTCCTACTGGAACCAAAATTAAGGTTGAAAACCTTTTTTACAACACGCCTGCTCGTCTCAAATAT
ATGAAAAGTTTACAGGCAGAATTAGCTCACATTGTAGATGTGGTCAACCGGTTGAGTTTGGCACATCCAGAAGTTGCTTT
CACACTGATTAGTGATGGTCGCCAATTAACTCAGACATCAGGAACTGGCGATTTACGCCAAGCAATTGCAGGGATTTATG
GTTTGAATACTACCAAAAAAATGCTGGCTATCTCTAATGCTGATTTGGATTTTGAAGTTTCCGGCTATGTTAGCTTGCCA
GAGTTGACACGCGCCAACCGTAATTACATGACGATTTTGGTTAATGGGCGTTACATCAAGAATTTCTTGCTTAATCGAGC
AATTCTTGATGGTTACGGTTCTAAGCTCATGGTTGGACGTTTCCCAATTGTTGTGATTGATATTCAGATTGATCCCTATT
TGGCCGATGTCAATGTTCACCCCACAAAACAAGAGGTTCGTATTTCAAAAGAGCGTGAATTAATGGCTTTAATTAGCACG
GCTATTTCAGAGAGTCTTAAGGAACAAGATTTGATTCCAGATGCTCTGGAAAATTTAGCCAAATCAAGCACACGACATTT
CTCTAAACCAGAGCAAACACAACTTCCTTTACAGTCTAGGGGACTTTATTATGATCCTCAAAAGAATGACTTTTTTGTCA
AAGAGTCGGCTGTCTCGGAAAAAATACCTGAAACTGATTTTTATTCCGGCGCTGTTGACAACAGTGTAAAGGTTGAAAAA
GTAGAGCTGTTACCCCACTCAGAAGAAGTTATAGGACCTTCTTCGGTTAAACACGCAAGTCGTCCCCAGAATACCTTTAC
CGAGACTGATCATCCTAATCTTGACTTAAAAAACAGACAAAAGTTATCTCAAATGCTAACCCGTTTGGAAAATGAAGGGC
AATCAGTGTTTCCCGAATTGGATTATTTTGGTCAGATGCACGGAACTTATCTCTTTGCTCAGGGAAAAGATGGTTTATTT
ATAATTGACCAACACGCTGCCCAGGAGCGGGTTAAATACGAATATTATCGTGATAAGATAGGTGAGGTTGACAGTAGTTT
ACAGCAATTGTTGGTGCCCTATTTGTTTGAGTTTTCTGGTTCTGATTTCATTAACTTACAGGAGAAAATGGCACTCTTAA
ATGAAGTTGGTATCTTCTTAGAAGTTTATGGGCACAATACTTTCATTTTGAGGGAGCATCCTATCTGGATGAAAGAAGAA
GAGATTGCATCTGGTGTCTATGAAATGTGTGACATGTTACTTCTAACCAATGAGGTATCTATTAAAACTTACCGAGCAGA
GTTAGCTATTATGATGAGTTGTAAACGATCTATCAAGGCAAATCATAGCTTGGATGATTATTCAGCAAGAAATCTGCTAC
TGCAATTGGCCCAATGTCAAAATCCTTATAACTGCCCTCATGGTAGACCCGTATTGATTAATTTTAGTAAGGCAGATATG
GAAAAAATGTTCCGTCGAATTCAAGAAAATCACACTAGCCTGCGAGAGCTAGGAAAATATTAG

Upstream 100 bases:

>100_bases
TTATAAGTCCACAAAAAAGTCCACAAATTAATATTTTGAGAGGTGTAAACCTAATGAAACCTTGTTATATCAACGTTTAG
AAAGTGTTAAAAACAAAATT

Downstream 100 bases:

>100_bases
AGAGGATGAGATGCAAGAGTTTTTAAACCTTCCTAAGCAGATTCAGCTGAGGCAACTGGTACGCTTTGTGACCATTACCT
TAGGCAGTAGTATCTTTCCC

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 660; Mature: 659

Protein sequence:

>660_residues
MTNIIELPEVLANQIAAGEVVERPASVVKELVENAIDAKSSQITVEIEESGLKMIQVTDNGEGMSHEDLPLSLRRHATSK
IKSQSDLFRIRTLGFRGEALPSVASISKITIKTATKEVTHGSLLIATGGEIETLEAISTPTGTKIKVENLFYNTPARLKY
MKSLQAELAHIVDVVNRLSLAHPEVAFTLISDGRQLTQTSGTGDLRQAIAGIYGLNTTKKMLAISNADLDFEVSGYVSLP
ELTRANRNYMTILVNGRYIKNFLLNRAILDGYGSKLMVGRFPIVVIDIQIDPYLADVNVHPTKQEVRISKERELMALIST
AISESLKEQDLIPDALENLAKSSTRHFSKPEQTQLPLQSRGLYYDPQKNDFFVKESAVSEKIPETDFYSGAVDNSVKVEK
VELLPHSEEVIGPSSVKHASRPQNTFTETDHPNLDLKNRQKLSQMLTRLENEGQSVFPELDYFGQMHGTYLFAQGKDGLF
IIDQHAAQERVKYEYYRDKIGEVDSSLQQLLVPYLFEFSGSDFINLQEKMALLNEVGIFLEVYGHNTFILREHPIWMKEE
EIASGVYEMCDMLLLTNEVSIKTYRAELAIMMSCKRSIKANHSLDDYSARNLLLQLAQCQNPYNCPHGRPVLINFSKADM
EKMFRRIQENHTSLRELGKY

Sequences:

>Translated_660_residues
MTNIIELPEVLANQIAAGEVVERPASVVKELVENAIDAKSSQITVEIEESGLKMIQVTDNGEGMSHEDLPLSLRRHATSK
IKSQSDLFRIRTLGFRGEALPSVASISKITIKTATKEVTHGSLLIATGGEIETLEAISTPTGTKIKVENLFYNTPARLKY
MKSLQAELAHIVDVVNRLSLAHPEVAFTLISDGRQLTQTSGTGDLRQAIAGIYGLNTTKKMLAISNADLDFEVSGYVSLP
ELTRANRNYMTILVNGRYIKNFLLNRAILDGYGSKLMVGRFPIVVIDIQIDPYLADVNVHPTKQEVRISKERELMALIST
AISESLKEQDLIPDALENLAKSSTRHFSKPEQTQLPLQSRGLYYDPQKNDFFVKESAVSEKIPETDFYSGAVDNSVKVEK
VELLPHSEEVIGPSSVKHASRPQNTFTETDHPNLDLKNRQKLSQMLTRLENEGQSVFPELDYFGQMHGTYLFAQGKDGLF
IIDQHAAQERVKYEYYRDKIGEVDSSLQQLLVPYLFEFSGSDFINLQEKMALLNEVGIFLEVYGHNTFILREHPIWMKEE
EIASGVYEMCDMLLLTNEVSIKTYRAELAIMMSCKRSIKANHSLDDYSARNLLLQLAQCQNPYNCPHGRPVLINFSKADM
EKMFRRIQENHTSLRELGKY
>Mature_659_residues
TNIIELPEVLANQIAAGEVVERPASVVKELVENAIDAKSSQITVEIEESGLKMIQVTDNGEGMSHEDLPLSLRRHATSKI
KSQSDLFRIRTLGFRGEALPSVASISKITIKTATKEVTHGSLLIATGGEIETLEAISTPTGTKIKVENLFYNTPARLKYM
KSLQAELAHIVDVVNRLSLAHPEVAFTLISDGRQLTQTSGTGDLRQAIAGIYGLNTTKKMLAISNADLDFEVSGYVSLPE
LTRANRNYMTILVNGRYIKNFLLNRAILDGYGSKLMVGRFPIVVIDIQIDPYLADVNVHPTKQEVRISKERELMALISTA
ISESLKEQDLIPDALENLAKSSTRHFSKPEQTQLPLQSRGLYYDPQKNDFFVKESAVSEKIPETDFYSGAVDNSVKVEKV
ELLPHSEEVIGPSSVKHASRPQNTFTETDHPNLDLKNRQKLSQMLTRLENEGQSVFPELDYFGQMHGTYLFAQGKDGLFI
IDQHAAQERVKYEYYRDKIGEVDSSLQQLLVPYLFEFSGSDFINLQEKMALLNEVGIFLEVYGHNTFILREHPIWMKEEE
IASGVYEMCDMLLLTNEVSIKTYRAELAIMMSCKRSIKANHSLDDYSARNLLLQLAQCQNPYNCPHGRPVLINFSKADME
KMFRRIQENHTSLRELGKY

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=341, Percent_Identity=35.1906158357771, Blast_Score=192, Evalue=8e-49,
Organism=Homo sapiens, GI310128478, Length=348, Percent_Identity=28.448275862069, Blast_Score=137, Evalue=5e-32,
Organism=Homo sapiens, GI4505913, Length=348, Percent_Identity=28.448275862069, Blast_Score=136, Evalue=5e-32,
Organism=Homo sapiens, GI4505911, Length=329, Percent_Identity=27.0516717325228, Blast_Score=123, Evalue=6e-28,
Organism=Homo sapiens, GI189458898, Length=329, Percent_Identity=27.0516717325228, Blast_Score=122, Evalue=8e-28,
Organism=Homo sapiens, GI91992160, Length=347, Percent_Identity=29.1066282420749, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI91992162, Length=347, Percent_Identity=29.1066282420749, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI310128480, Length=314, Percent_Identity=26.7515923566879, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI189458896, Length=320, Percent_Identity=27.8125, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI263191589, Length=247, Percent_Identity=28.7449392712551, Blast_Score=95, Evalue=3e-19,
Organism=Escherichia coli, GI1790612, Length=361, Percent_Identity=39.0581717451524, Blast_Score=236, Evalue=5e-63,
Organism=Caenorhabditis elegans, GI71991825, Length=319, Percent_Identity=32.9153605015674, Blast_Score=182, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI17562796, Length=347, Percent_Identity=25.3602305475504, Blast_Score=124, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6323819, Length=355, Percent_Identity=32.3943661971831, Blast_Score=183, Evalue=9e-47,
Organism=Saccharomyces cerevisiae, GI6324247, Length=362, Percent_Identity=27.9005524861878, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6325093, Length=718, Percent_Identity=21.4484679665738, Blast_Score=93, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6323063, Length=332, Percent_Identity=24.0963855421687, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI17136968, Length=358, Percent_Identity=32.9608938547486, Blast_Score=189, Evalue=6e-48,
Organism=Drosophila melanogaster, GI17136970, Length=353, Percent_Identity=24.929178470255, Blast_Score=103, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_STRP1 (Q99XN7)

Other databases:

- EMBL:   AE004092
- EMBL:   CP000017
- RefSeq:   NP_270045.1
- RefSeq:   YP_283167.1
- ProteinModelPortal:   Q99XN7
- SMR:   Q99XN7
- EnsemblBacteria:   EBSTRT00000000880
- EnsemblBacteria:   EBSTRT00000028727
- GeneID:   3571091
- GeneID:   901760
- GenomeReviews:   AE004092_GR
- GenomeReviews:   CP000017_GR
- KEGG:   spy:SPy_2121
- KEGG:   spz:M5005_Spy_1804
- GeneTree:   EBGT00050000027788
- HOGENOM:   HBG520262
- OMA:   FLFINNR
- ProtClustDB:   PRK00095
- BioCyc:   SPYO160490:SPY2121-MONOMER
- BioCyc:   SPYO293653:M5005_SPY1804-MONOMER
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 74287; Mature: 74156

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNIIELPEVLANQIAAGEVVERPASVVKELVENAIDAKSSQITVEIEESGLKMIQVTDN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECC
GEGMSHEDLPLSLRRHATSKIKSQSDLFRIRTLGFRGEALPSVASISKITIKTATKEVTH
CCCCCCCCCCHHHHHHHHHHHCCHHHHEEEEEECCCCCCCCCHHHHHEEEEEEHHHHCCC
GSLLIATGGEIETLEAISTPTGTKIKVENLFYNTPARLKYMKSLQAELAHIVDVVNRLSL
CEEEEEECCCEEEHHHHCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHC
AHPEVAFTLISDGRQLTQTSGTGDLRQAIAGIYGLNTTKKMLAISNADLDFEVSGYVSLP
CCCCEEEEEECCCCCEECCCCCHHHHHHHHHHHCCCCHHHEEEEECCCCCEEECCCEECH
ELTRANRNYMTILVNGRYIKNFLLNRAILDGYGSKLMVGRFPIVVIDIQIDPYLADVNVH
HHHCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEEEECCEEEECCCC
PTKQEVRISKERELMALISTAISESLKEQDLIPDALENLAKSSTRHFSKPEQTQLPLQSR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHCCCHHHC
GLYYDPQKNDFFVKESAVSEKIPETDFYSGAVDNSVKVEKVELLPHSEEVIGPSSVKHAS
CCEECCCCCCEEEEHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCHHCCCCHHCCCC
RPQNTFTETDHPNLDLKNRQKLSQMLTRLENEGQSVFPELDYFGQMHGTYLFAQGKDGLF
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCEEEEEECCCCEE
IIDQHAAQERVKYEYYRDKIGEVDSSLQQLLVPYLFEFSGSDFINLQEKMALLNEVGIFL
EEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCEEE
EVYGHNTFILREHPIWMKEEEIASGVYEMCDMLLLTNEVSIKTYRAELAIMMSCKRSIKA
EEECCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCC
NHSLDDYSARNLLLQLAQCQNPYNCPHGRPVLINFSKADMEKMFRRIQENHTSLRELGKY
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TNIIELPEVLANQIAAGEVVERPASVVKELVENAIDAKSSQITVEIEESGLKMIQVTDN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECC
GEGMSHEDLPLSLRRHATSKIKSQSDLFRIRTLGFRGEALPSVASISKITIKTATKEVTH
CCCCCCCCCCHHHHHHHHHHHCCHHHHEEEEEECCCCCCCCCHHHHHEEEEEEHHHHCCC
GSLLIATGGEIETLEAISTPTGTKIKVENLFYNTPARLKYMKSLQAELAHIVDVVNRLSL
CEEEEEECCCEEEHHHHCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHC
AHPEVAFTLISDGRQLTQTSGTGDLRQAIAGIYGLNTTKKMLAISNADLDFEVSGYVSLP
CCCCEEEEEECCCCCEECCCCCHHHHHHHHHHHCCCCHHHEEEEECCCCCEEECCCEECH
ELTRANRNYMTILVNGRYIKNFLLNRAILDGYGSKLMVGRFPIVVIDIQIDPYLADVNVH
HHHCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEEEECCEEEECCCC
PTKQEVRISKERELMALISTAISESLKEQDLIPDALENLAKSSTRHFSKPEQTQLPLQSR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHCCCHHHC
GLYYDPQKNDFFVKESAVSEKIPETDFYSGAVDNSVKVEKVELLPHSEEVIGPSSVKHAS
CCEECCCCCCEEEEHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCHHCCCCHHCCCC
RPQNTFTETDHPNLDLKNRQKLSQMLTRLENEGQSVFPELDYFGQMHGTYLFAQGKDGLF
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCEEEEEECCCCEE
IIDQHAAQERVKYEYYRDKIGEVDSSLQQLLVPYLFEFSGSDFINLQEKMALLNEVGIFL
EEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCEEE
EVYGHNTFILREHPIWMKEEEIASGVYEMCDMLLLTNEVSIKTYRAELAIMMSCKRSIKA
EEECCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCC
NHSLDDYSARNLLLQLAQCQNPYNCPHGRPVLINFSKADMEKMFRRIQENHTSLRELGKY
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11296296