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The map label for this gene is ahpC [H]

Identifier: 15675837

GI number: 15675837

Start: 1729073

End: 1729633

Strand: Direct

Name: ahpC [H]

Synonym: SPy_2079

Alternate gene names: 15675837

Gene position: 1729073-1729633 (Clockwise)

Preceding gene: 15675831

Following gene: 15675838

Centisome position: 93.34

GC content: 39.39

Gene sequence:

>561_bases
ATGTCTCTAATTGGAAAAGAAATTGCTGAATTTTCAGCTCAAGCTTATCACGATGGAAAATTCATCACTGTTACAAATGA
AGACGTTAAAGGAAAATGGGCAGTTTTTTGTTTCTACCCAGCAGACTTTTCATTTGTTTGCCCAACTGAACTCGGTGACC
TTCAAGAGCAATACGAAACACTGAAATCTCTTGGTGTAGAAGTTTATTCTGTCTCTACTGATACTCATTTTGTTCATAAA
GCTTGGCATGATGATTCAGATGTGGTTGGCACTATCACATACCCTATGATTGGTGACCCTTCACACCTTATTTCACAAGC
CTTTGAAGTGCTTGGCGAAGACGGACTTGCTCAACGTGGAACATTTATCGTTGATCCAGATGGTATTATCCAAATGATGG
AAATTAATGCTGATGGTATTGGACGTGACGCTAGCACCTTGATTGATAAAATTCACGCTGCCCAATACGTCCGTAAACAT
CCAGGTGAAGTTTGTCCAGCTAAATGGAAAGAAGGCGCTGAAACTTTGACACCAAGTCTTGATTTAGTTGGTAAAATTTA
A

Upstream 100 bases:

>100_bases
ATCGCTGATTTCCCAGTAAAATCAAGGGTTTCTGAGTAGACATAATCTTGTTGTTCTTTTATAATACAAGTATAAAACTA
TAAAAAAGGAGGACAACTAT

Downstream 100 bases:

>100_bases
TAAATTTTAGGAGGAAAGCTATGGCATTAAGTCCTGATATTAAAGAACAACTTGCCCAATACCTCACCCTGTTAGAAGCT
GATCTTGTTTTGCAAGTTTC

Product: putative alkyl hydroperoxidase

Products: NA

Alternate protein names: Alkyl hydroperoxide reductase protein C22; General stress protein 22; Peroxiredoxin; Thioredoxin peroxidase [H]

Number of amino acids: Translated: 186; Mature: 185

Protein sequence:

>186_residues
MSLIGKEIAEFSAQAYHDGKFITVTNEDVKGKWAVFCFYPADFSFVCPTELGDLQEQYETLKSLGVEVYSVSTDTHFVHK
AWHDDSDVVGTITYPMIGDPSHLISQAFEVLGEDGLAQRGTFIVDPDGIIQMMEINADGIGRDASTLIDKIHAAQYVRKH
PGEVCPAKWKEGAETLTPSLDLVGKI

Sequences:

>Translated_186_residues
MSLIGKEIAEFSAQAYHDGKFITVTNEDVKGKWAVFCFYPADFSFVCPTELGDLQEQYETLKSLGVEVYSVSTDTHFVHK
AWHDDSDVVGTITYPMIGDPSHLISQAFEVLGEDGLAQRGTFIVDPDGIIQMMEINADGIGRDASTLIDKIHAAQYVRKH
PGEVCPAKWKEGAETLTPSLDLVGKI
>Mature_185_residues
SLIGKEIAEFSAQAYHDGKFITVTNEDVKGKWAVFCFYPADFSFVCPTELGDLQEQYETLKSLGVEVYSVSTDTHFVHKA
WHDDSDVVGTITYPMIGDPSHLISQAFEVLGEDGLAQRGTFIVDPDGIIQMMEINADGIGRDASTLIDKIHAAQYVRKHP
GEVCPAKWKEGAETLTPSLDLVGKI

Specific function: Directly reduces organic hydroperoxides in its reduced dithiol form [H]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI32189392, Length=182, Percent_Identity=39.5604395604396, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI4505591, Length=182, Percent_Identity=39.010989010989, Blast_Score=135, Evalue=2e-32,
Organism=Homo sapiens, GI32455266, Length=182, Percent_Identity=39.010989010989, Blast_Score=135, Evalue=2e-32,
Organism=Homo sapiens, GI32455264, Length=182, Percent_Identity=39.010989010989, Blast_Score=135, Evalue=2e-32,
Organism=Homo sapiens, GI5453549, Length=187, Percent_Identity=39.0374331550802, Blast_Score=129, Evalue=1e-30,
Organism=Homo sapiens, GI32483377, Length=173, Percent_Identity=38.150289017341, Blast_Score=125, Evalue=2e-29,
Organism=Homo sapiens, GI5802974, Length=173, Percent_Identity=38.150289017341, Blast_Score=125, Evalue=2e-29,
Organism=Homo sapiens, GI33188454, Length=82, Percent_Identity=46.3414634146341, Blast_Score=81, Evalue=6e-16,
Organism=Escherichia coli, GI1786822, Length=187, Percent_Identity=62.5668449197861, Blast_Score=254, Evalue=2e-69,
Organism=Caenorhabditis elegans, GI32565831, Length=183, Percent_Identity=39.8907103825137, Blast_Score=140, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI193204376, Length=183, Percent_Identity=39.8907103825137, Blast_Score=140, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17554494, Length=177, Percent_Identity=37.8531073446328, Blast_Score=129, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6323613, Length=185, Percent_Identity=33.5135135135135, Blast_Score=111, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6320661, Length=181, Percent_Identity=33.7016574585635, Blast_Score=110, Evalue=1e-25,
Organism=Drosophila melanogaster, GI17738015, Length=172, Percent_Identity=38.953488372093, Blast_Score=130, Evalue=4e-31,
Organism=Drosophila melanogaster, GI21357347, Length=189, Percent_Identity=35.4497354497354, Blast_Score=127, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24656348, Length=182, Percent_Identity=35.1648351648352, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI17864676, Length=182, Percent_Identity=35.1648351648352, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI17157991, Length=180, Percent_Identity=34.4444444444444, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24641739, Length=180, Percent_Identity=34.4444444444444, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24581278, Length=158, Percent_Identity=26.5822784810127, Blast_Score=67, Evalue=9e-12,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR017559
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 20483; Mature: 20352

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLIGKEIAEFSAQAYHDGKFITVTNEDVKGKWAVFCFYPADFSFVCPTELGDLQEQYET
CCCHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEEEECCCCCEECCCHHHHHHHHHHH
LKSLGVEVYSVSTDTHFVHKAWHDDSDVVGTITYPMIGDPSHLISQAFEVLGEDGLAQRG
HHHCCEEEEEECCCCCEEHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCC
TFIVDPDGIIQMMEINADGIGRDASTLIDKIHAAQYVRKHPGEVCPAKWKEGAETLTPSL
CEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCHHHCCCCH
DLVGKI
HHCCCC
>Mature Secondary Structure 
SLIGKEIAEFSAQAYHDGKFITVTNEDVKGKWAVFCFYPADFSFVCPTELGDLQEQYET
CCHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEEEECCCCCEECCCHHHHHHHHHHH
LKSLGVEVYSVSTDTHFVHKAWHDDSDVVGTITYPMIGDPSHLISQAFEVLGEDGLAQRG
HHHCCEEEEEECCCCCEEHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCC
TFIVDPDGIIQMMEINADGIGRDASTLIDKIHAAQYVRKHPGEVCPAKWKEGAETLTPSL
CEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCHHHCCCCH
DLVGKI
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 8180695; 8012595 [H]