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The map label for this gene is nox1 [H]

Identifier: 15675838

GI number: 15675838

Start: 1729654

End: 1731186

Strand: Direct

Name: nox1 [H]

Synonym: SPy_2080

Alternate gene names: 15675838

Gene position: 1729654-1731186 (Clockwise)

Preceding gene: 15675837

Following gene: 15675840

Centisome position: 93.37

GC content: 43.64

Gene sequence:

>1533_bases
ATGGCATTAAGTCCTGATATTAAAGAACAACTTGCCCAATACCTCACCCTGTTAGAAGCTGATCTTGTTTTGCAAGTTTC
CCTTGGTGACAATGAGCAGTCTCAAAAAGTCAAAGACTTTGTGGAAGAAATAGCTGCTATGTCTGAGCGTATTTCTATTG
AAAACATCACTTTAGACCGACAACCAAGCTTTAAGGTTGCGAAAAAAGGTCACGGTAGTGGGGTTGTCTTTGCTGGTCTT
CCTTTAGGCCACGAATTGACGTCCTTTATTCTTGCTCTCTTGCAAGTATCTGGACGTGCTCCAAAAGTGGATCAAGATGT
TATTGATCGCATCAAGGCCATTGACCGTCCGTTGCATTTTGAAACTTATGTCAGCTTAACCTGCCATAACTGCCCAGATG
TTGTTCAAGCTTTAAACATTATGTCCGTCTTGAACGACAAGATTTCACACACTATGGTAGAAGGCGGCATGTTCCAAGAT
GAAGTGAAAGCAAAAGGCATTATGTCTGTCCCTACTGTCTTTTTAGACGGGGAAGAATTCACTTCTGGTCGCGCTACCAT
TGAGCAACTCTTAGAACAAATCGCTGGCCCACTTTCTGAGGAAGCCTTTGCTGATAAAGGCCTCTATGATGTCCTTGTTA
TTGGTGGTGGCCCTGCGGGCAATAGCGCTGCTATCTATGCAGCTCGTAAAGGACTAAAAACAGGTTTACTTGCTGAAACC
TTTGGTGGTCAGGTCATGGAAACGGTCGGCATCGAAAACATGATTGGTACCCTTTACACTGAAGGACCAAAATTAATGGC
CGAAGTGGAGGCCCATACTAAGTCTTATGATGTTGATATTATCAAAGCACAACTAGCTACTTCTATTGAGAAAAAAGAAA
ACATCGAGGTTACTCTAGCTAATGGTGCGGTTCTACAAGCCAAAACTGCTATCTTAGCTCTTGGGGCCAAATGGCGTAAC
ATTAATGTTCCTGGTGAAGATGAATTCCGTAATAAAGGGGTGACTTACTGCCCTCACTGTGACGGTCCTCTCTTTGAAGG
CAAAGATGTTGCTGTTATCGGTGGTGGGAACTCTGGATTAGAAGCGGCCCTTGACTTGGCTGGTCTTGCTAAACACGTTT
ACGTTTTAGAATTCTTGCCTGAACTTAAAGCTGACAAAGTGCTTCAAGACCGCGCAGCTAAGACTAACAATATGACCATC
ATCAAAAATGTTGCTACTAAGGACATTGTTGGAGAGGACCATGTTACAGGTCTTAACTACACTGAGCGTGATAGCGGTGA
AGACAAACACCTTGACCTTGAAGGGGTCTTTGTTCAAATTGGTCTTGTTCCAAACACAGCTTGGCTCAAAGATAGTGGTG
TCAACCTAACCGACCGCGGAGAAATCATTGTGGATAAACATGGGTCAACCAATATTCCTGGTATCTTTGCTGCTGGGGAC
TGTACTGATTCAGCTTATAAACAAATCATTATTTCCATGGGGTCTGGTGCTACTGCTGCCATCGGTGCCTTTGACTACTT
GATTCGTCAATAA

Upstream 100 bases:

>100_bases
CAGGTGAAGTTTGTCCAGCTAAATGGAAAGAAGGCGCTGAAACTTTGACACCAAGTCTTGATTTAGTTGGTAAAATTTAA
TAAATTTTAGGAGGAAAGCT

Downstream 100 bases:

>100_bases
AACAGCATATTTAAAAGAAGTTTTGAGCTAACGCTCAAAGCTTCTTTTTTAAATTTTTTAAAGAATACGACCTCGGTCAA
CTGTGAGTTGTCCTTTTTTA

Product: putative NADH oxidase/alkyl hydroperoxidase reductase

Products: NA

Alternate protein names: Alkyl hydroperoxide reductase [H]

Number of amino acids: Translated: 510; Mature: 509

Protein sequence:

>510_residues
MALSPDIKEQLAQYLTLLEADLVLQVSLGDNEQSQKVKDFVEEIAAMSERISIENITLDRQPSFKVAKKGHGSGVVFAGL
PLGHELTSFILALLQVSGRAPKVDQDVIDRIKAIDRPLHFETYVSLTCHNCPDVVQALNIMSVLNDKISHTMVEGGMFQD
EVKAKGIMSVPTVFLDGEEFTSGRATIEQLLEQIAGPLSEEAFADKGLYDVLVIGGGPAGNSAAIYAARKGLKTGLLAET
FGGQVMETVGIENMIGTLYTEGPKLMAEVEAHTKSYDVDIIKAQLATSIEKKENIEVTLANGAVLQAKTAILALGAKWRN
INVPGEDEFRNKGVTYCPHCDGPLFEGKDVAVIGGGNSGLEAALDLAGLAKHVYVLEFLPELKADKVLQDRAAKTNNMTI
IKNVATKDIVGEDHVTGLNYTERDSGEDKHLDLEGVFVQIGLVPNTAWLKDSGVNLTDRGEIIVDKHGSTNIPGIFAAGD
CTDSAYKQIIISMGSGATAAIGAFDYLIRQ

Sequences:

>Translated_510_residues
MALSPDIKEQLAQYLTLLEADLVLQVSLGDNEQSQKVKDFVEEIAAMSERISIENITLDRQPSFKVAKKGHGSGVVFAGL
PLGHELTSFILALLQVSGRAPKVDQDVIDRIKAIDRPLHFETYVSLTCHNCPDVVQALNIMSVLNDKISHTMVEGGMFQD
EVKAKGIMSVPTVFLDGEEFTSGRATIEQLLEQIAGPLSEEAFADKGLYDVLVIGGGPAGNSAAIYAARKGLKTGLLAET
FGGQVMETVGIENMIGTLYTEGPKLMAEVEAHTKSYDVDIIKAQLATSIEKKENIEVTLANGAVLQAKTAILALGAKWRN
INVPGEDEFRNKGVTYCPHCDGPLFEGKDVAVIGGGNSGLEAALDLAGLAKHVYVLEFLPELKADKVLQDRAAKTNNMTI
IKNVATKDIVGEDHVTGLNYTERDSGEDKHLDLEGVFVQIGLVPNTAWLKDSGVNLTDRGEIIVDKHGSTNIPGIFAAGD
CTDSAYKQIIISMGSGATAAIGAFDYLIRQ
>Mature_509_residues
ALSPDIKEQLAQYLTLLEADLVLQVSLGDNEQSQKVKDFVEEIAAMSERISIENITLDRQPSFKVAKKGHGSGVVFAGLP
LGHELTSFILALLQVSGRAPKVDQDVIDRIKAIDRPLHFETYVSLTCHNCPDVVQALNIMSVLNDKISHTMVEGGMFQDE
VKAKGIMSVPTVFLDGEEFTSGRATIEQLLEQIAGPLSEEAFADKGLYDVLVIGGGPAGNSAAIYAARKGLKTGLLAETF
GGQVMETVGIENMIGTLYTEGPKLMAEVEAHTKSYDVDIIKAQLATSIEKKENIEVTLANGAVLQAKTAILALGAKWRNI
NVPGEDEFRNKGVTYCPHCDGPLFEGKDVAVIGGGNSGLEAALDLAGLAKHVYVLEFLPELKADKVLQDRAAKTNNMTII
KNVATKDIVGEDHVTGLNYTERDSGEDKHLDLEGVFVQIGLVPNTAWLKDSGVNLTDRGEIIVDKHGSTNIPGIFAAGDC
TDSAYKQIIISMGSGATAAIGAFDYLIRQ

Specific function: Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone [H]

COG id: COG3634

COG function: function code O; Alkyl hydroperoxide reductase, large subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI21389617, Length=279, Percent_Identity=26.1648745519713, Blast_Score=68, Evalue=3e-11,
Organism=Homo sapiens, GI65787454, Length=279, Percent_Identity=26.1648745519713, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI226437568, Length=279, Percent_Identity=26.1648745519713, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI87081763, Length=518, Percent_Identity=50.1930501930502, Blast_Score=502, Evalue=1e-143,
Organism=Escherichia coli, GI1787114, Length=309, Percent_Identity=34.3042071197411, Blast_Score=152, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6321898, Length=323, Percent_Identity=32.8173374613003, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6320560, Length=319, Percent_Identity=33.8557993730408, Blast_Score=138, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012081
- InterPro:   IPR013027
- InterPro:   IPR002109
- InterPro:   IPR008255
- InterPro:   IPR001327
- InterPro:   IPR000103
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.6.99.3 [H]

Molecular weight: Translated: 54752; Mature: 54621

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS00573 PYRIDINE_REDOX_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALSPDIKEQLAQYLTLLEADLVLQVSLGDNEQSQKVKDFVEEIAAMSERISIENITLDR
CCCCHHHHHHHHHHHHHHHHCEEEEEEECCCHHHHHHHHHHHHHHHHHHHCEEEEEEECC
QPSFKVAKKGHGSGVVFAGLPLGHELTSFILALLQVSGRAPKVDQDVIDRIKAIDRPLHF
CCCCHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEE
ETYVSLTCHNCPDVVQALNIMSVLNDKISHTMVEGGMFQDEVKAKGIMSVPTVFLDGEEF
EEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCEECCEEEECCCCC
TSGRATIEQLLEQIAGPLSEEAFADKGLYDVLVIGGGPAGNSAAIYAARKGLKTGLLAET
CCHHHHHHHHHHHHCCCCCHHHHHCCCCEEEEEEECCCCCCCCEEEEEHHCCHHCHHHHH
FGGQVMETVGIENMIGTLYTEGPKLMAEVEAHTKSYDVDIIKAQLATSIEKKENIEVTLA
HCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEEE
NGAVLQAKTAILALGAKWRNINVPGEDEFRNKGVTYCPHCDGPLFEGKDVAVIGGGNSGL
CCCEEEHHHEEEEECCCEEECCCCCCHHHHCCCCEECCCCCCCCCCCCCEEEEECCCCCH
EAALDLAGLAKHVYVLEFLPELKADKVLQDRAAKTNNMTIIKNVATKDIVGEDHVTGLNY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECHHHCCCCCCCCCCCCC
TERDSGEDKHLDLEGVFVQIGLVPNTAWLKDSGVNLTDRGEIIVDKHGSTNIPGIFAAGD
CCCCCCCCCEEEEEEEEEEEEECCCCCEECCCCCCCCCCCCEEEECCCCCCCCEEEEECC
CTDSAYKQIIISMGSGATAAIGAFDYLIRQ
CCHHHHHHEEEECCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
ALSPDIKEQLAQYLTLLEADLVLQVSLGDNEQSQKVKDFVEEIAAMSERISIENITLDR
CCCHHHHHHHHHHHHHHHHCEEEEEEECCCHHHHHHHHHHHHHHHHHHHCEEEEEEECC
QPSFKVAKKGHGSGVVFAGLPLGHELTSFILALLQVSGRAPKVDQDVIDRIKAIDRPLHF
CCCCHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEE
ETYVSLTCHNCPDVVQALNIMSVLNDKISHTMVEGGMFQDEVKAKGIMSVPTVFLDGEEF
EEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCEECCEEEECCCCC
TSGRATIEQLLEQIAGPLSEEAFADKGLYDVLVIGGGPAGNSAAIYAARKGLKTGLLAET
CCHHHHHHHHHHHHCCCCCHHHHHCCCCEEEEEEECCCCCCCCEEEEEHHCCHHCHHHHH
FGGQVMETVGIENMIGTLYTEGPKLMAEVEAHTKSYDVDIIKAQLATSIEKKENIEVTLA
HCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEEE
NGAVLQAKTAILALGAKWRNINVPGEDEFRNKGVTYCPHCDGPLFEGKDVAVIGGGNSGL
CCCEEEHHHEEEEECCCEEECCCCCCHHHHCCCCEECCCCCCCCCCCCCEEEEECCCCCH
EAALDLAGLAKHVYVLEFLPELKADKVLQDRAAKTNNMTIIKNVATKDIVGEDHVTGLNY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECHHHCCCCCCCCCCCCC
TERDSGEDKHLDLEGVFVQIGLVPNTAWLKDSGVNLTDRGEIIVDKHGSTNIPGIFAAGD
CCCCCCCCCEEEEEEEEEEEEECCCCCEECCCCCCCCCCCCEEEECCCCCCCCEEEEECC
CTDSAYKQIIISMGSGATAAIGAFDYLIRQ
CCHHHHHHEEEECCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1917890; 2760020 [H]