| Definition | Streptococcus pyogenes M1 GAS chromosome, complete genome. |
|---|---|
| Accession | NC_002737 |
| Length | 1,852,441 |
Click here to switch to the map view.
The map label for this gene is hsdM [H]
Identifier: 15675719
GI number: 15675719
Start: 1589139
End: 1590719
Strand: Direct
Name: hsdM [H]
Synonym: SPy_1906
Alternate gene names: 15675719
Gene position: 1589139-1590719 (Clockwise)
Preceding gene: 15675718
Following gene: 15675732
Centisome position: 85.79
GC content: 36.94
Gene sequence:
>1581_bases ATGGCAGAGAAAACAACTTCACTCCGTCAAGCACTATGGCATTCGGCCGACCAATTACGTGGCCAAATGGATGCCAATGA CTATAAAAACTATCTTCTTGGACTTATTTTTTACAAACACTTATCTGATAAATTACTCTTGGCTGTTTGTGATAATCTAG AAAAACACTTCAATACCTTTACAGAGGCTCAAAAAATCTTTGAAGATGCTTATCAAGATGAAGGCCTAAAAGATGACCTC ATTTCTGTTGTTACTGGTGATTTAGGTTACTTTATCGAACCGACACTGACCTTTGAAAAACTCATCCAAGATGTTTATCA CAATACTTTCCAATTAGAATCATTAGCTCAAGGTTTTCGCGATATTGAACAAAGTGGTGAAGACTTTGAAAACTTATTTG AAGATATTGACCTCTACTCTAAAAAATTAGGCTCTACTCCTCAAAAACAAAATCAAACCATTTCTAATGTCATGAAAACA TTAAATGAAATTGACTTTGAGGCAGTAGATGGGGATACTTTAGGTGATGCTTATGAGTACTTGATTGGTGAATTTGCCAG TGAATCAGGAAAAAAAGCAGGTGAGTTCTATACCCCACAAGCTGTCTCTCACTTAATGACTCAGATTGTCTTTTTAGGTC GTGAAGATCAAAAAGGAATGACCCTCTATGACCCTGCTATGGGATCTGGATCACTCCTTTTAAATGCTAAGAAATATAGT AACCAATCCGATACCGTTTCTTACTATGGTCAAGAAATCAATACTTCTACTTATAACTTGGCTCGTATGAACATGATGCT TCATGGCGTTGCCATCGAGAACCAACACTTAAGTAACGCTGATACCTTGGATGCAGACTGGCCAACAGATGAACCAATCA ACTTTGATGGGGTGTTGATGAACCCACCTTATTCTTTGAAATGGTCAGCGACTGCTGGTTTCTTAACGGATCCACGGTTT TCAAGTTATGGTGTATTAGCACCAAAATCAAAAGCCGATTTTGCCTTTTTACTTCATGGTTTCTATCATTTAAAAAATAC AGGAACTATGGCGATTGTCTTACCACACGGTGTCCTTTTCCGTGGAGCTGCAGAAGGCAAGATTCGCCAAAAACTACTCG AACAAGGGGCTATCGATACCATTATCGGACTCCCATCAAATATCTTTTATAATACAAGCATCCCTACGACTATTATCATA TTAAAGAAGAACAGAACCAACAAAGATGTCTTCTTTATCGATGCTTCAAAAGAGTTTGATAAGGGTAAAAATCAAAACAC AATGACAGATAACCATATCAAAAAGATCCTTGATGCTTATAAGAGTCGTGATAATTCTGATAAGTTTTCATATTTAGCCT CATTTGATGAAATCATTGAAAATGACTATAACTTAAATATCCCACGCTATGTTGATACCTTTGAGGAAGTCCCAGTTAAA CCACTGCCAGAATTAGCTAAACAGCTCAGTGACATTGATCAAGAAATTGCCAAAACAAATGCCAAACTAGATCAACTCAT GAAACAACTAGTCGGAACAACCAAAGAAGCACAAGACGAATTGGATACTTTTAGAAACTAA
Upstream 100 bases:
>100_bases TTTAGACCAACAAATTGCTCAATCTGAAGAAAAACTAACAGAACTCAAAGCACTCAAACAAACATTACTCAATCGTTTAT TCGTATAAGAAAGGACTCAC
Downstream 100 bases:
>100_bases AAGACAAAAAAACACCACAGTAGATGATTACTACTGTGGCGTTTTATTTAAAATTGAGTAGTGAACCTTTATTGAGTACT TATCAAACAAGATTCTCCTT
Product: putative type I site-specific deoxyribonuclease
Products: NA
Alternate protein names: M.EcoR124II [H]
Number of amino acids: Translated: 526; Mature: 525
Protein sequence:
>526_residues MAEKTTSLRQALWHSADQLRGQMDANDYKNYLLGLIFYKHLSDKLLLAVCDNLEKHFNTFTEAQKIFEDAYQDEGLKDDL ISVVTGDLGYFIEPTLTFEKLIQDVYHNTFQLESLAQGFRDIEQSGEDFENLFEDIDLYSKKLGSTPQKQNQTISNVMKT LNEIDFEAVDGDTLGDAYEYLIGEFASESGKKAGEFYTPQAVSHLMTQIVFLGREDQKGMTLYDPAMGSGSLLLNAKKYS NQSDTVSYYGQEINTSTYNLARMNMMLHGVAIENQHLSNADTLDADWPTDEPINFDGVLMNPPYSLKWSATAGFLTDPRF SSYGVLAPKSKADFAFLLHGFYHLKNTGTMAIVLPHGVLFRGAAEGKIRQKLLEQGAIDTIIGLPSNIFYNTSIPTTIII LKKNRTNKDVFFIDASKEFDKGKNQNTMTDNHIKKILDAYKSRDNSDKFSYLASFDEIIENDYNLNIPRYVDTFEEVPVK PLPELAKQLSDIDQEIAKTNAKLDQLMKQLVGTTKEAQDELDTFRN
Sequences:
>Translated_526_residues MAEKTTSLRQALWHSADQLRGQMDANDYKNYLLGLIFYKHLSDKLLLAVCDNLEKHFNTFTEAQKIFEDAYQDEGLKDDL ISVVTGDLGYFIEPTLTFEKLIQDVYHNTFQLESLAQGFRDIEQSGEDFENLFEDIDLYSKKLGSTPQKQNQTISNVMKT LNEIDFEAVDGDTLGDAYEYLIGEFASESGKKAGEFYTPQAVSHLMTQIVFLGREDQKGMTLYDPAMGSGSLLLNAKKYS NQSDTVSYYGQEINTSTYNLARMNMMLHGVAIENQHLSNADTLDADWPTDEPINFDGVLMNPPYSLKWSATAGFLTDPRF SSYGVLAPKSKADFAFLLHGFYHLKNTGTMAIVLPHGVLFRGAAEGKIRQKLLEQGAIDTIIGLPSNIFYNTSIPTTIII LKKNRTNKDVFFIDASKEFDKGKNQNTMTDNHIKKILDAYKSRDNSDKFSYLASFDEIIENDYNLNIPRYVDTFEEVPVK PLPELAKQLSDIDQEIAKTNAKLDQLMKQLVGTTKEAQDELDTFRN >Mature_525_residues AEKTTSLRQALWHSADQLRGQMDANDYKNYLLGLIFYKHLSDKLLLAVCDNLEKHFNTFTEAQKIFEDAYQDEGLKDDLI SVVTGDLGYFIEPTLTFEKLIQDVYHNTFQLESLAQGFRDIEQSGEDFENLFEDIDLYSKKLGSTPQKQNQTISNVMKTL NEIDFEAVDGDTLGDAYEYLIGEFASESGKKAGEFYTPQAVSHLMTQIVFLGREDQKGMTLYDPAMGSGSLLLNAKKYSN QSDTVSYYGQEINTSTYNLARMNMMLHGVAIENQHLSNADTLDADWPTDEPINFDGVLMNPPYSLKWSATAGFLTDPRFS SYGVLAPKSKADFAFLLHGFYHLKNTGTMAIVLPHGVLFRGAAEGKIRQKLLEQGAIDTIIGLPSNIFYNTSIPTTIIIL KKNRTNKDVFFIDASKEFDKGKNQNTMTDNHIKKILDAYKSRDNSDKFSYLASFDEIIENDYNLNIPRYVDTFEEVPVKP LPELAKQLSDIDQEIAKTNAKLDQLMKQLVGTTKEAQDELDTFRN
Specific function: Methylation of specific adenine residues; required for both restriction and modification activities. The EcoR124/3 I enzyme recognizes 5'-GAAN(7)RTCG-3' [H]
COG id: COG0286
COG function: function code V; Type I restriction-modification system methyltransferase subunit
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the N(4)/N(6)-methyltransferase family [H]
Homologues:
Organism=Escherichia coli, GI1790808, Length=506, Percent_Identity=23.5177865612648, Blast_Score=94, Evalue=3e-20,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR022749 - InterPro: IPR003356 - InterPro: IPR002052 - InterPro: IPR002296 - InterPro: IPR004546 [H]
Pfam domain/function: PF12161 HsdM_N; PF02384 N6_Mtase [H]
EC number: =2.1.1.72 [H]
Molecular weight: Translated: 59499; Mature: 59368
Theoretical pI: Translated: 4.58; Mature: 4.58
Prosite motif: PS00092 N6_MTASE
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.2 %Cys (Translated Protein) 2.5 %Met (Translated Protein) 2.7 %Cys+Met (Translated Protein) 0.2 %Cys (Mature Protein) 2.3 %Met (Mature Protein) 2.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MAEKTTSLRQALWHSADQLRGQMDANDYKNYLLGLIFYKHLSDKLLLAVCDNLEKHFNTF CCCHHHHHHHHHHHCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH TEAQKIFEDAYQDEGLKDDLISVVTGDLGYFIEPTLTFEKLIQDVYHNTFQLESLAQGFR HHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEECCCHHHHHHHHHHHHCHHHHHHHHHHHH DIEQSGEDFENLFEDIDLYSKKLGSTPQKQNQTISNVMKTLNEIDFEAVDGDTLGDAYEY HHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEECCCCCHHHHHHH LIGEFASESGKKAGEFYTPQAVSHLMTQIVFLGREDQKGMTLYDPAMGSGSLLLNAKKYS HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCEEEEEHHHC NQSDTVSYYGQEINTSTYNLARMNMMLHGVAIENQHLSNADTLDADWPTDEPINFDGVLM CCCCHHHHCCCCCCCCHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEE NPPYSLKWSATAGFLTDPRFSSYGVLAPKSKADFAFLLHGFYHLKNTGTMAIVLPHGVLF CCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCEEE RGAAEGKIRQKLLEQGAIDTIIGLPSNIFYNTSIPTTIIILKKNRTNKDVFFIDASKEFD CCCCCHHHHHHHHHCCCHHHHHCCCCCCEECCCCCEEEEEEECCCCCCCEEEEECCHHHC KGKNQNTMTDNHIKKILDAYKSRDNSDKFSYLASFDEIIENDYNLNIPRYVDTFEEVPVK CCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCC PLPELAKQLSDIDQEIAKTNAKLDQLMKQLVGTTKEAQDELDTFRN CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCC >Mature Secondary Structure AEKTTSLRQALWHSADQLRGQMDANDYKNYLLGLIFYKHLSDKLLLAVCDNLEKHFNTF CCHHHHHHHHHHHCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH TEAQKIFEDAYQDEGLKDDLISVVTGDLGYFIEPTLTFEKLIQDVYHNTFQLESLAQGFR HHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEECCCHHHHHHHHHHHHCHHHHHHHHHHHH DIEQSGEDFENLFEDIDLYSKKLGSTPQKQNQTISNVMKTLNEIDFEAVDGDTLGDAYEY HHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEECCCCCHHHHHHH LIGEFASESGKKAGEFYTPQAVSHLMTQIVFLGREDQKGMTLYDPAMGSGSLLLNAKKYS HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCEEEEEHHHC NQSDTVSYYGQEINTSTYNLARMNMMLHGVAIENQHLSNADTLDADWPTDEPINFDGVLM CCCCHHHHCCCCCCCCHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEE NPPYSLKWSATAGFLTDPRFSSYGVLAPKSKADFAFLLHGFYHLKNTGTMAIVLPHGVLF CCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCEEE RGAAEGKIRQKLLEQGAIDTIIGLPSNIFYNTSIPTTIIILKKNRTNKDVFFIDASKEFD CCCCCHHHHHHHHHCCCHHHHHCCCCCCEECCCCCEEEEEEECCCCCCCEEEEECCHHHC KGKNQNTMTDNHIKKILDAYKSRDNSDKFSYLASFDEIIENDYNLNIPRYVDTFEEVPVK CCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCC PLPELAKQLSDIDQEIAKTNAKLDQLMKQLVGTTKEAQDELDTFRN CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 2784505 [H]