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The map label for this gene is pyrG [H]

Identifier: 15675707

GI number: 15675707

Start: 1569345

End: 1570949

Strand: Reverse

Name: pyrG [H]

Synonym: SPy_1894

Alternate gene names: 15675707

Gene position: 1570949-1569345 (Counterclockwise)

Preceding gene: 15675708

Following gene: 15675706

Centisome position: 84.8

GC content: 40.75

Gene sequence:

>1605_bases
ATGACGAAATACATTTTTGTAACTGGTGGTGTTGTATCATCAATTGGCAAAGGAATTGTTGCGGCAAGTCTTGGCCGATT
GTTAAAAAATCGTGGACTTAAGGTGACGATTCAAAAATTTGATCCTTATATTAATATTGATCCAGGGACGATGAGCCCCT
ATCAGCATGGAGAAGTATATGTGACAGATGACGGTGCTGAAACCGACTTGGATTTGGGTCACTATGAACGTTTTATTGAT
ATCAATCTTAATAAATATTCCAATGTTACAACAGGTAAAATTTATAGTGAAGTCCTTCGTAAAGAACGTAAAGGCGAGTA
CCTTGGAGCGACTGTTCAGGTGATTCCTCATATCACAGATGCCCTTAAAGAAAAAATCAAACGCGCAGCTTCAACAACGG
ACTCTGATGTAATTATTACTGAGGTCGGGGGGACTGTTGGCGATATTGAAAGTTTACCGTTCTTAGAAGCTCTTCGTCAG
ATGAAAGCTGATGTTGGTTCTGAAAATGTGATGTATATTCACACCACCTTGTTGCCATATTTAAAGGCAGCGGGTGAAAT
GAAAACTAAGCCAACGCAACATTCCGTTAAAGAATTGCGTGGTTTAGGGATTCAACCGAATATGTTGGTTATTCGTACGG
AAGAGCCAGTTGAGCAGGGGATTAAAAATAAATTGGCTCAGTTCTGTGATGTGAATTCAGAAGCTGTTATCGAGTCACGT
GATGTAGAACACTTGTATCAAATTCCATTGAACTTGCAAGCTCAATCAATGGATCAGATTGTTTGTGATCATTTGAAATT
GAATGCGCCACAAGCTGATATGACCGAGTGGTCAGCTATGGTTGACAAGGTGATGAATTTAAGAAAAACAACAAAAATTG
CCTTGGTTGGTAAATATGTGGAATTGCCAGATGCCTACTTATCTGTTGTGGAAGCCTTGAAACATTCTGGTTATGCCAAT
GATACCGCAATTGACCTAAAATGGGTCAATGCTAACGATGTGACGGTGGATAATGCAGCTGACTTGTTGGGAGATGCGGA
TGGGATTATTGTACCAGGTGGTTTTGGTCAACGTGGTACAGAAGGCAAGATCCAAGCGATTCGCTATGCCCGCGAAAATG
ATGTGCCAATGCTTGGTATTTGTCTTGGCATGCAGTTGACTTGTGTTGAATTTGCCCGCCATGTCCTCAATATGGAAGGT
GCAAACTCTTTTGAATTAGAGCCAAGTACTAAATACCCCATCATTGATATCATGCGTGATCAAATTGATATTGAAGATAT
GGGAGGTACGCTTCGTCTGGGATTGTACCCATGTAAATTGAAACCAGGTTCAAAAGCAGCAATGGCTTACAATAATCAAG
AGGTGGTGCAACGTCGTCATCGTCACCGTTATGAGTTCAACAACAAATTCCGTCCAGAATTTGAAGCAGCTGGTTTTGTT
TTCTCAGGGGTATCACCTGACAACCGCTTAGTTGAAATTGTAGAATTGAAAGAGAAAAAATTCTTTGTAGCAGCTCAATA
CCACCCAGAATTGCAAAGCCGTCCAAATCGTCCTGAGGAGCTATACACCGCTTTTGTTACAGCTGCTATTAAAAATAGCA
ATTAG

Upstream 100 bases:

>100_bases
ATATTTAGAAAACTAAGGTGATACCTAACCAATGTGGAACCAACTAATAGGGAATTAACAAGAAAGCAATGCTTTTATTC
AGCTTATATAAAGGAGTACT

Downstream 100 bases:

>100_bases
TGGTTTTAAGGGTAAGTTTGTGGCATTCTACTTGGCTGGCAGATACTGATAAAGATTACTAGCTATTAAAGGGATCTTTT
CTATAAAAATAGCATTAGAA

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase [H]

Number of amino acids: Translated: 534; Mature: 533

Protein sequence:

>534_residues
MTKYIFVTGGVVSSIGKGIVAASLGRLLKNRGLKVTIQKFDPYINIDPGTMSPYQHGEVYVTDDGAETDLDLGHYERFID
INLNKYSNVTTGKIYSEVLRKERKGEYLGATVQVIPHITDALKEKIKRAASTTDSDVIITEVGGTVGDIESLPFLEALRQ
MKADVGSENVMYIHTTLLPYLKAAGEMKTKPTQHSVKELRGLGIQPNMLVIRTEEPVEQGIKNKLAQFCDVNSEAVIESR
DVEHLYQIPLNLQAQSMDQIVCDHLKLNAPQADMTEWSAMVDKVMNLRKTTKIALVGKYVELPDAYLSVVEALKHSGYAN
DTAIDLKWVNANDVTVDNAADLLGDADGIIVPGGFGQRGTEGKIQAIRYARENDVPMLGICLGMQLTCVEFARHVLNMEG
ANSFELEPSTKYPIIDIMRDQIDIEDMGGTLRLGLYPCKLKPGSKAAMAYNNQEVVQRRHRHRYEFNNKFRPEFEAAGFV
FSGVSPDNRLVEIVELKEKKFFVAAQYHPELQSRPNRPEELYTAFVTAAIKNSN

Sequences:

>Translated_534_residues
MTKYIFVTGGVVSSIGKGIVAASLGRLLKNRGLKVTIQKFDPYINIDPGTMSPYQHGEVYVTDDGAETDLDLGHYERFID
INLNKYSNVTTGKIYSEVLRKERKGEYLGATVQVIPHITDALKEKIKRAASTTDSDVIITEVGGTVGDIESLPFLEALRQ
MKADVGSENVMYIHTTLLPYLKAAGEMKTKPTQHSVKELRGLGIQPNMLVIRTEEPVEQGIKNKLAQFCDVNSEAVIESR
DVEHLYQIPLNLQAQSMDQIVCDHLKLNAPQADMTEWSAMVDKVMNLRKTTKIALVGKYVELPDAYLSVVEALKHSGYAN
DTAIDLKWVNANDVTVDNAADLLGDADGIIVPGGFGQRGTEGKIQAIRYARENDVPMLGICLGMQLTCVEFARHVLNMEG
ANSFELEPSTKYPIIDIMRDQIDIEDMGGTLRLGLYPCKLKPGSKAAMAYNNQEVVQRRHRHRYEFNNKFRPEFEAAGFV
FSGVSPDNRLVEIVELKEKKFFVAAQYHPELQSRPNRPEELYTAFVTAAIKNSN
>Mature_533_residues
TKYIFVTGGVVSSIGKGIVAASLGRLLKNRGLKVTIQKFDPYINIDPGTMSPYQHGEVYVTDDGAETDLDLGHYERFIDI
NLNKYSNVTTGKIYSEVLRKERKGEYLGATVQVIPHITDALKEKIKRAASTTDSDVIITEVGGTVGDIESLPFLEALRQM
KADVGSENVMYIHTTLLPYLKAAGEMKTKPTQHSVKELRGLGIQPNMLVIRTEEPVEQGIKNKLAQFCDVNSEAVIESRD
VEHLYQIPLNLQAQSMDQIVCDHLKLNAPQADMTEWSAMVDKVMNLRKTTKIALVGKYVELPDAYLSVVEALKHSGYAND
TAIDLKWVNANDVTVDNAADLLGDADGIIVPGGFGQRGTEGKIQAIRYARENDVPMLGICLGMQLTCVEFARHVLNMEGA
NSFELEPSTKYPIIDIMRDQIDIEDMGGTLRLGLYPCKLKPGSKAAMAYNNQEVVQRRHRHRYEFNNKFRPEFEAAGFVF
SGVSPDNRLVEIVELKEKKFFVAAQYHPELQSRPNRPEELYTAFVTAAIKNSN

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen [H]

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI148491070, Length=551, Percent_Identity=47.3684210526316, Blast_Score=500, Evalue=1e-141,
Organism=Homo sapiens, GI28559085, Length=554, Percent_Identity=46.028880866426, Blast_Score=495, Evalue=1e-140,
Organism=Homo sapiens, GI28559083, Length=554, Percent_Identity=46.028880866426, Blast_Score=495, Evalue=1e-140,
Organism=Homo sapiens, GI221316689, Length=554, Percent_Identity=46.028880866426, Blast_Score=495, Evalue=1e-140,
Organism=Escherichia coli, GI1789142, Length=538, Percent_Identity=52.2304832713755, Blast_Score=571, Evalue=1e-164,
Organism=Caenorhabditis elegans, GI25148299, Length=605, Percent_Identity=37.1900826446281, Blast_Score=417, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6319432, Length=562, Percent_Identity=44.6619217081851, Blast_Score=476, Evalue=1e-135,
Organism=Saccharomyces cerevisiae, GI6322563, Length=559, Percent_Identity=44.3649373881932, Blast_Score=464, Evalue=1e-131,
Organism=Drosophila melanogaster, GI24664469, Length=552, Percent_Identity=44.9275362318841, Blast_Score=484, Evalue=1e-137,
Organism=Drosophila melanogaster, GI21357815, Length=497, Percent_Identity=42.4547283702213, Blast_Score=405, Evalue=1e-113,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase [H]

EC number: =6.3.4.2 [H]

Molecular weight: Translated: 59508; Mature: 59377

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKYIFVTGGVVSSIGKGIVAASLGRLLKNRGLKVTIQKFDPYINIDPGTMSPYQHGEVY
CCEEEEEECHHHHHHCCHHHHHHHHHHHHCCCCEEEEEECCCEEEECCCCCCCCCCCEEE
VTDDGAETDLDLGHYERFIDINLNKYSNVTTGKIYSEVLRKERKGEYLGATVQVIPHITD
EECCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
ALKEKIKRAASTTDSDVIITEVGGTVGDIESLPFLEALRQMKADVGSENVMYIHTTLLPY
HHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEHHHHHHH
LKAAGEMKTKPTQHSVKELRGLGIQPNMLVIRTEEPVEQGIKNKLAQFCDVNSEAVIESR
HHHCCCCCCCCHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCHHEECCC
DVEHLYQIPLNLQAQSMDQIVCDHLKLNAPQADMTEWSAMVDKVMNLRKTTKIALVGKYV
CHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEECHH
ELPDAYLSVVEALKHSGYANDTAIDLKWVNANDVTVDNAADLLGDADGIIVPGGFGQRGT
HCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEECCHHHHHCCCCCEEECCCCCCCCC
EGKIQAIRYARENDVPMLGICLGMQLTCVEFARHVLNMEGANSFELEPSTKYPIIDIMRD
CCHHHHEEECCCCCCCEEEHHHCCCHHHHHHHHHHHCCCCCCCEECCCCCCCCHHHHHHH
QIDIEDMGGTLRLGLYPCKLKPGSKAAMAYNNQEVVQRRHRHRYEFNNKFRPEFEAAGFV
HCCHHHCCCEEEEEEEEEECCCCCCCEEEECCHHHHHHHHHHCCCCCCCCCCCHHCCCEE
FSGVSPDNRLVEIVELKEKKFFVAAQYHPELQSRPNRPEELYTAFVTAAIKNSN
EECCCCCCHHHHHEECCCCEEEEEEECCCHHHCCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TKYIFVTGGVVSSIGKGIVAASLGRLLKNRGLKVTIQKFDPYINIDPGTMSPYQHGEVY
CEEEEEECHHHHHHCCHHHHHHHHHHHHCCCCEEEEEECCCEEEECCCCCCCCCCCEEE
VTDDGAETDLDLGHYERFIDINLNKYSNVTTGKIYSEVLRKERKGEYLGATVQVIPHITD
EECCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
ALKEKIKRAASTTDSDVIITEVGGTVGDIESLPFLEALRQMKADVGSENVMYIHTTLLPY
HHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEHHHHHHH
LKAAGEMKTKPTQHSVKELRGLGIQPNMLVIRTEEPVEQGIKNKLAQFCDVNSEAVIESR
HHHCCCCCCCCHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCHHEECCC
DVEHLYQIPLNLQAQSMDQIVCDHLKLNAPQADMTEWSAMVDKVMNLRKTTKIALVGKYV
CHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEECHH
ELPDAYLSVVEALKHSGYANDTAIDLKWVNANDVTVDNAADLLGDADGIIVPGGFGQRGT
HCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEECCHHHHHCCCCCEEECCCCCCCCC
EGKIQAIRYARENDVPMLGICLGMQLTCVEFARHVLNMEGANSFELEPSTKYPIIDIMRD
CCHHHHEEECCCCCCCEEEHHHCCCHHHHHHHHHHHCCCCCCCEECCCCCCCCHHHHHHH
QIDIEDMGGTLRLGLYPCKLKPGSKAAMAYNNQEVVQRRHRHRYEFNNKFRPEFEAAGFV
HCCHHHCCCEEEEEEEEEECCCCCCCEEEECCHHHHHHHHHHCCCCCCCCCCCHHCCCEE
FSGVSPDNRLVEIVELKEKKFFVAAQYHPELQSRPNRPEELYTAFVTAAIKNSN
EECCCCCCHHHHHEECCCCEEEEEEECCCHHHCCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA