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The map label for this gene is gcp

Identifier: 15675691

GI number: 15675691

Start: 1553468

End: 1554496

Strand: Reverse

Name: gcp

Synonym: SPy_1872

Alternate gene names: 15675691

Gene position: 1554496-1553468 (Counterclockwise)

Preceding gene: 15675692

Following gene: 15675688

Centisome position: 83.92

GC content: 41.98

Gene sequence:

>1029_bases
ATGACAGATAGGTATATTTTAGCAGTTGAGAGTTCTTGTGATGAGACCAGTGTAGCGATTTTAAAAAACGAAAGTACCCT
CTTAAGTAATGTCATTGCAAGTCAGGTTGAGAGCCACAAACGCTTTGGTGGTGTGGTGCCAGAAGTAGCTAGTAGACACC
ATGTCGAAGTGATTACGACTTGCTTTGAGGATGCTTTGCAAGAAGCTGGCATCAGTGCTTCAGATTTATCAGCAGTTGCG
GTAACTTATGGCCCTGGACTTGTTGGAGCCTTGTTAGTTGGATTAGCAGCTGCGAAGGCTTTTGCTTGGGCAAATCATTT
ACCTTTGATTCCGGTTAATCATATGGCAGGTCACTTAATGGCAGCGCGTGAACAAAAGCCTTTAGTTTATCCTTTAATAG
CACTGTTGGTTTCAGGAGGACACACAGAATTGGTTTATGTCCCAGAGCCAGGGGATTATCATATTATTGGCGAGACGCGT
GACGACGCTGTTGGTGAGGCTTATGATAAAGTTGGGCGTGTGATGGGCTTAACCTATCCGGCAGGACGTGAAATTGACCA
GTTGGCTCATAAAGGTCAAGATACTTATCATTTCCCTCGTGCTATGATAACAGAAGACCACTTAGAATTTTCCTTTTCAG
GACTCAAGTCCGCTTTTATCAATCTTCATCATAATGCTAAGCAAAAAGGCGATGAACTGATTCTAGAAGATTTGTGTGCA
TCTTTTCAAGCAGCTGTTCTAGATATTTTATTGGCCAAAACAAAAAAAGCTCTGAGCAGATACCCTGCAAAGATGCTTGT
AGTGGCTGGTGGTGTAGCGGCAAATCAAGGATTACGAGATAGATTAGCACAAGAAATTACACATATAGAAGTTGTGATTC
CTAAACTAAGACTCTGTGGAGATAACGCGGGTATGATTGCTTTAGCAGCAGCTATTGAGTATGACAAACAGCATTTTGCT
AATATGAGCCTAAACGCGAAGCCTAGTTTAGCTTTTGACCAGTTTCCAGACAGTTTTGTAATAAACTAG

Upstream 100 bases:

>100_bases
GGTTTATATCAGAAGTTTGGTTTTAAATTTATTGGCAAAAGACCAGACTACTATAGAAATCCTATAGAAACAGCTTTATT
GATGAAACGGGAAGGAAAAC

Downstream 100 bases:

>100_bases
TCACACTTGCTAGTTAGTAAGATTTATAATGGATAAGAATCTCCCTTTGAAAAAACAACCCGGTATCTTGGCATACCGGG
TTGTCATGATGATAAGTAAT

Product: putative DNA-binding/iron metalloprotein/AP endonuclease

Products: NA

Alternate protein names: Glycoprotease

Number of amino acids: Translated: 342; Mature: 341

Protein sequence:

>342_residues
MTDRYILAVESSCDETSVAILKNESTLLSNVIASQVESHKRFGGVVPEVASRHHVEVITTCFEDALQEAGISASDLSAVA
VTYGPGLVGALLVGLAAAKAFAWANHLPLIPVNHMAGHLMAAREQKPLVYPLIALLVSGGHTELVYVPEPGDYHIIGETR
DDAVGEAYDKVGRVMGLTYPAGREIDQLAHKGQDTYHFPRAMITEDHLEFSFSGLKSAFINLHHNAKQKGDELILEDLCA
SFQAAVLDILLAKTKKALSRYPAKMLVVAGGVAANQGLRDRLAQEITHIEVVIPKLRLCGDNAGMIALAAAIEYDKQHFA
NMSLNAKPSLAFDQFPDSFVIN

Sequences:

>Translated_342_residues
MTDRYILAVESSCDETSVAILKNESTLLSNVIASQVESHKRFGGVVPEVASRHHVEVITTCFEDALQEAGISASDLSAVA
VTYGPGLVGALLVGLAAAKAFAWANHLPLIPVNHMAGHLMAAREQKPLVYPLIALLVSGGHTELVYVPEPGDYHIIGETR
DDAVGEAYDKVGRVMGLTYPAGREIDQLAHKGQDTYHFPRAMITEDHLEFSFSGLKSAFINLHHNAKQKGDELILEDLCA
SFQAAVLDILLAKTKKALSRYPAKMLVVAGGVAANQGLRDRLAQEITHIEVVIPKLRLCGDNAGMIALAAAIEYDKQHFA
NMSLNAKPSLAFDQFPDSFVIN
>Mature_341_residues
TDRYILAVESSCDETSVAILKNESTLLSNVIASQVESHKRFGGVVPEVASRHHVEVITTCFEDALQEAGISASDLSAVAV
TYGPGLVGALLVGLAAAKAFAWANHLPLIPVNHMAGHLMAAREQKPLVYPLIALLVSGGHTELVYVPEPGDYHIIGETRD
DAVGEAYDKVGRVMGLTYPAGREIDQLAHKGQDTYHFPRAMITEDHLEFSFSGLKSAFINLHHNAKQKGDELILEDLCAS
FQAAVLDILLAKTKKALSRYPAKMLVVAGGVAANQGLRDRLAQEITHIEVVIPKLRLCGDNAGMIALAAAIEYDKQHFAN
MSLNAKPSLAFDQFPDSFVIN

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M22 family

Homologues:

Organism=Homo sapiens, GI116812636, Length=329, Percent_Identity=32.2188449848024, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI8923380, Length=323, Percent_Identity=30.9597523219814, Blast_Score=130, Evalue=2e-30,
Organism=Escherichia coli, GI1789445, Length=335, Percent_Identity=42.6865671641791, Blast_Score=268, Evalue=4e-73,
Organism=Caenorhabditis elegans, GI17557464, Length=326, Percent_Identity=33.7423312883436, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI71995670, Length=325, Percent_Identity=30.7692307692308, Blast_Score=119, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6320099, Length=337, Percent_Identity=32.0474777448071, Blast_Score=142, Evalue=9e-35,
Organism=Saccharomyces cerevisiae, GI6322891, Length=348, Percent_Identity=29.3103448275862, Blast_Score=117, Evalue=3e-27,
Organism=Drosophila melanogaster, GI20129063, Length=336, Percent_Identity=33.9285714285714, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI21357207, Length=323, Percent_Identity=30.030959752322, Blast_Score=128, Evalue=6e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCP_STRP1 (Q99Y46)

Other databases:

- EMBL:   AE004092
- EMBL:   CP000017
- RefSeq:   NP_269865.1
- RefSeq:   YP_282954.1
- ProteinModelPortal:   Q99Y46
- SMR:   Q99Y46
- MEROPS:   M22.001
- EnsemblBacteria:   EBSTRT00000000418
- EnsemblBacteria:   EBSTRT00000028884
- GeneID:   3571319
- GeneID:   902082
- GenomeReviews:   AE004092_GR
- GenomeReviews:   CP000017_GR
- KEGG:   spy:SPy_1872
- KEGG:   spz:M5005_Spy_1591
- GeneTree:   EBGT00050000027599
- HOGENOM:   HBG304663
- OMA:   PAVGVHH
- ProtClustDB:   PRK09604
- BioCyc:   SPYO160490:SPY1872-MONOMER
- BioCyc:   SPYO293653:M5005_SPY1591-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_01445
- InterPro:   IPR022450
- InterPro:   IPR000905
- InterPro:   IPR017861
- PANTHER:   PTHR11735
- PRINTS:   PR00789
- TIGRFAMs:   TIGR03723
- TIGRFAMs:   TIGR00329

Pfam domain/function: PF00814 Peptidase_M22

EC number: =3.4.24.57

Molecular weight: Translated: 36932; Mature: 36801

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS01016 GLYCOPROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDRYILAVESSCDETSVAILKNESTLLSNVIASQVESHKRFGGVVPEVASRHHVEVITT
CCCCEEEEEECCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHH
CFEDALQEAGISASDLSAVAVTYGPGLVGALLVGLAAAKAFAWANHLPLIPVNHMAGHLM
HHHHHHHHCCCCHHHCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHH
AAREQKPLVYPLIALLVSGGHTELVYVPEPGDYHIIGETRDDAVGEAYDKVGRVMGLTYP
HHHCCCCHHHHHHHHHHCCCCEEEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCC
AGREIDQLAHKGQDTYHFPRAMITEDHLEFSFSGLKSAFINLHHNAKQKGDELILEDLCA
CCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
SFQAAVLDILLAKTKKALSRYPAKMLVVAGGVAANQGLRDRLAQEITHIEVVIPKLRLCG
HHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHCCCHHHHHHHHHHHHHHEEHHHHCCC
DNAGMIALAAAIEYDKQHFANMSLNAKPSLAFDQFPDSFVIN
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCC
>Mature Secondary Structure 
TDRYILAVESSCDETSVAILKNESTLLSNVIASQVESHKRFGGVVPEVASRHHVEVITT
CCCEEEEEECCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHH
CFEDALQEAGISASDLSAVAVTYGPGLVGALLVGLAAAKAFAWANHLPLIPVNHMAGHLM
HHHHHHHHCCCCHHHCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHH
AAREQKPLVYPLIALLVSGGHTELVYVPEPGDYHIIGETRDDAVGEAYDKVGRVMGLTYP
HHHCCCCHHHHHHHHHHCCCCEEEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCC
AGREIDQLAHKGQDTYHFPRAMITEDHLEFSFSGLKSAFINLHHNAKQKGDELILEDLCA
CCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
SFQAAVLDILLAKTKKALSRYPAKMLVVAGGVAANQGLRDRLAQEITHIEVVIPKLRLCG
HHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHCCCHHHHHHHHHHHHHHEEHHHHCCC
DNAGMIALAAAIEYDKQHFANMSLNAKPSLAFDQFPDSFVIN
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296