Definition | Streptococcus pyogenes M1 GAS chromosome, complete genome. |
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Accession | NC_002737 |
Length | 1,852,441 |
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The map label for this gene is folD
Identifier: 15675405
GI number: 15675405
Start: 1232109
End: 1232963
Strand: Reverse
Name: folD
Synonym: SPy_1502
Alternate gene names: 15675405
Gene position: 1232963-1232109 (Counterclockwise)
Preceding gene: 15675406
Following gene: 15675404
Centisome position: 66.56
GC content: 39.88
Gene sequence:
>855_bases ATGACAGAACTAATTGATGGTAAAGCCTTAGCTCAAAAGATGCAACAAGAGTTAGCAGCTAAAGTCAACAATCTAAAACA AAAAAAAGGAATTGTACCAGGCTTAGCCGTTATTCTTGTAGGTGATGATCCTGCTAGTCAGGTGTATGTCCGTAATAAAG AGCGTGCAGCTCTTACTGTAGGTTTTAAAAGTGAGACCGTTAGATTATCAGAATTCATTTGTCAAGAAGAGCTTATTGCA GTAATCGAACGTTACAATGCAGATAACACTATTCATGGTATTTTAGTGCAGCTACCCCTGCCAAATCATATTAATGATAA AAAAATTATTCTCGCCATTGATCCCAAAAAAGATGTGGATGGTTTTCACCCGATGAATACAGGTCACCTTTGGTCAGGAC GTCCCTTGATGGTTCCTTGTACTCCATCAGGGATTATGGAATTGCTTCGAGAATATAATGTTAACCTTGAAGGTAAACAT GCCGTCATTATTGGCAGATCGAATATCGTTGGAAAACCAATGGCACAGCTCTTACTGGACAAAAATGCAACAGTCACGTT GACACATTCAAGAACACGTCAATTAGAAGAAGTATGTCGCTGTGCAGATGTGTTGATTGTGGCAATCGGACAAGGTCATT TCATAACAAAACAATATATAAAAGATGGTGCGATAGTGATTGATGTAGGAATGAACCGTGATGATAATGGCAAGCTAATT GGAGATGTGGCCTTTGATGAGGTGGCAGAAGTTGCAGCGAAAATCACCCCTGTACCAGGAGGTGTCGGTCCTATGACGAT TGCTATGTTGCTAGAGCAAACTTATCAATCTGCTCTCCGTAGTACTCATAAATAG
Upstream 100 bases:
>100_bases TTAATCGACTCAAACCAATACTAAAAAATAAGTAAGAGTATAAAGAACAGGCATCTATTTTTTTGTTATAATAGAAAAAT GAAATTAAAGGGAGATGTCA
Downstream 100 bases:
>100_bases TTATAATTAGACAATTCAACATAAGAGAATATAAGAAGTCAGCAATGGCTTCCTTTTTTGTTTTTCTGCTCACTATTTAT TCAGAAAAATGGTATAATTG
Product: bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase
Products: NA
Alternate protein names: Methylenetetrahydrofolate dehydrogenase; Methenyltetrahydrofolate cyclohydrolase
Number of amino acids: Translated: 284; Mature: 283
Protein sequence:
>284_residues MTELIDGKALAQKMQQELAAKVNNLKQKKGIVPGLAVILVGDDPASQVYVRNKERAALTVGFKSETVRLSEFICQEELIA VIERYNADNTIHGILVQLPLPNHINDKKIILAIDPKKDVDGFHPMNTGHLWSGRPLMVPCTPSGIMELLREYNVNLEGKH AVIIGRSNIVGKPMAQLLLDKNATVTLTHSRTRQLEEVCRCADVLIVAIGQGHFITKQYIKDGAIVIDVGMNRDDNGKLI GDVAFDEVAEVAAKITPVPGGVGPMTIAMLLEQTYQSALRSTHK
Sequences:
>Translated_284_residues MTELIDGKALAQKMQQELAAKVNNLKQKKGIVPGLAVILVGDDPASQVYVRNKERAALTVGFKSETVRLSEFICQEELIA VIERYNADNTIHGILVQLPLPNHINDKKIILAIDPKKDVDGFHPMNTGHLWSGRPLMVPCTPSGIMELLREYNVNLEGKH AVIIGRSNIVGKPMAQLLLDKNATVTLTHSRTRQLEEVCRCADVLIVAIGQGHFITKQYIKDGAIVIDVGMNRDDNGKLI GDVAFDEVAEVAAKITPVPGGVGPMTIAMLLEQTYQSALRSTHK >Mature_283_residues TELIDGKALAQKMQQELAAKVNNLKQKKGIVPGLAVILVGDDPASQVYVRNKERAALTVGFKSETVRLSEFICQEELIAV IERYNADNTIHGILVQLPLPNHINDKKIILAIDPKKDVDGFHPMNTGHLWSGRPLMVPCTPSGIMELLREYNVNLEGKHA VIIGRSNIVGKPMAQLLLDKNATVTLTHSRTRQLEEVCRCADVLIVAIGQGHFITKQYIKDGAIVIDVGMNRDDNGKLIG DVAFDEVAEVAAKITPVPGGVGPMTIAMLLEQTYQSALRSTHK
Specific function: Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
COG id: COG0190
COG function: function code H; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family
Homologues:
Organism=Homo sapiens, GI222136639, Length=293, Percent_Identity=45.3924914675768, Blast_Score=241, Evalue=8e-64, Organism=Homo sapiens, GI94721354, Length=290, Percent_Identity=44.1379310344828, Blast_Score=216, Evalue=2e-56, Organism=Homo sapiens, GI222418558, Length=290, Percent_Identity=43.1034482758621, Blast_Score=214, Evalue=9e-56, Organism=Homo sapiens, GI36796743, Length=199, Percent_Identity=27.6381909547739, Blast_Score=70, Evalue=3e-12, Organism=Escherichia coli, GI1786741, Length=277, Percent_Identity=51.6245487364621, Blast_Score=280, Evalue=1e-76, Organism=Caenorhabditis elegans, GI17568735, Length=291, Percent_Identity=39.5189003436426, Blast_Score=195, Evalue=2e-50, Organism=Saccharomyces cerevisiae, GI6319558, Length=286, Percent_Identity=44.7552447552448, Blast_Score=238, Evalue=6e-64, Organism=Saccharomyces cerevisiae, GI6321643, Length=295, Percent_Identity=42.7118644067797, Blast_Score=237, Evalue=2e-63, Organism=Saccharomyces cerevisiae, GI6322933, Length=311, Percent_Identity=27.0096463022508, Blast_Score=89, Evalue=1e-18, Organism=Drosophila melanogaster, GI17136818, Length=295, Percent_Identity=44.7457627118644, Blast_Score=233, Evalue=1e-61, Organism=Drosophila melanogaster, GI17136816, Length=295, Percent_Identity=44.7457627118644, Blast_Score=232, Evalue=2e-61, Organism=Drosophila melanogaster, GI62472483, Length=288, Percent_Identity=44.4444444444444, Blast_Score=232, Evalue=2e-61, Organism=Drosophila melanogaster, GI45551871, Length=288, Percent_Identity=44.4444444444444, Blast_Score=232, Evalue=2e-61, Organism=Drosophila melanogaster, GI24645718, Length=288, Percent_Identity=44.4444444444444, Blast_Score=232, Evalue=2e-61, Organism=Drosophila melanogaster, GI17137370, Length=288, Percent_Identity=44.4444444444444, Blast_Score=232, Evalue=2e-61,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): FOLD_STRP1 (Q99YX2)
Other databases:
- EMBL: AE004092 - EMBL: CP000017 - RefSeq: NP_269579.1 - RefSeq: YP_282597.1 - HSSP: P11586 - ProteinModelPortal: Q99YX2 - SMR: Q99YX2 - EnsemblBacteria: EBSTRT00000000641 - EnsemblBacteria: EBSTRT00000028647 - GeneID: 3571663 - GeneID: 901550 - GenomeReviews: AE004092_GR - GenomeReviews: CP000017_GR - KEGG: spy:SPy_1502 - KEGG: spz:M5005_Spy_1234 - GeneTree: EBGT00050000028163 - HOGENOM: HBG328751 - OMA: CLMMLRD - ProtClustDB: PRK14179 - BioCyc: SPYO160490:SPY1502-MONOMER - BioCyc: SPYO293653:M5005_SPY1234-MONOMER - GO: GO:0005488 - HAMAP: MF_01576 - InterPro: IPR016040 - InterPro: IPR000672 - InterPro: IPR020630 - InterPro: IPR020867 - InterPro: IPR020631 - Gene3D: G3DSA:3.40.50.720 - PRINTS: PR00085
Pfam domain/function: PF00763 THF_DHG_CYH; PF02882 THF_DHG_CYH_C
EC number: =1.5.1.5; =3.5.4.9
Molecular weight: Translated: 31083; Mature: 30952
Theoretical pI: Translated: 7.61; Mature: 7.61
Prosite motif: PS00766 THF_DHG_CYH_1; PS00767 THF_DHG_CYH_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.4 %Cys (Translated Protein) 3.2 %Met (Translated Protein) 4.6 %Cys+Met (Translated Protein) 1.4 %Cys (Mature Protein) 2.8 %Met (Mature Protein) 4.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MTELIDGKALAQKMQQELAAKVNNLKQKKGIVPGLAVILVGDDPASQVYVRNKERAALTV CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEECCCCEEEEE GFKSETVRLSEFICQEELIAVIERYNADNTIHGILVQLPLPNHINDKKIILAIDPKKDVD ECCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCEEEEEECCCCCCC GFHPMNTGHLWSGRPLMVPCTPSGIMELLREYNVNLEGKHAVIIGRSNIVGKPMAQLLLD CCCCCCCCCEECCCEEEEECCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHC KNATVTLTHSRTRQLEEVCRCADVLIVAIGQGHFITKQYIKDGAIVIDVGMNRDDNGKLI CCCEEEEECHHHHHHHHHHHHHHEEEEEECCCCEEHHHHHCCCCEEEEECCCCCCCCCEE GDVAFDEVAEVAAKITPVPGGVGPMTIAMLLEQTYQSALRSTHK EHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC >Mature Secondary Structure TELIDGKALAQKMQQELAAKVNNLKQKKGIVPGLAVILVGDDPASQVYVRNKERAALTV CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEECCCCEEEEE GFKSETVRLSEFICQEELIAVIERYNADNTIHGILVQLPLPNHINDKKIILAIDPKKDVD ECCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCEEEEEECCCCCCC GFHPMNTGHLWSGRPLMVPCTPSGIMELLREYNVNLEGKHAVIIGRSNIVGKPMAQLLLD CCCCCCCCCEECCCEEEEECCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHC KNATVTLTHSRTRQLEEVCRCADVLIVAIGQGHFITKQYIKDGAIVIDVGMNRDDNGKLI CCCEEEEECHHHHHHHHHHHHHHEEEEEECCCCEEHHHHHCCCCEEEEECCCCCCCCCEE GDVAFDEVAEVAAKITPVPGGVGPMTIAMLLEQTYQSALRSTHK EHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 11296296