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The map label for this gene is xseA

Identifier: 15675404

GI number: 15675404

Start: 1230616

End: 1231956

Strand: Reverse

Name: xseA

Synonym: SPy_1500

Alternate gene names: 15675404

Gene position: 1231956-1230616 (Counterclockwise)

Preceding gene: 15675405

Following gene: 15675403

Centisome position: 66.5

GC content: 42.36

Gene sequence:

>1341_bases
ATGGCAGATTATTTAACCGTCACTCATTTGACGAAATATTTAAAATTAAAATTTGACCGTGACCCTTATTTGGAACGGGT
TTATCTGACTGGTCAAGTGTCCAATTTTCGAAAACGACCAACTCATCAATATTTTTCCTTAAAAGATGAAAGTGCTGTGA
TTCAAGCCACCATGTGGGCAGGAGTCTATAAAAAACTAGGATTCGACCTAGAAGAAGGCATGAAAATTAATGTAATTGGG
CGAGTCCAACTTTATGAACCTAGTGGCTCTTACTCTATCGTGATTGAAAAGGCAGAGCCAGATGGTATAGGTGCCTTGGC
TTTGCAGTTTGAACAATTAAAGAAAAAATTAACGGCAGAAGGTTATTTTGAGCAAAAACACAAGCAGCCCTTGCCACAGT
TTGTATCAAAAATTGGGGTCATTACAAGTCCTAGTGGTGCTGTGATTCGAGATATTATCACAACCGTTTCACGGCGTTTT
CCAGGGGTTGAGATTTTATTATTCCCAACTAAAGTACAAGGTGATGGAGCCGCCCAAGAAGTAGTGGCTAATATTCGAAG
AGCCAATCAAAGAGAGGATTTGGACTTGCTCATTGTCGGCCGTGGAGGTGGCTCGATAGAAGACCTTTGGGCCTTCAACG
AGGAAATAGTGGTTCAGGCTATCTTTGAATCGCAACTTCCAGTGATTTCGAGTGTGGGTCATGAAACAGACACGACTTTA
GCGGATTTTGTGGCAGATCGCAGAGCAGCCACACCAACAGCAGCAGCAGAGTTAGCAACGCCTATTACAAAAACAGATCT
TATGTCTTGGATAGTAGAGCGGCAAAATCGTTCCTATCAGGCCTGCTTGAGGCGGATTAAGCAACGGCAAGAGTGGGTGG
ATAAACTCTCGCAATCTGTTATTTTTAGGCAACCAGAACGATTATATGATGCCTACCTGCAAAAAATTGATCGCCTTAGC
ATGACCCTGATGAATACGATGAAAGATCGTCTGAGTTCCGCCAAAGAAAACAAGGTTCAGTTGGACCATGCCTTGGCCAA
TAGTCAATTACAGACAAAAATCGAGCGATACCAAGACCGTGTTGCTACCGCTAAGCGTTTACTGATGGCTAATATGGCTA
GTCAATATGATAGTCAGCTGGCTCGCTTTGAAAAAGCACAGGATGCTTTGCTATCACTGGATGCCAGCCGAATTATCGCC
CGTGGTTATGCAATGATTGAAAAAAATCAAGCACTGGTAGCCTCTGTAAGTCAGATAACAAAGGGTGATCAGTTAACCAT
TAAGATGCGTGATGGACAATTAGATGTAGAGGTAAAAGATGTCAAAAACGAAAACATTTGA

Upstream 100 bases:

>100_bases
CTTTTTTGTTTTTCTGCTCACTATTTATTCAGAAAAATGGTATAATTGCATTAGTATGCAAAGGGACTATGTCAGGTCCA
ACTAAGTGAAAGGTGGCTTG

Downstream 100 bases:

>100_bases
AGAAAATTTACAAGATTTAGAGACTATTGTGAACAAACTTGAAAATGGGGATGTCCCTTTGGAAGAAGCTATTTCAGAAT
TTCAAAAAGGAATGCTTCTC

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MADYLTVTHLTKYLKLKFDRDPYLERVYLTGQVSNFRKRPTHQYFSLKDESAVIQATMWAGVYKKLGFDLEEGMKINVIG
RVQLYEPSGSYSIVIEKAEPDGIGALALQFEQLKKKLTAEGYFEQKHKQPLPQFVSKIGVITSPSGAVIRDIITTVSRRF
PGVEILLFPTKVQGDGAAQEVVANIRRANQREDLDLLIVGRGGGSIEDLWAFNEEIVVQAIFESQLPVISSVGHETDTTL
ADFVADRRAATPTAAAELATPITKTDLMSWIVERQNRSYQACLRRIKQRQEWVDKLSQSVIFRQPERLYDAYLQKIDRLS
MTLMNTMKDRLSSAKENKVQLDHALANSQLQTKIERYQDRVATAKRLLMANMASQYDSQLARFEKAQDALLSLDASRIIA
RGYAMIEKNQALVASVSQITKGDQLTIKMRDGQLDVEVKDVKNENI

Sequences:

>Translated_446_residues
MADYLTVTHLTKYLKLKFDRDPYLERVYLTGQVSNFRKRPTHQYFSLKDESAVIQATMWAGVYKKLGFDLEEGMKINVIG
RVQLYEPSGSYSIVIEKAEPDGIGALALQFEQLKKKLTAEGYFEQKHKQPLPQFVSKIGVITSPSGAVIRDIITTVSRRF
PGVEILLFPTKVQGDGAAQEVVANIRRANQREDLDLLIVGRGGGSIEDLWAFNEEIVVQAIFESQLPVISSVGHETDTTL
ADFVADRRAATPTAAAELATPITKTDLMSWIVERQNRSYQACLRRIKQRQEWVDKLSQSVIFRQPERLYDAYLQKIDRLS
MTLMNTMKDRLSSAKENKVQLDHALANSQLQTKIERYQDRVATAKRLLMANMASQYDSQLARFEKAQDALLSLDASRIIA
RGYAMIEKNQALVASVSQITKGDQLTIKMRDGQLDVEVKDVKNENI
>Mature_445_residues
ADYLTVTHLTKYLKLKFDRDPYLERVYLTGQVSNFRKRPTHQYFSLKDESAVIQATMWAGVYKKLGFDLEEGMKINVIGR
VQLYEPSGSYSIVIEKAEPDGIGALALQFEQLKKKLTAEGYFEQKHKQPLPQFVSKIGVITSPSGAVIRDIITTVSRRFP
GVEILLFPTKVQGDGAAQEVVANIRRANQREDLDLLIVGRGGGSIEDLWAFNEEIVVQAIFESQLPVISSVGHETDTTLA
DFVADRRAATPTAAAELATPITKTDLMSWIVERQNRSYQACLRRIKQRQEWVDKLSQSVIFRQPERLYDAYLQKIDRLSM
TLMNTMKDRLSSAKENKVQLDHALANSQLQTKIERYQDRVATAKRLLMANMASQYDSQLARFEKAQDALLSLDASRIIAR
GYAMIEKNQALVASVSQITKGDQLTIKMRDGQLDVEVKDVKNENI

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family

Homologues:

Organism=Escherichia coli, GI1788856, Length=455, Percent_Identity=35.3846153846154, Blast_Score=280, Evalue=2e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EX7L_STRP1 (P67452)

Other databases:

- EMBL:   AE004092
- EMBL:   CP000017
- RefSeq:   NP_269578.1
- RefSeq:   YP_282596.1
- ProteinModelPortal:   P67452
- EnsemblBacteria:   EBSTRT00000000261
- EnsemblBacteria:   EBSTRT00000028937
- GeneID:   3571662
- GeneID:   901549
- GenomeReviews:   AE004092_GR
- GenomeReviews:   CP000017_GR
- KEGG:   spy:SPy_1500
- KEGG:   spz:M5005_Spy_1233
- GeneTree:   EBGT00050000027533
- HOGENOM:   HBG634411
- OMA:   PWPVRTV
- ProtClustDB:   PRK00286
- BioCyc:   SPYO160490:SPY1500-MONOMER
- BioCyc:   SPYO293653:M5005_SPY1233-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00378
- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365
- TIGRFAMs:   TIGR00237

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti

EC number: =3.1.11.6

Molecular weight: Translated: 50457; Mature: 50325

Theoretical pI: Translated: 9.34; Mature: 9.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADYLTVTHLTKYLKLKFDRDPYLERVYLTGQVSNFRKRPTHQYFSLKDESAVIQATMWA
CCCHHHHHHHHHHHHEECCCCCCCEEEEEECCHHHHHCCCCCHHCCCCCCCHHHHHHHHH
GVYKKLGFDLEEGMKINVIGRVQLYEPSGSYSIVIEKAEPDGIGALALQFEQLKKKLTAE
HHHHHHCCCHHCCCEEEEEEEEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHC
GYFEQKHKQPLPQFVSKIGVITSPSGAVIRDIITTVSRRFPGVEILLFPTKVQGDGAAQE
HHHHHHHCCCHHHHHHHCCCEECCCCHHHHHHHHHHHHHCCCEEEEEEECEECCCCHHHH
VVANIRRANQREDLDLLIVGRGGGSIEDLWAFNEEIVVQAIFESQLPVISSVGHETDTTL
HHHHHHHCCCCCCCEEEEEECCCCCHHHHHHCCHHHHHHHHHHCCCCHHHHCCCCCCHHH
ADFVADRRAATPTAAAELATPITKTDLMSWIVERQNRSYQACLRRIKQRQEWVDKLSQSV
HHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
IFRQPERLYDAYLQKIDRLSMTLMNTMKDRLSSAKENKVQLDHALANSQLQTKIERYQDR
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VATAKRLLMANMASQYDSQLARFEKAQDALLSLDASRIIARGYAMIEKNQALVASVSQIT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
KGDQLTIKMRDGQLDVEVKDVKNENI
CCCEEEEEEECCEEEEEEECCCCCCC
>Mature Secondary Structure 
ADYLTVTHLTKYLKLKFDRDPYLERVYLTGQVSNFRKRPTHQYFSLKDESAVIQATMWA
CCHHHHHHHHHHHHEECCCCCCCEEEEEECCHHHHHCCCCCHHCCCCCCCHHHHHHHHH
GVYKKLGFDLEEGMKINVIGRVQLYEPSGSYSIVIEKAEPDGIGALALQFEQLKKKLTAE
HHHHHHCCCHHCCCEEEEEEEEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHC
GYFEQKHKQPLPQFVSKIGVITSPSGAVIRDIITTVSRRFPGVEILLFPTKVQGDGAAQE
HHHHHHHCCCHHHHHHHCCCEECCCCHHHHHHHHHHHHHCCCEEEEEEECEECCCCHHHH
VVANIRRANQREDLDLLIVGRGGGSIEDLWAFNEEIVVQAIFESQLPVISSVGHETDTTL
HHHHHHHCCCCCCCEEEEEECCCCCHHHHHHCCHHHHHHHHHHCCCCHHHHCCCCCCHHH
ADFVADRRAATPTAAAELATPITKTDLMSWIVERQNRSYQACLRRIKQRQEWVDKLSQSV
HHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
IFRQPERLYDAYLQKIDRLSMTLMNTMKDRLSSAKENKVQLDHALANSQLQTKIERYQDR
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VATAKRLLMANMASQYDSQLARFEKAQDALLSLDASRIIARGYAMIEKNQALVASVSQIT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
KGDQLTIKMRDGQLDVEVKDVKNENI
CCCEEEEEEECCEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11296296