Definition Streptococcus pyogenes M1 GAS chromosome, complete genome.
Accession NC_002737
Length 1,852,441

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The map label for this gene is gpmA

Identifier: 15675343

GI number: 15675343

Start: 1184752

End: 1185447

Strand: Reverse

Name: gpmA

Synonym: SPy_1429

Alternate gene names: 15675343

Gene position: 1185447-1184752 (Counterclockwise)

Preceding gene: 15675345

Following gene: 15675342

Centisome position: 63.99

GC content: 41.81

Gene sequence:

>696_bases
ATGGTAAAATTGGTTTTCGCTCGCCACGGTGAGTCAGAATGGAACAAAGCTAACCTCTTCACTGGTTGGGCAGATGTTGA
TCTTTCAGAAAAAGGGACACAACAAGCGATTGATGCAGGTAAATTGATCAAAGAAGCAGGTATTGAATTTGACCTTGCTT
TCACTTCAGTATTGACACGTGCTATCAAAACAACTAACCTTGCCCTTGAAAATGCAGGTCAATTGTGGGTTCCAACTGAA
AAATCATGGCGCTTGAACGAGCGTCACTATGGTGCTTTGACTGGCAAAAACAAAGCTGAAGCTGCAGAACAATTTTGTGA
TGAACAAGTTCATATCTGGCGTCGTTCATACGACGTGTTGCCGCCAGCTATGGCTAAAGATGATGAGTATTCAGCACACA
AAGACCGTCGTTATGCTGATCTTGACCCAGCCCTTATTCCAGATGCTGAAAACTTAAAAGTCACTCTTGAACGCGCAATG
CCTTACTGGGAAGAAAAAATTGCTCCAGCTCTTCTTGACGGTAAAAACGTCTTTGTTGGCGCACATGGTAACTCAATCCG
CGCTCTTGTGAAACACATTAAAGGTCTTTCAGATGACGAAATCATGGATGTGGAAATTCCAAACTTCCCACCACTTGTTT
TTGAATTAGATGAAAAACTTAACATTGTTAAAGAATACTACCTTGGTGGTGAATAA

Upstream 100 bases:

>100_bases
TTCAATAAAGTCAGAATAGACTAGCTTTTTTGCTATATTTTTTGTAAAATAGGAATTGTAAAAAGGTAGCAACCTTTAAA
TTAAAAGGAGATATTAACTC

Downstream 100 bases:

>100_bases
CTTAAAAACCAGACTTTGGTCTGGTTTTTTGGTTCTATATCCTAAGAAGAAAGAAAACCCTGCTTAAAAATATGATATGA
TAGAAATAAAAAAGGATAGA

Product: phosphoglyceromutase

Products: NA

Alternate protein names: BPG-dependent PGAM; PGAM; Phosphoglyceromutase; dPGM

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MVKLVFARHGESEWNKANLFTGWADVDLSEKGTQQAIDAGKLIKEAGIEFDLAFTSVLTRAIKTTNLALENAGQLWVPTE
KSWRLNERHYGALTGKNKAEAAEQFCDEQVHIWRRSYDVLPPAMAKDDEYSAHKDRRYADLDPALIPDAENLKVTLERAM
PYWEEKIAPALLDGKNVFVGAHGNSIRALVKHIKGLSDDEIMDVEIPNFPPLVFELDEKLNIVKEYYLGGE

Sequences:

>Translated_231_residues
MVKLVFARHGESEWNKANLFTGWADVDLSEKGTQQAIDAGKLIKEAGIEFDLAFTSVLTRAIKTTNLALENAGQLWVPTE
KSWRLNERHYGALTGKNKAEAAEQFCDEQVHIWRRSYDVLPPAMAKDDEYSAHKDRRYADLDPALIPDAENLKVTLERAM
PYWEEKIAPALLDGKNVFVGAHGNSIRALVKHIKGLSDDEIMDVEIPNFPPLVFELDEKLNIVKEYYLGGE
>Mature_231_residues
MVKLVFARHGESEWNKANLFTGWADVDLSEKGTQQAIDAGKLIKEAGIEFDLAFTSVLTRAIKTTNLALENAGQLWVPTE
KSWRLNERHYGALTGKNKAEAAEQFCDEQVHIWRRSYDVLPPAMAKDDEYSAHKDRRYADLDPALIPDAENLKVTLERAM
PYWEEKIAPALLDGKNVFVGAHGNSIRALVKHIKGLSDDEIMDVEIPNFPPLVFELDEKLNIVKEYYLGGE

Specific function: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate

COG id: COG0588

COG function: function code G; Phosphoglycerate mutase 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily

Homologues:

Organism=Homo sapiens, GI50593010, Length=232, Percent_Identity=50.4310344827586, Blast_Score=246, Evalue=9e-66,
Organism=Homo sapiens, GI4502445, Length=233, Percent_Identity=48.4978540772532, Blast_Score=233, Evalue=1e-61,
Organism=Homo sapiens, GI40353764, Length=233, Percent_Identity=48.4978540772532, Blast_Score=233, Evalue=1e-61,
Organism=Homo sapiens, GI4505753, Length=232, Percent_Identity=50.4310344827586, Blast_Score=233, Evalue=1e-61,
Organism=Homo sapiens, GI71274132, Length=232, Percent_Identity=47.8448275862069, Blast_Score=219, Evalue=2e-57,
Organism=Homo sapiens, GI310129614, Length=161, Percent_Identity=52.7950310559006, Blast_Score=162, Evalue=2e-40,
Organism=Escherichia coli, GI1786970, Length=229, Percent_Identity=54.585152838428, Blast_Score=260, Evalue=5e-71,
Organism=Saccharomyces cerevisiae, GI6322697, Length=232, Percent_Identity=52.1551724137931, Blast_Score=253, Evalue=2e-68,
Organism=Saccharomyces cerevisiae, GI6324516, Length=279, Percent_Identity=31.5412186379928, Blast_Score=126, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6320183, Length=285, Percent_Identity=28.4210526315789, Blast_Score=123, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6324857, Length=195, Percent_Identity=27.1794871794872, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24646216, Length=221, Percent_Identity=54.2986425339367, Blast_Score=248, Evalue=2e-66,
Organism=Drosophila melanogaster, GI85725270, Length=233, Percent_Identity=50.2145922746781, Blast_Score=229, Evalue=1e-60,
Organism=Drosophila melanogaster, GI85725272, Length=233, Percent_Identity=50.2145922746781, Blast_Score=229, Evalue=1e-60,
Organism=Drosophila melanogaster, GI24650981, Length=233, Percent_Identity=50.2145922746781, Blast_Score=229, Evalue=1e-60,
Organism=Drosophila melanogaster, GI28571817, Length=220, Percent_Identity=39.5454545454545, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI28571815, Length=220, Percent_Identity=39.5454545454545, Blast_Score=168, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24648979, Length=220, Percent_Identity=39.5454545454545, Blast_Score=168, Evalue=2e-42,

Paralogues:

None

Copy number: 960 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): GPMA_STRP1 (Q99Z29)

Other databases:

- EMBL:   AE004092
- EMBL:   CP000017
- RefSeq:   NP_269517.1
- RefSeq:   YP_282527.1
- ProteinModelPortal:   Q99Z29
- SMR:   Q99Z29
- EnsemblBacteria:   EBSTRT00000001271
- EnsemblBacteria:   EBSTRT00000028288
- GeneID:   3571749
- GeneID:   901487
- GenomeReviews:   AE004092_GR
- GenomeReviews:   CP000017_GR
- KEGG:   spy:SPy_1429
- KEGG:   spz:M5005_Spy_1164
- GeneTree:   EBGT00050000027479
- HOGENOM:   HBG658938
- OMA:   TGWKDPD
- ProtClustDB:   PRK14117
- BioCyc:   SPYO160490:SPY1429-MONOMER
- BioCyc:   SPYO293653:M5005_SPY1164-MONOMER
- GO:   GO:0006096
- HAMAP:   MF_01039
- InterPro:   IPR013078
- InterPro:   IPR005952
- PANTHER:   PTHR11931
- SMART:   SM00855
- TIGRFAMs:   TIGR01258

Pfam domain/function: PF00300 PGAM

EC number: =5.4.2.1

Molecular weight: Translated: 26083; Mature: 26083

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00175 PG_MUTASE

Important sites: ACT_SITE 9-9 ACT_SITE 182-182

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKLVFARHGESEWNKANLFTGWADVDLSEKGTQQAIDAGKLIKEAGIEFDLAFTSVLTR
CEEEEEECCCCCCCCCCCEEECEECCCCCCCCHHHHHHHHHHHHHHCCEEEHHHHHHHHH
AIKTTNLALENAGQLWVPTEKSWRLNERHYGALTGKNKAEAAEQFCDEQVHIWRRSYDVL
HHHHHHHHECCCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
PPAMAKDDEYSAHKDRRYADLDPALIPDAENLKVTLERAMPYWEEKIAPALLDGKNVFVG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHCCHHHHHHCHHEECCCEEEEE
AHGNSIRALVKHIKGLSDDEIMDVEIPNFPPLVFELDEKLNIVKEYYLGGE
CCCCHHHHHHHHHCCCCCCCEEEEECCCCCCCEEEHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVKLVFARHGESEWNKANLFTGWADVDLSEKGTQQAIDAGKLIKEAGIEFDLAFTSVLTR
CEEEEEECCCCCCCCCCCEEECEECCCCCCCCHHHHHHHHHHHHHHCCEEEHHHHHHHHH
AIKTTNLALENAGQLWVPTEKSWRLNERHYGALTGKNKAEAAEQFCDEQVHIWRRSYDVL
HHHHHHHHECCCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
PPAMAKDDEYSAHKDRRYADLDPALIPDAENLKVTLERAMPYWEEKIAPALLDGKNVFVG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHCCHHHHHHCHHEECCCEEEEE
AHGNSIRALVKHIKGLSDDEIMDVEIPNFPPLVFELDEKLNIVKEYYLGGE
CCCCHHHHHHHHHCCCCCCCEEEEECCCCCCCEEEHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296