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The map label for this gene is srtK [H]

Identifier: 15675070

GI number: 15675070

Start: 887205

End: 888551

Strand: Direct

Name: srtK [H]

Synonym: SPy_1082

Alternate gene names: 15675070

Gene position: 887205-888551 (Clockwise)

Preceding gene: 15675069

Following gene: 15675071

Centisome position: 47.89

GC content: 29.1

Gene sequence:

>1347_bases
ATGTTTAAAAAATATTCAATAAAAAATCGTGTTTGGCGCGCCGTCGTTGAAATTGTCTTTGGAGTTTGTATCACTGTTTT
AATGATTGCGATAATATCGCTTTCTTTTTCAAAGTTAAATATAGTGACATCTCATAATGTGGGAGAAGAATTTTATATTA
AAGATAAACAGTCAATCAAACAGTTGAACAATTATATGAAGACATTGGGATTAGATTATGTTGTTTTTGATAGAAAAACA
GATAAAGCTATGGAAGGAAAATATTTATCTAAAGAATTTTCTTTATTTAACGAAGTTGCAGAAGAAAAAAATAATCTGAC
TTTTAATTCTGTACATTATGATTTATATACTAATATCAATTATAATATTGTTATAAGATATAATGAGATACCGGAGTTCT
CTAACCATTACCTTAGAAATGTTTCATATAACATGTTGACATTTTATATTCTGGGAATAGGAACGAGTATCAGCATTGTA
GTTGCTTTAACACGGTTTGTAAAAGAAATTTCTTTGAATTTCAAGGAAATCAAGAAGTTAGCAAATAAAATGGGGATAGA
AGTCCTTTCTGAAAATGAAAATTATTCTCAAATAATCGAGTTTGATGATATACTTAGAACTTTACATATTAAAGGTGATA
ATTTGAAAAGTTTGATTGAGCGAGAAATATTGGAAAAGCAAGATCTATCCTTTCAAATTGCAGCACTTTCGCATGATATT
AAAACACCTTTAACGGTTTTAAAAGGAAATCTTGAGTTATTAGAATTGACTACTTTAAATAAAAATCAGGAAGGTTATAT
TGTATCTATGAACAATAGTATTTCTGTTTTTGAAGGCTATTTCAATTCTTTAATATCTTATACACGCATGCTTTCAGAGG
ATAGATCAGTGAAACTAATTTTAGTTGAGGAGCTATTAAGTGAGTTACATTTTGAAGTCGATGACTTATTGAATATCAAT
AATATTGAATTTTCTATTTGTAATAGACTTATTATCACTTCTTTTTATGGAGATGAGGAAAATCTGATAAGAGCTCTTTC
TAACCTTTTAGTTAATGCAATAAGATTTATGCCCGTATTAGATAAAAAAATCGAAGTTATACTGTCTGAGTCAGGAGAGC
AAATTCATTTTGAAATATGGAATAATGGTGAGCGTTTCAGTGATAGTACACTGAAAAAGGGAGATAAATTATTTTACACG
GAAGATTATAGCAGAGGTAACAAACATTATGGAATCGGTTTGGCATTTGTTAAAGGCGTTGCTATCAAACACGGTGGGAA
TCTTCAATTGAATAATCCAGCTAGAGGAGGTGCTAGCGCCATAATCTCGATAAAAAAGAAAATTTAA

Upstream 100 bases:

>100_bases
TTTCATTCTATTTCAGAATATATCTATCAGATTAGAATGAAATTTTCAAGTTTTGGAATTAATCCAATAAAAACTATTCG
CGGGATTGGTTATAAATGGG

Downstream 100 bases:

>100_bases
TAGATTTGATTGAAACTGGAGTATTTCAGGCAAAAAATCGTAAATTTTTGGCTAAAATACTTTTTTTCTGAACAAATTCT
GAACTTGGGGTGTCATAATA

Product: putative histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MFKKYSIKNRVWRAVVEIVFGVCITVLMIAIISLSFSKLNIVTSHNVGEEFYIKDKQSIKQLNNYMKTLGLDYVVFDRKT
DKAMEGKYLSKEFSLFNEVAEEKNNLTFNSVHYDLYTNINYNIVIRYNEIPEFSNHYLRNVSYNMLTFYILGIGTSISIV
VALTRFVKEISLNFKEIKKLANKMGIEVLSENENYSQIIEFDDILRTLHIKGDNLKSLIEREILEKQDLSFQIAALSHDI
KTPLTVLKGNLELLELTTLNKNQEGYIVSMNNSISVFEGYFNSLISYTRMLSEDRSVKLILVEELLSELHFEVDDLLNIN
NIEFSICNRLIITSFYGDEENLIRALSNLLVNAIRFMPVLDKKIEVILSESGEQIHFEIWNNGERFSDSTLKKGDKLFYT
EDYSRGNKHYGIGLAFVKGVAIKHGGNLQLNNPARGGASAIISIKKKI

Sequences:

>Translated_448_residues
MFKKYSIKNRVWRAVVEIVFGVCITVLMIAIISLSFSKLNIVTSHNVGEEFYIKDKQSIKQLNNYMKTLGLDYVVFDRKT
DKAMEGKYLSKEFSLFNEVAEEKNNLTFNSVHYDLYTNINYNIVIRYNEIPEFSNHYLRNVSYNMLTFYILGIGTSISIV
VALTRFVKEISLNFKEIKKLANKMGIEVLSENENYSQIIEFDDILRTLHIKGDNLKSLIEREILEKQDLSFQIAALSHDI
KTPLTVLKGNLELLELTTLNKNQEGYIVSMNNSISVFEGYFNSLISYTRMLSEDRSVKLILVEELLSELHFEVDDLLNIN
NIEFSICNRLIITSFYGDEENLIRALSNLLVNAIRFMPVLDKKIEVILSESGEQIHFEIWNNGERFSDSTLKKGDKLFYT
EDYSRGNKHYGIGLAFVKGVAIKHGGNLQLNNPARGGASAIISIKKKI
>Mature_448_residues
MFKKYSIKNRVWRAVVEIVFGVCITVLMIAIISLSFSKLNIVTSHNVGEEFYIKDKQSIKQLNNYMKTLGLDYVVFDRKT
DKAMEGKYLSKEFSLFNEVAEEKNNLTFNSVHYDLYTNINYNIVIRYNEIPEFSNHYLRNVSYNMLTFYILGIGTSISIV
VALTRFVKEISLNFKEIKKLANKMGIEVLSENENYSQIIEFDDILRTLHIKGDNLKSLIEREILEKQDLSFQIAALSHDI
KTPLTVLKGNLELLELTTLNKNQEGYIVSMNNSISVFEGYFNSLISYTRMLSEDRSVKLILVEELLSELHFEVDDLLNIN
NIEFSICNRLIITSFYGDEENLIRALSNLLVNAIRFMPVLDKKIEVILSESGEQIHFEIWNNGERFSDSTLKKGDKLFYT
EDYSRGNKHYGIGLAFVKGVAIKHGGNLQLNNPARGGASAIISIKKKI

Specific function: Member of the two-component regulatory system nisK/nisR involved in the regulation of the biosynthesis of lantibiotic nisin. NisK may function as a membrane-associated protein kinase that phosphorylates nisR in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786912, Length=227, Percent_Identity=27.7533039647577, Blast_Score=66, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR008358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51472; Mature: 51472

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKKYSIKNRVWRAVVEIVFGVCITVLMIAIISLSFSKLNIVTSHNVGEEFYIKDKQSIK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEEECCCCCEEEECCHHHHH
QLNNYMKTLGLDYVVFDRKTDKAMEGKYLSKEFSLFNEVAEEKNNLTFNSVHYDLYTNIN
HHHHHHHHHCCCEEEEECCCCCHHCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEEEECCC
YNIVIRYNEIPEFSNHYLRNVSYNMLTFYILGIGTSISIVVALTRFVKEISLNFKEIKKL
EEEEEEECCCCCHHHHHHHCCCHHHHHHEEHHCCCHHHHHHHHHHHHHHHCCCHHHHHHH
ANKMGIEVLSENENYSQIIEFDDILRTLHIKGDNLKSLIEREILEKQDLSFQIAALSHDI
HHHCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEHHCCC
KTPLTVLKGNLELLELTTLNKNQEGYIVSMNNSISVFEGYFNSLISYTRMLSEDRSVKLI
CCCHHHHCCCCEEEEEEECCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEEE
LVEELLSELHFEVDDLLNINNIEFSICNRLIITSFYGDEENLIRALSNLLVNAIRFMPVL
EHHHHHHHHCCCHHHHCCCCCCHHHHHHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
DKKIEVILSESGEQIHFEIWNNGERFSDSTLKKGDKLFYTEDYSRGNKHYGIGLAFVKGV
HHHHHHHCCCCCCEEEEEEECCCCCCCCHHHCCCCEEEEECCCCCCCCCEEEHHHHHHCE
AIKHGGNLQLNNPARGGASAIISIKKKI
EEECCCCEEECCCCCCCCCEEEEEECCC
>Mature Secondary Structure
MFKKYSIKNRVWRAVVEIVFGVCITVLMIAIISLSFSKLNIVTSHNVGEEFYIKDKQSIK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEEECCCCCEEEECCHHHHH
QLNNYMKTLGLDYVVFDRKTDKAMEGKYLSKEFSLFNEVAEEKNNLTFNSVHYDLYTNIN
HHHHHHHHHCCCEEEEECCCCCHHCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEEEECCC
YNIVIRYNEIPEFSNHYLRNVSYNMLTFYILGIGTSISIVVALTRFVKEISLNFKEIKKL
EEEEEEECCCCCHHHHHHHCCCHHHHHHEEHHCCCHHHHHHHHHHHHHHHCCCHHHHHHH
ANKMGIEVLSENENYSQIIEFDDILRTLHIKGDNLKSLIEREILEKQDLSFQIAALSHDI
HHHCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEHHCCC
KTPLTVLKGNLELLELTTLNKNQEGYIVSMNNSISVFEGYFNSLISYTRMLSEDRSVKLI
CCCHHHHCCCCEEEEEEECCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEEE
LVEELLSELHFEVDDLLNINNIEFSICNRLIITSFYGDEENLIRALSNLLVNAIRFMPVL
EHHHHHHHHCCCHHHHCCCCCCHHHHHHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
DKKIEVILSESGEQIHFEIWNNGERFSDSTLKKGDKLFYTEDYSRGNKHYGIGLAFVKGV
HHHHHHHCCCCCCEEEEEEECCCCCCCCHHHCCCCEEEEECCCCCCCCCEEEHHHHHHCE
AIKHGGNLQLNNPARGGASAIISIKKKI
EEECCCCEEECCCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8161176 [H]