Definition Streptococcus pyogenes M1 GAS chromosome, complete genome.
Accession NC_002737
Length 1,852,441

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The map label for this gene is acoC [H]

Identifier: 15675027

GI number: 15675027

Start: 836775

End: 838184

Strand: Direct

Name: acoC [H]

Synonym: SPy_1029

Alternate gene names: 15675027

Gene position: 836775-838184 (Clockwise)

Preceding gene: 15675026

Following gene: 15675028

Centisome position: 45.17

GC content: 42.62

Gene sequence:

>1410_bases
ATGGCATTTGAAATTATTATGCCAAAGCTGGGCGTTGACATGCAAGAAGGCGAGATCATCGAGTGGAAAAAACAAGAAGG
TGATACCGTCAATGAAGGTGATATCCTTCTTGAAATCATGTCAGACAAAACCAATATGGAACTTGAGGCAGAAGACTCAG
GTGTTCTTCTTAAAATTACACGTCAAGCAGGTGATACTGTACCTGTAACTGAAGTTATCGGTTACATTGGTGCAGAGGGT
GAATCAGTAGATACTATTGCTTCAAGTGAAAAAACAACAGAAATTCCAGTTCCTGCTTCAGCAGACGCTGGACCAGCAGT
TGCTCCAAAAGAAAATGTGGCAAGTCCAGCTCCTCAAGTGGCAGCGACAGCTATTCCGCAAGGAAATGGCGGAAAAGTTC
GTGCTACTCCAGCTGCACGTAAGGCAGCAGCAGAAATGGGCATTGACCTTGGCCAAGTTCCAGGAACAGGACCAAAAGGA
CGTGTCCATAAAGAAGACGTTGAAAACTTTAAAGGTGCTCAACCGAAAGCTTCACCACTTGCTCGTAAAATTGCAGCAGA
CAAAGGTATTGATTTGGCAACCGTATCAGGTACTGGCTTTAACGGTAAGGTCATGAAAGAAGACATCATGGCTATTCTTG
AAGCGGCTAAACCAGCTGAAGCAAAAGCCCCAGCAGCTAAAGAAGAAAAAGTTGTTGATCTTCCAGAAGGTGTGGAACAC
AAGCCAATGTCAGCTATGCGTAAGGCAATCTCTAAAGGTATGACAAACTCTTACCTTACTGCCCCTACCTTTACGCTTAA
CTACGATATTGACATGACAGAGATGATTGCCCTTCGTAAGAAGTTAATTGACCCAATCATGGCTAAAACAGGCCTTAAAG
TCAGCTTTACAGACTTGATTGGTATGGCAGTGGTTAAAACCTTGATGAAACCTGAGCATGAGTACATGAATGCTTCCCTC
ATCAATGATGCTAATGATATTGAATTGCACCGCTTTGTGAACCTTGGTATTGCCGTAGGTCTTGATGATGGTCTTATCGT
TCCTGTTATCCATGGGGCTAACAAGATGTGCTTGTCAGATTTCGTGCTTGCTTCAAAAGATGTGATTAAAAAAGCGCAAA
CTGGTAAGTTGAAAGCAGCTGAAATGTCTGGATCAACCTTCTCTATCACAAACTTGGGAATGTTTGGTACGAAGACATTT
AACCCAATTATTAACCAACCAAACTCAGCAATTCTTGGTGTTGGAGCAACTATCCCAACTCCAACGGTTGTGGATGGTGA
GATTGTTTCCCGTCCAATTATGGCAATGTGCCTAACCATCGACCACCGTTTAGTTGATGGTATGAACGGTGCAAAATTCA
TGGTTGATCTCAAGAAATTGATGGAAAATCCATTTGAATTGTTAATCTGA

Upstream 100 bases:

>100_bases
GAGTTGTCTTATCCCGTGTCGCGGCACCTCACCTTTCGTATGTTTTCGTAGCAAGGTGAGGATGTTGATGGCGCTTATCA
AATCGTGAAAGGATGTAGAA

Downstream 100 bases:

>100_bases
TCAATCAGTTTTAAACAAGAAAAGCATTCAATAATAAAAGGGATTTTGCTAAGTTTAGACTTGGTGCCCTTTTCTCAAAA
ATATAGAAAGGATGTAGAAC

Product: branched-chain alpha-keto acid dehydrogenase subunit E2

Products: NA

Alternate protein names: Acetoin dehydrogenase E2 component; Dihydrolipoamide acetyltransferase component of acetoin cleaving system [H]

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MAFEIIMPKLGVDMQEGEIIEWKKQEGDTVNEGDILLEIMSDKTNMELEAEDSGVLLKITRQAGDTVPVTEVIGYIGAEG
ESVDTIASSEKTTEIPVPASADAGPAVAPKENVASPAPQVAATAIPQGNGGKVRATPAARKAAAEMGIDLGQVPGTGPKG
RVHKEDVENFKGAQPKASPLARKIAADKGIDLATVSGTGFNGKVMKEDIMAILEAAKPAEAKAPAAKEEKVVDLPEGVEH
KPMSAMRKAISKGMTNSYLTAPTFTLNYDIDMTEMIALRKKLIDPIMAKTGLKVSFTDLIGMAVVKTLMKPEHEYMNASL
INDANDIELHRFVNLGIAVGLDDGLIVPVIHGANKMCLSDFVLASKDVIKKAQTGKLKAAEMSGSTFSITNLGMFGTKTF
NPIINQPNSAILGVGATIPTPTVVDGEIVSRPIMAMCLTIDHRLVDGMNGAKFMVDLKKLMENPFELLI

Sequences:

>Translated_469_residues
MAFEIIMPKLGVDMQEGEIIEWKKQEGDTVNEGDILLEIMSDKTNMELEAEDSGVLLKITRQAGDTVPVTEVIGYIGAEG
ESVDTIASSEKTTEIPVPASADAGPAVAPKENVASPAPQVAATAIPQGNGGKVRATPAARKAAAEMGIDLGQVPGTGPKG
RVHKEDVENFKGAQPKASPLARKIAADKGIDLATVSGTGFNGKVMKEDIMAILEAAKPAEAKAPAAKEEKVVDLPEGVEH
KPMSAMRKAISKGMTNSYLTAPTFTLNYDIDMTEMIALRKKLIDPIMAKTGLKVSFTDLIGMAVVKTLMKPEHEYMNASL
INDANDIELHRFVNLGIAVGLDDGLIVPVIHGANKMCLSDFVLASKDVIKKAQTGKLKAAEMSGSTFSITNLGMFGTKTF
NPIINQPNSAILGVGATIPTPTVVDGEIVSRPIMAMCLTIDHRLVDGMNGAKFMVDLKKLMENPFELLI
>Mature_468_residues
AFEIIMPKLGVDMQEGEIIEWKKQEGDTVNEGDILLEIMSDKTNMELEAEDSGVLLKITRQAGDTVPVTEVIGYIGAEGE
SVDTIASSEKTTEIPVPASADAGPAVAPKENVASPAPQVAATAIPQGNGGKVRATPAARKAAAEMGIDLGQVPGTGPKGR
VHKEDVENFKGAQPKASPLARKIAADKGIDLATVSGTGFNGKVMKEDIMAILEAAKPAEAKAPAAKEEKVVDLPEGVEHK
PMSAMRKAISKGMTNSYLTAPTFTLNYDIDMTEMIALRKKLIDPIMAKTGLKVSFTDLIGMAVVKTLMKPEHEYMNASLI
NDANDIELHRFVNLGIAVGLDDGLIVPVIHGANKMCLSDFVLASKDVIKKAQTGKLKAAEMSGSTFSITNLGMFGTKTFN
PIINQPNSAILGVGATIPTPTVVDGEIVSRPIMAMCLTIDHRLVDGMNGAKFMVDLKKLMENPFELLI

Specific function: The 2-Oxoglutarate Dehydrogenase Complex Catalyzes The Overall Conversion Of 2-Oxoglutarate To Succinyl-CoA And Co(2). It Contains Multiple Copies Of Three Enzymatic Components: 2- Oxoglutarate Dehydrogenase (E1), Dihydrolipoamide Succinyltransferase (E2)

COG id: COG0508

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 lipoyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI31711992, Length=477, Percent_Identity=30.188679245283, Blast_Score=176, Evalue=5e-44,
Organism=Homo sapiens, GI203098753, Length=479, Percent_Identity=28.8100208768267, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI203098816, Length=479, Percent_Identity=28.8100208768267, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI110671329, Length=468, Percent_Identity=26.7094017094017, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI19923748, Length=232, Percent_Identity=31.0344827586207, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI260898739, Length=141, Percent_Identity=34.0425531914894, Blast_Score=89, Evalue=7e-18,
Organism=Escherichia coli, GI1786946, Length=472, Percent_Identity=26.6949152542373, Blast_Score=167, Evalue=2e-42,
Organism=Escherichia coli, GI1786305, Length=293, Percent_Identity=33.4470989761092, Blast_Score=153, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17560088, Length=477, Percent_Identity=29.979035639413, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI25146366, Length=459, Percent_Identity=28.5403050108932, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17537937, Length=460, Percent_Identity=25, Blast_Score=122, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17538894, Length=324, Percent_Identity=28.0864197530864, Blast_Score=103, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6320352, Length=466, Percent_Identity=28.5407725321888, Blast_Score=153, Evalue=7e-38,
Organism=Saccharomyces cerevisiae, GI6324258, Length=176, Percent_Identity=33.5227272727273, Blast_Score=85, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6321632, Length=337, Percent_Identity=25.2225519287834, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI18859875, Length=465, Percent_Identity=26.0215053763441, Blast_Score=131, Evalue=9e-31,
Organism=Drosophila melanogaster, GI24645909, Length=246, Percent_Identity=31.7073170731707, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24582497, Length=298, Percent_Identity=28.5234899328859, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI20129315, Length=298, Percent_Identity=28.5234899328859, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3096 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001078
- InterPro:   IPR000089
- InterPro:   IPR023213
- InterPro:   IPR004167
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00198 2-oxoacid_dh; PF00364 Biotin_lipoyl; PF02817 E3_binding [H]

EC number: =2.3.1.12 [H]

Molecular weight: Translated: 49802; Mature: 49671

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS50968 BIOTINYL_LIPOYL ; PS00189 LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFEIIMPKLGVDMQEGEIIEWKKQEGDTVNEGDILLEIMSDKTNMELEAEDSGVLLKIT
CCEEEECHHHCCCCCCCCEEEEECCCCCCCCCCCEEEEEECCCCCCEEEECCCCEEEEEE
RQAGDTVPVTEVIGYIGAEGESVDTIASSEKTTEIPVPASADAGPAVAPKENVASPAPQV
CCCCCCCCHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCH
AATAIPQGNGGKVRATPAARKAAAEMGIDLGQVPGTGPKGRVHKEDVENFKGAQPKASPL
HHEECCCCCCCEEEECHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCHHHH
ARKIAADKGIDLATVSGTGFNGKVMKEDIMAILEAAKPAEAKAPAAKEEKVVDLPEGVEH
HHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCCCCCC
KPMSAMRKAISKGMTNSYLTAPTFTLNYDIDMTEMIALRKKLIDPIMAKTGLKVSFTDLI
CCHHHHHHHHHCCCCCCEEECCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCEEEHHHHH
GMAVVKTLMKPEHEYMNASLINDANDIELHRFVNLGIAVGLDDGLIVPVIHGANKMCLSD
HHHHHHHHHCCCHHHCCHHHCCCCCCCEEEEEEEEEEEEECCCCEEEEEEECCCHHHHHH
FVLASKDVIKKAQTGKLKAAEMSGSTFSITNLGMFGTKTFNPIINQPNSAILGVGATIPT
HHHHHHHHHHHHCCCCEEEEECCCCEEEEEECCCCCCCCCCHHHCCCCCEEEEECCCCCC
PTVVDGEIVSRPIMAMCLTIDHRLVDGMNGAKFMVDLKKLMENPFELLI
CCEECCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHCC
>Mature Secondary Structure 
AFEIIMPKLGVDMQEGEIIEWKKQEGDTVNEGDILLEIMSDKTNMELEAEDSGVLLKIT
CEEEECHHHCCCCCCCCEEEEECCCCCCCCCCCEEEEEECCCCCCEEEECCCCEEEEEE
RQAGDTVPVTEVIGYIGAEGESVDTIASSEKTTEIPVPASADAGPAVAPKENVASPAPQV
CCCCCCCCHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCH
AATAIPQGNGGKVRATPAARKAAAEMGIDLGQVPGTGPKGRVHKEDVENFKGAQPKASPL
HHEECCCCCCCEEEECHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCHHHH
ARKIAADKGIDLATVSGTGFNGKVMKEDIMAILEAAKPAEAKAPAAKEEKVVDLPEGVEH
HHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCCCCCC
KPMSAMRKAISKGMTNSYLTAPTFTLNYDIDMTEMIALRKKLIDPIMAKTGLKVSFTDLI
CCHHHHHHHHHCCCCCCEEECCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCEEEHHHHH
GMAVVKTLMKPEHEYMNASLINDANDIELHRFVNLGIAVGLDDGLIVPVIHGANKMCLSD
HHHHHHHHHCCCHHHCCHHHCCCCCCCEEEEEEEEEEEEECCCCEEEEEEECCCHHHHHH
FVLASKDVIKKAQTGKLKAAEMSGSTFSITNLGMFGTKTFNPIINQPNSAILGVGATIPT
HHHHHHHHHHHHCCCCEEEEECCCCEEEEEECCCCCCCCCCHHHCCCCCEEEEECCCCCC
PTVVDGEIVSRPIMAMCLTIDHRLVDGMNGAKFMVDLKKLMENPFELLI
CCEECCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969503; 9384377 [H]