Definition | Streptococcus pyogenes M1 GAS chromosome, complete genome. |
---|---|
Accession | NC_002737 |
Length | 1,852,441 |
Click here to switch to the map view.
The map label for this gene is acoC [H]
Identifier: 15675027
GI number: 15675027
Start: 836775
End: 838184
Strand: Direct
Name: acoC [H]
Synonym: SPy_1029
Alternate gene names: 15675027
Gene position: 836775-838184 (Clockwise)
Preceding gene: 15675026
Following gene: 15675028
Centisome position: 45.17
GC content: 42.62
Gene sequence:
>1410_bases ATGGCATTTGAAATTATTATGCCAAAGCTGGGCGTTGACATGCAAGAAGGCGAGATCATCGAGTGGAAAAAACAAGAAGG TGATACCGTCAATGAAGGTGATATCCTTCTTGAAATCATGTCAGACAAAACCAATATGGAACTTGAGGCAGAAGACTCAG GTGTTCTTCTTAAAATTACACGTCAAGCAGGTGATACTGTACCTGTAACTGAAGTTATCGGTTACATTGGTGCAGAGGGT GAATCAGTAGATACTATTGCTTCAAGTGAAAAAACAACAGAAATTCCAGTTCCTGCTTCAGCAGACGCTGGACCAGCAGT TGCTCCAAAAGAAAATGTGGCAAGTCCAGCTCCTCAAGTGGCAGCGACAGCTATTCCGCAAGGAAATGGCGGAAAAGTTC GTGCTACTCCAGCTGCACGTAAGGCAGCAGCAGAAATGGGCATTGACCTTGGCCAAGTTCCAGGAACAGGACCAAAAGGA CGTGTCCATAAAGAAGACGTTGAAAACTTTAAAGGTGCTCAACCGAAAGCTTCACCACTTGCTCGTAAAATTGCAGCAGA CAAAGGTATTGATTTGGCAACCGTATCAGGTACTGGCTTTAACGGTAAGGTCATGAAAGAAGACATCATGGCTATTCTTG AAGCGGCTAAACCAGCTGAAGCAAAAGCCCCAGCAGCTAAAGAAGAAAAAGTTGTTGATCTTCCAGAAGGTGTGGAACAC AAGCCAATGTCAGCTATGCGTAAGGCAATCTCTAAAGGTATGACAAACTCTTACCTTACTGCCCCTACCTTTACGCTTAA CTACGATATTGACATGACAGAGATGATTGCCCTTCGTAAGAAGTTAATTGACCCAATCATGGCTAAAACAGGCCTTAAAG TCAGCTTTACAGACTTGATTGGTATGGCAGTGGTTAAAACCTTGATGAAACCTGAGCATGAGTACATGAATGCTTCCCTC ATCAATGATGCTAATGATATTGAATTGCACCGCTTTGTGAACCTTGGTATTGCCGTAGGTCTTGATGATGGTCTTATCGT TCCTGTTATCCATGGGGCTAACAAGATGTGCTTGTCAGATTTCGTGCTTGCTTCAAAAGATGTGATTAAAAAAGCGCAAA CTGGTAAGTTGAAAGCAGCTGAAATGTCTGGATCAACCTTCTCTATCACAAACTTGGGAATGTTTGGTACGAAGACATTT AACCCAATTATTAACCAACCAAACTCAGCAATTCTTGGTGTTGGAGCAACTATCCCAACTCCAACGGTTGTGGATGGTGA GATTGTTTCCCGTCCAATTATGGCAATGTGCCTAACCATCGACCACCGTTTAGTTGATGGTATGAACGGTGCAAAATTCA TGGTTGATCTCAAGAAATTGATGGAAAATCCATTTGAATTGTTAATCTGA
Upstream 100 bases:
>100_bases GAGTTGTCTTATCCCGTGTCGCGGCACCTCACCTTTCGTATGTTTTCGTAGCAAGGTGAGGATGTTGATGGCGCTTATCA AATCGTGAAAGGATGTAGAA
Downstream 100 bases:
>100_bases TCAATCAGTTTTAAACAAGAAAAGCATTCAATAATAAAAGGGATTTTGCTAAGTTTAGACTTGGTGCCCTTTTCTCAAAA ATATAGAAAGGATGTAGAAC
Product: branched-chain alpha-keto acid dehydrogenase subunit E2
Products: NA
Alternate protein names: Acetoin dehydrogenase E2 component; Dihydrolipoamide acetyltransferase component of acetoin cleaving system [H]
Number of amino acids: Translated: 469; Mature: 468
Protein sequence:
>469_residues MAFEIIMPKLGVDMQEGEIIEWKKQEGDTVNEGDILLEIMSDKTNMELEAEDSGVLLKITRQAGDTVPVTEVIGYIGAEG ESVDTIASSEKTTEIPVPASADAGPAVAPKENVASPAPQVAATAIPQGNGGKVRATPAARKAAAEMGIDLGQVPGTGPKG RVHKEDVENFKGAQPKASPLARKIAADKGIDLATVSGTGFNGKVMKEDIMAILEAAKPAEAKAPAAKEEKVVDLPEGVEH KPMSAMRKAISKGMTNSYLTAPTFTLNYDIDMTEMIALRKKLIDPIMAKTGLKVSFTDLIGMAVVKTLMKPEHEYMNASL INDANDIELHRFVNLGIAVGLDDGLIVPVIHGANKMCLSDFVLASKDVIKKAQTGKLKAAEMSGSTFSITNLGMFGTKTF NPIINQPNSAILGVGATIPTPTVVDGEIVSRPIMAMCLTIDHRLVDGMNGAKFMVDLKKLMENPFELLI
Sequences:
>Translated_469_residues MAFEIIMPKLGVDMQEGEIIEWKKQEGDTVNEGDILLEIMSDKTNMELEAEDSGVLLKITRQAGDTVPVTEVIGYIGAEG ESVDTIASSEKTTEIPVPASADAGPAVAPKENVASPAPQVAATAIPQGNGGKVRATPAARKAAAEMGIDLGQVPGTGPKG RVHKEDVENFKGAQPKASPLARKIAADKGIDLATVSGTGFNGKVMKEDIMAILEAAKPAEAKAPAAKEEKVVDLPEGVEH KPMSAMRKAISKGMTNSYLTAPTFTLNYDIDMTEMIALRKKLIDPIMAKTGLKVSFTDLIGMAVVKTLMKPEHEYMNASL INDANDIELHRFVNLGIAVGLDDGLIVPVIHGANKMCLSDFVLASKDVIKKAQTGKLKAAEMSGSTFSITNLGMFGTKTF NPIINQPNSAILGVGATIPTPTVVDGEIVSRPIMAMCLTIDHRLVDGMNGAKFMVDLKKLMENPFELLI >Mature_468_residues AFEIIMPKLGVDMQEGEIIEWKKQEGDTVNEGDILLEIMSDKTNMELEAEDSGVLLKITRQAGDTVPVTEVIGYIGAEGE SVDTIASSEKTTEIPVPASADAGPAVAPKENVASPAPQVAATAIPQGNGGKVRATPAARKAAAEMGIDLGQVPGTGPKGR VHKEDVENFKGAQPKASPLARKIAADKGIDLATVSGTGFNGKVMKEDIMAILEAAKPAEAKAPAAKEEKVVDLPEGVEHK PMSAMRKAISKGMTNSYLTAPTFTLNYDIDMTEMIALRKKLIDPIMAKTGLKVSFTDLIGMAVVKTLMKPEHEYMNASLI NDANDIELHRFVNLGIAVGLDDGLIVPVIHGANKMCLSDFVLASKDVIKKAQTGKLKAAEMSGSTFSITNLGMFGTKTFN PIINQPNSAILGVGATIPTPTVVDGEIVSRPIMAMCLTIDHRLVDGMNGAKFMVDLKKLMENPFELLI
Specific function: The 2-Oxoglutarate Dehydrogenase Complex Catalyzes The Overall Conversion Of 2-Oxoglutarate To Succinyl-CoA And Co(2). It Contains Multiple Copies Of Three Enzymatic Components: 2- Oxoglutarate Dehydrogenase (E1), Dihydrolipoamide Succinyltransferase (E2)
COG id: COG0508
COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 lipoyl-binding domain [H]
Homologues:
Organism=Homo sapiens, GI31711992, Length=477, Percent_Identity=30.188679245283, Blast_Score=176, Evalue=5e-44, Organism=Homo sapiens, GI203098753, Length=479, Percent_Identity=28.8100208768267, Blast_Score=160, Evalue=2e-39, Organism=Homo sapiens, GI203098816, Length=479, Percent_Identity=28.8100208768267, Blast_Score=160, Evalue=3e-39, Organism=Homo sapiens, GI110671329, Length=468, Percent_Identity=26.7094017094017, Blast_Score=139, Evalue=6e-33, Organism=Homo sapiens, GI19923748, Length=232, Percent_Identity=31.0344827586207, Blast_Score=124, Evalue=2e-28, Organism=Homo sapiens, GI260898739, Length=141, Percent_Identity=34.0425531914894, Blast_Score=89, Evalue=7e-18, Organism=Escherichia coli, GI1786946, Length=472, Percent_Identity=26.6949152542373, Blast_Score=167, Evalue=2e-42, Organism=Escherichia coli, GI1786305, Length=293, Percent_Identity=33.4470989761092, Blast_Score=153, Evalue=2e-38, Organism=Caenorhabditis elegans, GI17560088, Length=477, Percent_Identity=29.979035639413, Blast_Score=162, Evalue=3e-40, Organism=Caenorhabditis elegans, GI25146366, Length=459, Percent_Identity=28.5403050108932, Blast_Score=146, Evalue=2e-35, Organism=Caenorhabditis elegans, GI17537937, Length=460, Percent_Identity=25, Blast_Score=122, Evalue=5e-28, Organism=Caenorhabditis elegans, GI17538894, Length=324, Percent_Identity=28.0864197530864, Blast_Score=103, Evalue=3e-22, Organism=Saccharomyces cerevisiae, GI6320352, Length=466, Percent_Identity=28.5407725321888, Blast_Score=153, Evalue=7e-38, Organism=Saccharomyces cerevisiae, GI6324258, Length=176, Percent_Identity=33.5227272727273, Blast_Score=85, Evalue=3e-17, Organism=Saccharomyces cerevisiae, GI6321632, Length=337, Percent_Identity=25.2225519287834, Blast_Score=65, Evalue=3e-11, Organism=Drosophila melanogaster, GI18859875, Length=465, Percent_Identity=26.0215053763441, Blast_Score=131, Evalue=9e-31, Organism=Drosophila melanogaster, GI24645909, Length=246, Percent_Identity=31.7073170731707, Blast_Score=129, Evalue=4e-30, Organism=Drosophila melanogaster, GI24582497, Length=298, Percent_Identity=28.5234899328859, Blast_Score=107, Evalue=1e-23, Organism=Drosophila melanogaster, GI20129315, Length=298, Percent_Identity=28.5234899328859, Blast_Score=107, Evalue=2e-23,
Paralogues:
None
Copy number: 420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3096 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001078 - InterPro: IPR000089 - InterPro: IPR023213 - InterPro: IPR004167 - InterPro: IPR011053 [H]
Pfam domain/function: PF00198 2-oxoacid_dh; PF00364 Biotin_lipoyl; PF02817 E3_binding [H]
EC number: =2.3.1.12 [H]
Molecular weight: Translated: 49802; Mature: 49671
Theoretical pI: Translated: 4.98; Mature: 4.98
Prosite motif: PS50968 BIOTINYL_LIPOYL ; PS00189 LIPOYL
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.4 %Cys (Translated Protein) 5.3 %Met (Translated Protein) 5.8 %Cys+Met (Translated Protein) 0.4 %Cys (Mature Protein) 5.1 %Met (Mature Protein) 5.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MAFEIIMPKLGVDMQEGEIIEWKKQEGDTVNEGDILLEIMSDKTNMELEAEDSGVLLKIT CCEEEECHHHCCCCCCCCEEEEECCCCCCCCCCCEEEEEECCCCCCEEEECCCCEEEEEE RQAGDTVPVTEVIGYIGAEGESVDTIASSEKTTEIPVPASADAGPAVAPKENVASPAPQV CCCCCCCCHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCH AATAIPQGNGGKVRATPAARKAAAEMGIDLGQVPGTGPKGRVHKEDVENFKGAQPKASPL HHEECCCCCCCEEEECHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCHHHH ARKIAADKGIDLATVSGTGFNGKVMKEDIMAILEAAKPAEAKAPAAKEEKVVDLPEGVEH HHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCCCCCC KPMSAMRKAISKGMTNSYLTAPTFTLNYDIDMTEMIALRKKLIDPIMAKTGLKVSFTDLI CCHHHHHHHHHCCCCCCEEECCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCEEEHHHHH GMAVVKTLMKPEHEYMNASLINDANDIELHRFVNLGIAVGLDDGLIVPVIHGANKMCLSD HHHHHHHHHCCCHHHCCHHHCCCCCCCEEEEEEEEEEEEECCCCEEEEEEECCCHHHHHH FVLASKDVIKKAQTGKLKAAEMSGSTFSITNLGMFGTKTFNPIINQPNSAILGVGATIPT HHHHHHHHHHHHCCCCEEEEECCCCEEEEEECCCCCCCCCCHHHCCCCCEEEEECCCCCC PTVVDGEIVSRPIMAMCLTIDHRLVDGMNGAKFMVDLKKLMENPFELLI CCEECCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHCC >Mature Secondary Structure AFEIIMPKLGVDMQEGEIIEWKKQEGDTVNEGDILLEIMSDKTNMELEAEDSGVLLKIT CEEEECHHHCCCCCCCCEEEEECCCCCCCCCCCEEEEEECCCCCCEEEECCCCEEEEEE RQAGDTVPVTEVIGYIGAEGESVDTIASSEKTTEIPVPASADAGPAVAPKENVASPAPQV CCCCCCCCHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCH AATAIPQGNGGKVRATPAARKAAAEMGIDLGQVPGTGPKGRVHKEDVENFKGAQPKASPL HHEECCCCCCCEEEECHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCHHHH ARKIAADKGIDLATVSGTGFNGKVMKEDIMAILEAAKPAEAKAPAAKEEKVVDLPEGVEH HHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCCCCCC KPMSAMRKAISKGMTNSYLTAPTFTLNYDIDMTEMIALRKKLIDPIMAKTGLKVSFTDLI CCHHHHHHHHHCCCCCCEEECCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCEEEHHHHH GMAVVKTLMKPEHEYMNASLINDANDIELHRFVNLGIAVGLDDGLIVPVIHGANKMCLSD HHHHHHHHHCCCHHHCCHHHCCCCCCCEEEEEEEEEEEEECCCCEEEEEEECCCHHHHHH FVLASKDVIKKAQTGKLKAAEMSGSTFSITNLGMFGTKTFNPIINQPNSAILGVGATIPT HHHHHHHHHHHHCCCCEEEEECCCCEEEEEECCCCCCCCCCHHHCCCCCEEEEECCCCCC PTVVDGEIVSRPIMAMCLTIDHRLVDGMNGAKFMVDLKKLMENPFELLI CCEECCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 8969503; 9384377 [H]