Definition | Streptococcus pyogenes M1 GAS chromosome, complete genome. |
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Accession | NC_002737 |
Length | 1,852,441 |
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The map label for this gene is acoL [C]
Identifier: 15675028
GI number: 15675028
Start: 838511
End: 840274
Strand: Direct
Name: acoL [C]
Synonym: SPy_1031
Alternate gene names: 15675028
Gene position: 838511-840274 (Clockwise)
Preceding gene: 15675027
Following gene: 15675030
Centisome position: 45.27
GC content: 41.27
Gene sequence:
>1764_bases ATGGCTGTTGAAATTATTATGCCAAAACTCGGTGTTGACATGCAAGAAGGTGAAATCATCGAGTGGAAAAAACAAGAAGG TGATACTGTCAATGAAGGCGATATTCTTCTTGAAATCATGTCAGATAAAACCAATATGGAACTTGAGGCAGAAGACTCAG GTGTTCTTCTTAAAATTACACGTCAAGCAGGTGAAACAGTACCTGTAACAGAAGTTATCGGATATATCGGTGCTGAAGGT GAATCTGTTGAGGTTTCTAGCCCAGCTGCTTCAGATGTGAATGTTGCTCGTACAACAGAAGATTTAGAAGCTGCTGGACT TGAAGTGCCAAAAGCACCAGCTCAAGCTGCTTCAGCTGCACCAAAAGCTGCACTTGCTGATGATGAGTATGACATCATCG TTGTTGGTGGTGGCCCTGCAGGTTATTATGCAGCTATTCGTGGTGCTCAACTTGGTGGTAAAATTGCCATCGTTGAGAAA TCTGAATTTGGTGGAACTTGCTTGAACGTAGGGTGTATCCCAACCAAAACTTACCTTAAAAATGCTGAAATCCTTGATGG TATTAAGATTGCAGCAGGACGTGGGATTAACCTTGCCTCAACTAACTATACTATTGACATGGACAAAACAGTTGACTTTA AAAACACCGTTGTTAAAACCTTAACAGGCGGCGTTCAAGGTCTTCTAAAAGCTAATAAAGTCACTATCTTTAATGGGCTT GGTCAAGTCAACCCTGACAAGACTGTAACCATTGGGTCACAAACCATTAAGGGTCGCAACGTTATCCTTGCTACAGGTTC TAAAGTATCACGTATCAATATCCCAGGTATTGACTCTAAACTTGTCTTAACGTCAGATGATATCCTTGACCTCCGTGAAA TGCCAAAATCACTAGCAGTTATGGGCGGTGGTGTTGTTGGTATCGAGCTTGGACTTGTTTGGGCATCTTACGGTGTGGAT GTTACCGTTATTGAAATGGCTGACCGTATTATCCCAGCTATGGATAAAGAAGTCTCTCTTGAACTTCAAAAAATCCTTTC TAAGAAAGGCATGAAGATCAAAACATCTGTTGGTGTCTCTGAAATTGTTGAAGCAAATAACCAATTGACTTTGAAACTTA ACAATGGTGAAGAAGTTGTTGCTGAAAAAGCTCTTCTTTCTATCGGACGTGTATCACAAATGAACGGTCTGGAAAATCTT AACCTTGAAATGGATCGTAACCGTATCAAAGTTAATGACTACCAAGAGACATCAATTCCAGGTATCTATGCGCCAGGTGA CGTTAACGGAACGAAAATGCTTGCTCACGCTGCTTACCGTATGGGTGAAGTGGCTGCAGAAAATGCGATGCATGGCAACA CAACTCGTAAAGCTAACCTTAAATACACTCCAGCAGCTGTTTACACACACCCTGAAGTGGCAATGGTTGGTTTAACTGAA GAACAAGCGCGTGAACAATATGGTGATGTGCTTATTGGTAAAAACAGCTTTACTGGTAATGGACGCGCGATTGCTTCAAA TGAAGCACATGGTTTTGTTAAAGTTATTGCTGATGCCAAATACCACGAAATCTTAGGTGTTCATATTATTGGTCCAGCTG CAGCTGAGATGATTAACGAAGCAGCTACTATTATGGAATCTGAATTAACCGTTGATGAATTGTTATTATCAATTCATGGA CACCCAACCTTCTCTGAAGTGATGTACGAAGCCTTTGCAGATGTGCTTGGCGAAGCTATCCATAACCCACCAAAACGTAA GTAA
Upstream 100 bases:
>100_bases AGTCCTAGTCGTCCTGACGTGGGTGCGTCAACGAAATCAAAGATTTCTGACTTACCGCAAAAATTCAATCGCTTTCTCCT TGCTCTTGGTATCTTAAATT
Downstream 100 bases:
>100_bases AACGTCTTTGTCTTATTAACTAATGAAAAATATCATCACATAACAGATCACAAAAAAGACTAGCACAACTATGAACTGCA CCCCAAACGTTAGATATAAA
Product: putative dihydrolipoamide dehydrogenase, component E3
Products: NA
Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of pyruvate complex [H]
Number of amino acids: Translated: 587; Mature: 586
Protein sequence:
>587_residues MAVEIIMPKLGVDMQEGEIIEWKKQEGDTVNEGDILLEIMSDKTNMELEAEDSGVLLKITRQAGETVPVTEVIGYIGAEG ESVEVSSPAASDVNVARTTEDLEAAGLEVPKAPAQAASAAPKAALADDEYDIIVVGGGPAGYYAAIRGAQLGGKIAIVEK SEFGGTCLNVGCIPTKTYLKNAEILDGIKIAAGRGINLASTNYTIDMDKTVDFKNTVVKTLTGGVQGLLKANKVTIFNGL GQVNPDKTVTIGSQTIKGRNVILATGSKVSRINIPGIDSKLVLTSDDILDLREMPKSLAVMGGGVVGIELGLVWASYGVD VTVIEMADRIIPAMDKEVSLELQKILSKKGMKIKTSVGVSEIVEANNQLTLKLNNGEEVVAEKALLSIGRVSQMNGLENL NLEMDRNRIKVNDYQETSIPGIYAPGDVNGTKMLAHAAYRMGEVAAENAMHGNTTRKANLKYTPAAVYTHPEVAMVGLTE EQAREQYGDVLIGKNSFTGNGRAIASNEAHGFVKVIADAKYHEILGVHIIGPAAAEMINEAATIMESELTVDELLLSIHG HPTFSEVMYEAFADVLGEAIHNPPKRK
Sequences:
>Translated_587_residues MAVEIIMPKLGVDMQEGEIIEWKKQEGDTVNEGDILLEIMSDKTNMELEAEDSGVLLKITRQAGETVPVTEVIGYIGAEG ESVEVSSPAASDVNVARTTEDLEAAGLEVPKAPAQAASAAPKAALADDEYDIIVVGGGPAGYYAAIRGAQLGGKIAIVEK SEFGGTCLNVGCIPTKTYLKNAEILDGIKIAAGRGINLASTNYTIDMDKTVDFKNTVVKTLTGGVQGLLKANKVTIFNGL GQVNPDKTVTIGSQTIKGRNVILATGSKVSRINIPGIDSKLVLTSDDILDLREMPKSLAVMGGGVVGIELGLVWASYGVD VTVIEMADRIIPAMDKEVSLELQKILSKKGMKIKTSVGVSEIVEANNQLTLKLNNGEEVVAEKALLSIGRVSQMNGLENL NLEMDRNRIKVNDYQETSIPGIYAPGDVNGTKMLAHAAYRMGEVAAENAMHGNTTRKANLKYTPAAVYTHPEVAMVGLTE EQAREQYGDVLIGKNSFTGNGRAIASNEAHGFVKVIADAKYHEILGVHIIGPAAAEMINEAATIMESELTVDELLLSIHG HPTFSEVMYEAFADVLGEAIHNPPKRK >Mature_586_residues AVEIIMPKLGVDMQEGEIIEWKKQEGDTVNEGDILLEIMSDKTNMELEAEDSGVLLKITRQAGETVPVTEVIGYIGAEGE SVEVSSPAASDVNVARTTEDLEAAGLEVPKAPAQAASAAPKAALADDEYDIIVVGGGPAGYYAAIRGAQLGGKIAIVEKS EFGGTCLNVGCIPTKTYLKNAEILDGIKIAAGRGINLASTNYTIDMDKTVDFKNTVVKTLTGGVQGLLKANKVTIFNGLG QVNPDKTVTIGSQTIKGRNVILATGSKVSRINIPGIDSKLVLTSDDILDLREMPKSLAVMGGGVVGIELGLVWASYGVDV TVIEMADRIIPAMDKEVSLELQKILSKKGMKIKTSVGVSEIVEANNQLTLKLNNGEEVVAEKALLSIGRVSQMNGLENLN LEMDRNRIKVNDYQETSIPGIYAPGDVNGTKMLAHAAYRMGEVAAENAMHGNTTRKANLKYTPAAVYTHPEVAMVGLTEE QAREQYGDVLIGKNSFTGNGRAIASNEAHGFVKVIADAKYHEILGVHIIGPAAAEMINEAATIMESELTVDELLLSIHGH PTFSEVMYEAFADVLGEAIHNPPKRK
Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge
COG id: COG1249
COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]
Homologues:
Organism=Homo sapiens, GI91199540, Length=488, Percent_Identity=38.3196721311475, Blast_Score=298, Evalue=7e-81, Organism=Homo sapiens, GI50301238, Length=456, Percent_Identity=26.5350877192982, Blast_Score=148, Evalue=2e-35, Organism=Homo sapiens, GI33519430, Length=479, Percent_Identity=27.7661795407098, Blast_Score=137, Evalue=2e-32, Organism=Homo sapiens, GI33519428, Length=479, Percent_Identity=27.7661795407098, Blast_Score=137, Evalue=2e-32, Organism=Homo sapiens, GI33519426, Length=479, Percent_Identity=27.7661795407098, Blast_Score=137, Evalue=2e-32, Organism=Homo sapiens, GI148277065, Length=479, Percent_Identity=27.7661795407098, Blast_Score=137, Evalue=3e-32, Organism=Homo sapiens, GI148277071, Length=479, Percent_Identity=27.7661795407098, Blast_Score=137, Evalue=3e-32, Organism=Homo sapiens, GI291045266, Length=437, Percent_Identity=27.2311212814645, Blast_Score=118, Evalue=2e-26, Organism=Homo sapiens, GI22035672, Length=480, Percent_Identity=29.1666666666667, Blast_Score=111, Evalue=2e-24, Organism=Homo sapiens, GI291045268, Length=434, Percent_Identity=24.6543778801843, Blast_Score=91, Evalue=4e-18, Organism=Escherichia coli, GI1786307, Length=468, Percent_Identity=36.5384615384615, Blast_Score=255, Evalue=6e-69, Organism=Escherichia coli, GI1789915, Length=429, Percent_Identity=28.2051282051282, Blast_Score=176, Evalue=3e-45, Organism=Escherichia coli, GI87082354, Length=458, Percent_Identity=27.0742358078603, Blast_Score=166, Evalue=3e-42, Organism=Escherichia coli, GI87081717, Length=457, Percent_Identity=26.9146608315098, Blast_Score=155, Evalue=9e-39, Organism=Caenorhabditis elegans, GI32565766, Length=507, Percent_Identity=37.4753451676529, Blast_Score=289, Evalue=3e-78, Organism=Caenorhabditis elegans, GI17557007, Length=479, Percent_Identity=28.6012526096033, Blast_Score=153, Evalue=3e-37, Organism=Caenorhabditis elegans, GI71983429, Length=446, Percent_Identity=27.3542600896861, Blast_Score=147, Evalue=2e-35, Organism=Caenorhabditis elegans, GI71983419, Length=446, Percent_Identity=27.3542600896861, Blast_Score=147, Evalue=2e-35, Organism=Caenorhabditis elegans, GI71982272, Length=454, Percent_Identity=26.8722466960352, Blast_Score=111, Evalue=8e-25, Organism=Saccharomyces cerevisiae, GI6321091, Length=494, Percent_Identity=37.4493927125506, Blast_Score=275, Evalue=1e-74, Organism=Saccharomyces cerevisiae, GI6325166, Length=458, Percent_Identity=26.8558951965066, Blast_Score=155, Evalue=2e-38, Organism=Saccharomyces cerevisiae, GI6325240, Length=473, Percent_Identity=28.5412262156448, Blast_Score=155, Evalue=2e-38, Organism=Drosophila melanogaster, GI21358499, Length=462, Percent_Identity=41.1255411255411, Blast_Score=301, Evalue=1e-81, Organism=Drosophila melanogaster, GI24640549, Length=466, Percent_Identity=27.6824034334764, Blast_Score=149, Evalue=7e-36, Organism=Drosophila melanogaster, GI24640553, Length=466, Percent_Identity=27.6824034334764, Blast_Score=148, Evalue=1e-35, Organism=Drosophila melanogaster, GI24640551, Length=466, Percent_Identity=27.8969957081545, Blast_Score=147, Evalue=2e-35, Organism=Drosophila melanogaster, GI17737741, Length=473, Percent_Identity=27.6955602536998, Blast_Score=139, Evalue=5e-33,
Paralogues:
None
Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR016156 - InterPro: IPR013027 - InterPro: IPR006258 - InterPro: IPR004099 - InterPro: IPR012999 - InterPro: IPR001327 [H]
Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]
EC number: =1.8.1.4 [H]
Molecular weight: Translated: 62467; Mature: 62336
Theoretical pI: Translated: 4.63; Mature: 4.63
Prosite motif: PS00076 PYRIDINE_REDOX_1 ; PS50968 BIOTINYL_LIPOYL ; PS00189 LIPOYL
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.3 %Cys (Translated Protein) 3.4 %Met (Translated Protein) 3.7 %Cys+Met (Translated Protein) 0.3 %Cys (Mature Protein) 3.2 %Met (Mature Protein) 3.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MAVEIIMPKLGVDMQEGEIIEWKKQEGDTVNEGDILLEIMSDKTNMELEAEDSGVLLKIT CEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEECCCCCCEEEECCCCEEEEEE RQAGETVPVTEVIGYIGAEGESVEVSSPAASDVNVARTTEDLEAAGLEVPKAPAQAASAA CCCCCCCCHHHHHHHHCCCCCEEEECCCCCCCCEEEECCHHHHHCCCCCCCCCHHHHCCC PKAALADDEYDIIVVGGGPAGYYAAIRGAQLGGKIAIVEKSEFGGTCLNVGCIPTKTYLK CCCCCCCCCEEEEEECCCCCCHHHEEECCCCCCEEEEEECCCCCCEEEEECCCCCHHHHC NAEILDGIKIAAGRGINLASTNYTIDMDKTVDFKNTVVKTLTGGVQGLLKANKVTIFNGL CCHHHCCEEEECCCCCEEECCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECC GQVNPDKTVTIGSQTIKGRNVILATGSKVSRINIPGIDSKLVLTSDDILDLREMPKSLAV CCCCCCCEEEECCEEECCCEEEEECCCCEEEEECCCCCCEEEEECCCHHHHHHCCHHHHH MGGGVVGIELGLVWASYGVDVTVIEMADRIIPAMDKEVSLELQKILSKKGMKIKTSVGVS HCCCEEEEEEEEEEECCCCCEEEEEHHHHHHCCCCHHHHHHHHHHHHHCCCEEEECCCHH EIVEANNQLTLKLNNGEEVVAEKALLSIGRVSQMNGLENLNLEMDRNRIKVNDYQETSIP HHHHCCCEEEEEECCCHHHHHHHHHHHHCCHHHHCCCCCCCEEECCCEEEECCCCCCCCC GIYAPGDVNGTKMLAHAAYRMGEVAAENAMHGNTTRKANLKYTPAAVYTHPEVAMVGLTE CEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCEEEEECCCEEEEECCH EQAREQYGDVLIGKNSFTGNGRAIASNEAHGFVKVIADAKYHEILGVHIIGPAAAEMINE HHHHHHHCCEEEECCCCCCCCEEEECCCCCCEEEEEECCCCCEEEEEEEECHHHHHHHHH AATIMESELTVDELLLSIHGHPTFSEVMYEAFADVLGEAIHNPPKRK HHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCC >Mature Secondary Structure AVEIIMPKLGVDMQEGEIIEWKKQEGDTVNEGDILLEIMSDKTNMELEAEDSGVLLKIT EEEEEECCCCCCCCCCCEEEEECCCCCCCCCCCEEEEEECCCCCCEEEECCCCEEEEEE RQAGETVPVTEVIGYIGAEGESVEVSSPAASDVNVARTTEDLEAAGLEVPKAPAQAASAA CCCCCCCCHHHHHHHHCCCCCEEEECCCCCCCCEEEECCHHHHHCCCCCCCCCHHHHCCC PKAALADDEYDIIVVGGGPAGYYAAIRGAQLGGKIAIVEKSEFGGTCLNVGCIPTKTYLK CCCCCCCCCEEEEEECCCCCCHHHEEECCCCCCEEEEEECCCCCCEEEEECCCCCHHHHC NAEILDGIKIAAGRGINLASTNYTIDMDKTVDFKNTVVKTLTGGVQGLLKANKVTIFNGL CCHHHCCEEEECCCCCEEECCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECC GQVNPDKTVTIGSQTIKGRNVILATGSKVSRINIPGIDSKLVLTSDDILDLREMPKSLAV CCCCCCCEEEECCEEECCCEEEEECCCCEEEEECCCCCCEEEEECCCHHHHHHCCHHHHH MGGGVVGIELGLVWASYGVDVTVIEMADRIIPAMDKEVSLELQKILSKKGMKIKTSVGVS HCCCEEEEEEEEEEECCCCCEEEEEHHHHHHCCCCHHHHHHHHHHHHHCCCEEEECCCHH EIVEANNQLTLKLNNGEEVVAEKALLSIGRVSQMNGLENLNLEMDRNRIKVNDYQETSIP HHHHCCCEEEEEECCCHHHHHHHHHHHHCCHHHHCCCCCCCEEECCCEEEECCCCCCCCC GIYAPGDVNGTKMLAHAAYRMGEVAAENAMHGNTTRKANLKYTPAAVYTHPEVAMVGLTE CEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCEEEEECCCEEEEECCH EQAREQYGDVLIGKNSFTGNGRAIASNEAHGFVKVIADAKYHEILGVHIIGPAAAEMINE HHHHHHHCCEEEECCCCCCCCEEEECCCCCCEEEEEECCCCCEEEEEEEECHHHHHHHHH AATIMESELTVDELLLSIHGHPTFSEVMYEAFADVLGEAIHNPPKRK HHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 2832161; 2404760; 1880807 [H]