Click here to switch to the map view.

The map label for this gene is ung

Identifier: 15674927

GI number: 15674927

Start: 749465

End: 750118

Strand: Direct

Name: ung

Synonym: SPy_0905

Alternate gene names: 15674927

Gene position: 749465-750118 (Clockwise)

Preceding gene: 15674926

Following gene: 15674928

Centisome position: 40.46

GC content: 42.2

Gene sequence:

>654_bases
ATGGCTCATTCAATTTGGCATGAGAAAATCAAATCATTTTTGCCGGAGCATTACTACGGTCGCATCAATCACTTTTTAGA
TGAAGCCTATGCTTCCGGTCTTGTCTATCCTCCACGAGAAAATGTCTTTAAAGCCTTACAAGTCACTCCTTTGGAAGAAA
CCAAAGTGTTGATTTTAGGACAAGACCCTTATCATGGCCCCAAACAGGCCCAGGGCTTATCATTTTCAGTTCCAGAAGAG
ATTTCTGCTCCGCCATCCCTTATTAATATTTTAAAAGAATTAGCAGATGACATTGGTCCTCGTGACCATCATGATTTAAG
CACTTGGGCTAGTCAAGGGGTTCTGCTTTTGAATGCTTGCTTAACAGTGCCAGCAGGCCAGGCTAATGGGCATGCAGGCT
TAATATGGGAGCCATTTACAGATGCTGTTATTAAAGTGCTGAATGAGAAAGACAGCCCTGTAGTTTTCATTTTGTGGGGA
GCTTATGCAAGGAAGAAAAAAGCCTTCATTACTAATCCAAAGCACCACATCATCGAGAGCCCTCATCCAAGCCCTTTGTC
ATCTTATCGTGGCTTTTTTGGCAGCAAACCCTTTTCAAGAACCAATGCTATTTTAGAAAAAGAGGGCATGACTGGCGTAG
ATTGGCTAAAATAA

Upstream 100 bases:

>100_bases
ATATCATATTTTCAGGGTCTTTCTATTTAAAATGTGGTAAACTAGATAGAAAAGGACATCGTATTTAACTTAGAAACTGA
CGTGATTAGAAAGGAATCTT

Downstream 100 bases:

>100_bases
GCCAGCCATTTCAACTAAATAGCTTAATCTAGACATTTTGATACCTTTAATAAGTGAAATGAGTGCAGTAGATTTTTCCT
ATTAAAGAACGTAAGGTCTT

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG

Number of amino acids: Translated: 217; Mature: 216

Protein sequence:

>217_residues
MAHSIWHEKIKSFLPEHYYGRINHFLDEAYASGLVYPPRENVFKALQVTPLEETKVLILGQDPYHGPKQAQGLSFSVPEE
ISAPPSLINILKELADDIGPRDHHDLSTWASQGVLLLNACLTVPAGQANGHAGLIWEPFTDAVIKVLNEKDSPVVFILWG
AYARKKKAFITNPKHHIIESPHPSPLSSYRGFFGSKPFSRTNAILEKEGMTGVDWLK

Sequences:

>Translated_217_residues
MAHSIWHEKIKSFLPEHYYGRINHFLDEAYASGLVYPPRENVFKALQVTPLEETKVLILGQDPYHGPKQAQGLSFSVPEE
ISAPPSLINILKELADDIGPRDHHDLSTWASQGVLLLNACLTVPAGQANGHAGLIWEPFTDAVIKVLNEKDSPVVFILWG
AYARKKKAFITNPKHHIIESPHPSPLSSYRGFFGSKPFSRTNAILEKEGMTGVDWLK
>Mature_216_residues
AHSIWHEKIKSFLPEHYYGRINHFLDEAYASGLVYPPRENVFKALQVTPLEETKVLILGQDPYHGPKQAQGLSFSVPEEI
SAPPSLINILKELADDIGPRDHHDLSTWASQGVLLLNACLTVPAGQANGHAGLIWEPFTDAVIKVLNEKDSPVVFILWGA
YARKKKAFITNPKHHIIESPHPSPLSSYRGFFGSKPFSRTNAILEKEGMTGVDWLK

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family

Homologues:

Organism=Homo sapiens, GI6224979, Length=213, Percent_Identity=49.2957746478873, Blast_Score=206, Evalue=1e-53,
Organism=Homo sapiens, GI19718751, Length=213, Percent_Identity=49.2957746478873, Blast_Score=206, Evalue=2e-53,
Organism=Escherichia coli, GI1788934, Length=215, Percent_Identity=48.3720930232558, Blast_Score=204, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI17556304, Length=215, Percent_Identity=42.7906976744186, Blast_Score=178, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6323620, Length=217, Percent_Identity=40.5529953917051, Blast_Score=144, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UNG_STRP1 (Q9A072)

Other databases:

- EMBL:   AE004092
- EMBL:   CP000017
- RefSeq:   NP_269101.1
- RefSeq:   YP_282071.1
- ProteinModelPortal:   Q9A072
- SMR:   Q9A072
- EnsemblBacteria:   EBSTRT00000000468
- EnsemblBacteria:   EBSTRT00000027521
- GeneID:   3572220
- GeneID:   901060
- GenomeReviews:   AE004092_GR
- GenomeReviews:   CP000017_GR
- KEGG:   spy:SPy_0905
- KEGG:   spz:M5005_Spy_0708
- GeneTree:   EBGT00050000028393
- HOGENOM:   HBG605450
- OMA:   GAHAQKK
- ProtClustDB:   PRK05254
- BioCyc:   SPYO160490:SPY0905-MONOMER
- BioCyc:   SPYO293653:M5005_SPY0708-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00148
- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122
- Gene3D:   G3DSA:3.40.470.10
- PANTHER:   PTHR11264
- TIGRFAMs:   TIGR00628

Pfam domain/function: PF03167 UDG; SSF52141 UDNA_glycsylseSF

EC number: =3.2.2.27

Molecular weight: Translated: 24213; Mature: 24082

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: ACT_SITE 62-62

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHSIWHEKIKSFLPEHYYGRINHFLDEAYASGLVYPPRENVFKALQVTPLEETKVLILG
CCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCEEEEEE
QDPYHGPKQAQGLSFSVPEEISAPPSLINILKELADDIGPRDHHDLSTWASQGVLLLNAC
CCCCCCCHHCCCCCCCCCHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHEEHHH
LTVPAGQANGHAGLIWEPFTDAVIKVLNEKDSPVVFILWGAYARKKKAFITNPKHHIIES
HHCCCCCCCCCCCEEECHHHHHHHHHHCCCCCCEEEEEECCHHHHCCCEECCCHHHCCCC
PHPSPLSSYRGFFGSKPFSRTNAILEKEGMTGVDWLK
CCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
AHSIWHEKIKSFLPEHYYGRINHFLDEAYASGLVYPPRENVFKALQVTPLEETKVLILG
CCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCEEEEEE
QDPYHGPKQAQGLSFSVPEEISAPPSLINILKELADDIGPRDHHDLSTWASQGVLLLNAC
CCCCCCCHHCCCCCCCCCHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHEEHHH
LTVPAGQANGHAGLIWEPFTDAVIKVLNEKDSPVVFILWGAYARKKKAFITNPKHHIIES
HHCCCCCCCCCCCEEECHHHHHHHHHHCCCCCCEEEEEECCHHHHCCCEECCCHHHCCCC
PHPSPLSSYRGFFGSKPFSRTNAILEKEGMTGVDWLK
CCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296