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The map label for this gene is fpg

Identifier: 15674603

GI number: 15674603

Start: 398928

End: 399755

Strand: Direct

Name: fpg

Synonym: SPy_0497

Alternate gene names: 15674603

Gene position: 398928-399755 (Clockwise)

Preceding gene: 15674602

Following gene: 15674604

Centisome position: 21.54

GC content: 42.39

Gene sequence:

>828_bases
ATGCCAGAATTACCAGAAGTTGAAACGGTCCGACGAGGACTTGAGACTTTAGTGCTTGGCCAAGAAATTGTGGCTGTTAC
GCTTAAAGTGCCAAAAATGGTTAAAACCGACTTAGAGACGTTTGCCCTGACCCTACCTGGTCAAATCATTCAGTCAGTTG
GCCGTCGGGGAAAATATTTATTAATTGATTTGGGGCAATTAGTGTTGGTATCACATTTGCGGATGGAAGGCAAATATTTG
CTTTTTCCAGATGAGGTCCCTGATAACAAACACTTTCATGTCTTTTTTGAATTGAAAAATGGTTCGACCTTGGTTTACCA
AGATGTGCGTAAATTTGGAACCTTTGATTTGATAGCAAAATCTCAATTATCAGCGTTTTTTGCCAAACGAAAACTAGGCC
CTGAACCAAAGAAAGAGACCTTTAAGTTAAAAACCTTTGAGGCTGCTCTGCTATCCTCCCAAAAACCCATAAAACCACAT
CTTTTAGACCAGACCTTGGTTGCTGGTTTAGGGAATATTTATGTGGACGAGGTACTTTGGGCTGCTAAGGTTCATCCAGA
AACTGCGTCTTCTAGGTTGAATAAGGCGGAGATAAAACGGCTGCATGATGAAACCATACGAATCCTAGCTTTAGGAATTG
AAAAGGGCGGTTCGACCGTCCGTACTTACCGTAATGCTTTGGGAGCTGATGGCACCATGCAGGACTATTTGCAGGTTTAT
GGTCAAACTGGGAAACCGTGTCCTCGTTGTGGACAGGCTATTGTCAAATTAAAAGTTGGAGGAAGGGGGACGCACATTTG
TCCAAAATGCCAGAAAAAAAGACTATGA

Upstream 100 bases:

>100_bases
GCAGTCAGTAGCCTAGACCTGAGTCTATTGAGTGACTTTTTTATACTGAGTTTATTCTTTGTAGGAGCAAAGGGTCTAGC
TGTCCTTTAAATAACGGATT

Downstream 100 bases:

>100_bases
TTATTGGCATCACAGGAGGCATTGCATCAGGAAAATCGACTGTGGTTAAGGTCATTAGAAAAGCTGGTTATCAGGTGATT
GATGCGGATCAAGTGGTCCA

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM

Number of amino acids: Translated: 275; Mature: 274

Protein sequence:

>275_residues
MPELPEVETVRRGLETLVLGQEIVAVTLKVPKMVKTDLETFALTLPGQIIQSVGRRGKYLLIDLGQLVLVSHLRMEGKYL
LFPDEVPDNKHFHVFFELKNGSTLVYQDVRKFGTFDLIAKSQLSAFFAKRKLGPEPKKETFKLKTFEAALLSSQKPIKPH
LLDQTLVAGLGNIYVDEVLWAAKVHPETASSRLNKAEIKRLHDETIRILALGIEKGGSTVRTYRNALGADGTMQDYLQVY
GQTGKPCPRCGQAIVKLKVGGRGTHICPKCQKKRL

Sequences:

>Translated_275_residues
MPELPEVETVRRGLETLVLGQEIVAVTLKVPKMVKTDLETFALTLPGQIIQSVGRRGKYLLIDLGQLVLVSHLRMEGKYL
LFPDEVPDNKHFHVFFELKNGSTLVYQDVRKFGTFDLIAKSQLSAFFAKRKLGPEPKKETFKLKTFEAALLSSQKPIKPH
LLDQTLVAGLGNIYVDEVLWAAKVHPETASSRLNKAEIKRLHDETIRILALGIEKGGSTVRTYRNALGADGTMQDYLQVY
GQTGKPCPRCGQAIVKLKVGGRGTHICPKCQKKRL
>Mature_274_residues
PELPEVETVRRGLETLVLGQEIVAVTLKVPKMVKTDLETFALTLPGQIIQSVGRRGKYLLIDLGQLVLVSHLRMEGKYLL
FPDEVPDNKHFHVFFELKNGSTLVYQDVRKFGTFDLIAKSQLSAFFAKRKLGPEPKKETFKLKTFEAALLSSQKPIKPHL
LDQTLVAGLGNIYVDEVLWAAKVHPETASSRLNKAEIKRLHDETIRILALGIEKGGSTVRTYRNALGADGTMQDYLQVYG
QTGKPCPRCGQAIVKLKVGGRGTHICPKCQKKRL

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger

Homologues:

Organism=Escherichia coli, GI1790066, Length=272, Percent_Identity=37.5, Blast_Score=179, Evalue=1e-46,
Organism=Escherichia coli, GI1786932, Length=277, Percent_Identity=24.9097472924188, Blast_Score=77, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FPG_STRP1 (Q9A131)

Other databases:

- EMBL:   AE004092
- EMBL:   CP000017
- RefSeq:   NP_268777.1
- RefSeq:   YP_281771.1
- ProteinModelPortal:   Q9A131
- SMR:   Q9A131
- EnsemblBacteria:   EBSTRT00000000164
- EnsemblBacteria:   EBSTRT00000027929
- GeneID:   3572502
- GeneID:   900727
- GenomeReviews:   AE004092_GR
- GenomeReviews:   CP000017_GR
- KEGG:   spy:SPy_0497
- KEGG:   spz:M5005_Spy_0408
- GeneTree:   EBGT00050000027561
- HOGENOM:   HBG690070
- OMA:   RSTFYCA
- ProtClustDB:   PRK01103
- BioCyc:   SPYO160490:SPY0497-MONOMER
- BioCyc:   SPYO293653:M5005_SPY0408-MONOMER
- HAMAP:   MF_00103
- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663
- SMART:   SM00898
- TIGRFAMs:   TIGR00577

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS; SSF81624 Form_DNAglyc_cat; SSF46946 Ribosomal_H2TH

EC number: =3.2.2.23; =4.2.99.18

Molecular weight: Translated: 30702; Mature: 30571

Theoretical pI: Translated: 10.18; Mature: 10.18

Prosite motif: PS51068 FPG_CAT; PS01242 ZF_FPG_1; PS51066 ZF_FPG_2

Important sites: ACT_SITE 2-2 ACT_SITE 3-3 ACT_SITE 58-58 ACT_SITE 262-262 BINDING 91-91 BINDING 110-110

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETVRRGLETLVLGQEIVAVTLKVPKMVKTDLETFALTLPGQIIQSVGRRGKYL
CCCCCCHHHHHHHHHHHHHCCHHEEEEECCHHHHHHHHHHHEEECCHHHHHHHCCCCCEE
LIDLGQLVLVSHLRMEGKYLLFPDEVPDNKHFHVFFELKNGSTLVYQDVRKFGTFDLIAK
EEEHHHHHHHHHHHHCCCEEECCCCCCCCCEEEEEEEECCCCEEHHHHHHHCCCHHHHHH
SQLSAFFAKRKLGPEPKKETFKLKTFEAALLSSQKPIKPHLLDQTLVAGLGNIYVDEVLW
HHHHHHHHHHHCCCCCCCHHEEHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AAKVHPETASSRLNKAEIKRLHDETIRILALGIEKGGSTVRTYRNALGADGTMQDYLQVY
HHHCCCHHHHHHCCHHHHHHHHHHHEEEEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHH
GQTGKPCPRCGQAIVKLKVGGRGTHICPKCQKKRL
CCCCCCCHHHHHEEEEEEECCCCCCCCCCHHCCCC
>Mature Secondary Structure 
PELPEVETVRRGLETLVLGQEIVAVTLKVPKMVKTDLETFALTLPGQIIQSVGRRGKYL
CCCCCHHHHHHHHHHHHHCCHHEEEEECCHHHHHHHHHHHEEECCHHHHHHHCCCCCEE
LIDLGQLVLVSHLRMEGKYLLFPDEVPDNKHFHVFFELKNGSTLVYQDVRKFGTFDLIAK
EEEHHHHHHHHHHHHCCCEEECCCCCCCCCEEEEEEEECCCCEEHHHHHHHCCCHHHHHH
SQLSAFFAKRKLGPEPKKETFKLKTFEAALLSSQKPIKPHLLDQTLVAGLGNIYVDEVLW
HHHHHHHHHHHCCCCCCCHHEEHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AAKVHPETASSRLNKAEIKRLHDETIRILALGIEKGGSTVRTYRNALGADGTMQDYLQVY
HHHCCCHHHHHHCCHHHHHHHHHHHEEEEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHH
GQTGKPCPRCGQAIVKLKVGGRGTHICPKCQKKRL
CCCCCCCHHHHHEEEEEEECCCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296