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The map label for this gene is coaE

Identifier: 15674604

GI number: 15674604

Start: 399752

End: 400345

Strand: Direct

Name: coaE

Synonym: SPy_0498

Alternate gene names: 15674604

Gene position: 399752-400345 (Clockwise)

Preceding gene: 15674603

Following gene: 15674605

Centisome position: 21.58

GC content: 41.75

Gene sequence:

>594_bases
ATGATTATTGGCATCACAGGAGGCATTGCATCAGGAAAATCGACTGTGGTTAAGGTCATTAGAAAAGCTGGTTATCAGGT
GATTGATGCGGATCAAGTGGTCCATGACTTGCAAGAAAAAGGCGGTCGTCTTTACGAGGCTCTTAGAGAAGCTTTTGGGA
ATCAGATTTTAAAAGCAGATGGTGAGTTAGATCGCACAAAGCTGTCAGAAATGCTTTTTTCAAACCCAGATAATATGGCA
ACATCCTCAGCCATTCAAAATCAAATCATTAAGGAAGAATTGGCGGCTAAGCGTGACCACTTAGCACAGAGCCAAGCCAT
TTTTTTCATGGATATTCCCCTTTTAATGGAATTGGGCTACCAAGACTGGTTTGATGCGATTTGGCTGGTTTATGTAGATG
CTCAGACACAATTGCAGCGCTTAATGGCTAGAAATCGTTTAGACAAAGGAAAAGCAAGGCAGCGAATAGCCAGTCAGTTA
CCAATAGAGGAAAAAAAGCCCTATGCCAGTCTAGTGATTGATAATAGTGGGGATATTGCAGCCTTAATAAAGCAAGTACA
ATCTGCGTTGTTGTTATTAGCCAATCCGAGGTAG

Upstream 100 bases:

>100_bases
AAACTGGGAAACCGTGTCCTCGTTGTGGACAGGCTATTGTCAAATTAAAAGTTGGAGGAAGGGGGACGCACATTTGTCCA
AAATGCCAGAAAAAAAGACT

Downstream 100 bases:

>100_bases
CTAAGCTGAGAGATTCGTATCATAGCTGTCAAAATCAAGCTATTTCTGTCTAAAACTAGCTGGTCCCTTTTAAATTAGCG
CATCAAGGGTTATATGTTAT

Product: dephospho-CoA kinase

Products: NA

Alternate protein names: Dephosphocoenzyme A kinase

Number of amino acids: Translated: 197; Mature: 197

Protein sequence:

>197_residues
MIIGITGGIASGKSTVVKVIRKAGYQVIDADQVVHDLQEKGGRLYEALREAFGNQILKADGELDRTKLSEMLFSNPDNMA
TSSAIQNQIIKEELAAKRDHLAQSQAIFFMDIPLLMELGYQDWFDAIWLVYVDAQTQLQRLMARNRLDKGKARQRIASQL
PIEEKKPYASLVIDNSGDIAALIKQVQSALLLLANPR

Sequences:

>Translated_197_residues
MIIGITGGIASGKSTVVKVIRKAGYQVIDADQVVHDLQEKGGRLYEALREAFGNQILKADGELDRTKLSEMLFSNPDNMA
TSSAIQNQIIKEELAAKRDHLAQSQAIFFMDIPLLMELGYQDWFDAIWLVYVDAQTQLQRLMARNRLDKGKARQRIASQL
PIEEKKPYASLVIDNSGDIAALIKQVQSALLLLANPR
>Mature_197_residues
MIIGITGGIASGKSTVVKVIRKAGYQVIDADQVVHDLQEKGGRLYEALREAFGNQILKADGELDRTKLSEMLFSNPDNMA
TSSAIQNQIIKEELAAKRDHLAQSQAIFFMDIPLLMELGYQDWFDAIWLVYVDAQTQLQRLMARNRLDKGKARQRIASQL
PIEEKKPYASLVIDNSGDIAALIKQVQSALLLLANPR

Specific function: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A

COG id: COG0237

COG function: function code H; Dephospho-CoA kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DPCK (dephospho-CoA kinase) domain

Homologues:

Organism=Homo sapiens, GI191252797, Length=188, Percent_Identity=35.1063829787234, Blast_Score=117, Evalue=8e-27,
Organism=Homo sapiens, GI191252795, Length=188, Percent_Identity=35.1063829787234, Blast_Score=117, Evalue=8e-27,
Organism=Homo sapiens, GI205277394, Length=193, Percent_Identity=27.4611398963731, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI110227607, Length=193, Percent_Identity=27.4611398963731, Blast_Score=85, Evalue=4e-17,
Organism=Homo sapiens, GI110227605, Length=193, Percent_Identity=27.4611398963731, Blast_Score=84, Evalue=9e-17,
Organism=Homo sapiens, GI110227603, Length=193, Percent_Identity=27.4611398963731, Blast_Score=84, Evalue=9e-17,
Organism=Homo sapiens, GI110227601, Length=193, Percent_Identity=27.4611398963731, Blast_Score=84, Evalue=9e-17,
Organism=Escherichia coli, GI1786292, Length=197, Percent_Identity=32.48730964467, Blast_Score=89, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17554944, Length=197, Percent_Identity=35.5329949238579, Blast_Score=127, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI25143409, Length=180, Percent_Identity=29.4444444444444, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320402, Length=196, Percent_Identity=28.0612244897959, Blast_Score=85, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24644728, Length=185, Percent_Identity=35.6756756756757, Blast_Score=124, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24658602, Length=197, Percent_Identity=30.9644670050761, Blast_Score=101, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAE_STRP1 (P58102)

Other databases:

- EMBL:   AE004092
- EMBL:   CP000017
- RefSeq:   NP_268778.1
- RefSeq:   YP_281772.1
- ProteinModelPortal:   P58102
- SMR:   P58102
- EnsemblBacteria:   EBSTRT00000000690
- EnsemblBacteria:   EBSTRT00000028249
- GeneID:   3572503
- GeneID:   900728
- GenomeReviews:   AE004092_GR
- GenomeReviews:   CP000017_GR
- KEGG:   spy:SPy_0498
- KEGG:   spz:M5005_Spy_0409
- GeneTree:   EBGT00050000027720
- HOGENOM:   HBG650290
- OMA:   IIAREVV
- ProtClustDB:   PRK00081
- BioCyc:   SPYO160490:SPY0498-MONOMER
- BioCyc:   SPYO293653:M5005_SPY0409-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00376
- InterPro:   IPR001977
- TIGRFAMs:   TIGR00152

Pfam domain/function: PF01121 CoaE

EC number: =2.7.1.24

Molecular weight: Translated: 21968; Mature: 21968

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: PS51219 DPCK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIGITGGIASGKSTVVKVIRKAGYQVIDADQVVHDLQEKGGRLYEALREAFGNQILKAD
CEEEECCCCCCCHHHHHHHHHHCCCEEECHHHHHHHHHHCCCHHHHHHHHHHCCHHHHCC
GELDRTKLSEMLFSNPDNMATSSAIQNQIIKEELAAKRDHLAQSQAIFFMDIPLLMELGY
CCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHCCH
QDWFDAIWLVYVDAQTQLQRLMARNRLDKGKARQRIASQLPIEEKKPYASLVIDNSGDIA
HHHHHHHHHHEECHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCCHH
ALIKQVQSALLLLANPR
HHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIIGITGGIASGKSTVVKVIRKAGYQVIDADQVVHDLQEKGGRLYEALREAFGNQILKAD
CEEEECCCCCCCHHHHHHHHHHCCCEEECHHHHHHHHHHCCCHHHHHHHHHHCCHHHHCC
GELDRTKLSEMLFSNPDNMATSSAIQNQIIKEELAAKRDHLAQSQAIFFMDIPLLMELGY
CCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHCCH
QDWFDAIWLVYVDAQTQLQRLMARNRLDKGKARQRIASQLPIEEKKPYASLVIDNSGDIA
HHHHHHHHHHEECHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCCHH
ALIKQVQSALLLLANPR
HHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296