Definition Streptococcus pyogenes M1 GAS chromosome, complete genome.
Accession NC_002737
Length 1,852,441

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The map label for this gene is purD

Identifier: 15674274

GI number: 15674274

Start: 46500

End: 47765

Strand: Direct

Name: purD

Synonym: SPy_0032

Alternate gene names: 15674274

Gene position: 46500-47765 (Clockwise)

Preceding gene: 15674272

Following gene: 15674275

Centisome position: 2.51

GC content: 48.74

Gene sequence:

>1266_bases
TTGAAATTACTTGTTGTTGGTTCAGGTGGTCGTGAACATGCGATTGCTAAGAAGTTGTTAGCGTCTAAGGGTGTGGATCA
GGTTTTTGTGGCACCTGGTAATGATGGTATGACCTTGGATGGTCTGGACTTGGTGAATATAGTAGTTTCCGAACATTCCA
GGTTGATTGCCTTTGCTAAGGAGAATGAGATTTCTTGGGCCTTTATTGGTCCTGATGATGCGCTAGCAGCTGGTATCGTT
GATGATTTCAACAGTGCTGGACTCAGAGCTTTTGGTCCAACAAAGGCAGCAGCGGAGCTAGAGTGGTCAAAAGACTTTGC
CAAGGAAATCATGGTCAAATACAATGTCCCAACAGCAGCCTATGGCACATTTTCAGACTTTGAAAAAGCCAAAGCCTACA
TCGAAGAGCAGGGCGCACCTATCGTGGTCAAGGCTGATGGCTTGGCGCTAGGTAAGGGTGTGGTCGTGGCTGAAACCGTT
GAGCAGGCGGTAGAGGCGGCGCAAGAGATGCTTCTGGACAATAAGTTTGGCGATTCAGGAGCGCGTGTGGTTATCGAGGA
ATTCTTGGATGGCGAGGAGTTTTCCCTCTTTGCCTTTGCTAATGGCGATAAGTTCTACATCATGCCGACAGCTCAGGATC
ACAAGCGTGCCTTTGACGGAGACAAGGGGCCAAACACTGGTGGTATGGGTGCCTATGCGCCAGTTCCTCATCTACCTCAG
AGCGTGGTAGACACAGCGGTTGAGATGATCGTTAGGCCTGTCCTTGAGGGCATGGTTGCCGAAGGGCGTCCTTATCTAGG
TGTCCTCTATGTGGGGCTTATCCTGACAGCTGATGGACCTAAGGTTATCGAGTTCAACTCACGTTTCGGTGACCCTGAAA
CTCAGATTATCCTCCCTCGCCTGACTTCTGATTTCGCTCAGAATATTGACGATATCATGATGGGCATTGAGCCTTACATC
ACTTGGCAGAAGGACGGTGTGACTTTGGGTGTTGTCGTTGCCTCAGAAGGCTATCCATTCGATTATGAGAAAGGTGTGCC
ACTGCCTGAAAAGACCGACGGCGATATCATCACCTACTACGCAGGAGTTAAGTTTTCGGAAAATAGCGAGCTACTTCTCT
CAAACGGAGGACGTGTCTATATGCTCGTCACCACAGAAGACAGCGTCAAAGCAGGGCAGGACAAAATCTATACCCAACTG
GCCCAACAAGACACAACAGGTCTCTTCTACCGAAATGATATCGGAAGCAAAGCTATAAGAGAATAA

Upstream 100 bases:

>100_bases
CATTTTTACAATGTTTCAATTATTGATAACTAATACATTATGTAAAAAAGCGAACGTTTATGATATAATATCTAATTATA
ATACGAAAGAGGTGGATGTT

Downstream 100 bases:

>100_bases
GACTAACCATTCAAATATTAGCGTCAGCAATCAGCGACCGAAGGTCGCTCCAAAAAGAAAGAAGAAAGGAACTGAACACG
GGACTAATTTCCCAGGAAAA

Product: phosphoribosylamine--glycine ligase

Products: NA

Alternate protein names: GARS; Glycinamide ribonucleotide synthetase; Phosphoribosylglycinamide synthetase

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MKLLVVGSGGREHAIAKKLLASKGVDQVFVAPGNDGMTLDGLDLVNIVVSEHSRLIAFAKENEISWAFIGPDDALAAGIV
DDFNSAGLRAFGPTKAAAELEWSKDFAKEIMVKYNVPTAAYGTFSDFEKAKAYIEEQGAPIVVKADGLALGKGVVVAETV
EQAVEAAQEMLLDNKFGDSGARVVIEEFLDGEEFSLFAFANGDKFYIMPTAQDHKRAFDGDKGPNTGGMGAYAPVPHLPQ
SVVDTAVEMIVRPVLEGMVAEGRPYLGVLYVGLILTADGPKVIEFNSRFGDPETQIILPRLTSDFAQNIDDIMMGIEPYI
TWQKDGVTLGVVVASEGYPFDYEKGVPLPEKTDGDIITYYAGVKFSENSELLLSNGGRVYMLVTTEDSVKAGQDKIYTQL
AQQDTTGLFYRNDIGSKAIRE

Sequences:

>Translated_421_residues
MKLLVVGSGGREHAIAKKLLASKGVDQVFVAPGNDGMTLDGLDLVNIVVSEHSRLIAFAKENEISWAFIGPDDALAAGIV
DDFNSAGLRAFGPTKAAAELEWSKDFAKEIMVKYNVPTAAYGTFSDFEKAKAYIEEQGAPIVVKADGLALGKGVVVAETV
EQAVEAAQEMLLDNKFGDSGARVVIEEFLDGEEFSLFAFANGDKFYIMPTAQDHKRAFDGDKGPNTGGMGAYAPVPHLPQ
SVVDTAVEMIVRPVLEGMVAEGRPYLGVLYVGLILTADGPKVIEFNSRFGDPETQIILPRLTSDFAQNIDDIMMGIEPYI
TWQKDGVTLGVVVASEGYPFDYEKGVPLPEKTDGDIITYYAGVKFSENSELLLSNGGRVYMLVTTEDSVKAGQDKIYTQL
AQQDTTGLFYRNDIGSKAIRE
>Mature_421_residues
MKLLVVGSGGREHAIAKKLLASKGVDQVFVAPGNDGMTLDGLDLVNIVVSEHSRLIAFAKENEISWAFIGPDDALAAGIV
DDFNSAGLRAFGPTKAAAELEWSKDFAKEIMVKYNVPTAAYGTFSDFEKAKAYIEEQGAPIVVKADGLALGKGVVVAETV
EQAVEAAQEMLLDNKFGDSGARVVIEEFLDGEEFSLFAFANGDKFYIMPTAQDHKRAFDGDKGPNTGGMGAYAPVPHLPQ
SVVDTAVEMIVRPVLEGMVAEGRPYLGVLYVGLILTADGPKVIEFNSRFGDPETQIILPRLTSDFAQNIDDIMMGIEPYI
TWQKDGVTLGVVVASEGYPFDYEKGVPLPEKTDGDIITYYAGVKFSENSELLLSNGGRVYMLVTTEDSVKAGQDKIYTQL
AQQDTTGLFYRNDIGSKAIRE

Specific function: De novo purine biosynthesis; second step. [C]

COG id: COG0151

COG function: function code F; Phosphoribosylamine-glycine ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain

Homologues:

Organism=Homo sapiens, GI4503915, Length=425, Percent_Identity=43.0588235294118, Blast_Score=349, Evalue=3e-96,
Organism=Homo sapiens, GI209869995, Length=425, Percent_Identity=43.0588235294118, Blast_Score=349, Evalue=3e-96,
Organism=Homo sapiens, GI209869993, Length=425, Percent_Identity=43.0588235294118, Blast_Score=349, Evalue=3e-96,
Organism=Homo sapiens, GI28416899, Length=425, Percent_Identity=43.0588235294118, Blast_Score=349, Evalue=3e-96,
Organism=Escherichia coli, GI1790438, Length=427, Percent_Identity=45.6674473067916, Blast_Score=355, Evalue=4e-99,
Organism=Caenorhabditis elegans, GI17567511, Length=425, Percent_Identity=37.6470588235294, Blast_Score=245, Evalue=3e-65,
Organism=Saccharomyces cerevisiae, GI6321203, Length=447, Percent_Identity=38.7024608501119, Blast_Score=302, Evalue=8e-83,
Organism=Drosophila melanogaster, GI62471619, Length=432, Percent_Identity=42.5925925925926, Blast_Score=304, Evalue=7e-83,
Organism=Drosophila melanogaster, GI24582400, Length=432, Percent_Identity=42.5925925925926, Blast_Score=304, Evalue=9e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PUR2_STRP1 (Q9A1Y7)

Other databases:

- EMBL:   AE004092
- EMBL:   CP000017
- RefSeq:   NP_268447.1
- RefSeq:   YP_281393.1
- ProteinModelPortal:   Q9A1Y7
- SMR:   Q9A1Y7
- EnsemblBacteria:   EBSTRT00000001431
- EnsemblBacteria:   EBSTRT00000027444
- GeneID:   3572913
- GeneID:   900390
- GenomeReviews:   AE004092_GR
- GenomeReviews:   CP000017_GR
- KEGG:   spy:SPy_0032
- KEGG:   spz:M5005_Spy_0029
- GeneTree:   EBGT00050000027598
- HOGENOM:   HBG404060
- OMA:   GVPIVIK
- ProtClustDB:   PRK00885
- BioCyc:   SPYO160490:SPY0032-MONOMER
- BioCyc:   SPYO293653:M5005_SPY0029-MONOMER
- HAMAP:   MF_00138
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR020561
- InterPro:   IPR000115
- InterPro:   IPR020560
- InterPro:   IPR020559
- InterPro:   IPR020562
- InterPro:   IPR011054
- Gene3D:   G3DSA:3.30.1490.20
- Gene3D:   G3DSA:3.30.470.20
- Gene3D:   G3DSA:3.90.600.10
- Gene3D:   G3DSA:3.40.50.20
- TIGRFAMs:   TIGR00877

Pfam domain/function: PF01071 GARS_A; PF02843 GARS_C; PF02844 GARS_N; SSF52440 PreATP-grasp-like; SSF51246 Rudmnt_hyb_motif

EC number: =6.3.4.13

Molecular weight: Translated: 45481; Mature: 45481

Theoretical pI: Translated: 4.28; Mature: 4.28

Prosite motif: PS50975 ATP_GRASP; PS00184 GARS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLVVGSGGREHAIAKKLLASKGVDQVFVAPGNDGMTLDGLDLVNIVVSEHSRLIAFAK
CEEEEECCCCCHHHHHHHHHHHCCCCEEEEECCCCCCEECCHHHHHHHHHCCCEEEEEEE
ENEISWAFIGPDDALAAGIVDDFNSAGLRAFGPTKAAAELEWSKDFAKEIMVKYNVPTAA
CCCEEEEEECCCHHHHHHHHHCCCCCCCEECCCCCCHHCCHHHHHHHHHEEEEECCCCCC
YGTFSDFEKAKAYIEEQGAPIVVKADGLALGKGVVVAETVEQAVEAAQEMLLDNKFGDSG
CCCHHHHHHHHHHHHHCCCEEEEEECCEEECCCEEEHHHHHHHHHHHHHHHHCCCCCCCC
ARVVIEEFLDGEEFSLFAFANGDKFYIMPTAQDHKRAFDGDKGPNTGGMGAYAPVPHLPQ
HHHHHHHHCCCCCEEEEEEECCCEEEEECCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCH
SVVDTAVEMIVRPVLEGMVAEGRPYLGVLYVGLILTADGPKVIEFNSRFGDPETQIILPR
HHHHHHHHHHHHHHHHHHHHCCCCHHHEEEEEEEEECCCCEEEEECCCCCCCCCEEEEHH
LTSDFAQNIDDIMMGIEPYITWQKDGVTLGVVVASEGYPFDYEKGVPLPEKTDGDIITYY
HHHHHHHCHHHHHHCCCCEEEEECCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEE
AGVKFSENSELLLSNGGRVYMLVTTEDSVKAGQDKIYTQLAQQDTTGLFYRNDIGSKAIR
ECEEECCCCCEEEECCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCHHHC
E
C
>Mature Secondary Structure
MKLLVVGSGGREHAIAKKLLASKGVDQVFVAPGNDGMTLDGLDLVNIVVSEHSRLIAFAK
CEEEEECCCCCHHHHHHHHHHHCCCCEEEEECCCCCCEECCHHHHHHHHHCCCEEEEEEE
ENEISWAFIGPDDALAAGIVDDFNSAGLRAFGPTKAAAELEWSKDFAKEIMVKYNVPTAA
CCCEEEEEECCCHHHHHHHHHCCCCCCCEECCCCCCHHCCHHHHHHHHHEEEEECCCCCC
YGTFSDFEKAKAYIEEQGAPIVVKADGLALGKGVVVAETVEQAVEAAQEMLLDNKFGDSG
CCCHHHHHHHHHHHHHCCCEEEEEECCEEECCCEEEHHHHHHHHHHHHHHHHCCCCCCCC
ARVVIEEFLDGEEFSLFAFANGDKFYIMPTAQDHKRAFDGDKGPNTGGMGAYAPVPHLPQ
HHHHHHHHCCCCCEEEEEEECCCEEEEECCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCH
SVVDTAVEMIVRPVLEGMVAEGRPYLGVLYVGLILTADGPKVIEFNSRFGDPETQIILPR
HHHHHHHHHHHHHHHHHHHHCCCCHHHEEEEEEEEECCCCEEEEECCCCCCCCCEEEEHH
LTSDFAQNIDDIMMGIEPYITWQKDGVTLGVVVASEGYPFDYEKGVPLPEKTDGDIITYY
HHHHHHHCHHHHHHCCCCEEEEECCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEE
AGVKFSENSELLLSNGGRVYMLVTTEDSVKAGQDKIYTQLAQQDTTGLFYRNDIGSKAIR
ECEEECCCCCEEEECCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCHHHC
E
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11296296