Definition Streptococcus pyogenes M1 GAS chromosome, complete genome.
Accession NC_002737
Length 1,852,441

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The map label for this gene is tilS

Identifier: 15674260

GI number: 15674260

Start: 10951

End: 12237

Strand: Direct

Name: tilS

Synonym: SPy_0013

Alternate gene names: 15674260

Gene position: 10951-12237 (Clockwise)

Preceding gene: 15674259

Following gene: 15674261

Centisome position: 0.59

GC content: 28.44

Gene sequence:

>1287_bases
ATGATGACCTATCAAGAAATTTTTAATGAAATAAAAAATAAAGCCTACTTTAAAAATCATAGACATGTGTTAATAGCCGT
ATCTGGTGGAGTAGATTCAATGAATTTATTGCACTTTTTATACCTGTTTCAAGACAAATTGAAAATTCGTATTGGTATTG
CTCATGTTAATCACAAACAAAGATCAGAATCAGATTCAGAAGAAGCTTATTTAAAGTGTTGGGCTAAAAAACATGACATA
CCTATTTATGTTTCTAATTTTGAAGGAATATTTTCAGAAAAAGCAGCACGTGATTGGCGCTATGCTTTTTTTAAGAGTAT
TATGTTAAAAAATAACTATTCAGCTTTAGTAACAGCTCACCATTCAGATGATCAAGCAGAAACTATTTTGATGAGGCTAA
TTAGAGGAAGCCGATTGAGGCACTTGTCGGGTATAAAAAGCGTGCAACCATTTGCCAATGGTCAACTTATAAGACCTTTT
TTAACTTTCTCAAAAAAGGACTTGCCAGAAATTTTTCATTTTGAAGATTCTTCAAATAGAGAATTATCATTTTTAAGAAA
TAGAGTTAGAAATAATTATTTACCACTGTTAAAGCAGGAAAATCCTAGGTTCATTCAGGGATTAAATCAATTAGCACTTG
AAAATAGCTTACTTTTTCAAGCTTTTAAGGAGCTAACAAATCATATTACTACCACTGATTTAACAGAATTTAATGAGCAA
TCTAAGTCAATTCAATACTTTTTGTTACAAGATTATTTAGAAGGTTTTCCAGATTTAGATTTAAAAAAATCTCAATTTAC
TCAATTATTGCAAATTATCCAAACTGCTAAACAAGGCTATTATTATCTCAAAAAAGACTATTATATATTCATTGATAAAT
TCTCTTTTAAAATTACAAAAATCGTTCCTAAGACTGAGTTAGTTAAAGAAGAAAAAATGTTAGAATACGATAGTAACTTA
TGCTACAGAGATTATTATTTTTCATTTATGCCAAAAAGTAACGAAGATCAAGGACAGGTAAGTATACCTTTATTTAGTTT
ATCGTCTATTAAATTAAGAAGTCGCCAATCTGGAGATTATATTTCTTTTGGTCACTTTTCAAAAAAAATAAGACGTTTAT
TTATAGATGAAAAATTCACAATAGCTGAACGTCAAAATGCTATTATTGGAGAGCAAGATGAGCAGATTATATTTGTATTG
ATAGGTAATAAAACTTATTTGAGAAAAGCTTGTAAACATGATATAATGTTGGCTAAACTGTATATTGATAAATTAGAAAA
AGGGTGA

Upstream 100 bases:

>100_bases
TTGTTTACGGTAATACTCCATTTATTTTGTCTATTTTTACAAATAAATCAACCTATGAAGATATTACGGCTATTGCAGAT
GACGTTTATGGTATTTTAAA

Downstream 100 bases:

>100_bases
CAGCATGCTCGAGCAAGATATTCAAAAAATTCTTTACTCTGAAAATGATATTATTCGGAAAACTAAAAAATTAGGAGAAC
AATTAACAAAAGATTATCAA

Product: putative cell-cycle protein

Products: NA

Alternate protein names: tRNA(Ile)-2-lysyl-cytidine synthase; tRNA(Ile)-lysidine synthetase

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MMTYQEIFNEIKNKAYFKNHRHVLIAVSGGVDSMNLLHFLYLFQDKLKIRIGIAHVNHKQRSESDSEEAYLKCWAKKHDI
PIYVSNFEGIFSEKAARDWRYAFFKSIMLKNNYSALVTAHHSDDQAETILMRLIRGSRLRHLSGIKSVQPFANGQLIRPF
LTFSKKDLPEIFHFEDSSNRELSFLRNRVRNNYLPLLKQENPRFIQGLNQLALENSLLFQAFKELTNHITTTDLTEFNEQ
SKSIQYFLLQDYLEGFPDLDLKKSQFTQLLQIIQTAKQGYYYLKKDYYIFIDKFSFKITKIVPKTELVKEEKMLEYDSNL
CYRDYYFSFMPKSNEDQGQVSIPLFSLSSIKLRSRQSGDYISFGHFSKKIRRLFIDEKFTIAERQNAIIGEQDEQIIFVL
IGNKTYLRKACKHDIMLAKLYIDKLEKG

Sequences:

>Translated_428_residues
MMTYQEIFNEIKNKAYFKNHRHVLIAVSGGVDSMNLLHFLYLFQDKLKIRIGIAHVNHKQRSESDSEEAYLKCWAKKHDI
PIYVSNFEGIFSEKAARDWRYAFFKSIMLKNNYSALVTAHHSDDQAETILMRLIRGSRLRHLSGIKSVQPFANGQLIRPF
LTFSKKDLPEIFHFEDSSNRELSFLRNRVRNNYLPLLKQENPRFIQGLNQLALENSLLFQAFKELTNHITTTDLTEFNEQ
SKSIQYFLLQDYLEGFPDLDLKKSQFTQLLQIIQTAKQGYYYLKKDYYIFIDKFSFKITKIVPKTELVKEEKMLEYDSNL
CYRDYYFSFMPKSNEDQGQVSIPLFSLSSIKLRSRQSGDYISFGHFSKKIRRLFIDEKFTIAERQNAIIGEQDEQIIFVL
IGNKTYLRKACKHDIMLAKLYIDKLEKG
>Mature_428_residues
MMTYQEIFNEIKNKAYFKNHRHVLIAVSGGVDSMNLLHFLYLFQDKLKIRIGIAHVNHKQRSESDSEEAYLKCWAKKHDI
PIYVSNFEGIFSEKAARDWRYAFFKSIMLKNNYSALVTAHHSDDQAETILMRLIRGSRLRHLSGIKSVQPFANGQLIRPF
LTFSKKDLPEIFHFEDSSNRELSFLRNRVRNNYLPLLKQENPRFIQGLNQLALENSLLFQAFKELTNHITTTDLTEFNEQ
SKSIQYFLLQDYLEGFPDLDLKKSQFTQLLQIIQTAKQGYYYLKKDYYIFIDKFSFKITKIVPKTELVKEEKMLEYDSNL
CYRDYYFSFMPKSNEDQGQVSIPLFSLSSIKLRSRQSGDYISFGHFSKKIRRLFIDEKFTIAERQNAIIGEQDEQIIFVL
IGNKTYLRKACKHDIMLAKLYIDKLEKG

Specific function: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionin

COG id: COG0037

COG function: function code D; Predicted ATPase of the PP-loop superfamily implicated in cell cycle control

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tRNA(Ile)-lysidine synthase family

Homologues:

Organism=Escherichia coli, GI1786386, Length=197, Percent_Identity=34.010152284264, Blast_Score=100, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TILS_STRP1 (Q9A201)

Other databases:

- EMBL:   AE004092
- EMBL:   CP000017
- RefSeq:   NP_268433.1
- RefSeq:   YP_281375.1
- ProteinModelPortal:   Q9A201
- SMR:   Q9A201
- EnsemblBacteria:   EBSTRT00000000176
- EnsemblBacteria:   EBSTRT00000027617
- GeneID:   3572950
- GeneID:   900376
- GenomeReviews:   AE004092_GR
- GenomeReviews:   CP000017_GR
- KEGG:   spy:SPy_0013
- KEGG:   spz:M5005_Spy_0011
- GeneTree:   EBGT00050000027463
- HOGENOM:   HBG697356
- OMA:   HVECKKI
- ProtClustDB:   CLSK876678
- BioCyc:   SPYO160490:SPY0013-MONOMER
- BioCyc:   SPYO293653:M5005_SPY0011-MONOMER
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_01161
- InterPro:   IPR012094
- InterPro:   IPR012796
- InterPro:   IPR012795
- InterPro:   IPR014729
- InterPro:   IPR011063
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR11807:SF2
- SMART:   SM00977
- TIGRFAMs:   TIGR02433
- TIGRFAMs:   TIGR02432

Pfam domain/function: PF01171 ATP_bind_3

EC number: NA

Molecular weight: Translated: 50547; Mature: 50547

Theoretical pI: Translated: 9.64; Mature: 9.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMTYQEIFNEIKNKAYFKNHRHVLIAVSGGVDSMNLLHFLYLFQDKLKIRIGIAHVNHKQ
CCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHCCEEEEEEEEECCCHH
RSESDSEEAYLKCWAKKHDIPIYVSNFEGIFSEKAARDWRYAFFKSIMLKNNYSALVTAH
CCCCCCHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEE
HSDDQAETILMRLIRGSRLRHLSGIKSVQPFANGQLIRPFLTFSKKDLPEIFHFEDSSNR
CCCCHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCEEHHHHHCCCCCCCHHEECCCCCCC
ELSFLRNRVRNNYLPLLKQENPRFIQGLNQLALENSLLFQAFKELTNHITTTDLTEFNEQ
HHHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
SKSIQYFLLQDYLEGFPDLDLKKSQFTQLLQIIQTAKQGYYYLKKDYYIFIDKFSFKITK
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEECCEEEEEEECCEEEEE
IVPKTELVKEEKMLEYDSNLCYRDYYFSFMPKSNEDQGQVSIPLFSLSSIKLRSRQSGDY
ECCHHHHHHHHHHHHHCCCCEEEEHEEEECCCCCCCCCEEEEEEEECCCEEEECCCCCCE
ISFGHFSKKIRRLFIDEKFTIAERQNAIIGEQDEQIIFVLIGNKTYLRKACKHDIMLAKL
EEHHHHHHHHHHHHCCCCEEHHHHCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHH
YIDKLEKG
HHHHHCCC
>Mature Secondary Structure
MMTYQEIFNEIKNKAYFKNHRHVLIAVSGGVDSMNLLHFLYLFQDKLKIRIGIAHVNHKQ
CCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHCCEEEEEEEEECCCHH
RSESDSEEAYLKCWAKKHDIPIYVSNFEGIFSEKAARDWRYAFFKSIMLKNNYSALVTAH
CCCCCCHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEE
HSDDQAETILMRLIRGSRLRHLSGIKSVQPFANGQLIRPFLTFSKKDLPEIFHFEDSSNR
CCCCHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCEEHHHHHCCCCCCCHHEECCCCCCC
ELSFLRNRVRNNYLPLLKQENPRFIQGLNQLALENSLLFQAFKELTNHITTTDLTEFNEQ
HHHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
SKSIQYFLLQDYLEGFPDLDLKKSQFTQLLQIIQTAKQGYYYLKKDYYIFIDKFSFKITK
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEECCEEEEEEECCEEEEE
IVPKTELVKEEKMLEYDSNLCYRDYYFSFMPKSNEDQGQVSIPLFSLSSIKLRSRQSGDY
ECCHHHHHHHHHHHHHCCCCEEEEHEEEECCCCCCCCCEEEEEEEECCCEEEECCCCCCE
ISFGHFSKKIRRLFIDEKFTIAERQNAIIGEQDEQIIFVLIGNKTYLRKACKHDIMLAKL
EEHHHHHHHHHHHHCCCCEEHHHHCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHH
YIDKLEKG
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11296296