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The map label for this gene is lig [H]

Identifier: 161621447

GI number: 161621447

Start: 4396202

End: 4397803

Strand: Reverse

Name: lig [H]

Synonym: mll5481

Alternate gene names: 161621447

Gene position: 4397803-4396202 (Counterclockwise)

Preceding gene: 13474573

Following gene: 13474567

Centisome position: 62.5

GC content: 65.54

Gene sequence:

>1602_bases
ATGAACCGCTTCGCCGAACTTCTCGACCGCCTGGTGCTGACGCCGTCGCGCAACGGCAAGCTGACGCTGCTGGTCGACTA
TTTCCGAACCGTCGAGGACCCGGATCGCGGGCTGGCGCTGGCCGCCATCACCGGCGATCTCAAAATAGCCGCGGTCAAAC
CGGCCATGCTGCGCATGCTGGTCACCGAACGCATGGACCCGGTGCTGTTCGGCTATTCCTACGACTATGTCGGCGACCTC
GCCGAGACGGTGTCGCTGGTCTGGCCGCAGACGCCGGGCAAGATCCCCAACCGCGAGCCGACGCTCGGCGAGGTCGTGGC
CAAACTGCAGGCGGCAAGCCGCTCCGACGGACCGAAAGTGCTGGCCAGCCTGCTCGACAGCGCCGGCATCTCGGCGCGCT
TCGCCATCATCAAGCTGGTCACCGGCGGCCTGCGCATCGGCGTCTCGGCGCGGCTGGCCAAACAGGCGCTGGCGGATTTC
GGCAAGGTCGACGTCGCCGAGATCGAGGAGCTCTGGCACGGACTGTCGCCGCCCTATACGGCGTTGTTCGCCTGGCTGGA
AGGCAAGGCCGAAAAACCCCGCAACACGGCGATGGCTTTGTTCCGTCCGGTCATGCTGTCGAACCCGGTTGGCGACGGCG
ATCTCGAAAAACTCGATCCGGCGGACTACGCGGCCGAATGGAAATGGGACGGCATCCGTGTCCAGGCGGTGGCGGAAGGC
GGCATCCGCCGGCTCTATTCGCGCACCGGCGACGATGTCTCCGGCGCCTTTCCCGACCTCGCAGACGCCATGCATTTTTC
CGCGACGCTGGACGGCGAATTGCTGGTCGGCGACCCGCGAGAGGCGACGGGAACCTTCTCGGATTTGCAGCAGCGGTTGA
ACCGCAAGACGGTGACGCCGAAGATGCAGCAGCAATATCCGGCCTTCATGCGCTGCTACGACCTGCTTCAGGTCGGCGAT
GAAGACCTTCGCGCATTGCCGTTCCGGGAACGGCGCGGCCGCCTCGAAGCCTTCGTGAAAACGCTCGACCCCGGCCGTTT
CGACCTGTCGCCCTTCGTCGCCTTCGCGGACTGGCAGGTGCTGGAGGATTTGCGCCGCGCGCCGCCGCATCCGATCATCG
AGGGCGTGATGCTGAAACGCTGGGATTCGCCCTATGTCGCCGGCCGGCCGAAAGGCCCGTGGTTCAAGTGGAAGCGCGAT
CCGCACACGGTGGACGCGGTGCTGATGTATGCCCAGCGCGGCCATGGCAAGCGCTCGAGTTTTTACTCCGACTACACGTT
CGGCGTCTGGTCCGGAGCTGAGGGCGAGGAGGAACTGGTGCCGGTCGGCAAGGCCTATTTCGGCTTCACCGACGAGGAGC
TGAAGCAGATCGACAAATATGTCCGGGACAACACGGTCGAGCGTTTCGGGCCGGTGCGTTCGGTGCGGGCGGACCGCGAC
AATGGCCTGGTGCTGGAAGTCGCCTTCGAGGGGCTCAACCGCTCGACCCGACACAAATCCGGCGTCGCCATGCGCTTTCC
CCGCATTTCACGGCTGCGCTGGGACAAGCCGGCCAACGAAGCCGACCGCATCGAGACGCTGCAAGCGCTGCTCGACCGCT
AG

Upstream 100 bases:

>100_bases
CATGGCCGCGAGGAGGCCCTCGTGCGCTGGTGCGAGCTCGAAGGCATCGCCGCCCGGCCGTTGCATCTGGTGGGGTATGA
GGACGAGGGCGATTGAAGGC

Downstream 100 bases:

>100_bases
AGTCCTACGGCTCGATCGAGACGCGGATCTCGTAGATGTCGACCGCCTTGCCCTGCTTGTCGAAATCGGAATTGACGGCG
ATGGTTCCGGCCGAGCCCGG

Product: ATP-dependent DNA ligase

Products: NA

Alternate protein names: Polydeoxyribonucleotide synthase [ATP] [H]

Number of amino acids: Translated: 533; Mature: 533

Protein sequence:

>533_residues
MNRFAELLDRLVLTPSRNGKLTLLVDYFRTVEDPDRGLALAAITGDLKIAAVKPAMLRMLVTERMDPVLFGYSYDYVGDL
AETVSLVWPQTPGKIPNREPTLGEVVAKLQAASRSDGPKVLASLLDSAGISARFAIIKLVTGGLRIGVSARLAKQALADF
GKVDVAEIEELWHGLSPPYTALFAWLEGKAEKPRNTAMALFRPVMLSNPVGDGDLEKLDPADYAAEWKWDGIRVQAVAEG
GIRRLYSRTGDDVSGAFPDLADAMHFSATLDGELLVGDPREATGTFSDLQQRLNRKTVTPKMQQQYPAFMRCYDLLQVGD
EDLRALPFRERRGRLEAFVKTLDPGRFDLSPFVAFADWQVLEDLRRAPPHPIIEGVMLKRWDSPYVAGRPKGPWFKWKRD
PHTVDAVLMYAQRGHGKRSSFYSDYTFGVWSGAEGEEELVPVGKAYFGFTDEELKQIDKYVRDNTVERFGPVRSVRADRD
NGLVLEVAFEGLNRSTRHKSGVAMRFPRISRLRWDKPANEADRIETLQALLDR

Sequences:

>Translated_533_residues
MNRFAELLDRLVLTPSRNGKLTLLVDYFRTVEDPDRGLALAAITGDLKIAAVKPAMLRMLVTERMDPVLFGYSYDYVGDL
AETVSLVWPQTPGKIPNREPTLGEVVAKLQAASRSDGPKVLASLLDSAGISARFAIIKLVTGGLRIGVSARLAKQALADF
GKVDVAEIEELWHGLSPPYTALFAWLEGKAEKPRNTAMALFRPVMLSNPVGDGDLEKLDPADYAAEWKWDGIRVQAVAEG
GIRRLYSRTGDDVSGAFPDLADAMHFSATLDGELLVGDPREATGTFSDLQQRLNRKTVTPKMQQQYPAFMRCYDLLQVGD
EDLRALPFRERRGRLEAFVKTLDPGRFDLSPFVAFADWQVLEDLRRAPPHPIIEGVMLKRWDSPYVAGRPKGPWFKWKRD
PHTVDAVLMYAQRGHGKRSSFYSDYTFGVWSGAEGEEELVPVGKAYFGFTDEELKQIDKYVRDNTVERFGPVRSVRADRD
NGLVLEVAFEGLNRSTRHKSGVAMRFPRISRLRWDKPANEADRIETLQALLDR
>Mature_533_residues
MNRFAELLDRLVLTPSRNGKLTLLVDYFRTVEDPDRGLALAAITGDLKIAAVKPAMLRMLVTERMDPVLFGYSYDYVGDL
AETVSLVWPQTPGKIPNREPTLGEVVAKLQAASRSDGPKVLASLLDSAGISARFAIIKLVTGGLRIGVSARLAKQALADF
GKVDVAEIEELWHGLSPPYTALFAWLEGKAEKPRNTAMALFRPVMLSNPVGDGDLEKLDPADYAAEWKWDGIRVQAVAEG
GIRRLYSRTGDDVSGAFPDLADAMHFSATLDGELLVGDPREATGTFSDLQQRLNRKTVTPKMQQQYPAFMRCYDLLQVGD
EDLRALPFRERRGRLEAFVKTLDPGRFDLSPFVAFADWQVLEDLRRAPPHPIIEGVMLKRWDSPYVAGRPKGPWFKWKRD
PHTVDAVLMYAQRGHGKRSSFYSDYTFGVWSGAEGEEELVPVGKAYFGFTDEELKQIDKYVRDNTVERFGPVRSVRADRD
NGLVLEVAFEGLNRSTRHKSGVAMRFPRISRLRWDKPANEADRIETLQALLDR

Specific function: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair [H]

COG id: COG1793

COG function: function code L; ATP-dependent DNA ligase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent DNA ligase family [H]

Homologues:

Organism=Homo sapiens, GI4557719, Length=353, Percent_Identity=27.4787535410765, Blast_Score=87, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71985269, Length=485, Percent_Identity=26.5979381443299, Blast_Score=108, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6320038, Length=520, Percent_Identity=23.6538461538462, Blast_Score=87, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022865
- InterPro:   IPR000977
- InterPro:   IPR012309
- InterPro:   IPR012310
- InterPro:   IPR016059
- InterPro:   IPR012308
- InterPro:   IPR012340
- InterPro:   IPR016027 [H]

Pfam domain/function: PF04679 DNA_ligase_A_C; PF01068 DNA_ligase_A_M; PF04675 DNA_ligase_A_N [H]

EC number: =6.5.1.1 [H]

Molecular weight: Translated: 59731; Mature: 59731

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: PS00697 DNA_LIGASE_A1 ; PS50160 DNA_LIGASE_A3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRFAELLDRLVLTPSRNGKLTLLVDYFRTVEDPDRGLALAAITGDLKIAAVKPAMLRML
CCHHHHHHHHHHCCCCCCCCEEEEEHHHHHCCCCCCCEEEEEEECCEEEEEECHHHHHHH
VTERMDPVLFGYSYDYVGDLAETVSLVWPQTPGKIPNREPTLGEVVAKLQAASRSDGPKV
HHHCCCCEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHH
LASLLDSAGISARFAIIKLVTGGLRIGVSARLAKQALADFGKVDVAEIEELWHGLSPPYT
HHHHHHCCCCHHHHHHHHHHHCCCEECHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHH
ALFAWLEGKAEKPRNTAMALFRPVMLSNPVGDGDLEKLDPADYAAEWKWDGIRVQAVAEG
HHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEECCEEEEEEHHH
GIRRLYSRTGDDVSGAFPDLADAMHFSATLDGELLVGDPREATGTFSDLQQRLNRKTVTP
HHHHHHHCCCCCCCCCCCHHHHHHHHHEECCCEEEECCCCHHCCCHHHHHHHHHHCCCCC
KMQQQYPAFMRCYDLLQVGDEDLRALPFRERRGRLEAFVKTLDPGRFDLSPFVAFADWQV
HHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
LEDLRRAPPHPIIEGVMLKRWDSPYVAGRPKGPWFKWKRDPHTVDAVLMYAQRGHGKRSS
HHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCC
FYSDYTFGVWSGAEGEEELVPVGKAYFGFTDEELKQIDKYVRDNTVERFGPVRSVRADRD
CCCCCCEEECCCCCCCHHHEECCHHHCCCCHHHHHHHHHHHHHCCHHHHCCHHHHCCCCC
NGLVLEVAFEGLNRSTRHKSGVAMRFPRISRLRWDKPANEADRIETLQALLDR
CCEEEEEEECCCCCCHHCCCCCEEECCCHHHCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MNRFAELLDRLVLTPSRNGKLTLLVDYFRTVEDPDRGLALAAITGDLKIAAVKPAMLRML
CCHHHHHHHHHHCCCCCCCCEEEEEHHHHHCCCCCCCEEEEEEECCEEEEEECHHHHHHH
VTERMDPVLFGYSYDYVGDLAETVSLVWPQTPGKIPNREPTLGEVVAKLQAASRSDGPKV
HHHCCCCEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHH
LASLLDSAGISARFAIIKLVTGGLRIGVSARLAKQALADFGKVDVAEIEELWHGLSPPYT
HHHHHHCCCCHHHHHHHHHHHCCCEECHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHH
ALFAWLEGKAEKPRNTAMALFRPVMLSNPVGDGDLEKLDPADYAAEWKWDGIRVQAVAEG
HHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEECCEEEEEEHHH
GIRRLYSRTGDDVSGAFPDLADAMHFSATLDGELLVGDPREATGTFSDLQQRLNRKTVTP
HHHHHHHCCCCCCCCCCCHHHHHHHHHEECCCEEEECCCCHHCCCHHHHHHHHHHCCCCC
KMQQQYPAFMRCYDLLQVGDEDLRALPFRERRGRLEAFVKTLDPGRFDLSPFVAFADWQV
HHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
LEDLRRAPPHPIIEGVMLKRWDSPYVAGRPKGPWFKWKRDPHTVDAVLMYAQRGHGKRSS
HHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCC
FYSDYTFGVWSGAEGEEELVPVGKAYFGFTDEELKQIDKYVRDNTVERFGPVRSVRADRD
CCCCCCEEECCCCCCCHHHEECCHHHCCCCHHHHHHHHHHHHHCCHHHHCCHHHHCCCCC
NGLVLEVAFEGLNRSTRHKSGVAMRFPRISRLRWDKPANEADRIETLQALLDR
CCEEEEEEECCCCCCHHCCCCCEEECCCHHHCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA