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The map label for this gene is trxA [C]

Identifier: 13474806

GI number: 13474806

Start: 4655769

End: 4656089

Strand: Direct

Name: trxA [C]

Synonym: mlr5775

Alternate gene names: 13474806

Gene position: 4655769-4656089 (Clockwise)

Preceding gene: 13474804

Following gene: 13474807

Centisome position: 66.17

GC content: 55.45

Gene sequence:

>321_bases
ATGGCTACCGTGAAAGTCGATATAAATAACTTCCAGTCGGAAGTTCTGGAATCCGCAGCACCCGTCGTCGTCGATTTCTG
GGCCGAATGGTGCGATCCCTGCAAGATGATTGCTCCGAGCCTCGAGGAAATCTCCGTCGAGATGGAAAGCAAGATCAAGG
TCGCCAAGCTCAACATCGATGAAAACCCGGAACTCGCCGCCCAATTGGGCGTGCGCTCCATTCCGGCGCTCGCGATCTTC
AAGGGCGGCGAAGTGGCCGATTTCTCGGTCGGCGCCAAACCGAAGACTGCTCTTTTGAACTGGATTTCGAACGCTGCCTG
A

Upstream 100 bases:

>100_bases
ATCTTGCCGATCAGGATCAGTGTCGGGTCCAACATGAAGCCGGAACTTCAGCTCCGGTAGAGGAAGCGCAAACTGGAGCG
GCCGATGAGAAGGAGCAGCC

Downstream 100 bases:

>100_bases
TCGATATCGCTCAATCTGTACCGCAATGAAAAAACCGTAGATTCTCCCCGCAAAGCGGTACGGTTCACAGTGATTTAGGG
GCCTTTGTATAGGGCTCAGC

Product: thioredoxin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 106; Mature: 105

Protein sequence:

>106_residues
MATVKVDINNFQSEVLESAAPVVVDFWAEWCDPCKMIAPSLEEISVEMESKIKVAKLNIDENPELAAQLGVRSIPALAIF
KGGEVADFSVGAKPKTALLNWISNAA

Sequences:

>Translated_106_residues
MATVKVDINNFQSEVLESAAPVVVDFWAEWCDPCKMIAPSLEEISVEMESKIKVAKLNIDENPELAAQLGVRSIPALAIF
KGGEVADFSVGAKPKTALLNWISNAA
>Mature_105_residues
ATVKVDINNFQSEVLESAAPVVVDFWAEWCDPCKMIAPSLEEISVEMESKIKVAKLNIDENPELAAQLGVRSIPALAIFK
GGEVADFSVGAKPKTALLNWISNAA

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=92, Percent_Identity=40.2173913043478, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI87082331, Length=95, Percent_Identity=51.5789473684211, Blast_Score=107, Evalue=1e-25,
Organism=Escherichia coli, GI1788936, Length=93, Percent_Identity=39.7849462365591, Blast_Score=90, Evalue=3e-20,
Organism=Escherichia coli, GI87081747, Length=97, Percent_Identity=32.9896907216495, Blast_Score=63, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI212646193, Length=83, Percent_Identity=39.7590361445783, Blast_Score=76, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI115532380, Length=74, Percent_Identity=35.1351351351351, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI115532378, Length=74, Percent_Identity=35.1351351351351, Blast_Score=63, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=73, Percent_Identity=46.5753424657534, Blast_Score=68, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323072, Length=73, Percent_Identity=45.2054794520548, Blast_Score=64, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6319925, Length=83, Percent_Identity=33.7349397590361, Blast_Score=62, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28573567, Length=96, Percent_Identity=40.625, Blast_Score=88, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24639826, Length=80, Percent_Identity=40, Blast_Score=78, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21358065, Length=96, Percent_Identity=37.5, Blast_Score=69, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24639068, Length=85, Percent_Identity=36.4705882352941, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24664269, Length=79, Percent_Identity=36.7088607594937, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17648013, Length=78, Percent_Identity=37.1794871794872, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24583090, Length=78, Percent_Identity=37.1794871794872, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11431; Mature: 11300

Theoretical pI: Translated: 4.23; Mature: 4.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATVKVDINNFQSEVLESAAPVVVDFWAEWCDPCKMIAPSLEEISVEMESKIKVAKLNID
CCEEEEEHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHCCCHHHHHHHHCCCEEEEEECCC
ENPELAAQLGVRSIPALAIFKGGEVADFSVGAKPKTALLNWISNAA
CCCHHHHHCCCCCCCEEEEECCCCEEECCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
ATVKVDINNFQSEVLESAAPVVVDFWAEWCDPCKMIAPSLEEISVEMESKIKVAKLNID
CEEEEEHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHCCCHHHHHHHHCCCEEEEEECCC
ENPELAAQLGVRSIPALAIFKGGEVADFSVGAKPKTALLNWISNAA
CCCHHHHHCCCCCCCEEEEECCCCEEECCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7021558 [H]