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The map label for this gene is ggt [H]

Identifier: 13474753

GI number: 13474753

Start: 4599035

End: 4600774

Strand: Direct

Name: ggt [H]

Synonym: mlr5711

Alternate gene names: 13474753

Gene position: 4599035-4600774 (Clockwise)

Preceding gene: 13474752

Following gene: 13474756

Centisome position: 65.36

GC content: 64.02

Gene sequence:

>1740_bases
ATGCACGTCACCCGTCGGACACTGATCGCCGCCAGTCTTTCCATCACCTTTGCCCTGGCGCCATTGACCAGCGTCTTCGC
CGCGTCGCCGGCGCCGGCCAAGGGCGAGCACGGCATGGTGGTCACGGCCCAGCACCTGGCGTCGGAAGTCGGCGTCGAGG
TCTTGAAGAAGGGCGGCAATGCCGTCGATGCGGCGGTCGCCGTCGGCTATGCGCTGGCCGTCGTCTACCCCAATGCCGGC
AATATCGGCGGCGGCGGCTTCATGACCATCCGGTTCGCCGATGGCAAATCGACCTTCCTCGATTTTCGAGAGCGCGCGCC
GCTGGCCGCGACCAAGACCATGTATCTCGACAAGGATGGCAATCCGGTGAAGGGCGCCAGCCTCGACGGCTATCTCGCCG
TCGGCGTGCCGGGCTCGGTGGCCGGTTTCGAAATAGCGCGCGAGAAATATGGCACACTCTCAAGGCAAGACCTGATGGCG
CCGGCGATCGGCTATGCCAAGGATGGGTTCATCCTCAATCAGGGCGATGCCGCCTCGTTCGCCGGCAGCGCGGATCGGCT
GGCGAAGAACGCGGCCGCGGCCGCAGCCTTCCTGAAACCCGATGGCAAGCCCTACGGCATCGGCGAGCGGCTCACCCAAC
CGGACCTTGCCGCCTCGCTTTCGGCGATATCCGAGAAAGGTCCCGACGCCTTCTACAAGGGCGCCATCGCCGACGCCATC
GTCAAGGCGAGTGGCGCCAAGGGCGGCATCCTGGCCAAGCAGGATTTCGAGCAATATGCGGTGCGTGAACTGAAACCGGT
CACTTGCTCCTATCGCGGCTATGAGATCACTTCCTCGCCGCCGCCAAGCTCCGGTGGCGTCATCATCTGCGAAATCCTCA
ACGTGCTGGAAGGCTACCCGCTGTCTTATCTCGGCGCCGGTTCGGCCGAGACGGTGCATGTCATGGTCGAGGCGATGCGC
CATGCCTATGTCGACCGCAACTCCGCGCTCGGCGATCCCGATTTCGTCGACAATCCGGTCTCGAAATTGCTGGATAAAGC
CTACGCCAAGGGCATCCGCGACAAGATCGACCCGTTCCGGGCCGGCGTGTCGCAGGACCTGATGCCGAAGGGTTTCGGCG
AGTCGAAGGAGACGACGCACTATTCGATCATCGACAAGGATGGCAACGCGGTCGCGGTCACCTACACGCTGAACGGCTCC
TTCGGCGCCGGCGTCGTCGCCGACGGCACCGGCATCCTACTCAACAACGAGATGGACGATTTCACCCAGAAGCCGGGCGT
GCCTAACCTCTATGGGTTGGTCCAGGGCGAGGCCAATGCCATTCAGCCGAAGAAGACGCCGCTGTCATCGATGAGCCCGA
CCATCGTGGCCAGGGACGGCAAGCCGTTCATGGTCATCGGCAGCCCGGGCGGCTCGCGCATCATCACCATCACGCTTGAA
GCGATCGTCAACGTCATCGACCATGGCATGAACATCCAGGAAGCGATCGACGCGCCGCGCATCCACCATCAATGGCTGCC
CGATAAGGTCTATGTCGAGCCGTTCGGCCTGTCGCCGGACACCGAAAGGCTGTTGGCCGGCATGGGCTACCACCTTGATC
TCGGCGACCAGACCTGGGGCCAGGCGGCCGGCATCTTGGTCGGCGGCAAAAGCCTCGCGGAGATCGAGAAAGGCGGCGGC
GCGCGCTACAATGGCGCCATCGACAGCCGGGCGGCCTCTGGCGAGGCGCTCGGATATTGA

Upstream 100 bases:

>100_bases
ACGCGCCTGACATCCGAATTGATCCGCCTGGCCCATCGTTGATGGTGGACACGGCCGCAGCGACGGGTTCTTCTAGGCGT
CCCCGCCAGGAGAACCCGCC

Downstream 100 bases:

>100_bases
TGCCGGCGTGGACTCCCGGACAGGCTCACGGCCCGACAAGAACCGTCAGGTAACCAGCGTGATGGTCGATGCGATCAGCA
TCAGGGCGGCGATGCCGACG

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 579; Mature: 579

Protein sequence:

>579_residues
MHVTRRTLIAASLSITFALAPLTSVFAASPAPAKGEHGMVVTAQHLASEVGVEVLKKGGNAVDAAVAVGYALAVVYPNAG
NIGGGGFMTIRFADGKSTFLDFRERAPLAATKTMYLDKDGNPVKGASLDGYLAVGVPGSVAGFEIAREKYGTLSRQDLMA
PAIGYAKDGFILNQGDAASFAGSADRLAKNAAAAAAFLKPDGKPYGIGERLTQPDLAASLSAISEKGPDAFYKGAIADAI
VKASGAKGGILAKQDFEQYAVRELKPVTCSYRGYEITSSPPPSSGGVIICEILNVLEGYPLSYLGAGSAETVHVMVEAMR
HAYVDRNSALGDPDFVDNPVSKLLDKAYAKGIRDKIDPFRAGVSQDLMPKGFGESKETTHYSIIDKDGNAVAVTYTLNGS
FGAGVVADGTGILLNNEMDDFTQKPGVPNLYGLVQGEANAIQPKKTPLSSMSPTIVARDGKPFMVIGSPGGSRIITITLE
AIVNVIDHGMNIQEAIDAPRIHHQWLPDKVYVEPFGLSPDTERLLAGMGYHLDLGDQTWGQAAGILVGGKSLAEIEKGGG
ARYNGAIDSRAASGEALGY

Sequences:

>Translated_579_residues
MHVTRRTLIAASLSITFALAPLTSVFAASPAPAKGEHGMVVTAQHLASEVGVEVLKKGGNAVDAAVAVGYALAVVYPNAG
NIGGGGFMTIRFADGKSTFLDFRERAPLAATKTMYLDKDGNPVKGASLDGYLAVGVPGSVAGFEIAREKYGTLSRQDLMA
PAIGYAKDGFILNQGDAASFAGSADRLAKNAAAAAAFLKPDGKPYGIGERLTQPDLAASLSAISEKGPDAFYKGAIADAI
VKASGAKGGILAKQDFEQYAVRELKPVTCSYRGYEITSSPPPSSGGVIICEILNVLEGYPLSYLGAGSAETVHVMVEAMR
HAYVDRNSALGDPDFVDNPVSKLLDKAYAKGIRDKIDPFRAGVSQDLMPKGFGESKETTHYSIIDKDGNAVAVTYTLNGS
FGAGVVADGTGILLNNEMDDFTQKPGVPNLYGLVQGEANAIQPKKTPLSSMSPTIVARDGKPFMVIGSPGGSRIITITLE
AIVNVIDHGMNIQEAIDAPRIHHQWLPDKVYVEPFGLSPDTERLLAGMGYHLDLGDQTWGQAAGILVGGKSLAEIEKGGG
ARYNGAIDSRAASGEALGY
>Mature_579_residues
MHVTRRTLIAASLSITFALAPLTSVFAASPAPAKGEHGMVVTAQHLASEVGVEVLKKGGNAVDAAVAVGYALAVVYPNAG
NIGGGGFMTIRFADGKSTFLDFRERAPLAATKTMYLDKDGNPVKGASLDGYLAVGVPGSVAGFEIAREKYGTLSRQDLMA
PAIGYAKDGFILNQGDAASFAGSADRLAKNAAAAAAFLKPDGKPYGIGERLTQPDLAASLSAISEKGPDAFYKGAIADAI
VKASGAKGGILAKQDFEQYAVRELKPVTCSYRGYEITSSPPPSSGGVIICEILNVLEGYPLSYLGAGSAETVHVMVEAMR
HAYVDRNSALGDPDFVDNPVSKLLDKAYAKGIRDKIDPFRAGVSQDLMPKGFGESKETTHYSIIDKDGNAVAVTYTLNGS
FGAGVVADGTGILLNNEMDDFTQKPGVPNLYGLVQGEANAIQPKKTPLSSMSPTIVARDGKPFMVIGSPGGSRIITITLE
AIVNVIDHGMNIQEAIDAPRIHHQWLPDKVYVEPFGLSPDTERLLAGMGYHLDLGDQTWGQAAGILVGGKSLAEIEKGGG
ARYNGAIDSRAASGEALGY

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=481, Percent_Identity=35.7588357588358, Blast_Score=253, Evalue=4e-67,
Organism=Homo sapiens, GI73915090, Length=481, Percent_Identity=35.7588357588358, Blast_Score=253, Evalue=4e-67,
Organism=Homo sapiens, GI73915096, Length=481, Percent_Identity=35.7588357588358, Blast_Score=253, Evalue=4e-67,
Organism=Homo sapiens, GI73915094, Length=481, Percent_Identity=35.7588357588358, Blast_Score=253, Evalue=4e-67,
Organism=Homo sapiens, GI113429324, Length=475, Percent_Identity=33.8947368421053, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI113429326, Length=480, Percent_Identity=33.3333333333333, Blast_Score=220, Evalue=3e-57,
Organism=Homo sapiens, GI109148539, Length=528, Percent_Identity=30.4924242424242, Blast_Score=177, Evalue=3e-44,
Organism=Homo sapiens, GI153266885, Length=477, Percent_Identity=28.5115303983228, Blast_Score=166, Evalue=8e-41,
Organism=Homo sapiens, GI153266901, Length=478, Percent_Identity=28.6610878661088, Blast_Score=165, Evalue=8e-41,
Organism=Homo sapiens, GI153266907, Length=476, Percent_Identity=27.5210084033613, Blast_Score=151, Evalue=2e-36,
Organism=Homo sapiens, GI30581157, Length=137, Percent_Identity=45.2554744525547, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI30581155, Length=137, Percent_Identity=45.2554744525547, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI218505805, Length=137, Percent_Identity=40.8759124087591, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI310124095, Length=137, Percent_Identity=36.4963503649635, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1789856, Length=519, Percent_Identity=52.0231213872832, Blast_Score=540, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI17506189, Length=499, Percent_Identity=35.0701402805611, Blast_Score=243, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI212646519, Length=500, Percent_Identity=33.4, Blast_Score=223, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI72000294, Length=500, Percent_Identity=33.4, Blast_Score=222, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI193208245, Length=509, Percent_Identity=33.3988212180747, Blast_Score=214, Evalue=7e-56,
Organism=Caenorhabditis elegans, GI193208247, Length=509, Percent_Identity=33.3988212180747, Blast_Score=214, Evalue=8e-56,
Organism=Caenorhabditis elegans, GI17542894, Length=564, Percent_Identity=32.4468085106383, Blast_Score=214, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17564448, Length=430, Percent_Identity=26.046511627907, Blast_Score=95, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6323330, Length=515, Percent_Identity=30.873786407767, Blast_Score=166, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24642670, Length=509, Percent_Identity=30.4518664047151, Blast_Score=226, Evalue=4e-59,
Organism=Drosophila melanogaster, GI24642666, Length=509, Percent_Identity=30.4518664047151, Blast_Score=226, Evalue=4e-59,
Organism=Drosophila melanogaster, GI161077880, Length=509, Percent_Identity=30.4518664047151, Blast_Score=226, Evalue=5e-59,
Organism=Drosophila melanogaster, GI45551474, Length=509, Percent_Identity=30.4518664047151, Blast_Score=225, Evalue=5e-59,
Organism=Drosophila melanogaster, GI161077878, Length=509, Percent_Identity=30.4518664047151, Blast_Score=225, Evalue=6e-59,
Organism=Drosophila melanogaster, GI161077496, Length=479, Percent_Identity=31.9415448851775, Blast_Score=211, Evalue=1e-54,
Organism=Drosophila melanogaster, GI18859893, Length=500, Percent_Identity=32.2, Blast_Score=207, Evalue=2e-53,
Organism=Drosophila melanogaster, GI18859741, Length=512, Percent_Identity=28.515625, Blast_Score=185, Evalue=7e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 60445; Mature: 60445

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS00462 G_GLU_TRANSPEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHVTRRTLIAASLSITFALAPLTSVFAASPAPAKGEHGMVVTAQHLASEVGVEVLKKGGN
CCCCHHHHHHHHHHHEEHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHHHHCCCC
AVDAAVAVGYALAVVYPNAGNIGGGGFMTIRFADGKSTFLDFRERAPLAATKTMYLDKDG
HHHHHHHHEEEEEEEECCCCCCCCCEEEEEEEECCCCHHHHHHHCCCCEEEEEEEECCCC
NPVKGASLDGYLAVGVPGSVAGFEIAREKYGTLSRQDLMAPAIGYAKDGFILNQGDAASF
CCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCCEEEECCCCCCC
AGSADRLAKNAAAAAAFLKPDGKPYGIGERLTQPDLAASLSAISEKGPDAFYKGAIADAI
CCCHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHH
VKASGAKGGILAKQDFEQYAVRELKPVTCSYRGYEITSSPPPSSGGVIICEILNVLEGYP
HHCCCCCCCCCCHHHHHHHHHHHCCCCEECCCCEEECCCCCCCCCCEEHHHHHHHHCCCC
LSYLGAGSAETVHVMVEAMRHAYVDRNSALGDPDFVDNPVSKLLDKAYAKGIRDKIDPFR
CEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHH
AGVSQDLMPKGFGESKETTHYSIIDKDGNAVAVTYTLNGSFGAGVVADGTGILLNNEMDD
CCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEEECCCCCCCEEECCCEEEECCCHHH
FTQKPGVPNLYGLVQGEANAIQPKKTPLSSMSPTIVARDGKPFMVIGSPGGSRIITITLE
HHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEECCCEEEEEECCCCCEEEEEEHH
AIVNVIDHGMNIQEAIDAPRIHHQWLPDKVYVEPFGLSPDTERLLAGMGYHLDLGDQTWG
HHHHHHHCCCCHHHHHCCCCHHHHCCCCEEEEEECCCCCCHHHHHHCCCCEEECCCCCCC
QAAGILVGGKSLAEIEKGGGARYNGAIDSRAASGEALGY
CCCEEEECCCHHHHHHHCCCCEECCCCCCCCCCCCCCCC
>Mature Secondary Structure
MHVTRRTLIAASLSITFALAPLTSVFAASPAPAKGEHGMVVTAQHLASEVGVEVLKKGGN
CCCCHHHHHHHHHHHEEHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHHHHCCCC
AVDAAVAVGYALAVVYPNAGNIGGGGFMTIRFADGKSTFLDFRERAPLAATKTMYLDKDG
HHHHHHHHEEEEEEEECCCCCCCCCEEEEEEEECCCCHHHHHHHCCCCEEEEEEEECCCC
NPVKGASLDGYLAVGVPGSVAGFEIAREKYGTLSRQDLMAPAIGYAKDGFILNQGDAASF
CCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCCEEEECCCCCCC
AGSADRLAKNAAAAAAFLKPDGKPYGIGERLTQPDLAASLSAISEKGPDAFYKGAIADAI
CCCHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHH
VKASGAKGGILAKQDFEQYAVRELKPVTCSYRGYEITSSPPPSSGGVIICEILNVLEGYP
HHCCCCCCCCCCHHHHHHHHHHHCCCCEECCCCEEECCCCCCCCCCEEHHHHHHHHCCCC
LSYLGAGSAETVHVMVEAMRHAYVDRNSALGDPDFVDNPVSKLLDKAYAKGIRDKIDPFR
CEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHH
AGVSQDLMPKGFGESKETTHYSIIDKDGNAVAVTYTLNGSFGAGVVADGTGILLNNEMDD
CCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEEECCCCCCCEEECCCEEEECCCHHH
FTQKPGVPNLYGLVQGEANAIQPKKTPLSSMSPTIVARDGKPFMVIGSPGGSRIITITLE
HHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEECCCEEEEEECCCCCEEEEEEHH
AIVNVIDHGMNIQEAIDAPRIHHQWLPDKVYVEPFGLSPDTERLLAGMGYHLDLGDQTWG
HHHHHHHCCCCHHHHHCCCCHHHHCCCCEEEEEECCCCCCHHHHHHCCCCEEECCCCCCC
QAAGILVGGKSLAEIEKGGGARYNGAIDSRAASGEALGY
CCCEEEECCCHHHHHHHCCCCEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7765305 [H]