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The map label for this gene is yngJ [H]

Identifier: 13474528

GI number: 13474528

Start: 4344182

End: 4345330

Strand: Reverse

Name: yngJ [H]

Synonym: mll5430

Alternate gene names: 13474528

Gene position: 4345330-4344182 (Counterclockwise)

Preceding gene: 13474529

Following gene: 13474527

Centisome position: 61.76

GC content: 65.27

Gene sequence:

>1149_bases
ATGGCTGACAAGAGTTTCCTTAACTGGCCGTTCTTCGAGAACCGTCATCGCGAACTGGCCGAAGTCCTGGAAGCGTGGTG
CTCGAAGAGCCTCCCCGTCGATCATCACGACGTCGACGCCGCATGCCGCGAGCTGGTGCAAAAACTTGGCCGCGACGGGT
GGCTGAAACCGACAGCTGTCGACACCGTGAATCCCGGACCGCTCGACGTGCGGACACTATGCATCACGCGCGAGACGCTC
TCCCGCCATGACGGGCTCGCCGATTTCGCCTTTGCCATGCAGGGGCTGGGCACAGGTGCGCTCAGCCTGTTCGGCACGCC
GGACCAGCAGCAATGGCTGGCAAGGACACGCGCCGGCAAGGCGATCTCCGCCTTCGCTTTGTCGGAGCCGCGCTCTGGCT
CGGATGTCGCCAACACCGAGATGACGGCGACCCGCGACGGCGACAGCTATGTGCTCACCGGCGAGAAGACCTGGATCTCC
AATGGCGGCATCGCCGATCTCTACATCGTCTTTGCCCGCACCGGCGAAGCGCCGGGCGCCAAGGGGCTTTCCGCCTTTAT
CGTACCGGGTGACGTCAAGGGCCTCGGCATTGCCGAACGCCTCGAAGTGATCGCGCCGCATCCGCTGGCGCGGCTGTCCT
TCGATCAGGTCCGCCTGCCGACCTCGGCGCTGATCGGCAAGCCCGGCGATGGCTTTCGCATCGCCATGTCGGTGCTCGAC
GTGTTCCGCTCGACCGTCGGCGCTGCGGCGCTCGGCTTTGCCCGCCGGGCGCTCGATGAAAGCATCAAACGAGTGGCCGA
ACGCAAACTGTTCGGCGCTCCGATGGCGGAGTTGCAGATGGTGCAGGGCCACATCGCCGACATGGCCCTCGACATCGACG
CGGCGGCACTTCTGGTCTATCGCGCCGCCTGGACCAAGGATATGGGCGCGGCGCGGGTAACGCGCGAGGCGGCGATGGCC
AAACTGTTCGCCACCGACAAGGCGCAGGACGTGATCGACAAGGCGGTGCAGCTGCATGGCGGCGACGGCGTCCGCAAAGG
CCACATTGTCGAAAGCCTGTATCGCGAAATCCGCGCGCTGCGCATCTATGAGGGTGCCTCCGACGTGCAGAAAGTGGTCA
TCGCGCGGCAAGTGATGGGCGCGGCCTAA

Upstream 100 bases:

>100_bases
CGGAAGCCCAGGCGCAAGCGATCTGCATGCAGACGCGCGATTTCGAGCGCGCCTACAAGGCATTCGTGGCCAAGGAAAAG
CCGGTGTTCGAGGGGAACTG

Downstream 100 bases:

>100_bases
CGGTGGGAAATTGAAGAGTATTCGATTTTGAGACTTGGTTTTCAGAAATACCGGGAGGCTTCAAATGCATGAGATTCTGC
AGCCGGAAGGCTGGGCCAAA

Product: acyl-CoA dehydrogenase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MADKSFLNWPFFENRHRELAEVLEAWCSKSLPVDHHDVDAACRELVQKLGRDGWLKPTAVDTVNPGPLDVRTLCITRETL
SRHDGLADFAFAMQGLGTGALSLFGTPDQQQWLARTRAGKAISAFALSEPRSGSDVANTEMTATRDGDSYVLTGEKTWIS
NGGIADLYIVFARTGEAPGAKGLSAFIVPGDVKGLGIAERLEVIAPHPLARLSFDQVRLPTSALIGKPGDGFRIAMSVLD
VFRSTVGAAALGFARRALDESIKRVAERKLFGAPMAELQMVQGHIADMALDIDAAALLVYRAAWTKDMGAARVTREAAMA
KLFATDKAQDVIDKAVQLHGGDGVRKGHIVESLYREIRALRIYEGASDVQKVVIARQVMGAA

Sequences:

>Translated_382_residues
MADKSFLNWPFFENRHRELAEVLEAWCSKSLPVDHHDVDAACRELVQKLGRDGWLKPTAVDTVNPGPLDVRTLCITRETL
SRHDGLADFAFAMQGLGTGALSLFGTPDQQQWLARTRAGKAISAFALSEPRSGSDVANTEMTATRDGDSYVLTGEKTWIS
NGGIADLYIVFARTGEAPGAKGLSAFIVPGDVKGLGIAERLEVIAPHPLARLSFDQVRLPTSALIGKPGDGFRIAMSVLD
VFRSTVGAAALGFARRALDESIKRVAERKLFGAPMAELQMVQGHIADMALDIDAAALLVYRAAWTKDMGAARVTREAAMA
KLFATDKAQDVIDKAVQLHGGDGVRKGHIVESLYREIRALRIYEGASDVQKVVIARQVMGAA
>Mature_381_residues
ADKSFLNWPFFENRHRELAEVLEAWCSKSLPVDHHDVDAACRELVQKLGRDGWLKPTAVDTVNPGPLDVRTLCITRETLS
RHDGLADFAFAMQGLGTGALSLFGTPDQQQWLARTRAGKAISAFALSEPRSGSDVANTEMTATRDGDSYVLTGEKTWISN
GGIADLYIVFARTGEAPGAKGLSAFIVPGDVKGLGIAERLEVIAPHPLARLSFDQVRLPTSALIGKPGDGFRIAMSVLDV
FRSTVGAAALGFARRALDESIKRVAERKLFGAPMAELQMVQGHIADMALDIDAAALLVYRAAWTKDMGAARVTREAAMAK
LFATDKAQDVIDKAVQLHGGDGVRKGHIVESLYREIRALRIYEGASDVQKVVIARQVMGAA

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=340, Percent_Identity=38.5294117647059, Blast_Score=207, Evalue=2e-53,
Organism=Homo sapiens, GI187960098, Length=325, Percent_Identity=35.0769230769231, Blast_Score=184, Evalue=9e-47,
Organism=Homo sapiens, GI4557231, Length=325, Percent_Identity=35.0769230769231, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI76496475, Length=350, Percent_Identity=32, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI4557235, Length=350, Percent_Identity=32, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI7656849, Length=279, Percent_Identity=32.9749103942652, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI21361497, Length=295, Percent_Identity=32.2033898305085, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI4501859, Length=276, Percent_Identity=32.9710144927536, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI226958412, Length=372, Percent_Identity=28.2258064516129, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI226958414, Length=340, Percent_Identity=29.4117647058824, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI4501857, Length=344, Percent_Identity=30.2325581395349, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI211971008, Length=294, Percent_Identity=33.6734693877551, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI48976061, Length=294, Percent_Identity=33.6734693877551, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI38505218, Length=302, Percent_Identity=31.7880794701987, Blast_Score=122, Evalue=8e-28,
Organism=Homo sapiens, GI4503943, Length=356, Percent_Identity=26.9662921348315, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI7669494, Length=340, Percent_Identity=27.0588235294118, Blast_Score=96, Evalue=7e-20,
Organism=Escherichia coli, GI1786223, Length=278, Percent_Identity=28.0575539568345, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI87081958, Length=281, Percent_Identity=30.2491103202847, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI87082384, Length=263, Percent_Identity=28.5171102661597, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17534899, Length=323, Percent_Identity=36.2229102167183, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17569725, Length=346, Percent_Identity=34.393063583815, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17570075, Length=343, Percent_Identity=33.2361516034985, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17508101, Length=277, Percent_Identity=37.9061371841155, Blast_Score=181, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI71985184, Length=293, Percent_Identity=35.1535836177474, Blast_Score=168, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17506239, Length=278, Percent_Identity=35.2517985611511, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17533517, Length=263, Percent_Identity=34.6007604562738, Blast_Score=165, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI71990804, Length=225, Percent_Identity=38.6666666666667, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17538396, Length=338, Percent_Identity=28.4023668639053, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI71985192, Length=240, Percent_Identity=33.75, Blast_Score=128, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17531909, Length=239, Percent_Identity=30.9623430962343, Blast_Score=114, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI17505929, Length=285, Percent_Identity=29.8245614035088, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17551932, Length=285, Percent_Identity=29.8245614035088, Blast_Score=111, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17534353, Length=313, Percent_Identity=28.7539936102236, Blast_Score=111, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI71982178, Length=273, Percent_Identity=27.8388278388278, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI32563615, Length=181, Percent_Identity=30.939226519337, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17562446, Length=309, Percent_Identity=29.126213592233, Blast_Score=104, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17531913, Length=169, Percent_Identity=30.1775147928994, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI86563381, Length=281, Percent_Identity=25.9786476868327, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI86563383, Length=277, Percent_Identity=24.5487364620939, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24646207, Length=349, Percent_Identity=37.2492836676218, Blast_Score=209, Evalue=3e-54,
Organism=Drosophila melanogaster, GI24660351, Length=321, Percent_Identity=36.7601246105919, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI21356377, Length=340, Percent_Identity=36.1764705882353, Blast_Score=194, Evalue=9e-50,
Organism=Drosophila melanogaster, GI281363737, Length=294, Percent_Identity=33.3333333333333, Blast_Score=168, Evalue=5e-42,
Organism=Drosophila melanogaster, GI24666513, Length=314, Percent_Identity=32.8025477707006, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI21355753, Length=352, Percent_Identity=30.6818181818182, Blast_Score=159, Evalue=2e-39,
Organism=Drosophila melanogaster, GI19920834, Length=348, Percent_Identity=27.5862068965517, Blast_Score=111, Evalue=6e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 41253; Mature: 41122

Theoretical pI: Translated: 7.26; Mature: 7.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADKSFLNWPFFENRHRELAEVLEAWCSKSLPVDHHDVDAACRELVQKLGRDGWLKPTAV
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCC
DTVNPGPLDVRTLCITRETLSRHDGLADFAFAMQGLGTGALSLFGTPDQQQWLARTRAGK
CCCCCCCCCCEEHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHCCC
AISAFALSEPRSGSDVANTEMTATRDGDSYVLTGEKTWISNGGIADLYIVFARTGEAPGA
CEEEHCCCCCCCCCCCCCCCEEEECCCCCEEEECCEEEECCCCCEEEEEEEEECCCCCCC
KGLSAFIVPGDVKGLGIAERLEVIAPHPLARLSFDQVRLPTSALIGKPGDGFRIAMSVLD
CCCEEEEECCCCCCCCHHHHHHHHCCCCHHHCCHHHHCCCHHHHCCCCCCCHHHHHHHHH
VFRSTVGAAALGFARRALDESIKRVAERKLFGAPMAELQMVQGHIADMALDIDAAALLVY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RAAWTKDMGAARVTREAAMAKLFATDKAQDVIDKAVQLHGGDGVRKGHIVESLYREIRAL
HHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
RIYEGASDVQKVVIARQVMGAA
HHHCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ADKSFLNWPFFENRHRELAEVLEAWCSKSLPVDHHDVDAACRELVQKLGRDGWLKPTAV
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCC
DTVNPGPLDVRTLCITRETLSRHDGLADFAFAMQGLGTGALSLFGTPDQQQWLARTRAGK
CCCCCCCCCCEEHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHCCC
AISAFALSEPRSGSDVANTEMTATRDGDSYVLTGEKTWISNGGIADLYIVFARTGEAPGA
CEEEHCCCCCCCCCCCCCCCEEEECCCCCEEEECCEEEECCCCCEEEEEEEEECCCCCCC
KGLSAFIVPGDVKGLGIAERLEVIAPHPLARLSFDQVRLPTSALIGKPGDGFRIAMSVLD
CCCEEEEECCCCCCCCHHHHHHHHCCCCHHHCCHHHHCCCHHHHCCCCCCCHHHHHHHHH
VFRSTVGAAALGFARRALDESIKRVAERKLFGAPMAELQMVQGHIADMALDIDAAALLVY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RAAWTKDMGAARVTREAAMAKLFATDKAQDVIDKAVQLHGGDGVRKGHIVESLYREIRAL
HHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
RIYEGASDVQKVVIARQVMGAA
HHHCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]