Click here to switch to the map view.

The map label for this gene is echA12 [H]

Identifier: 13474529

GI number: 13474529

Start: 4345330

End: 4346133

Strand: Reverse

Name: echA12 [H]

Synonym: mll5431

Alternate gene names: 13474529

Gene position: 4346133-4345330 (Counterclockwise)

Preceding gene: 13474530

Following gene: 13474528

Centisome position: 61.77

GC content: 64.68

Gene sequence:

>804_bases
ATGGCCGGGCTGAAGCCGAAGCATTTCCTGTGGGAGGTCGAGGGCAGGATCGCCAAGGTCCGGCTCGACCGGCCCGAGCG
CAAGAACCCGCTGACCTTCGACAGCTATGCCGAGTTGCGCGATACGTTCCGCGACCTCGTCTATGCCGACGATATCGACG
CCGTGGTGTTCCTCTCCAATGGCGGCAATTTCTGCTCCGGCGGCGATGTCCACGACATTATCGGTCCGCTGGTCAAGATG
GACATGAAGCAGCTTCTCGCCTTCACTCGCATGACCGGCGATTTCGTCAAGGCGATGCTGAATTGCGGCAAGCCGATCAT
CGCCGCCGTCGACGGCGTGGCGGTCGGTGCCGGCGCCATCATCGCCATGAGCTCGGACATCCGCATCGCCACGCCGGAGG
CCAAGACCGCGTTTCTGTTCACCCGCGTCGGCCTTGCCGGCTGCGACATGGGCGCCTGTGCGATCCTGCCGCGCATCATC
GGCCAGGGCCGCGCCGCCGAACTGCTCTATACCGGCCGCACCATGACGGCAGCGGAAGGCGAGCGCTGGGGGTTTTACAA
CAGGCTGGTCGACGCGGCCTCCCTCGAGGCGGATGCACTCGACATGGCAGCGCGCATCGTCTCAGGCCCGACCTTCGCCC
ACGGCATCACCAAGACGCAGCTCAACCAGGAATGGTCGATGGGCCTCGACCAGGCGATCGAGGCGGAAGCCCAGGCGCAA
GCGATCTGCATGCAGACGCGCGATTTCGAGCGCGCCTACAAGGCATTCGTGGCCAAGGAAAAGCCGGTGTTCGAGGGGAA
CTGA

Upstream 100 bases:

>100_bases
TCGGCGAATTGCTGGGCAAGGTCAGCGAGGAGGATGCCCGCCGCCTGACCGGCATGCTGACCTCGTTCCGCAGCAACTGG
GAGGGACGCGAATGACCGGG

Downstream 100 bases:

>100_bases
TGGCTGACAAGAGTTTCCTTAACTGGCCGTTCTTCGAGAACCGTCATCGCGAACTGGCCGAAGTCCTGGAAGCGTGGTGC
TCGAAGAGCCTCCCCGTCGA

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 267; Mature: 266

Protein sequence:

>267_residues
MAGLKPKHFLWEVEGRIAKVRLDRPERKNPLTFDSYAELRDTFRDLVYADDIDAVVFLSNGGNFCSGGDVHDIIGPLVKM
DMKQLLAFTRMTGDFVKAMLNCGKPIIAAVDGVAVGAGAIIAMSSDIRIATPEAKTAFLFTRVGLAGCDMGACAILPRII
GQGRAAELLYTGRTMTAAEGERWGFYNRLVDAASLEADALDMAARIVSGPTFAHGITKTQLNQEWSMGLDQAIEAEAQAQ
AICMQTRDFERAYKAFVAKEKPVFEGN

Sequences:

>Translated_267_residues
MAGLKPKHFLWEVEGRIAKVRLDRPERKNPLTFDSYAELRDTFRDLVYADDIDAVVFLSNGGNFCSGGDVHDIIGPLVKM
DMKQLLAFTRMTGDFVKAMLNCGKPIIAAVDGVAVGAGAIIAMSSDIRIATPEAKTAFLFTRVGLAGCDMGACAILPRII
GQGRAAELLYTGRTMTAAEGERWGFYNRLVDAASLEADALDMAARIVSGPTFAHGITKTQLNQEWSMGLDQAIEAEAQAQ
AICMQTRDFERAYKAFVAKEKPVFEGN
>Mature_266_residues
AGLKPKHFLWEVEGRIAKVRLDRPERKNPLTFDSYAELRDTFRDLVYADDIDAVVFLSNGGNFCSGGDVHDIIGPLVKMD
MKQLLAFTRMTGDFVKAMLNCGKPIIAAVDGVAVGAGAIIAMSSDIRIATPEAKTAFLFTRVGLAGCDMGACAILPRIIG
QGRAAELLYTGRTMTAAEGERWGFYNRLVDAASLEADALDMAARIVSGPTFAHGITKTQLNQEWSMGLDQAIEAEAQAQA
ICMQTRDFERAYKAFVAKEKPVFEGN

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI20127408, Length=238, Percent_Identity=25.6302521008403, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI31542718, Length=249, Percent_Identity=25.7028112449799, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI116235487, Length=155, Percent_Identity=35.4838709677419, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI194097323, Length=272, Percent_Identity=24.6323529411765, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI70995211, Length=251, Percent_Identity=27.4900398406374, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI68989263, Length=194, Percent_Identity=26.2886597938144, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI4502327, Length=270, Percent_Identity=25.9259259259259, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1787660, Length=262, Percent_Identity=31.2977099236641, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1788597, Length=253, Percent_Identity=27.2727272727273, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI221142681, Length=263, Percent_Identity=25.4752851711027, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1787659, Length=254, Percent_Identity=24.8031496062992, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1790281, Length=187, Percent_Identity=25.668449197861, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17560910, Length=197, Percent_Identity=28.9340101522843, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17540714, Length=247, Percent_Identity=27.9352226720648, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17536985, Length=261, Percent_Identity=25.2873563218391, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17535521, Length=252, Percent_Identity=25, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17554946, Length=253, Percent_Identity=24.901185770751, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17534483, Length=254, Percent_Identity=25.9842519685039, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI25145438, Length=247, Percent_Identity=23.4817813765182, Blast_Score=67, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17549921, Length=203, Percent_Identity=31.5270935960591, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI19920382, Length=275, Percent_Identity=29.8181818181818, Blast_Score=98, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24653139, Length=261, Percent_Identity=30.2681992337165, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21357171, Length=211, Percent_Identity=27.4881516587678, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24654903, Length=258, Percent_Identity=25.1937984496124, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI20129971, Length=256, Percent_Identity=25.390625, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24653477, Length=256, Percent_Identity=25.390625, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24650670, Length=209, Percent_Identity=25.8373205741627, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 29035; Mature: 28904

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGLKPKHFLWEVEGRIAKVRLDRPERKNPLTFDSYAELRDTFRDLVYADDIDAVVFLSN
CCCCCCCCEEEEECCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEC
GGNFCSGGDVHDIIGPLVKMDMKQLLAFTRMTGDFVKAMLNCGKPIIAAVDGVAVGAGAI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHCCHHCCCCEE
IAMSSDIRIATPEAKTAFLFTRVGLAGCDMGACAILPRIIGQGRAAELLYTGRTMTAAEG
EEEECCCEEECCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEEEECCEEECCCC
ERWGFYNRLVDAASLEADALDMAARIVSGPTFAHGITKTQLNQEWSMGLDQAIEAEAQAQ
CCCHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHCCHHHHCCCHHHCCHHHHHHHHHHHH
AICMQTRDFERAYKAFVAKEKPVFEGN
HHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
AGLKPKHFLWEVEGRIAKVRLDRPERKNPLTFDSYAELRDTFRDLVYADDIDAVVFLSN
CCCCCCCEEEEECCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEC
GGNFCSGGDVHDIIGPLVKMDMKQLLAFTRMTGDFVKAMLNCGKPIIAAVDGVAVGAGAI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHCCHHCCCCEE
IAMSSDIRIATPEAKTAFLFTRVGLAGCDMGACAILPRIIGQGRAAELLYTGRTMTAAEG
EEEECCCEEECCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEEEECCEEECCCC
ERWGFYNRLVDAASLEADALDMAARIVSGPTFAHGITKTQLNQEWSMGLDQAIEAEAQAQ
CCCHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHCCHHHHCCCHHHCCHHHHHHHHHHHH
AICMQTRDFERAYKAFVAKEKPVFEGN
HHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]