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The map label for this gene is metC [H]

Identifier: 13473790

GI number: 13473790

Start: 3581957

End: 3583141

Strand: Reverse

Name: metC [H]

Synonym: mll4503

Alternate gene names: 13473790

Gene position: 3583141-3581957 (Counterclockwise)

Preceding gene: 13473791

Following gene: 13473789

Centisome position: 50.93

GC content: 65.06

Gene sequence:

>1185_bases
ATGACCAGCCACACACCACCACCATCGGGCAAGAATCGCCTGGCCTTCTCGACACGCACCATCCATGGCGGCCAGAGCCA
CGATCCGCTGACCGGCGCGGTGATGGTGCCGATCTATGCGACCTCGACCTATGGCCAGCAGTCGCCGGGCGTGCACAAGG
GGTTTGAGTACGCCCGCAGCCAGAACCCGACGCGCTTCGCCTTCGAGCGCGCGGTGGCCGATCTCGAAAGCGGAACGGCG
GCTTTCGCCTTCGCCTCCGGCCTGGCGGCGATCTCGACGGTGCTGGAGTTGCTCGATTCCGGCGCGCATATCGTCGCCAC
CGACGATATCTATGGCGGGTCGTTCCGGCTGATGGAGCGGGTGCGCAAGCGCTCGGCGGGCCTGCAGGTCTCGTTCGTCG
ACTTCACCGACCTTGCGGCGGTCGAAGCCGCGATCCGGCCGGAGACGAAGCTGCTCTGGGTCGAGACGCCGACCAACCCG
CTGCTGCGCATCGTCGACCTCGAAGGCGTCGCCGCGCTCGCCAAGCGCAAGGGCGTCCTCACCGTCGCCGACAACACGTT
CTGCAGCCCCTATATCCAGCGGCCGCTGGAACTCGGCATCGATATCGTCGTGCACTCGACAACCAAATATCTCAACGGCC
ATTCCGACATGGTCGGCGGCGTGGCTGTGGTAGGCGACAACAAGGAATTGGCGACCCAGCTGAAATTCCTGCAGAACGCC
ATCGGCGCCATATCGGGCCCGTTCGACAGTTTCCTGGCGCTGCGCGGCCTGAAGACGCTGGCGCTCCGCATGGAGCGGCA
TTCCGACAACGGGCTGAAAATCGCGCAGTGGCTGGAGGCCCGCAAGGACGTGCGCCGCGTCCTCTATCCCGGCCTCGCCA
GCCATCCGCAGCATTCCATCGCCGTCCAGCAGATGCACGCCTTCGGCGGCATGATCACGGCCGTGCTCGACCGCGATCTC
GCCGGCACAAAACGTTTCCTCGAACGCACGCAATTGTTCACGCTGGCCGAAAGCCTCGGCGGGGTGGAGAGCCTGATCGA
GCATCCGGCGCTGATGACGCATGGGTCTATTCCGGCCGAGAAACGGTCGGAGATCGGCATTTCGGATTCGCTGGTAAGGC
TGTCGGCGGGGATCGAGGATGGCGATGATCTGATCGCGGATCTGGAGCAGGCGCTGGGGGGATGA

Upstream 100 bases:

>100_bases
CGGTGTTCGACCGCAACGAGGTCGCCATCATCTTCGACGGCGACGAGTTCGTCGGCCTGATCACCCGGATCGACCTGATC
AACCATTTGAGGCGCGCACG

Downstream 100 bases:

>100_bases
GTGGTGGTTCAGCATGGCCGAAGGAGACGCGCTGGCAGGTGCGCTGGCATTGCAAGGGCGTGCTCGTCGGCTAAGTCACG
GCATGGATCCTAGGGTCTGC

Product: cystathionine gamma-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MTSHTPPPSGKNRLAFSTRTIHGGQSHDPLTGAVMVPIYATSTYGQQSPGVHKGFEYARSQNPTRFAFERAVADLESGTA
AFAFASGLAAISTVLELLDSGAHIVATDDIYGGSFRLMERVRKRSAGLQVSFVDFTDLAAVEAAIRPETKLLWVETPTNP
LLRIVDLEGVAALAKRKGVLTVADNTFCSPYIQRPLELGIDIVVHSTTKYLNGHSDMVGGVAVVGDNKELATQLKFLQNA
IGAISGPFDSFLALRGLKTLALRMERHSDNGLKIAQWLEARKDVRRVLYPGLASHPQHSIAVQQMHAFGGMITAVLDRDL
AGTKRFLERTQLFTLAESLGGVESLIEHPALMTHGSIPAEKRSEIGISDSLVRLSAGIEDGDDLIADLEQALGG

Sequences:

>Translated_394_residues
MTSHTPPPSGKNRLAFSTRTIHGGQSHDPLTGAVMVPIYATSTYGQQSPGVHKGFEYARSQNPTRFAFERAVADLESGTA
AFAFASGLAAISTVLELLDSGAHIVATDDIYGGSFRLMERVRKRSAGLQVSFVDFTDLAAVEAAIRPETKLLWVETPTNP
LLRIVDLEGVAALAKRKGVLTVADNTFCSPYIQRPLELGIDIVVHSTTKYLNGHSDMVGGVAVVGDNKELATQLKFLQNA
IGAISGPFDSFLALRGLKTLALRMERHSDNGLKIAQWLEARKDVRRVLYPGLASHPQHSIAVQQMHAFGGMITAVLDRDL
AGTKRFLERTQLFTLAESLGGVESLIEHPALMTHGSIPAEKRSEIGISDSLVRLSAGIEDGDDLIADLEQALGG
>Mature_393_residues
TSHTPPPSGKNRLAFSTRTIHGGQSHDPLTGAVMVPIYATSTYGQQSPGVHKGFEYARSQNPTRFAFERAVADLESGTAA
FAFASGLAAISTVLELLDSGAHIVATDDIYGGSFRLMERVRKRSAGLQVSFVDFTDLAAVEAAIRPETKLLWVETPTNPL
LRIVDLEGVAALAKRKGVLTVADNTFCSPYIQRPLELGIDIVVHSTTKYLNGHSDMVGGVAVVGDNKELATQLKFLQNAI
GAISGPFDSFLALRGLKTLALRMERHSDNGLKIAQWLEARKDVRRVLYPGLASHPQHSIAVQQMHAFGGMITAVLDRDLA
GTKRFLERTQLFTLAESLGGVESLIEHPALMTHGSIPAEKRSEIGISDSLVRLSAGIEDGDDLIADLEQALGG

Specific function: Methionine biosynthesis; second step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=379, Percent_Identity=50.131926121372, Blast_Score=364, Evalue=1e-101,
Organism=Homo sapiens, GI299473759, Length=381, Percent_Identity=45.1443569553806, Blast_Score=311, Evalue=7e-85,
Organism=Homo sapiens, GI25453487, Length=378, Percent_Identity=44.4444444444444, Blast_Score=291, Evalue=1e-78,
Organism=Escherichia coli, GI1790375, Length=380, Percent_Identity=45.5263157894737, Blast_Score=311, Evalue=4e-86,
Organism=Escherichia coli, GI1789383, Length=343, Percent_Identity=30.0291545189504, Blast_Score=160, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17560056, Length=380, Percent_Identity=49.2105263157895, Blast_Score=367, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17538055, Length=380, Percent_Identity=50, Blast_Score=364, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI71980708, Length=410, Percent_Identity=40.9756097560976, Blast_Score=256, Evalue=1e-68,
Organism=Saccharomyces cerevisiae, GI6319307, Length=387, Percent_Identity=48.062015503876, Blast_Score=338, Evalue=7e-94,
Organism=Saccharomyces cerevisiae, GI6323333, Length=439, Percent_Identity=30.9794988610478, Blast_Score=176, Evalue=5e-45,
Organism=Saccharomyces cerevisiae, GI6321254, Length=403, Percent_Identity=31.5136476426799, Blast_Score=176, Evalue=5e-45,
Organism=Saccharomyces cerevisiae, GI6321170, Length=324, Percent_Identity=30.8641975308642, Blast_Score=148, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6321904, Length=396, Percent_Identity=29.2929292929293, Blast_Score=126, Evalue=7e-30,
Organism=Drosophila melanogaster, GI19922554, Length=388, Percent_Identity=48.7113402061856, Blast_Score=390, Evalue=1e-108,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 42377; Mature: 42246

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSHTPPPSGKNRLAFSTRTIHGGQSHDPLTGAVMVPIYATSTYGQQSPGVHKGFEYARS
CCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHC
QNPTRFAFERAVADLESGTAAFAFASGLAAISTVLELLDSGAHIVATDDIYGGSFRLMER
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHH
VRKRSAGLQVSFVDFTDLAAVEAAIRPETKLLWVETPTNPLLRIVDLEGVAALAKRKGVL
HHHHHCCCEEEEECHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEECHHHHHHHHCCCEE
TVADNTFCSPYIQRPLELGIDIVVHSTTKYLNGHSDMVGGVAVVGDNKELATQLKFLQNA
EECCCCCCCHHHHCHHHCCCEEEEECHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHH
IGAISGPFDSFLALRGLKTLALRMERHSDNGLKIAQWLEARKDVRRVLYPGLASHPQHSI
HHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHH
AVQQMHAFGGMITAVLDRDLAGTKRFLERTQLFTLAESLGGVESLIEHPALMTHGSIPAE
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCEECCCCCCH
KRSEIGISDSLVRLSAGIEDGDDLIADLEQALGG
HHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
TSHTPPPSGKNRLAFSTRTIHGGQSHDPLTGAVMVPIYATSTYGQQSPGVHKGFEYARS
CCCCCCCCCCCCEEEEEEEECCCCCCCCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHC
QNPTRFAFERAVADLESGTAAFAFASGLAAISTVLELLDSGAHIVATDDIYGGSFRLMER
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHH
VRKRSAGLQVSFVDFTDLAAVEAAIRPETKLLWVETPTNPLLRIVDLEGVAALAKRKGVL
HHHHHCCCEEEEECHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEECHHHHHHHHCCCEE
TVADNTFCSPYIQRPLELGIDIVVHSTTKYLNGHSDMVGGVAVVGDNKELATQLKFLQNA
EECCCCCCCHHHHCHHHCCCEEEEECHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHH
IGAISGPFDSFLALRGLKTLALRMERHSDNGLKIAQWLEARKDVRRVLYPGLASHPQHSI
HHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHH
AVQQMHAFGGMITAVLDRDLAGTKRFLERTQLFTLAESLGGVESLIEHPALMTHGSIPAE
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCEECCCCCCH
KRSEIGISDSLVRLSAGIEDGDDLIADLEQALGG
HHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]