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The map label for this gene is aroE

Identifier: 13473783

GI number: 13473783

Start: 3574712

End: 3575554

Strand: Direct

Name: aroE

Synonym: mlr4492

Alternate gene names: 13473783

Gene position: 3574712-3575554 (Clockwise)

Preceding gene: 13473782

Following gene: 13473784

Centisome position: 50.81

GC content: 67.14

Gene sequence:

>843_bases
ATGGTTGAGGCAACGAAGAAGGCCTTCGTCACCGGGCATCCGATCAAGCATTCGCGCTCGCCGAAGATCCACGGCCACTG
GCTGGCCCAGCACGGCATCGACGGCAGCTACGAGGCGATCGACGTGGCGCCGCAGGATTTTGCCGAATTCATCGCGGCAT
TGCAGGCAAACGGGTTTCGCGGCGGCAATGTCACCATTCCGCACAAGGAAGCCGCCTTCGCTGTTGCCCAGCGCCGCGAC
CAGGCGGCTGAAGAGATCGGCGCCGTCAACACGCTGTGGTTCGAGGACGGCGTCCTGCGGGGCGGCAACACCGATGGTCA
CGGCTTTGCCGCCAATCTCGATGACTGCGCGCCGGGCTGGGCGAACACCGGCCCCGCGGTCGTGCTCGGCGCCGGCGGCG
CGTCGCGCGCCGTCATCCAGGCGCTGAAGCAACGCGGTTTTTCCGACATCCGCATCGTCAACCGCACGCTCGCCCGGGCG
CAGGAATTGCGGGATCGTTTCGGCGCCGGCGTTTCGGCGCATGGCACGGCGGCGACCGACGAATTGCTGGCCGACGCCGG
CCTGCTGGTCAACACCACGGCACTTGGCATGGTCGGCAATGAAGGCCTCGCCGCCGATCCGGCCTTGCTGCCGGACCATG
CCATCGTCACCGACCTTGTCTATGTGCCGCTCGAAACACCCTTGCTCGCCGCCGCGCGCGCCAGGGGGCTGAAGACGGTC
GACGGCCTCGGCATGCTGCTCAACCAGGCCGTGCCCGGCTTCGAACATTGGTTCGGCGTCAGGCCTCAGGTCACGGCTGA
GCTGCGCGCACTCATCGTTGCCGATCTGGTGCCGAAGCCATGA

Upstream 100 bases:

>100_bases
GGCATCCAGCTCTTCGAAAAGATCGAAGGCGATTATTTCACCATTGTCGGCCTGCCGCTACTGCCGCTGCTGGCGGAACT
GCGCACGCTGGGAGCCATCG

Downstream 100 bases:

>100_bases
TCGTGCTCGGCCTCACCGGCTCGATCGGCTTGGGCAAGTCGACGACGGCAAAAATGTTTGCCGAGGCGGGCGTGCCGGTC
CACGATTCCGACGAGGCGGT

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MVEATKKAFVTGHPIKHSRSPKIHGHWLAQHGIDGSYEAIDVAPQDFAEFIAALQANGFRGGNVTIPHKEAAFAVAQRRD
QAAEEIGAVNTLWFEDGVLRGGNTDGHGFAANLDDCAPGWANTGPAVVLGAGGASRAVIQALKQRGFSDIRIVNRTLARA
QELRDRFGAGVSAHGTAATDELLADAGLLVNTTALGMVGNEGLAADPALLPDHAIVTDLVYVPLETPLLAAARARGLKTV
DGLGMLLNQAVPGFEHWFGVRPQVTAELRALIVADLVPKP

Sequences:

>Translated_280_residues
MVEATKKAFVTGHPIKHSRSPKIHGHWLAQHGIDGSYEAIDVAPQDFAEFIAALQANGFRGGNVTIPHKEAAFAVAQRRD
QAAEEIGAVNTLWFEDGVLRGGNTDGHGFAANLDDCAPGWANTGPAVVLGAGGASRAVIQALKQRGFSDIRIVNRTLARA
QELRDRFGAGVSAHGTAATDELLADAGLLVNTTALGMVGNEGLAADPALLPDHAIVTDLVYVPLETPLLAAARARGLKTV
DGLGMLLNQAVPGFEHWFGVRPQVTAELRALIVADLVPKP
>Mature_280_residues
MVEATKKAFVTGHPIKHSRSPKIHGHWLAQHGIDGSYEAIDVAPQDFAEFIAALQANGFRGGNVTIPHKEAAFAVAQRRD
QAAEEIGAVNTLWFEDGVLRGGNTDGHGFAANLDDCAPGWANTGPAVVLGAGGASRAVIQALKQRGFSDIRIVNRTLARA
QELRDRFGAGVSAHGTAATDELLADAGLLVNTTALGMVGNEGLAADPALLPDHAIVTDLVYVPLETPLLAAARARGLKTV
DGLGMLLNQAVPGFEHWFGVRPQVTAELRALIVADLVPKP

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1789675, Length=269, Percent_Identity=38.2899628252788, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1787983, Length=260, Percent_Identity=36.9230769230769, Blast_Score=131, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6320332, Length=272, Percent_Identity=27.5735294117647, Blast_Score=84, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROE_RHILO (Q98DY3)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_105351.1
- ProteinModelPortal:   Q98DY3
- SMR:   Q98DY3
- GeneID:   1228012
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mlr4492
- NMPDR:   fig|266835.1.peg.3455
- HOGENOM:   HBG553408
- OMA:   CEVVIAN
- ProtClustDB:   PRK00258
- BRENDA:   1.1.1.25
- GO:   GO:0005737
- HAMAP:   MF_00222
- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR00507

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N

EC number: =1.1.1.25

Molecular weight: Translated: 29402; Mature: 29402

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: ACT_SITE 69-69

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEATKKAFVTGHPIKHSRSPKIHGHWLAQHGIDGSYEAIDVAPQDFAEFIAALQANGFR
CCCCCCHHEECCCCCCCCCCCCCCEEEHHHCCCCCCCCEEECCHHHHHHHHHHHHCCCCC
GGNVTIPHKEAAFAVAQRRDQAAEEIGAVNTLWFEDGVLRGGNTDGHGFAANLDDCAPGW
CCCEECCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEECCCCCCCCEECCCCCCCCCC
ANTGPAVVLGAGGASRAVIQALKQRGFSDIRIVNRTLARAQELRDRFGAGVSAHGTAATD
CCCCCEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
ELLADAGLLVNTTALGMVGNEGLAADPALLPDHAIVTDLVYVPLETPLLAAARARGLKTV
HHHHHCCCEEEHHHHEEECCCCCCCCCCCCCCHHHHHHHHEECCCCHHHHHHHHCCCCHH
DGLGMLLNQAVPGFEHWFGVRPQVTAELRALIVADLVPKP
HHHHHHHHHCCCCHHHHHCCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MVEATKKAFVTGHPIKHSRSPKIHGHWLAQHGIDGSYEAIDVAPQDFAEFIAALQANGFR
CCCCCCHHEECCCCCCCCCCCCCCEEEHHHCCCCCCCCEEECCHHHHHHHHHHHHCCCCC
GGNVTIPHKEAAFAVAQRRDQAAEEIGAVNTLWFEDGVLRGGNTDGHGFAANLDDCAPGW
CCCEECCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEECCCCCCCCEECCCCCCCCCC
ANTGPAVVLGAGGASRAVIQALKQRGFSDIRIVNRTLARAQELRDRFGAGVSAHGTAATD
CCCCCEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
ELLADAGLLVNTTALGMVGNEGLAADPALLPDHAIVTDLVYVPLETPLLAAARARGLKTV
HHHHHCCCEEEHHHHEEECCCCCCCCCCCCCCHHHHHHHHEECCCCHHHHHHHHCCCCHH
DGLGMLLNQAVPGFEHWFGVRPQVTAELRALIVADLVPKP
HHHHHHHHHCCCCHHHHHCCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968