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The map label for this gene is coaE

Identifier: 13473784

GI number: 13473784

Start: 3575551

End: 3576144

Strand: Direct

Name: coaE

Synonym: mlr4493

Alternate gene names: 13473784

Gene position: 3575551-3576144 (Clockwise)

Preceding gene: 13473783

Following gene: 13473785

Centisome position: 50.82

GC content: 66.67

Gene sequence:

>594_bases
ATGATCGTGCTCGGCCTCACCGGCTCGATCGGCTTGGGCAAGTCGACGACGGCAAAAATGTTTGCCGAGGCGGGCGTGCC
GGTCCACGATTCCGACGAGGCGGTGCATCGCCTCTATTCCGGTGTGGCGGCGCCTTTGGTCGAGGCCGCTTTTCCCGGAA
CGGTTGTCGACGGCGTAGTCGACCGCGCAAAACTTGGCGCTCGCGTCCTTGGCGATGCGGCTGCGCTGAAGCGGCTGGAA
GCGATCATCCATCCGCTGGTGCGCGCCGACGCCGACGCCTTCCTGGCCAGGCATCGTACCGCAGGCGAATCGATCGCCGT
GCTCGACATTCCGCTGCTCTTCGAAACCGGCGGCCGTGGCCGCGTCGACAAGGTTGTCGTCGTCACGGCGCCCGCCGAAG
TGCAGCGCCAGCGCGTGCTGGCCCGGCCGGGCATGACGGAAGAAAAACTGGCGGCGATCCTGGCCAAGCAGGTGCCGGAT
GAGGAGAAGCGCAGGCTGGCCGATTTCATCATCGACACCGGCCAGGGGCTGGAGGCCGCGCGGGCAGAGGTCGATGCGAT
CATCGACGAACTCCGGGGACAAAGGGGCTCCTGA

Upstream 100 bases:

>100_bases
TCAACCAGGCCGTGCCCGGCTTCGAACATTGGTTCGGCGTCAGGCCTCAGGTCACGGCTGAGCTGCGCGCACTCATCGTT
GCCGATCTGGTGCCGAAGCC

Downstream 100 bases:

>100_bases
CGGCGGGCTGTCAGCATTGCCCATTGCCATTTTGTTCCGGTCTCGTGATTCTGCTCGCCCAGGAGCAAACTGATTCGATG
CGCGAGATCATCTTCGATAC

Product: dephospho-CoA kinase

Products: NA

Alternate protein names: Dephosphocoenzyme A kinase

Number of amino acids: Translated: 197; Mature: 197

Protein sequence:

>197_residues
MIVLGLTGSIGLGKSTTAKMFAEAGVPVHDSDEAVHRLYSGVAAPLVEAAFPGTVVDGVVDRAKLGARVLGDAAALKRLE
AIIHPLVRADADAFLARHRTAGESIAVLDIPLLFETGGRGRVDKVVVVTAPAEVQRQRVLARPGMTEEKLAAILAKQVPD
EEKRRLADFIIDTGQGLEAARAEVDAIIDELRGQRGS

Sequences:

>Translated_197_residues
MIVLGLTGSIGLGKSTTAKMFAEAGVPVHDSDEAVHRLYSGVAAPLVEAAFPGTVVDGVVDRAKLGARVLGDAAALKRLE
AIIHPLVRADADAFLARHRTAGESIAVLDIPLLFETGGRGRVDKVVVVTAPAEVQRQRVLARPGMTEEKLAAILAKQVPD
EEKRRLADFIIDTGQGLEAARAEVDAIIDELRGQRGS
>Mature_197_residues
MIVLGLTGSIGLGKSTTAKMFAEAGVPVHDSDEAVHRLYSGVAAPLVEAAFPGTVVDGVVDRAKLGARVLGDAAALKRLE
AIIHPLVRADADAFLARHRTAGESIAVLDIPLLFETGGRGRVDKVVVVTAPAEVQRQRVLARPGMTEEKLAAILAKQVPD
EEKRRLADFIIDTGQGLEAARAEVDAIIDELRGQRGS

Specific function: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A

COG id: COG0237

COG function: function code H; Dephospho-CoA kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DPCK (dephospho-CoA kinase) domain

Homologues:

Organism=Homo sapiens, GI110227607, Length=177, Percent_Identity=30.5084745762712, Blast_Score=74, Evalue=9e-14,
Organism=Homo sapiens, GI191252797, Length=196, Percent_Identity=29.5918367346939, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI191252795, Length=196, Percent_Identity=29.5918367346939, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI110227605, Length=179, Percent_Identity=30.7262569832402, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI110227603, Length=179, Percent_Identity=30.7262569832402, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI110227601, Length=179, Percent_Identity=30.7262569832402, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI205277394, Length=179, Percent_Identity=30.7262569832402, Blast_Score=72, Evalue=3e-13,
Organism=Escherichia coli, GI1786292, Length=193, Percent_Identity=28.4974093264249, Blast_Score=72, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17554944, Length=198, Percent_Identity=27.2727272727273, Blast_Score=83, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6320402, Length=206, Percent_Identity=26.6990291262136, Blast_Score=78, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24644728, Length=208, Percent_Identity=27.8846153846154, Blast_Score=87, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24658602, Length=166, Percent_Identity=29.5180722891566, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAE_RHILO (Q98DY2)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_105352.1
- ProteinModelPortal:   Q98DY2
- SMR:   Q98DY2
- GeneID:   1228013
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mlr4493
- NMPDR:   fig|266835.1.peg.3456
- HOGENOM:   HBG650290
- OMA:   ARPGMTE
- ProtClustDB:   PRK00081
- BRENDA:   2.7.1.24
- GO:   GO:0005737
- HAMAP:   MF_00376
- InterPro:   IPR001977
- TIGRFAMs:   TIGR00152

Pfam domain/function: PF01121 CoaE

EC number: =2.7.1.24

Molecular weight: Translated: 20785; Mature: 20785

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS51219 DPCK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVLGLTGSIGLGKSTTAKMFAEAGVPVHDSDEAVHRLYSGVAAPLVEAAFPGTVVDGVV
CEEEEECCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
DRAKLGARVLGDAAALKRLEAIIHPLVRADADAFLARHRTAGESIAVLDIPLLFETGGRG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEEEEEEEECCCCC
RVDKVVVVTAPAEVQRQRVLARPGMTEEKLAAILAKQVPDEEKRRLADFIIDTGQGLEAA
CCCEEEEEECCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHH
RAEVDAIIDELRGQRGS
HHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MIVLGLTGSIGLGKSTTAKMFAEAGVPVHDSDEAVHRLYSGVAAPLVEAAFPGTVVDGVV
CEEEEECCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
DRAKLGARVLGDAAALKRLEAIIHPLVRADADAFLARHRTAGESIAVLDIPLLFETGGRG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEEEEEEEECCCCC
RVDKVVVVTAPAEVQRQRVLARPGMTEEKLAAILAKQVPDEEKRRLADFIIDTGQGLEAA
CCCEEEEEECCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHH
RAEVDAIIDELRGQRGS
HHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968