Click here to switch to the map view.

The map label for this gene is rho [H]

Identifier: 13473778

GI number: 13473778

Start: 3569578

End: 3570834

Strand: Reverse

Name: rho [H]

Synonym: mll4485

Alternate gene names: 13473778

Gene position: 3570834-3569578 (Counterclockwise)

Preceding gene: 13473779

Following gene: 13473776

Centisome position: 50.75

GC content: 60.54

Gene sequence:

>1257_bases
ATGAAACTTACCGAATTCAAGAACAAGAAACCGCCAGAGCTGATCGCTTATGCCGAATCGCTCGAGGTCGAGAACGCCAG
CGTCATGCGCAAGCAGGAACTGATGTTCGCGATCCTGAAGAAGCTGGCCGCCCAGGACGTCGAGATCATCGGCGACGGCG
TGGTCGAGGTGCTTCAGGACGGTTTCGGCTTCCTGCGCTCGGCCAACGCCAACTATCTGCCAGGCCCCGACGACATCTAT
ATCTCGCCGTCGCAGATCCGGCGCTTTTCGCTGAAGACCGGCGATACGGTCGAAGGACCGATCCGCAGCCCGAAAGAGGG
CGAGCGCTATTTCGCGCTGCTCAAGGTCAACACCATCAATTTCGACGACCCCGAAAAGATCCGCCACAAGATCCATTTCG
ACAATCTGACGCCGCTCTATCCGACTTCGCGGCTGAAGATGGAAATGGAGGTTCCGACCTCCAAGGATATCTCGCCGCGC
GTCATCGACCTGGTGGCGCCGCTCGGCAAGGGCCAGCGCGCTTTGATTGTCGCGCAGCCGCGCACCGGTAAGACGGTGCT
GCTGCAGAACATCGCCCACTCCATCACCACCAATCACCCGGAATGCTATCTGATCGTGCTTCTGATCGACGAGCGGCCGG
AAGAAGTGACCGACATGCAGCGCTCGGTGAAGGGCGAGGTCGTCTCCTCGACCTTCGACGAACCGGCGGTGCGCCACGTC
CAGGTCGCCGAAATGGTCATCGAAAAGGCCAAGCGCCTGGTCGAACATGGCCGCGACGTCGTCATCCTGCTCGATTCCAT
CACCCGCCTCGGCCGCGCCTACAACACCGTCGTGCCGTCATCCGGCAAGGTGCTGACCGGCGGTGTCGACGCCAACGCGC
TGCAGCGCCCGAAGCGCTTCTTCGGTGCCGCGCGTAACATCGAGGAAGGCGGCTCGCTGACCATCATCGCCACCGCGCTG
ATCGATACCGGCAGCCGCATGGACGAAGTCATCTTCGAAGAGTTCAAGGGCACCGGCAATTCGGAAATCGTGCTCGACCG
CAAGGTCGCCGACAAGCGCATCTATCCGGCCATGGACATCCTCAAATCCGGCACCCGCAAGGAAGACCTGCTGGTGCCGC
GTCAGGATCTGCAGAAGATCTTCGTGCTGCGCCGCATCCTGGCGCCGATGGGAACCACCGACGCGATCGAGTTCCTCATC
GACAAGCTGAAGCAGACCAAGACCAATGCGGACTTCTTCGATTCGATGAATACGTAA

Upstream 100 bases:

>100_bases
TCATGCGCCGCCCCTCATTGTTTTCGGCCGCGCCCGGCATTTGTCGCATCCCGCCGATATTTTTCTCCCAAAGCTCACCC
AGAGTCCGTCTATGCAAGAA

Downstream 100 bases:

>100_bases
GGGCTTACCCTCCCCCTCGTGGGGAGGGTCGATCCGCGCAGCGGAGCGGGGTGGGGGTCAGCACTGAGGCTGGCGTTTCA
CACCCACCCCTTCTCCCGAT

Product: transcription termination factor Rho

Products: NA

Alternate protein names: ATP-dependent helicase Rho [H]

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MKLTEFKNKKPPELIAYAESLEVENASVMRKQELMFAILKKLAAQDVEIIGDGVVEVLQDGFGFLRSANANYLPGPDDIY
ISPSQIRRFSLKTGDTVEGPIRSPKEGERYFALLKVNTINFDDPEKIRHKIHFDNLTPLYPTSRLKMEMEVPTSKDISPR
VIDLVAPLGKGQRALIVAQPRTGKTVLLQNIAHSITTNHPECYLIVLLIDERPEEVTDMQRSVKGEVVSSTFDEPAVRHV
QVAEMVIEKAKRLVEHGRDVVILLDSITRLGRAYNTVVPSSGKVLTGGVDANALQRPKRFFGAARNIEEGGSLTIIATAL
IDTGSRMDEVIFEEFKGTGNSEIVLDRKVADKRIYPAMDILKSGTRKEDLLVPRQDLQKIFVLRRILAPMGTTDAIEFLI
DKLKQTKTNADFFDSMNT

Sequences:

>Translated_418_residues
MKLTEFKNKKPPELIAYAESLEVENASVMRKQELMFAILKKLAAQDVEIIGDGVVEVLQDGFGFLRSANANYLPGPDDIY
ISPSQIRRFSLKTGDTVEGPIRSPKEGERYFALLKVNTINFDDPEKIRHKIHFDNLTPLYPTSRLKMEMEVPTSKDISPR
VIDLVAPLGKGQRALIVAQPRTGKTVLLQNIAHSITTNHPECYLIVLLIDERPEEVTDMQRSVKGEVVSSTFDEPAVRHV
QVAEMVIEKAKRLVEHGRDVVILLDSITRLGRAYNTVVPSSGKVLTGGVDANALQRPKRFFGAARNIEEGGSLTIIATAL
IDTGSRMDEVIFEEFKGTGNSEIVLDRKVADKRIYPAMDILKSGTRKEDLLVPRQDLQKIFVLRRILAPMGTTDAIEFLI
DKLKQTKTNADFFDSMNT
>Mature_418_residues
MKLTEFKNKKPPELIAYAESLEVENASVMRKQELMFAILKKLAAQDVEIIGDGVVEVLQDGFGFLRSANANYLPGPDDIY
ISPSQIRRFSLKTGDTVEGPIRSPKEGERYFALLKVNTINFDDPEKIRHKIHFDNLTPLYPTSRLKMEMEVPTSKDISPR
VIDLVAPLGKGQRALIVAQPRTGKTVLLQNIAHSITTNHPECYLIVLLIDERPEEVTDMQRSVKGEVVSSTFDEPAVRHV
QVAEMVIEKAKRLVEHGRDVVILLDSITRLGRAYNTVVPSSGKVLTGGVDANALQRPKRFFGAARNIEEGGSLTIIATAL
IDTGSRMDEVIFEEFKGTGNSEIVLDRKVADKRIYPAMDILKSGTRKEDLLVPRQDLQKIFVLRRILAPMGTTDAIEFLI
DKLKQTKTNADFFDSMNT

Specific function: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template [H]

COG id: COG1158

COG function: function code K; Transcription termination factor

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Rho family [H]

Homologues:

Organism=Escherichia coli, GI1790217, Length=416, Percent_Identity=70.1923076923077, Blast_Score=613, Evalue=1e-177,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000194
- InterPro:   IPR003593
- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR011112
- InterPro:   IPR011113
- InterPro:   IPR004665 [H]

Pfam domain/function: PF00006 ATP-synt_ab; PF07498 Rho_N; PF07497 Rho_RNA_bind [H]

EC number: NA

Molecular weight: Translated: 46745; Mature: 46745

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLTEFKNKKPPELIAYAESLEVENASVMRKQELMFAILKKLAAQDVEIIGDGVVEVLQD
CCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
GFGFLRSANANYLPGPDDIYISPSQIRRFSLKTGDTVEGPIRSPKEGERYFALLKVNTIN
HHHHHHCCCCCCCCCCCCEEECHHHHHEEECCCCCCCCCCCCCCCCCCEEEEEEEEEEEC
FDDPEKIRHKIHFDNLTPLYPTSRLKMEMEVPTSKDISPRVIDLVAPLGKGQRALIVAQP
CCCHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHCCCCCCEEEEEECC
RTGKTVLLQNIAHSITTNHPECYLIVLLIDERPEEVTDMQRSVKGEVVSSTFDEPAVRHV
CCCCHHHHHHHHHHHCCCCCCEEEEEEEECCCCHHHHHHHHHHCCHHHHHCCCCHHHHHH
QVAEMVIEKAKRLVEHGRDVVILLDSITRLGRAYNTVVPSSGKVLTGGVDANALQRPKRF
HHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHH
FGAARNIEEGGSLTIIATALIDTGSRMDEVIFEEFKGTGNSEIVLDRKVADKRIYPAMDI
HHHHCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHCCCCCCEEEEECHHHCCHHHHHHHH
LKSGTRKEDLLVPRQDLQKIFVLRRILAPMGTTDAIEFLIDKLKQTKTNADFFDSMNT
HHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHCCCC
>Mature Secondary Structure
MKLTEFKNKKPPELIAYAESLEVENASVMRKQELMFAILKKLAAQDVEIIGDGVVEVLQD
CCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
GFGFLRSANANYLPGPDDIYISPSQIRRFSLKTGDTVEGPIRSPKEGERYFALLKVNTIN
HHHHHHCCCCCCCCCCCCEEECHHHHHEEECCCCCCCCCCCCCCCCCCEEEEEEEEEEEC
FDDPEKIRHKIHFDNLTPLYPTSRLKMEMEVPTSKDISPRVIDLVAPLGKGQRALIVAQP
CCCHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHCCCCCCEEEEEECC
RTGKTVLLQNIAHSITTNHPECYLIVLLIDERPEEVTDMQRSVKGEVVSSTFDEPAVRHV
CCCCHHHHHHHHHHHCCCCCCEEEEEEEECCCCHHHHHHHHHHCCHHHHHCCCCHHHHHH
QVAEMVIEKAKRLVEHGRDVVILLDSITRLGRAYNTVVPSSGKVLTGGVDANALQRPKRF
HHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHH
FGAARNIEEGGSLTIIATALIDTGSRMDEVIFEEFKGTGNSEIVLDRKVADKRIYPAMDI
HHHHCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHCCCCCCEEEEECHHHCCHHHHHHHH
LKSGTRKEDLLVPRQDLQKIFVLRRILAPMGTTDAIEFLIDKLKQTKTNADFFDSMNT
HHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8606169 [H]