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The map label for this gene is creC [H]

Identifier: 13473722

GI number: 13473722

Start: 3499484

End: 3500998

Strand: Reverse

Name: creC [H]

Synonym: mll4418

Alternate gene names: 13473722

Gene position: 3500998-3499484 (Counterclockwise)

Preceding gene: 13473723

Following gene: 13473721

Centisome position: 49.76

GC content: 67.06

Gene sequence:

>1515_bases
ATGGCGCTGCCTTTGGTCGGCCTGTTCTTCTTCCGCCTCTACGAGAACCAGCTGATCCGCCAGACCGAGGCGGAGCTGAT
CGCGCAAGGCGCGGCCATCGCCGCCATCTATGCGCAGGACGTGCGCGACGCCCACATTCCTCCGGAAAAACTTGGCGCGC
CGATGCCGCAGGCCAATGGCAGTGCCAGCCGCGCCGCCAATCCCGATGGACCGTACCGGCCGATCGAGCCGCGCCTCGAT
CTCGCTTCGGACACTGTGCTTCCGACCCGGCCGGCGGCGGTCGCCGCTACCGCCGATCCGGCCTTCGCCGCGATCGGCGT
GCGCCTGTCGGGCATTCTCGACGCGACGCAGAAAACCACGCTGGCCGGCTTCCGGCTGCTTGATCCCACAGGTGTCGTCA
TTGCCGGACGTGGCGAGGTCGGGCAGTCGCTTGGCGAGGTCGATGAGGTGCGCACGGCACTTGCCGGCCATTATGCCAGT
GCGCTCAGGCTGCGCATTCCCGACCAGCCGACGCCACCGCTCTATTCGGTCAGCCGCGGCACCAAGGTACGGGTCTTCGT
CGCCCTGCCGGTGGTCGTCGATGGCCGGGTCGTCGGCGTGGTCTATGTCTCGCGGACGCCCAACAACATCATCAAGCATC
TCTATGGCGAACGCGGCAAGGTGACCCTGGCGGCGATCGCCATCCTCGGCGGCACGCTGCTGATCGGCCTGGTGTTCCTG
CGCACCGTCAGCCGGCCGATCTATGCGCTGATCGACCGCACGCAACGCATCGCCGCCGGCGAACGTGACGCGATCCGGCC
GCTCGACCATCACGGCACCTATGAAATGGCCGAGCTGTCCGCCGCCTTCCTCGACATGGCGGAAAAGCTGCAGGCGCGAT
CGGATAGCATCCAGACTTTCGCCACCCATGTCTCGCACGAGCTCAAATCGCCGCTGACGGCGATCCAGGGCGCGGCCGAA
TTGCTGCGCGATTCCGGCAGCACGATGGATGATGAGGAGCGGCGGCGCTTCTCCAACAACATCGTCACCGACGCCGGACG
ACTCAATCTGCTGGTGCGGCGGCTGCTCGATCTGGCCAAGGCCGAAAATCTCGCACCGAGCGGCGAAAGCACCTCGATCG
GTGCCGCGCTGGCCCTGCTGCCCGCCGACACCAGGCTGGCGGTCCGCATCGAGGCGGGCGGCGATCTCGCCTTACGCATC
TCGGCCGAGAACGCGGCGATCGTGCTGGCCAATCTCATCGACAATTCCGTCAGGCATGGCGCGACGCTGGTTTCGATTAC
GGCGGCGAGCTCCGGCGGCAAGGCCACGCTGCTGGTCGGCGATGACGGCGCCGGCATTTCGCCGAGCAACCGGGCGCGCA
TCTTCGAGCCGTTCTTCACCACGCGGCGCTCGACCGGCGGCACAGGCATGGGGCTCGGTATCGTGCTGGCCCTCCTGAAA
GCGCATGATGGCATGATCCGGCTGGTTGACTCCGAGCGCGGCACGCGCTTCGAGATCACACTGCCGGCGGCATAG

Upstream 100 bases:

>100_bases
TCCGGCTCGGCCGATGCGGCTGAGCACGTCCAGCAAATGGATCGGCCGCAAATGGCGGCCAAGGCTTGCCACGGTCGTCG
TCGCCATCCTGATCATGGTG

Downstream 100 bases:

>100_bases
ACAGGCCGCCGGCTCGGATCGGAGAAAAAATGCGCTACGACATCGTCATCATCGGCGGGGCCATCGTCGGGTCCTCCATT
GCCTACTATCTGCGCGAGGA

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 504; Mature: 503

Protein sequence:

>504_residues
MALPLVGLFFFRLYENQLIRQTEAELIAQGAAIAAIYAQDVRDAHIPPEKLGAPMPQANGSASRAANPDGPYRPIEPRLD
LASDTVLPTRPAAVAATADPAFAAIGVRLSGILDATQKTTLAGFRLLDPTGVVIAGRGEVGQSLGEVDEVRTALAGHYAS
ALRLRIPDQPTPPLYSVSRGTKVRVFVALPVVVDGRVVGVVYVSRTPNNIIKHLYGERGKVTLAAIAILGGTLLIGLVFL
RTVSRPIYALIDRTQRIAAGERDAIRPLDHHGTYEMAELSAAFLDMAEKLQARSDSIQTFATHVSHELKSPLTAIQGAAE
LLRDSGSTMDDEERRRFSNNIVTDAGRLNLLVRRLLDLAKAENLAPSGESTSIGAALALLPADTRLAVRIEAGGDLALRI
SAENAAIVLANLIDNSVRHGATLVSITAASSGGKATLLVGDDGAGISPSNRARIFEPFFTTRRSTGGTGMGLGIVLALLK
AHDGMIRLVDSERGTRFEITLPAA

Sequences:

>Translated_504_residues
MALPLVGLFFFRLYENQLIRQTEAELIAQGAAIAAIYAQDVRDAHIPPEKLGAPMPQANGSASRAANPDGPYRPIEPRLD
LASDTVLPTRPAAVAATADPAFAAIGVRLSGILDATQKTTLAGFRLLDPTGVVIAGRGEVGQSLGEVDEVRTALAGHYAS
ALRLRIPDQPTPPLYSVSRGTKVRVFVALPVVVDGRVVGVVYVSRTPNNIIKHLYGERGKVTLAAIAILGGTLLIGLVFL
RTVSRPIYALIDRTQRIAAGERDAIRPLDHHGTYEMAELSAAFLDMAEKLQARSDSIQTFATHVSHELKSPLTAIQGAAE
LLRDSGSTMDDEERRRFSNNIVTDAGRLNLLVRRLLDLAKAENLAPSGESTSIGAALALLPADTRLAVRIEAGGDLALRI
SAENAAIVLANLIDNSVRHGATLVSITAASSGGKATLLVGDDGAGISPSNRARIFEPFFTTRRSTGGTGMGLGIVLALLK
AHDGMIRLVDSERGTRFEITLPAA
>Mature_503_residues
ALPLVGLFFFRLYENQLIRQTEAELIAQGAAIAAIYAQDVRDAHIPPEKLGAPMPQANGSASRAANPDGPYRPIEPRLDL
ASDTVLPTRPAAVAATADPAFAAIGVRLSGILDATQKTTLAGFRLLDPTGVVIAGRGEVGQSLGEVDEVRTALAGHYASA
LRLRIPDQPTPPLYSVSRGTKVRVFVALPVVVDGRVVGVVYVSRTPNNIIKHLYGERGKVTLAAIAILGGTLLIGLVFLR
TVSRPIYALIDRTQRIAAGERDAIRPLDHHGTYEMAELSAAFLDMAEKLQARSDSIQTFATHVSHELKSPLTAIQGAAEL
LRDSGSTMDDEERRRFSNNIVTDAGRLNLLVRRLLDLAKAENLAPSGESTSIGAALALLPADTRLAVRIEAGGDLALRIS
AENAAIVLANLIDNSVRHGATLVSITAASSGGKATLLVGDDGAGISPSNRARIFEPFFTTRRSTGGTGMGLGIVLALLKA
HDGMIRLVDSERGTRFEITLPAA

Specific function: Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. CreC may function as a membrane- associated protein kinase that phosphorylates CreB in response to environmental signals. CreC can also phosphorylate PhoB [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790861, Length=371, Percent_Identity=29.6495956873315, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1789808, Length=282, Percent_Identity=27.3049645390071, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1787894, Length=288, Percent_Identity=29.5138888888889, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1790346, Length=247, Percent_Identity=30.3643724696356, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1786783, Length=345, Percent_Identity=25.2173913043478, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1790436, Length=214, Percent_Identity=30.8411214953271, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI87082128, Length=313, Percent_Identity=27.1565495207668, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1788393, Length=322, Percent_Identity=26.0869565217391, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788549, Length=211, Percent_Identity=27.9620853080569, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1786600, Length=221, Percent_Identity=26.2443438914027, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI87081816, Length=337, Percent_Identity=25.5192878338279, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790551, Length=290, Percent_Identity=24.8275862068966, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1786912, Length=212, Percent_Identity=28.7735849056604, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 53346; Mature: 53215

Theoretical pI: Translated: 8.74; Mature: 8.74

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALPLVGLFFFRLYENQLIRQTEAELIAQGAAIAAIYAQDVRDAHIPPEKLGAPMPQANG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHCCCCCHHHHCCCCCCCCC
SASRAANPDGPYRPIEPRLDLASDTVLPTRPAAVAATADPAFAAIGVRLSGILDATQKTT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHH
LAGFRLLDPTGVVIAGRGEVGQSLGEVDEVRTALAGHYASALRLRIPDQPTPPLYSVSRG
HHCEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCEECCCC
TKVRVFVALPVVVDGRVVGVVYVSRTPNNIIKHLYGERGKVTLAAIAILGGTLLIGLVFL
CEEEEEEEEEEEECCEEEEEEEEECCCHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHH
RTVSRPIYALIDRTQRIAAGERDAIRPLDHHGTYEMAELSAAFLDMAEKLQARSDSIQTF
HHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATHVSHELKSPLTAIQGAAELLRDSGSTMDDEERRRFSNNIVTDAGRLNLLVRRLLDLAK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
AENLAPSGESTSIGAALALLPADTRLAVRIEAGGDLALRISAENAAIVLANLIDNSVRHG
HCCCCCCCCCCCCCEEEEEECCCCEEEEEEECCCCEEEEEECCCCEEEEEHHHHHHHHCC
ATLVSITAASSGGKATLLVGDDGAGISPSNRARIFEPFFTTRRSTGGTGMGLGIVLALLK
CEEEEEEEECCCCEEEEEECCCCCCCCCCCCCEEECHHHHHCCCCCCCCHHHHHHHHHHH
AHDGMIRLVDSERGTRFEITLPAA
HCCCEEEEEECCCCCEEEEEECCC
>Mature Secondary Structure 
ALPLVGLFFFRLYENQLIRQTEAELIAQGAAIAAIYAQDVRDAHIPPEKLGAPMPQANG
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHCCCCCHHHHCCCCCCCCC
SASRAANPDGPYRPIEPRLDLASDTVLPTRPAAVAATADPAFAAIGVRLSGILDATQKTT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHH
LAGFRLLDPTGVVIAGRGEVGQSLGEVDEVRTALAGHYASALRLRIPDQPTPPLYSVSRG
HHCEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCEECCCC
TKVRVFVALPVVVDGRVVGVVYVSRTPNNIIKHLYGERGKVTLAAIAILGGTLLIGLVFL
CEEEEEEEEEEEECCEEEEEEEEECCCHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHH
RTVSRPIYALIDRTQRIAAGERDAIRPLDHHGTYEMAELSAAFLDMAEKLQARSDSIQTF
HHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATHVSHELKSPLTAIQGAAELLRDSGSTMDDEERRRFSNNIVTDAGRLNLLVRRLLDLAK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
AENLAPSGESTSIGAALALLPADTRLAVRIEAGGDLALRISAENAAIVLANLIDNSVRHG
HCCCCCCCCCCCCCEEEEEECCCCEEEEEEECCCCEEEEEECCCCEEEEEHHHHHHHHCC
ATLVSITAASSGGKATLLVGDDGAGISPSNRARIFEPFFTTRRSTGGTGMGLGIVLALLK
CEEEEEEEECCCCEEEEEECCCCCCCCCCCCCEEECHHHHHCCCCCCCCHHHHHHHHHHH
AHDGMIRLVDSERGTRFEITLPAA
HCCCEEEEEECCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3531171; 7610040; 9278503; 2835585; 2228961 [H]