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The map label for this gene is lpd [H]

Identifier: 13473631

GI number: 13473631

Start: 3418851

End: 3420257

Strand: Reverse

Name: lpd [H]

Synonym: mll4296

Alternate gene names: 13473631

Gene position: 3420257-3418851 (Counterclockwise)

Preceding gene: 13473632

Following gene: 13473630

Centisome position: 48.61

GC content: 64.61

Gene sequence:

>1407_bases
ATGGCTTATGACGTCGTTATCATCGGATCGGGACCCGGCGGCTATGTCTGCGCCATCAAGGCGGCACAGCTCGACCTGAA
GGTCGCGGTGGTCGAAAAGAACGCGACCTTCGGCGGCACCTGCCTCAACATCGGCTGCATCCCGTCCAAGGCGCTGCTCC
ATGCCTCCGAAATGTTCGCCGAGGCCGGCCATTCCTTCGACACGCTGGGCGTCGAGATCCCGGCGCCGAAGCTCAATCTG
ACGAAGATGATGGCGCACAAGGATGCGACGGTGGCGTCCAACGTCAACGGCGTCGCCTTCCTGTTCAAGAAGAACAAGAT
CGACAGCTTCCGCGGCACCGGCAAGGTGGTGGCGGCCGGCAAGGTGTCGGTGACGGGCGAGGACGGCAAGGTCGAGGAGA
TCGAGACGAAGAACATCGTCATCGCCACCGGTTCCGATGTCGCCGGCATTCCCGGCGTCAAGGTCGACTTCGACGAGAAA
ATCATCGTGTCGTCGACCGGCGCGCTGTCGCTGGACAAGGTTCCGGGCCACCTGGTGGTGGTCGGTGGCGGCGTCATCGG
GCTCGAGCTCGGCTCGGTCTGGGCGCGGCTCGGCGCCAAGGTCACCGTGGTCGAGTTCCTCGACACGATCCTCGGCGGCA
TGGACGGCGAGGTCTCCAAGCAGTTCCAGAGGATGCTGTCGAAGCAGGGTTTCGAGTTCAAGCTCGGCGCCAAGGTCACC
GGCGTCGCCAAGGCCAAGAAAGGTGCAACCGTCACCTTCGAGCCGGTGAAGGGCGGCGCCGCCGAAACCATCGCGGCCGA
TGTCGTGCTGATCGCCACCGGGCGCCGTGCCTATGCCGACAGTCTCGGGTTGAAGGAAGCAGGCGTCGAGGTCGACGAGC
GCGGCCGCGTCAAGACCGACGGGCATCTCAAGACCAACGTCCCCGGCATCTACGCCATCGGCGATGTCATCGCCGGGCCG
ATGCTGGCGCACAAGGCCGAGGACGAGGGCGTGGCGGTGGCCGAAACCATCGCCGGCCAGGCCGGCCATGTGAACTATGA
GGTCATCCCGAGCGTCGTCTACACCAGCCCGGAAATCGCCTCGGTCGGCAAGACCGAGGAAGAGCTGAAGAAGGCCGGCA
TCGATTACAAGGTCGGCAAATTCCCGTTCAGCGCCAATGGCCGTGCGCGCGCCATGCTGCACACGGACGGTTTCGTGAAA
ATCCTCGCCGACAAGGCCAGCGACCGCGTGCTCGGCGTGCACATTGTCGGCTTCGGCGCCGGCGAGATGATCCACGAGGC
GGCGGTGCTGATGGAATTTGGCGGCTCGTCGGAAGACCTCGCCCGCACCTGCCACGCGCATCCGACGATGTCGGAAGCGG
TGAAGGAAGCGGCGCTGGCCACCTTCTTCAAGCCGATCCACATCTAA

Upstream 100 bases:

>100_bases
TCAGCGGCGGCCGCTGAGCGCTCATGCAGTTCGAGCATGATGTTATCCGAAAACCGCGTCACACTTTTCGGCATCATGCT
CAAAACAGAAGGACACTATC

Downstream 100 bases:

>100_bases
AGCACCAGCGCTTGGTCATCCTCGGGCAAGCCCGAAGATGACGAACCCGTAGCGCCATCATCCAAAGCAAAACGGCCCGC
CTTTCAGCGGGCCGTTCGTA

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes [H]

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MAYDVVIIGSGPGGYVCAIKAAQLDLKVAVVEKNATFGGTCLNIGCIPSKALLHASEMFAEAGHSFDTLGVEIPAPKLNL
TKMMAHKDATVASNVNGVAFLFKKNKIDSFRGTGKVVAAGKVSVTGEDGKVEEIETKNIVIATGSDVAGIPGVKVDFDEK
IIVSSTGALSLDKVPGHLVVVGGGVIGLELGSVWARLGAKVTVVEFLDTILGGMDGEVSKQFQRMLSKQGFEFKLGAKVT
GVAKAKKGATVTFEPVKGGAAETIAADVVLIATGRRAYADSLGLKEAGVEVDERGRVKTDGHLKTNVPGIYAIGDVIAGP
MLAHKAEDEGVAVAETIAGQAGHVNYEVIPSVVYTSPEIASVGKTEEELKKAGIDYKVGKFPFSANGRARAMLHTDGFVK
ILADKASDRVLGVHIVGFGAGEMIHEAAVLMEFGGSSEDLARTCHAHPTMSEAVKEAALATFFKPIHI

Sequences:

>Translated_468_residues
MAYDVVIIGSGPGGYVCAIKAAQLDLKVAVVEKNATFGGTCLNIGCIPSKALLHASEMFAEAGHSFDTLGVEIPAPKLNL
TKMMAHKDATVASNVNGVAFLFKKNKIDSFRGTGKVVAAGKVSVTGEDGKVEEIETKNIVIATGSDVAGIPGVKVDFDEK
IIVSSTGALSLDKVPGHLVVVGGGVIGLELGSVWARLGAKVTVVEFLDTILGGMDGEVSKQFQRMLSKQGFEFKLGAKVT
GVAKAKKGATVTFEPVKGGAAETIAADVVLIATGRRAYADSLGLKEAGVEVDERGRVKTDGHLKTNVPGIYAIGDVIAGP
MLAHKAEDEGVAVAETIAGQAGHVNYEVIPSVVYTSPEIASVGKTEEELKKAGIDYKVGKFPFSANGRARAMLHTDGFVK
ILADKASDRVLGVHIVGFGAGEMIHEAAVLMEFGGSSEDLARTCHAHPTMSEAVKEAALATFFKPIHI
>Mature_467_residues
AYDVVIIGSGPGGYVCAIKAAQLDLKVAVVEKNATFGGTCLNIGCIPSKALLHASEMFAEAGHSFDTLGVEIPAPKLNLT
KMMAHKDATVASNVNGVAFLFKKNKIDSFRGTGKVVAAGKVSVTGEDGKVEEIETKNIVIATGSDVAGIPGVKVDFDEKI
IVSSTGALSLDKVPGHLVVVGGGVIGLELGSVWARLGAKVTVVEFLDTILGGMDGEVSKQFQRMLSKQGFEFKLGAKVTG
VAKAKKGATVTFEPVKGGAAETIAADVVLIATGRRAYADSLGLKEAGVEVDERGRVKTDGHLKTNVPGIYAIGDVIAGPM
LAHKAEDEGVAVAETIAGQAGHVNYEVIPSVVYTSPEIASVGKTEEELKKAGIDYKVGKFPFSANGRARAMLHTDGFVKI
LADKASDRVLGVHIVGFGAGEMIHEAAVLMEFGGSSEDLARTCHAHPTMSEAVKEAALATFFKPIHI

Specific function: Lipoamide dehydrogenase is a component of the alpha- ketoacid dehydrogenase complexes [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=463, Percent_Identity=57.2354211663067, Blast_Score=527, Evalue=1e-149,
Organism=Homo sapiens, GI50301238, Length=467, Percent_Identity=29.5503211991435, Blast_Score=165, Evalue=7e-41,
Organism=Homo sapiens, GI22035672, Length=461, Percent_Identity=28.8503253796095, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI291045266, Length=474, Percent_Identity=28.6919831223629, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI33519430, Length=480, Percent_Identity=27.5, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI33519428, Length=480, Percent_Identity=27.5, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI33519426, Length=480, Percent_Identity=27.5, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI148277071, Length=480, Percent_Identity=27.5, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI148277065, Length=480, Percent_Identity=27.5, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI291045268, Length=468, Percent_Identity=27.5641025641026, Blast_Score=117, Evalue=3e-26,
Organism=Escherichia coli, GI1786307, Length=454, Percent_Identity=42.511013215859, Blast_Score=333, Evalue=9e-93,
Organism=Escherichia coli, GI87082354, Length=464, Percent_Identity=31.6810344827586, Blast_Score=227, Evalue=1e-60,
Organism=Escherichia coli, GI87081717, Length=467, Percent_Identity=30.406852248394, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI1789915, Length=440, Percent_Identity=30.2272727272727, Blast_Score=175, Evalue=5e-45,
Organism=Escherichia coli, GI1789065, Length=205, Percent_Identity=27.8048780487805, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI32565766, Length=460, Percent_Identity=55.4347826086957, Blast_Score=502, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI17557007, Length=472, Percent_Identity=28.3898305084746, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI71982272, Length=481, Percent_Identity=26.4033264033264, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI71983419, Length=451, Percent_Identity=25.4988913525499, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI71983429, Length=451, Percent_Identity=25.4988913525499, Blast_Score=99, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17559934, Length=264, Percent_Identity=25.3787878787879, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321091, Length=475, Percent_Identity=50.9473684210526, Blast_Score=453, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6325240, Length=476, Percent_Identity=33.1932773109244, Blast_Score=243, Evalue=4e-65,
Organism=Saccharomyces cerevisiae, GI6325166, Length=471, Percent_Identity=27.6008492569002, Blast_Score=155, Evalue=1e-38,
Organism=Drosophila melanogaster, GI21358499, Length=468, Percent_Identity=55.982905982906, Blast_Score=518, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24640553, Length=483, Percent_Identity=30.2277432712215, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24640549, Length=483, Percent_Identity=30.2277432712215, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24640551, Length=483, Percent_Identity=30.2277432712215, Blast_Score=149, Evalue=6e-36,
Organism=Drosophila melanogaster, GI17737741, Length=480, Percent_Identity=27.0833333333333, Blast_Score=125, Evalue=7e-29,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 48667; Mature: 48535

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYDVVIIGSGPGGYVCAIKAAQLDLKVAVVEKNATFGGTCLNIGCIPSKALLHASEMFA
CEEEEEEEECCCCCEEEEEEEEEEEEEEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHH
EAGHSFDTLGVEIPAPKLNLTKMMAHKDATVASNVNGVAFLFKKNKIDSFRGTGKVVAAG
HCCCCCCCCEEECCCCCCCHHHHHHHCCCHHHCCCCCEEEEEECCCCCCCCCCCEEEEEE
KVSVTGEDGKVEEIETKNIVIATGSDVAGIPGVKVDFDEKIIVSSTGALSLDKVPGHLVV
EEEEECCCCCEEEEECCEEEEECCCCCCCCCCEEECCCCEEEEECCCCEEECCCCCEEEE
VGGGVIGLELGSVWARLGAKVTVVEFLDTILGGMDGEVSKQFQRMLSKQGFEFKLGAKVT
EECCEEEEEHHHHHHHHCCCEEHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEECCEEE
GVAKAKKGATVTFEPVKGGAAETIAADVVLIATGRRAYADSLGLKEAGVEVDERGRVKTD
EEEECCCCCEEEEECCCCCCCHHHEEEEEEEECCCHHHHHHCCCHHCCCCCCCCCCEEEC
GHLKTNVPGIYAIGDVIAGPMLAHKAEDEGVAVAETIAGQAGHVNYEVIPSVVYTSPEIA
CEEECCCCCEEEEHHHHCCCHHHCCCCCCCCEEEHHHCCCCCCCCCEEECEEEECCCCHH
SVGKTEEELKKAGIDYKVGKFPFSANGRARAMLHTDGFVKILADKASDRVLGVHIVGFGA
HCCCCHHHHHHCCCCEEECCCCCCCCCCEEEEEECCCEEEEEECCCCCCEEEEEEEEECC
GEMIHEAAVLMEFGGSSEDLARTCHAHPTMSEAVKEAALATFFKPIHI
HHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AYDVVIIGSGPGGYVCAIKAAQLDLKVAVVEKNATFGGTCLNIGCIPSKALLHASEMFA
EEEEEEEECCCCCEEEEEEEEEEEEEEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHH
EAGHSFDTLGVEIPAPKLNLTKMMAHKDATVASNVNGVAFLFKKNKIDSFRGTGKVVAAG
HCCCCCCCCEEECCCCCCCHHHHHHHCCCHHHCCCCCEEEEEECCCCCCCCCCCEEEEEE
KVSVTGEDGKVEEIETKNIVIATGSDVAGIPGVKVDFDEKIIVSSTGALSLDKVPGHLVV
EEEEECCCCCEEEEECCEEEEECCCCCCCCCCEEECCCCEEEEECCCCEEECCCCCEEEE
VGGGVIGLELGSVWARLGAKVTVVEFLDTILGGMDGEVSKQFQRMLSKQGFEFKLGAKVT
EECCEEEEEHHHHHHHHCCCEEHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEECCEEE
GVAKAKKGATVTFEPVKGGAAETIAADVVLIATGRRAYADSLGLKEAGVEVDERGRVKTD
EEEECCCCCEEEEECCCCCCCHHHEEEEEEEECCCHHHHHHCCCHHCCCCCCCCCCEEEC
GHLKTNVPGIYAIGDVIAGPMLAHKAEDEGVAVAETIAGQAGHVNYEVIPSVVYTSPEIA
CEEECCCCCEEEEHHHHCCCHHHCCCCCCCCEEEHHHCCCCCCCCCEEECEEEECCCCHH
SVGKTEEELKKAGIDYKVGKFPFSANGRARAMLHTDGFVKILADKASDRVLGVHIVGFGA
HCCCCHHHHHHCCCCEEECCCCCCCCCCEEEEEECCCEEEEEECCCCCCEEEEEEEEECC
GEMIHEAAVLMEFGGSSEDLARTCHAHPTMSEAVKEAALATFFKPIHI
HHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9226266 [H]