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The map label for this gene is sdhA [H]

Identifier: 13473607

GI number: 13473607

Start: 3399189

End: 3400997

Strand: Reverse

Name: sdhA [H]

Synonym: mll4263

Alternate gene names: 13473607

Gene position: 3400997-3399189 (Counterclockwise)

Preceding gene: 13473608

Following gene: 13473606

Centisome position: 48.34

GC content: 66.17

Gene sequence:

>1809_bases
ATGGCAGGCTATAATTTTGTCGACCACAAATTCGATGTGGTGGTGGTCGGCGCCGGGGGTGCGGGCCTGCGTGCCACGCT
CGGCATGGCCGAACAGGGCCTGCGCACCGCCTGCATCACCAAAGTGTTCCCGACGCGCTCGCACACGGTGGCCGCGCAAG
GCGGCATTGCCGCTTCGCTGTCCAATATGGGTCCCGATTCCTGGCAGTGGCACATGTACGACACCGTCAAGGGGTCGGAC
TGGCTCGGCGATGTCGACGCCATGGAATATCTGGTGCGCGAAGCGCCGGCCGCGGTCTACGAGCTCGAGCACTATGGCGT
GCCGTTCTCGCGCACCGAAGAGGGCAAGATCTACCAGCGGCCGTTCGGCGGCCACATGATGAATTACGGCGAAGGCCCGC
CGGTGCAGCGCACCTGTGCCGCCGCCGACCGCACCGGCCACGCGATCCTGCACACGCTCTACGGCCAGTCGCTGAAGAAC
AACGCACAGTTCTTCATCGAGTATTTCGCCCTCGACCTGATCATGGAGCCGGATGGCACCTGCACCGGCGTCGTCGCCTG
GAACCTCGACGACGGCACCATCCACCGTTTCTCGGCCAAGATGGTGGTGCTGGCGACCGGCGGCTATGGCCGCGCCTATT
TCTCGGCCACCTCGGCGCACACCTGCACCGGCGACGGCGGCGGCATGGCGTCGCGGGCCGGTTTCCCGCTGCAGGACATG
GAATTCGTGCAGTTCCATCCGACCGGCATCTACGGCGCCGGCTGCCTGATCACCGAAGGCGCGCGCGGCGAGGGCGGCTA
TCTCGTCAATTCCGAGGGCGAGCGCTTCATGGAGCGCTATGCGCCGTCGGCCAAGGACCTTGCCTCGCGCGACGTCGTCT
CGCGCTGCATGACGCTGGAGATCCGCGAGGGTCGCGGCGTCGGCAAGAAGAAGGACCATATCTTCCTGCATCTCGACCAT
CTCGATCCGGCCGTGCTGCACGAGCGGCTGCCCGGCATTTCGGAATCGGCCAAGATCTTCGCCGGCGTCGACCTCACCAA
GGAGCCGATCCCGGTGCTGCCGACGGTGCACTACAATATGGGCGGCGTGCCGACCAACTACTGGGGCGAGGTGCTGAACC
CGACGACGCGCAGCCCCGACAAGGTGTCACCCGGGCTGATGGCGGTCGGCGAGGCCGGCTGCGCCTCGGTGCATGGCGCC
AACCGGCTGGGCTCGAACTCGCTGATCGATCTCGTCGTGTTCGGCCGCGCCGCGGCAATCCGCGCCGGCCAGGTCATCGA
CCGCAAATCGGCGATCCCGTCACCCAACGAAGCCTCGGTCGAGAAGATCATGGATCGCTTCGACGGGCTGCGCCACGCCA
ATGGCTCGACGCCGACGGCCGTGCTGCGCGAGAAGATGCAGAAGGCGATGCAGGAAGACGCCGCCGTGTTCCGCACGCAG
GAATCGCTGGAGAACGGCTGCAAGCGCATTTCGCAGATCTGGGGCGAGCTCAAGGACATCAAGGTGTTCGACCGCTCGAT
GATCTGGAACTCCGACCTGGTCGAGACGCTGGAGCTGGAAAACCTGATGGCCAACGCCATCACCACCGTCTATAGCGCCG
AGGCACGCAAGGAGAGCCGCGGCGCGCATGCCCGTGAAGACTTTTCCGCGCGCGACGACGCCGCCTGGCGCAAGCACACG
CTGGCCAGGGTGAGCGAAGACGGCAAGGTGACGCTCAGCTACCGGCCGGTGCACACCGAGCCGCTGCTGGCCGAGAAGGA
CGGCGGCATCAGCCTCGCCAAGATCGCGCCCAAGGCCAGGGTGTACTGA

Upstream 100 bases:

>100_bases
AACACATTTTTCACTGTAGCGGTCGGCGTCGCCTCGATCTTCGCCCTGCTCAAGCTGGCATTCGGAGGCTGAGTTGGCCA
AGGACGCGAAATCAGCCAAA

Downstream 100 bases:

>100_bases
CGATGGCGCCGGCGGCCACGGGATATTCCGGCAAGCCCCTTCCGGCCAAGCTCGGCCTGAGGGACGGCATGACTGCCGCT
TTCATCGCGCTGCCGCCGGA

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 602; Mature: 601

Protein sequence:

>602_residues
MAGYNFVDHKFDVVVVGAGGAGLRATLGMAEQGLRTACITKVFPTRSHTVAAQGGIAASLSNMGPDSWQWHMYDTVKGSD
WLGDVDAMEYLVREAPAAVYELEHYGVPFSRTEEGKIYQRPFGGHMMNYGEGPPVQRTCAAADRTGHAILHTLYGQSLKN
NAQFFIEYFALDLIMEPDGTCTGVVAWNLDDGTIHRFSAKMVVLATGGYGRAYFSATSAHTCTGDGGGMASRAGFPLQDM
EFVQFHPTGIYGAGCLITEGARGEGGYLVNSEGERFMERYAPSAKDLASRDVVSRCMTLEIREGRGVGKKKDHIFLHLDH
LDPAVLHERLPGISESAKIFAGVDLTKEPIPVLPTVHYNMGGVPTNYWGEVLNPTTRSPDKVSPGLMAVGEAGCASVHGA
NRLGSNSLIDLVVFGRAAAIRAGQVIDRKSAIPSPNEASVEKIMDRFDGLRHANGSTPTAVLREKMQKAMQEDAAVFRTQ
ESLENGCKRISQIWGELKDIKVFDRSMIWNSDLVETLELENLMANAITTVYSAEARKESRGAHAREDFSARDDAAWRKHT
LARVSEDGKVTLSYRPVHTEPLLAEKDGGISLAKIAPKARVY

Sequences:

>Translated_602_residues
MAGYNFVDHKFDVVVVGAGGAGLRATLGMAEQGLRTACITKVFPTRSHTVAAQGGIAASLSNMGPDSWQWHMYDTVKGSD
WLGDVDAMEYLVREAPAAVYELEHYGVPFSRTEEGKIYQRPFGGHMMNYGEGPPVQRTCAAADRTGHAILHTLYGQSLKN
NAQFFIEYFALDLIMEPDGTCTGVVAWNLDDGTIHRFSAKMVVLATGGYGRAYFSATSAHTCTGDGGGMASRAGFPLQDM
EFVQFHPTGIYGAGCLITEGARGEGGYLVNSEGERFMERYAPSAKDLASRDVVSRCMTLEIREGRGVGKKKDHIFLHLDH
LDPAVLHERLPGISESAKIFAGVDLTKEPIPVLPTVHYNMGGVPTNYWGEVLNPTTRSPDKVSPGLMAVGEAGCASVHGA
NRLGSNSLIDLVVFGRAAAIRAGQVIDRKSAIPSPNEASVEKIMDRFDGLRHANGSTPTAVLREKMQKAMQEDAAVFRTQ
ESLENGCKRISQIWGELKDIKVFDRSMIWNSDLVETLELENLMANAITTVYSAEARKESRGAHAREDFSARDDAAWRKHT
LARVSEDGKVTLSYRPVHTEPLLAEKDGGISLAKIAPKARVY
>Mature_601_residues
AGYNFVDHKFDVVVVGAGGAGLRATLGMAEQGLRTACITKVFPTRSHTVAAQGGIAASLSNMGPDSWQWHMYDTVKGSDW
LGDVDAMEYLVREAPAAVYELEHYGVPFSRTEEGKIYQRPFGGHMMNYGEGPPVQRTCAAADRTGHAILHTLYGQSLKNN
AQFFIEYFALDLIMEPDGTCTGVVAWNLDDGTIHRFSAKMVVLATGGYGRAYFSATSAHTCTGDGGGMASRAGFPLQDME
FVQFHPTGIYGAGCLITEGARGEGGYLVNSEGERFMERYAPSAKDLASRDVVSRCMTLEIREGRGVGKKKDHIFLHLDHL
DPAVLHERLPGISESAKIFAGVDLTKEPIPVLPTVHYNMGGVPTNYWGEVLNPTTRSPDKVSPGLMAVGEAGCASVHGAN
RLGSNSLIDLVVFGRAAAIRAGQVIDRKSAIPSPNEASVEKIMDRFDGLRHANGSTPTAVLREKMQKAMQEDAAVFRTQE
SLENGCKRISQIWGELKDIKVFDRSMIWNSDLVETLELENLMANAITTVYSAEARKESRGAHAREDFSARDDAAWRKHTL
ARVSEDGKVTLSYRPVHTEPLLAEKDGGISLAKIAPKARVY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=621, Percent_Identity=62.6409017713366, Blast_Score=747, Evalue=0.0,
Organism=Escherichia coli, GI1786942, Length=594, Percent_Identity=52.020202020202, Blast_Score=560, Evalue=1e-160,
Organism=Escherichia coli, GI1790597, Length=587, Percent_Identity=41.396933560477, Blast_Score=397, Evalue=1e-111,
Organism=Escherichia coli, GI1788928, Length=557, Percent_Identity=32.3159784560144, Blast_Score=213, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17550100, Length=621, Percent_Identity=61.1916264090177, Blast_Score=730, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505833, Length=619, Percent_Identity=59.4507269789984, Blast_Score=706, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322701, Length=602, Percent_Identity=64.1196013289037, Blast_Score=767, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322416, Length=607, Percent_Identity=63.0971993410214, Blast_Score=757, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6320788, Length=488, Percent_Identity=26.4344262295082, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17137288, Length=617, Percent_Identity=62.5607779578606, Blast_Score=759, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655642, Length=617, Percent_Identity=62.5607779578606, Blast_Score=759, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655647, Length=617, Percent_Identity=62.5607779578606, Blast_Score=759, Evalue=0.0,
Organism=Drosophila melanogaster, GI24663005, Length=619, Percent_Identity=55.2504038772213, Blast_Score=689, Evalue=0.0,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 65493; Mature: 65362

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGYNFVDHKFDVVVVGAGGAGLRATLGMAEQGLRTACITKVFPTRSHTVAAQGGIAASL
CCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCHHHHHHHHHCCCCCCEEEECCCCHHHH
SNMGPDSWQWHMYDTVKGSDWLGDVDAMEYLVREAPAAVYELEHYGVPFSRTEEGKIYQR
HCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHCCHHHEEHHHCCCCCCCCCCCCEEEC
PFGGHMMNYGEGPPVQRTCAAADRTGHAILHTLYGQSLKNNAQFFIEYFALDLIMEPDGT
CCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHEEHHHEEECCCCC
CTGVVAWNLDDGTIHRFSAKMVVLATGGYGRAYFSATSAHTCTGDGGGMASRAGFPLQDM
EEEEEEEECCCCCEEEEEEEEEEEEECCCCEEEEECCCCCEECCCCCCCCCCCCCCCCCC
EFVQFHPTGIYGAGCLITEGARGEGGYLVNSEGERFMERYAPSAKDLASRDVVSRCMTLE
CEEEECCCCEEECCEEEECCCCCCCCEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHEEE
IREGRGVGKKKDHIFLHLDHLDPAVLHERLPGISESAKIFAGVDLTKEPIPVLPTVHYNM
EECCCCCCCCCCEEEEEECCCCHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCEEECCC
GGVPTNYWGEVLNPTTRSPDKVSPGLMAVGEAGCASVHGANRLGSNSLIDLVVFGRAAAI
CCCCCHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCEEEEEECCCHHHH
RAGQVIDRKSAIPSPNEASVEKIMDRFDGLRHANGSTPTAVLREKMQKAMQEDAAVFRTQ
HHCCHHHHHCCCCCCCHHHHHHHHHHHCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ESLENGCKRISQIWGELKDIKVFDRSMIWNSDLVETLELENLMANAITTVYSAEARKESR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GAHAREDFSARDDAAWRKHTLARVSEDGKVTLSYRPVHTEPLLAEKDGGISLAKIAPKAR
CCCCHHCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCEEECCCCEEEEEECCCCC
VY
CC
>Mature Secondary Structure 
AGYNFVDHKFDVVVVGAGGAGLRATLGMAEQGLRTACITKVFPTRSHTVAAQGGIAASL
CCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCHHHHHHHHHCCCCCCEEEECCCCHHHH
SNMGPDSWQWHMYDTVKGSDWLGDVDAMEYLVREAPAAVYELEHYGVPFSRTEEGKIYQR
HCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHCCHHHEEHHHCCCCCCCCCCCCEEEC
PFGGHMMNYGEGPPVQRTCAAADRTGHAILHTLYGQSLKNNAQFFIEYFALDLIMEPDGT
CCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHEEHHHEEECCCCC
CTGVVAWNLDDGTIHRFSAKMVVLATGGYGRAYFSATSAHTCTGDGGGMASRAGFPLQDM
EEEEEEEECCCCCEEEEEEEEEEEEECCCCEEEEECCCCCEECCCCCCCCCCCCCCCCCC
EFVQFHPTGIYGAGCLITEGARGEGGYLVNSEGERFMERYAPSAKDLASRDVVSRCMTLE
CEEEECCCCEEECCEEEECCCCCCCCEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHEEE
IREGRGVGKKKDHIFLHLDHLDPAVLHERLPGISESAKIFAGVDLTKEPIPVLPTVHYNM
EECCCCCCCCCCEEEEEECCCCHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCEEECCC
GGVPTNYWGEVLNPTTRSPDKVSPGLMAVGEAGCASVHGANRLGSNSLIDLVVFGRAAAI
CCCCCHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCEEEEEECCCHHHH
RAGQVIDRKSAIPSPNEASVEKIMDRFDGLRHANGSTPTAVLREKMQKAMQEDAAVFRTQ
HHCCHHHHHCCCCCCCHHHHHHHHHHHCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ESLENGCKRISQIWGELKDIKVFDRSMIWNSDLVETLELENLMANAITTVYSAEARKESR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GAHAREDFSARDDAAWRKHTLARVSEDGKVTLSYRPVHTEPLLAEKDGGISLAKIAPKAR
CCCCHHCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCEEECCCCEEEEEECCCCC
VY
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA