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The map label for this gene is gpsA

Identifier: 13473579

GI number: 13473579

Start: 3375501

End: 3376532

Strand: Direct

Name: gpsA

Synonym: mlr4225

Alternate gene names: 13473579

Gene position: 3375501-3376532 (Clockwise)

Preceding gene: 13473578

Following gene: 13473580

Centisome position: 47.97

GC content: 69.19

Gene sequence:

>1032_bases
ATGACAGGTGAAGCGGTGAGCGGCCAAGACGTCAGCAATCCCGGCAAAAGCAGCTGGCGTGTCACCGTGCTGGGCGGCGG
CGCCTGGGGCACGGCGCTGGCGCTGGCCATGCTGCGCGCCGGCCATAAGGTGCGGCTGTTCGCGCGCGATCCGCAAACCG
TGGCCGCGATCGGCCAAGGCCAGAATCCGCGCTATCTGCCCGGCATCGCCATTGCGCCCGGCATCGAGGCGACATCGGAC
ATTGCGGCAGCGCTCTCCGGCGCCGATTGCGTGCTGGCGGTGACGCCGGCGCAATCGCTGCGGGCGACGCTGGCTGTGGC
GAAGGACAATATGCCGGACGGCATCCCGCTTGTCCTCTGCGCCAAGGGCATCGAGCGCGACACCGGCGCCTTGCTGTCGG
CAATTGTCGAGGAAATCCTGCCGCGAAATCCGGTTGCCGCACTGTCGGGCCCGAGCTTCGCCACCGATGTCGCCCGCGGC
CTGCCGACGGCGGTCGTTGTCGCCGCCCGTGACGAGGCGCTAGCAGCTGACCTTGCCGCTCGCTTTTCCGCGCAAAACCT
GCGTTGCTATTCAAGCGACGACCTGATCGGCGTCGAGATCGGCGGCGCCTTGAAGAATGTCTTTGCCATCGCCGCGGGCG
CCGTCACCGGCGCCGGACTTGGCGCCAGTGCCCAGGCCGCCATGGTGACGCGCGGCTTCGTCGAACTGCGCCGCATCGGT
GCCGCCTTCGGCGCCAGGCCCGAGACTCTGATGGGGCTTTCCGGCCTTGGCGACCTGCTGCTGACCTGCTCGTCCGCCCA
ATCGCGCAACTTCGCCTACGGGCTGACGCTCGGGCAAGGAAAGGCGCTTGCTGGCCTGCCGCTGGCCGAGGGCGTGCCGA
CGGCGGCGATCGCCGCCCGCATCGCCGTCGAGCGCGGCATCGACGCGCCGATCATCGCCGCCGTGGCGGCCATACTGGAC
GGCGCCATCACCATCAGCCAGGCCGTGACCGCCTTGATGACCCGGCCGCTGAAGACCGAAACCAACGATTGA

Upstream 100 bases:

>100_bases
TGGCGCAGGAGAACGGCTTCGATTTCGTGCCGCGCTCGCGCTGGCCGCTGGACAGCATCTCGGCGCCGATGGTCGGTTCC
GGCCGGCGCGGAGCCAAGGC

Downstream 100 bases:

>100_bases
TCCCCCAACTTCAACCCCCCAACTTCAATCCCAACGACCAGGAGAAAGACCATGCTGTTTGCTTTTGTTTGCAAGGACAA
GCCGGGAAGCCTGCAGGTGC

Product: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Products: NA

Alternate protein names: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Number of amino acids: Translated: 343; Mature: 342

Protein sequence:

>343_residues
MTGEAVSGQDVSNPGKSSWRVTVLGGGAWGTALALAMLRAGHKVRLFARDPQTVAAIGQGQNPRYLPGIAIAPGIEATSD
IAAALSGADCVLAVTPAQSLRATLAVAKDNMPDGIPLVLCAKGIERDTGALLSAIVEEILPRNPVAALSGPSFATDVARG
LPTAVVVAARDEALAADLAARFSAQNLRCYSSDDLIGVEIGGALKNVFAIAAGAVTGAGLGASAQAAMVTRGFVELRRIG
AAFGARPETLMGLSGLGDLLLTCSSAQSRNFAYGLTLGQGKALAGLPLAEGVPTAAIAARIAVERGIDAPIIAAVAAILD
GAITISQAVTALMTRPLKTETND

Sequences:

>Translated_343_residues
MTGEAVSGQDVSNPGKSSWRVTVLGGGAWGTALALAMLRAGHKVRLFARDPQTVAAIGQGQNPRYLPGIAIAPGIEATSD
IAAALSGADCVLAVTPAQSLRATLAVAKDNMPDGIPLVLCAKGIERDTGALLSAIVEEILPRNPVAALSGPSFATDVARG
LPTAVVVAARDEALAADLAARFSAQNLRCYSSDDLIGVEIGGALKNVFAIAAGAVTGAGLGASAQAAMVTRGFVELRRIG
AAFGARPETLMGLSGLGDLLLTCSSAQSRNFAYGLTLGQGKALAGLPLAEGVPTAAIAARIAVERGIDAPIIAAVAAILD
GAITISQAVTALMTRPLKTETND
>Mature_342_residues
TGEAVSGQDVSNPGKSSWRVTVLGGGAWGTALALAMLRAGHKVRLFARDPQTVAAIGQGQNPRYLPGIAIAPGIEATSDI
AAALSGADCVLAVTPAQSLRATLAVAKDNMPDGIPLVLCAKGIERDTGALLSAIVEEILPRNPVAALSGPSFATDVARGL
PTAVVVAARDEALAADLAARFSAQNLRCYSSDDLIGVEIGGALKNVFAIAAGAVTGAGLGASAQAAMVTRGFVELRRIGA
AFGARPETLMGLSGLGDLLLTCSSAQSRNFAYGLTLGQGKALAGLPLAEGVPTAAIAARIAVERGIDAPIIAAVAAILDG
AITISQAVTALMTRPLKTETND

Specific function: De novo phospholipid biosynthesis; glycerol-3 phosphate formation. [C]

COG id: COG0240

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI33695088, Length=352, Percent_Identity=25.2840909090909, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI24307999, Length=350, Percent_Identity=25.1428571428571, Blast_Score=84, Evalue=1e-16,
Organism=Escherichia coli, GI1790037, Length=328, Percent_Identity=38.4146341463415, Blast_Score=218, Evalue=5e-58,
Organism=Caenorhabditis elegans, GI32564399, Length=351, Percent_Identity=25.3561253561254, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI193210136, Length=361, Percent_Identity=25.207756232687, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI32564403, Length=358, Percent_Identity=25.1396648044693, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17507425, Length=366, Percent_Identity=24.0437158469945, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI193210134, Length=218, Percent_Identity=28.4403669724771, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6320181, Length=279, Percent_Identity=30.1075268817204, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324513, Length=277, Percent_Identity=29.2418772563177, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI17136200, Length=353, Percent_Identity=26.0623229461756, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI17136204, Length=348, Percent_Identity=26.1494252873563, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17136202, Length=348, Percent_Identity=26.1494252873563, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI22026922, Length=355, Percent_Identity=23.943661971831, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI281362270, Length=336, Percent_Identity=23.8095238095238, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI45551945, Length=320, Percent_Identity=23.4375, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24648969, Length=267, Percent_Identity=24.3445692883895, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GPDA_RHILO (P58142)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_105147.1
- ProteinModelPortal:   P58142
- SMR:   P58142
- GeneID:   1227808
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mlr4225
- NMPDR:   fig|266835.1.peg.3251
- HOGENOM:   HBG586392
- OMA:   ALVACCK
- ProtClustDB:   PRK00094
- BRENDA:   1.1.1.94
- HAMAP:   MF_00394
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR006168
- InterPro:   IPR006109
- InterPro:   IPR011128
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR11728
- PIRSF:   PIRSF000114
- PRINTS:   PR00077

Pfam domain/function: PF07479 NAD_Gly3P_dh_C; PF01210 NAD_Gly3P_dh_N; SSF48179 6DGDH_C_like

EC number: =1.1.1.94

Molecular weight: Translated: 34438; Mature: 34307

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00957 NAD_G3PDH

Important sites: ACT_SITE 205-205 BINDING 122-122 BINDING 122-122 BINDING 154-154 BINDING 269-269 BINDING 290-290

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGEAVSGQDVSNPGKSSWRVTVLGGGAWGTALALAMLRAGHKVRLFARDPQTVAAIGQG
CCCCCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHCCCEEEEEECCCCEEEEECCC
QNPRYLPGIAIAPGIEATSDIAAALSGADCVLAVTPAQSLRATLAVAKDNMPDGIPLVLC
CCCCCCCCEEECCCCCCHHHHHHHHCCCCEEEEECCHHHHHHHHHHHCCCCCCCCEEEEE
AKGIERDTGALLSAIVEEILPRNPVAALSGPSFATDVARGLPTAVVVAARDEALAADLAA
ECCCCCHHHHHHHHHHHHHCCCCCCEECCCCCHHHHHHHCCCCEEEEEECCHHHHHHHHH
RFSAQNLRCYSSDDLIGVEIGGALKNVFAIAAGAVTGAGLGASAQAAMVTRGFVELRRIG
HHCCCCCEEECCCCEEEEEECHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
AAFGARPETLMGLSGLGDLLLTCSSAQSRNFAYGLTLGQGKALAGLPLAEGVPTAAIAAR
HHHCCCCHHHHCHHHHHHHHEEECCCCCCCEEEEEEECCCCCEECCCCCCCCCHHHHHHH
IAVERGIDAPIIAAVAAILDGAITISQAVTALMTRPLKTETND
HHHHCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TGEAVSGQDVSNPGKSSWRVTVLGGGAWGTALALAMLRAGHKVRLFARDPQTVAAIGQG
CCCCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHCCCEEEEEECCCCEEEEECCC
QNPRYLPGIAIAPGIEATSDIAAALSGADCVLAVTPAQSLRATLAVAKDNMPDGIPLVLC
CCCCCCCCEEECCCCCCHHHHHHHHCCCCEEEEECCHHHHHHHHHHHCCCCCCCCEEEEE
AKGIERDTGALLSAIVEEILPRNPVAALSGPSFATDVARGLPTAVVVAARDEALAADLAA
ECCCCCHHHHHHHHHHHHHCCCCCCEECCCCCHHHHHHHCCCCEEEEEECCHHHHHHHHH
RFSAQNLRCYSSDDLIGVEIGGALKNVFAIAAGAVTGAGLGASAQAAMVTRGFVELRRIG
HHCCCCCEEECCCCEEEEEECHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
AAFGARPETLMGLSGLGDLLLTCSSAQSRNFAYGLTLGQGKALAGLPLAEGVPTAAIAAR
HHHCCCCHHHHCHHHHHHHHEEECCCCCCCEEEEEEECCCCCEECCCCCCCCCHHHHHHH
IAVERGIDAPIIAAVAAILDGAITISQAVTALMTRPLKTETND
HHHHCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968