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The map label for this gene is yqeC [H]

Identifier: 13473563

GI number: 13473563

Start: 3360710

End: 3361726

Strand: Direct

Name: yqeC [H]

Synonym: mlr4206

Alternate gene names: 13473563

Gene position: 3360710-3361726 (Clockwise)

Preceding gene: 13473562

Following gene: 13473564

Centisome position: 47.76

GC content: 66.27

Gene sequence:

>1017_bases
ATGCAGATCGGAATGATGGGACTGGGCCGGATGGGCGCCAACATGGTGCGGCGCCTGATGCGAGACGGCCATGAATGCGT
CGTCTACGACATCAACCCGGCAAGCGTCGCGGCTCTGGTCAGCGACGGCGCGCTCGGCGCGGCCTCCCTGACGGAATTCG
TCGGCAAGCTCGCCAAGCCGCGCTGTGTCTGGCTGATGCTGCCGGCGGCGATCACCGGCAAGATTATCGATCAGGTCTCG
GCCCTGATGGAACCCGGCGACATCGTCATCGACGGCGGCAATTCCTACTATCACGACGCCGTCAACCAGGCGGCCAAACT
GGCCGCCAAGGGCATCCATCTTGTCGATGTTGGCACCAGCGGCGGTGTCTGGGGCCTGGAGCGCGGCTACTGCCTGATGA
TCGGCGGTCCCGACGTAGCGGTGCAGCACCTCGATTCGATCTTCGCCACGCTAGCGCCCGGCGCCGATGCCGGCGCGCCG
GCTCCCGACAAGGCCGCCGGAACCGCGCCCTTCGGCTACCTGCATTGCGGGCCGAGCGGCGCCGGCCATTTCGTCAAGAT
GGTGCACAACGGCATCGAGTATGGCGTCATGGCCGCCTATGCCGAAGGCATGAACATCTTGAAGTCGGCCAATGCCGGCA
AGCGGCAACGCACGGCCGACGCCGAGACCAGCCCGCTGGAAAACCCGCAATATTATCAGTTCGACATCGACCTCCCGCAG
GTGGCCGAGGTCTGGCGGCATGGCAGCGTCATCGGCTCCTGGCTGCTCGATCTCACCGCCGGCGCGCTGAAGAGCGATCC
GGGCCTGGCCCAGTTCGGCGGCCGCGTCTCGGATTCCGGCGAAGGACGCTGGACGCTGAAGGCGGCGATCGACACCGGCG
TGCCGGCGCCGGTGCTGTCCTCGGCGCTGTTCGACCGCTTCTCCTCGCAAGGCGAATCCGAATTCGCCGACAAGCTGTTG
TCCGCCATGCGCTATGCCTTCGGCGGCCATGTCGAAAAGCCGAAGGCCGGCAAGTGA

Upstream 100 bases:

>100_bases
TGGGAGAATGTCGACTTCTCCGTCACATCAGGCGAGCGGGATAGCGGCTAACATCCTTCCTCGATATATCAAGACAATCT
CTAGGAAACAGGACGAAACC

Downstream 100 bases:

>100_bases
CGCCACAGCGGGAGACGCACGCATGAGCCAGGAACGGTCCGACACGCTGGTGCTCTTCGGCGCCACCGGCGACCTCGCCC
ACAAGAAGATATTTCCGGCG

Product: 6-phosphogluconate dehydrogenase-like protein

Products: D-ribulose 5-phosphate; CO2; NADPH

Alternate protein names: NA

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MQIGMMGLGRMGANMVRRLMRDGHECVVYDINPASVAALVSDGALGAASLTEFVGKLAKPRCVWLMLPAAITGKIIDQVS
ALMEPGDIVIDGGNSYYHDAVNQAAKLAAKGIHLVDVGTSGGVWGLERGYCLMIGGPDVAVQHLDSIFATLAPGADAGAP
APDKAAGTAPFGYLHCGPSGAGHFVKMVHNGIEYGVMAAYAEGMNILKSANAGKRQRTADAETSPLENPQYYQFDIDLPQ
VAEVWRHGSVIGSWLLDLTAGALKSDPGLAQFGGRVSDSGEGRWTLKAAIDTGVPAPVLSSALFDRFSSQGESEFADKLL
SAMRYAFGGHVEKPKAGK

Sequences:

>Translated_338_residues
MQIGMMGLGRMGANMVRRLMRDGHECVVYDINPASVAALVSDGALGAASLTEFVGKLAKPRCVWLMLPAAITGKIIDQVS
ALMEPGDIVIDGGNSYYHDAVNQAAKLAAKGIHLVDVGTSGGVWGLERGYCLMIGGPDVAVQHLDSIFATLAPGADAGAP
APDKAAGTAPFGYLHCGPSGAGHFVKMVHNGIEYGVMAAYAEGMNILKSANAGKRQRTADAETSPLENPQYYQFDIDLPQ
VAEVWRHGSVIGSWLLDLTAGALKSDPGLAQFGGRVSDSGEGRWTLKAAIDTGVPAPVLSSALFDRFSSQGESEFADKLL
SAMRYAFGGHVEKPKAGK
>Mature_338_residues
MQIGMMGLGRMGANMVRRLMRDGHECVVYDINPASVAALVSDGALGAASLTEFVGKLAKPRCVWLMLPAAITGKIIDQVS
ALMEPGDIVIDGGNSYYHDAVNQAAKLAAKGIHLVDVGTSGGVWGLERGYCLMIGGPDVAVQHLDSIFATLAPGADAGAP
APDKAAGTAPFGYLHCGPSGAGHFVKMVHNGIEYGVMAAYAEGMNILKSANAGKRQRTADAETSPLENPQYYQFDIDLPQ
VAEVWRHGSVIGSWLLDLTAGALKSDPGLAQFGGRVSDSGEGRWTLKAAIDTGVPAPVLSSALFDRFSSQGESEFADKLL
SAMRYAFGGHVEKPKAGK

Specific function: May act as NAD-dependent 6-P-gluconate dehydrogenase [H]

COG id: COG1023

COG function: function code G; Predicted 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=341, Percent_Identity=32.258064516129, Blast_Score=132, Evalue=5e-31,
Organism=Escherichia coli, GI1788341, Length=318, Percent_Identity=28.9308176100629, Blast_Score=136, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17542558, Length=326, Percent_Identity=32.5153374233129, Blast_Score=141, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6321695, Length=332, Percent_Identity=32.2289156626506, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6321977, Length=323, Percent_Identity=32.1981424148607, Blast_Score=139, Evalue=8e-34,
Organism=Drosophila melanogaster, GI24639279, Length=322, Percent_Identity=32.6086956521739, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24655230, Length=209, Percent_Identity=28.7081339712919, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI19922568, Length=209, Percent_Identity=28.7081339712919, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR004849
- InterPro:   IPR006114
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: 1.1.1.44

Molecular weight: Translated: 35376; Mature: 35376

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIGMMGLGRMGANMVRRLMRDGHECVVYDINPASVAALVSDGALGAASLTEFVGKLAKP
CCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHCCCCCHHHHHHHHHHHCCC
RCVWLMLPAAITGKIIDQVSALMEPGDIVIDGGNSYYHDAVNQAAKLAAKGIHLVDVGTS
CEEEEEECHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHCCEEEEEECCC
GGVWGLERGYCLMIGGPDVAVQHLDSIFATLAPGADAGAPAPDKAAGTAPFGYLHCGPSG
CCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCC
AGHFVKMVHNGIEYGVMAAYAEGMNILKSANAGKRQRTADAETSPLENPQYYQFDIDLPQ
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCCCCCEEEEECCCHH
VAEVWRHGSVIGSWLLDLTAGALKSDPGLAQFGGRVSDSGEGRWTLKAAIDTGVPAPVLS
HHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCEEEEEEECCCCCHHHHH
SALFDRFSSQGESEFADKLLSAMRYAFGGHVEKPKAGK
HHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MQIGMMGLGRMGANMVRRLMRDGHECVVYDINPASVAALVSDGALGAASLTEFVGKLAKP
CCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHCCCCCHHHHHHHHHHHCCC
RCVWLMLPAAITGKIIDQVSALMEPGDIVIDGGNSYYHDAVNQAAKLAAKGIHLVDVGTS
CEEEEEECHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHCCEEEEEECCC
GGVWGLERGYCLMIGGPDVAVQHLDSIFATLAPGADAGAPAPDKAAGTAPFGYLHCGPSG
CCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCC
AGHFVKMVHNGIEYGVMAAYAEGMNILKSANAGKRQRTADAETSPLENPQYYQFDIDLPQ
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCCCCCEEEEECCCHH
VAEVWRHGSVIGSWLLDLTAGALKSDPGLAQFGGRVSDSGEGRWTLKAAIDTGVPAPVLS
HHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCEEEEEEECCCCCHHHHH
SALFDRFSSQGESEFADKLLSAMRYAFGGHVEKPKAGK
HHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.05 {6-phosphogluconate}} 0.01 {6-phosphogluconate}} [C]

Substrates: 6-phospho-D-gluconate; NADP+

Specific reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]